CN101810814A - Medicament for curing cerebral palsy, hyperkinetic syndrome and dementia and preparation method thereof - Google Patents
Medicament for curing cerebral palsy, hyperkinetic syndrome and dementia and preparation method thereof Download PDFInfo
- Publication number
- CN101810814A CN101810814A CN201010161857A CN201010161857A CN101810814A CN 101810814 A CN101810814 A CN 101810814A CN 201010161857 A CN201010161857 A CN 201010161857A CN 201010161857 A CN201010161857 A CN 201010161857A CN 101810814 A CN101810814 A CN 101810814A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- cerebral palsy
- medicament
- hyperkinetic syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicament for curing cerebral palsy, hyperkinetic syndrome and dementia and a preparation method thereof. The preparation method for the medicament of the invention comprises the following steps: extracting volatile oil from grassleaf sweelflag rhizome and sharpleaf galangal fruit by a steam distillation method, filtering aqueous solution and storing the obtained product in the container for later use; grinding ginseng and Chinese caterpillar fungus into fine powder and filing and grinding hairy antler into fine powder; decocting the rest ten gouts of medicaments such as processed tuber fleeceflower root and dregs of grassleaf sweelflag rhizome and sharpleaf galangal fruit by using 30 percent ethanol for two times and filtering decoction solution; mixing the filtrate, standing and filtering the mixture, performing concentration on the filtrate under reduced pressure to form thick paste, adding the fine powder of ginseng, Chinese caterpillar fungus and hairy antler into the thick paste, uniformly mixing the mixture, pelletizing, drying and cooling the obtained product sequentially, uniformly spraying the volatile oil into the obtained product and filling the product into capsules to obtain the medicament of the invention. The medicament of the invention has the effects of strengthening the spleen, tonifying the kidney, benefiting brain and inducing resuscitation and is mainly used for curing cerebral palsy, amentia, hyperkinetic syndrome, cerebral dysplasia, encephalatrophy, senile dementia and the like. The medicament has the advantages of simple preparation process, convenient production process and exact curative effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, is a kind of Chinese medicine composition for the treatment of cerebral palsy, hyperkinetic syndrome and dementia and preparation method thereof specifically.
Background technology
Cerebral palsy is the diseases that can't treat In the view of common people, at first be that the treatment medicine is few, only can see two kinds of medicines of ganglioside and cerebrolysin in the market, and these two kinds of medicines cost an arm and a leg not only, and be to use before 3 years old some effects are just arranged, just there has not been therapeutical effect later on by 3 years old.Next is the children with spastic of 70%-80%, and medication and rehabilitation efficacy are bad before operation is carried out, and most of doctors is reluctant has been the effort of treatment cerebral palsy again, has taked the attitude of abandoning more.Also just because of this, in the exploitation of cerebral palsy new drug, be in the space state that nobody sets foot in.
And hyperkinetic syndrome not only 95% crowd do not understand, just be that the doctor also seldom payes attention to, do not have the Chinese medicine of special for treating hyperkinetic syndrome so far.
Summary of the invention
The purpose of this invention is to provide a kind of cerebral palsy, hyperkinetic syndrome and dull-witted medicine for the treatment of.
Another object of the present invention provides a kind of preparation method for the treatment of the medicine of cerebral palsy, hyperkinetic syndrome and dementia.
The present invention is the medicament of being made by the following weight parts proportion raw material:
Radix Polygoni Multiflori Preparata 40-60 part, Carapax et Plastrum Testudinis 40-60 part, Radix Achyranthis Bidentatae 40-60 part, Fructus Corni 32-48 part, Radix Polygalae 32-48 part, Herba Cistanches 32-48 part, Rhizoma Acori Graminei 20-30 part, Radix Ginseng 24-36 part, Cornu Cervi Pantotrichum 24-36, Fructus Alpiniae Oxyphyllae 24-36 part, Cordyceps 12-18 part, Radix Rehmanniae Preparata 32-48 part, Os Draconis 16-24 part, RHIIZOMA DIOSCOREAE frOm Henan of China 24-36 part and Fructus Schisandrae Chinensis 16-24 part.
The weight portion proportion optimization of each raw material is:
20 parts of 50 parts of Radix Polygoni Multiflori Preparata, 50 parts of Carapax et Plastrum Testudiniss, 50 parts of Radix Achyranthis Bidentataes, 40 parts of Fructus Corni, 40 parts of Radix Polygalaes, 40 parts of Herba Cistanches, 25 parts of Rhizoma Acori Graminei, 30 parts of Radix Ginsengs, 30 parts in Cornu Cervi Pantotrichum, 30 parts of Fructus Alpiniae Oxyphyllae, 15 parts of Cordyceps, 40 parts of Radix Rehmanniae Preparata, 20 parts of Os Draconis, 30 parts of RHIIZOMA DIOSCOREAE frOm Henan of China and Fructus Schisandrae Chinensis.
The preparation method of medicine of the present invention has provided capsular method for making, is Rhizoma Acori Graminei, the medicinal steam distillation of Fructus Alpiniae Oxyphyllae two flavors are extracted volatile oil, and aqueous solution filters, and device is stored in addition, and is standby; Radix Ginseng, Cordyceps are ground into fine powder, and the Cornu Cervi Pantotrichum file is ground into fine powder; The medicinal residues of ten flavor medicines such as all the other Radix Polygoni Multiflori Preparata and Rhizoma Acori Graminei, Fructus Alpiniae Oxyphyllae decoct twice with 30% ethanol, decocting liquid filters, merge with the filtrate of Rhizoma Acori Graminei, Fructus Alpiniae Oxyphyllae, leave standstill, filter, filtrate decompression is condensed into thick paste, add the fine powder of Radix Ginseng, Cordyceps, Cornu Cervi Pantotrichum three flavor medicines, after conventional mixing, granulation, drying, cooling means, evenly spray into volatile oil, incapsulate, promptly.The fineness of each material medicine is a 80-100 purpose pulverulent mixture in the capsule.
Oral dose is each 3-6 grain, obeys every day 3 times.
Medicine of the present invention also can be made into other dosage forms.
The present invention cures mainly cerebral dysplasia, cerebral palsy, amentia, hyperkinetic syndrome, mental retardation, brain atrophy, senile dementia etc., above disease belongs to cerebral dysplasia or encephalatrophy together, in Chinese traditional treatment is principle with " deficiency syndrome should be treated by tonifying method " all, many medicines in the side with strengthening spleen, tonifying kidney, with Radix Rehmanniae Preparata, Fructus Corni tonifying kidney-yin, Cornu Cervi Pantotrichum, Herba Cistanches kidney-replenishing are monarch drug altogether; With Radix Polygoni Multiflori Preparata, Carapax et Plastrum Testudinis, Radix Achyranthis Bidentatae, RHIIZOMA DIOSCOREAE frOm Henan of China, Radix Ginseng is ministerial drug altogether, strengthening the spleen and stomach, bone and muscle strengthening; With Rhizoma Acori Graminei, Radix Polygalae restoring normal coordination between the heart and kidney, inducing resuscitation and resolving phlegm, Fructus Alpiniae Oxyphyllae, Fructus Schisandrae Chinensis, Cordyceps, Os Draconis help the monarch and his subjects to be adjuvant altogether, and all medicines share the merit that becomes strengthening spleen, tonifying kidney, beneficial brain to have one's ideas straightened out altogether.
Medicine of the present invention has the merit that strengthening spleen, tonifying kidney, beneficial brain are had one's ideas straightened out, and mainly treats cerebral palsy, amentia, hyperkinetic syndrome, senile dementia etc., and cerebral dysplasia and brain atrophy etc. are all had obvious effects because of the disease that causes.This pharmaceutical preparation is simple, and production and processing is convenient, determined curative effect.
Medicine of the present invention is summed up after clinical treatment demonstration repeatedly through me, originally dosage form is a decoction, after consider the convenience that the patient takes, so change dosage form into capsule, for the clinical efficacy of comprehensive assessment this product, so 1136 routine patients with cerebral palsy, 693 routine hyperkinetic syndrome patients and 89 routine dementia patients have been carried out clinical efficacy research.The own control relative method is adopted in this research, relatively symptom, sign and the results change before and after the patient treatment.Result of study shows that (1) treatment cerebral palsy 1136 examples are wherein cured 397 examples, produce effects 581 examples; Effective 113 examples; Invalid 45 examples; Total effective rate 97%, total obvious effective rate 76%; (2) treatment hyperkinetic syndrome 693 examples are wherein cured 526 examples; Produce effects 103 examples; Effective 43 examples; Invalid 21 examples, total effective rate 97%, total obvious effective rate 75.5%; (3) dull-witted 89 examples, produce effects 31 examples wherein, effective 29 examples, invalid 19 examples, total effective rate 78.65%, total obvious effective rate 67.4%.
For the clinical efficacy that makes medicine of the present invention has more cogency, so with medicine of the present invention is the treatment group, merging cerebrolysin with ganglioside is the cerebral palsy matched group, with the methylphenidate is the hyperkinetic syndrome matched group, with aricept is dull-witted matched group, take random packet own control relative method, carried out clinical experiment, the clinical efficacy of medicine of the present invention is described.
The discrimination method of Chinese medicine composition of the present invention
(1) get this product content, porphyrize is put microscopically and is observed, and the body wall fragment is yellow to faint yellow, calcium oxalate cluster crystal diameter 20～68 μ m, the sharp point of corner angle.The resin canal fragment is easily seen, contains yellow block secretions.Horny layer of epidermis surface particles shape, the trichopore after fine hair comes off are round hole shape, and how cataclasm young pilose antler is, the most irregular block-like protrusions things of unossified organization table mask, and there are longitudinal grin and pin point in the GUSUIPIAN surface, and the keratinization spindle cell is dispersed in more.
(2) get this product content 2g, add methanol 50ml, reflux 1h filters, and filtrate is concentrated near doing, and residue adds methanol 3ml makes dissolving, as need testing solution.Other gets the 5 hydroxymethyl furfural reference substance, add methanol and make the solution that every 1ml contains 0.5mg,, draw need testing solution 10ul according to thin layer chromatography (2005 editions one appendix VI B of Chinese Pharmacopoeia) test, reference substance solution 5ul, put respectively in same be the silica gel G F of adhesive with the sodium carboxymethyl cellulose
254On the lamellae, be developing solvent, launch, take out, dry, put under the ultra-violet lamp (254nm) and inspect with petroleum ether (60～90 ℃)-ethyl acetate (1: 1).In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(3) get echinacoside reference substance, verbascoside reference substance in addition, add methanol respectively and make the solution that every 1ml contains 1mg.According to thin layer chromatography (2005 editions one appendix VI B of Chinese Pharmacopoeia) test, draw above-mentioned three kinds of each 2ul of solution, put respectively on same polyamide lamellae, with methanol-acetic acid-water (2: 1: 7) is developing solvent, launches, and takes out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color.
Embodiment 1
Take by weighing: the Radix Polygoni Multiflori Preparata 50g Carapax et Plastrum Testudinis 50g Radix Achyranthis Bidentatae 50g Fructus Corni 40g Radix Ginseng 30g Herba Cistanches 40g Radix Polygalae 40g Rhizoma Acori Graminei 25g Fructus Alpiniae Oxyphyllae 30g Cornu Cervi Pantotrichum 30g Cordyceps 15g Radix Rehmanniae Preparata 40g 20g RHIIZOMA DIOSCOREAE frOm Henan of China 30g Os Draconis 20g that distinguishes the flavor of
Rhizoma Acori Graminei, the medicinal steam distillation of Fructus Alpiniae Oxyphyllae two flavors extract volatile oil, and aqueous solution filters, and device is stored in addition, and is standby; Radix Ginseng, Cordyceps are ground into fine powder, and the Cornu Cervi Pantotrichum file is ground into fine powder; The medicinal residues of ten flavor medicines such as all the other Radix Polygoni Multiflori Preparata and Rhizoma Acori Graminei, Fructus Alpiniae Oxyphyllae decoct twice with 30% ethanol, for the first time 1.5h, 1h for the second time, decocting liquid filters, and with the filtrate merging of Rhizoma Acori Graminei, Fructus Alpiniae Oxyphyllae, leaves standstill, filter, filtrate decompression is condensed into thick paste, the fine powder of three flavor medicines such as adding Radix Ginseng, mixing is granulated drying, cooling evenly sprays into volatile oil, incapsulates, make 1000, promptly.
Oral dose is each 3-6 grain, obeys every day 3 times.
Experimental example
One, case choice criteria
(1) diagnostic criteria
1, patients with cerebral palsy diagnostic criteria
1.1 tcm diagnosis standard
The traditional Chinese medical science thinks that cerebral palsy is mainly due to infant natural endowment deficiency, " brain being the marrow sea ", " the kidney generating marrow and dominating bone ".Because of the congenital bone insufficiency of essence of children's, it is main that brains lose to be supported, or blood stasis is arranged, or expectorant is turbid hinders in the brain network, loses it and supports and cause brains.
1.2 Chinese medical discrimination standard
(1) brain injury that causes cerebral palsy is non-carrying out property.
(2) cause that dyskinetic diseased region is at brain.
(3) symptom occurs at infancy stage.
(4) merge dysnoesia, epilepsy, sensory perception obstacle sometimes and other is unusual.
(5) should differentiate with diseases such as kentrokiness obstacle due to the PD and the temporary Motor development of normal children's are slow.
1.3 Western medicine diagnose standard
The diagnosis cerebral palsy should meet following 2 conditions:
(1) symptom appears in cradle, as grows backward or the various dyskinesia.
(2) central paralysis due to the PD and normal children's one cross the sexual development backwardness except the need.
1.4 the Clinical types of cerebral palsy
Be divided into by dyskinesia character:
1. spasm type: account for the 70%-80% of CP children, the major lesions position is at pyramidal system.Muscular tension is hyperfunction to be the primary disease feature, shows as muscular hypertonia, muscular strength is poor, knee jerk is hyperfunction, the pathologic reflex positive.Elbow joint, knee joint, hip joint flexing, toe lands when holding up the station, and knee joint is counter to be opened, and is abnormal postures such as pushed together gait during walking.
2. athetosis type: the sick position of decreasing is in the cerebral deep Basal ganglia, the extrapyramidal system part.To be difficult to the limbs involuntary movement that will is controlled is main performance, face muscle, and sounding, structure sound organ is got involved more, so normal companion's aphasis.
3. the low mo(u)ld bottom half of muscular tension: the soft but tendon reflex of limbs can exist.
4. tetanic type: the whole body muscular tension significantly increases stiff, the impaired symptom of extrapyramidal system.
5. ataxia type: its main cause is because the organic disease of cerebellum, also has the pathological changes of the depth perception system of pyramidal system and extrapyramidal system, shows as exercise not harmony, and hands and head tremble, drunken man gait, voice lack, tone low, paraesthesia.
6. type trembles: be the relevant static tremor of extrapyramidal system.
7. mixed type: the cerebral palsy that two or more type hybrid is arranged.Cerebral palsy the pathogenesis of the traditional Chinese medical science belong to congenital and the day after tomorrow deficiency, so the effect of just definite " kidney-tonifying and brain tonic capsule " is a strengthening spleen, tonifying kidney at the beginning of research and development, beneficial brain is had one's ideas straightened out.
2, hyperkinetic syndrome infant diagnostic criteria
2.1 tcm diagnosis standard
Hyperkinetic syndrome claims attention deficit and many moving obstacles again, belongs to categories such as " becoming deaf ", " forgetful ", " infantile malnutrition disease ", " fidgets due to deficiency " in the traditional Chinese medical science.With void is many, accidental simulataneous insufficiency and excessive type, and deficient syndrome belongs to conscience more suffers from a deficiency of the kidney, and the simulataneous insufficiency and excessive type also is the insufficiency of the spleen expectorant that is mingled with.
2.2 Chinese medical discrimination standard
(1) deficiency of the kidney yin loses: how moving multi-lingual, and irritated irritability, it is not autonomous to move, dysphoria with feverish sensation in the chest palms and soles, dry mouth and tougue, little sleep disturbed by dreams, thready and rapid pulse, the red few rule of tongue.
(2) deficiency of both the heart and spleen: it is not autonomous to move, and lustreless complexion is easily shied and slept less, and is forgetful.
(3) phlegm-fire is disturbed god: how moving multi-lingual, cry and laugh by turns, without any apparent reason, and restlessness, impulsion is wilful.
2.3 Western medicine diagnose standard
(1) attention deficit or how moving.
(2) before many moving or attention problem all came across 7 years old.
(3) some performance is present in two above occasions.
(4) in social activity, school work or occupation, open defect is arranged.
(7) possibility of eliminating pervasive developmental disorders, schizophrenia or other mental disorder can not make an explanation with other mental disorder.
2.4 the clinical manifestation of hyperkinetic syndrome
(1) over-activity: show as with disproportionate level of activation of age too high.
(2) attention is concentrated difficulty: show as absent mindedly, voluntary attention is laxed, and selects to note of short duration.
(3) impulsive behavior: show as easily and be overexcited, doing things is wanting in consideration, and the behavior impulsion is ignore the consequences.
(4) learning difficulty: it is low to show as the audiovisual resolving ability, hand-eye coordination difficulty, short term memory difficulty.
3, dementia patients diagnostic criteria
3.1 tcm diagnosis standard
Dementia is to be a kind of mind disease of main clinical manifestation with the slow-witted and stupid, and the visible speaking scarcely,taciturn of the lighter is slow in reacting, and the is forgetful disease that Dengs; Heavy then show as dull spirit, keeping silence all day is cryed and laugh by turns, without any apparent reason, and differentiates round the clock unclearly, goes out not know the homeward journey, and loss of appetite is not known famine, and incontinence of urination and defecation be can't take care of oneself.
3.2 Chinese medical discrimination standard
(1) deficiency syndrome
1. deficiency of marrow-reservoir: memory, computing power obviously go down, dull expression, and normal closed gate is solitary, and language is not expressed one's ideas, and slip of the tongue is often arranged, and companion's soreness of the waist and knees is walked with difficulty deep-thready pulse.
2. asthenia of both the spleen and kidney: forgetful, lack emotion, dull of few words, companion's soreness of waist, anorexia and short breath, diarrhea before dawn, extremity are not warm, and light red tongue is fat big, deep-thready pulse.
(2) excess syndrome
1. the turbid illiteracy key of expectorant: forgetful, blunt, expression is unusual, crieses and laugh by turns, without any apparent reason white and greasy fur.
2. congestion internal resistance: forgetful dull, slurred speech is unclear, oddity of behavior, and in time, laugh at when crying, numb hand and foot, weak breath is weak, thready and hesitant pulse.
3. qi depression to blood stasis: forgetful dull, slurred speech, oddity of behavior, two orders are dark and gloomy, thready and hesitant pulse.
3.3 Western medicine diagnose standard
(1) dementia is acquired, but not congenital mentally disabled.
(2) dementia is chronic persistence, and majority is made slow progress, rather than one is that cross property or ictal.
(3) knowing under the situation in patient's consciousness of dementia occurs.
(4) mostly dementia is on the basis of organic disease, cause by the disorder of brain function diffusivity, but not due to a certain local function infringement of brain, but organic disease might not be consistent with dementia degree.
(5) dementia is a syndrome, can cause by the different causes of disease, but not due to certain special disease.
(6) dull-witted patients more than half follow various mental symptoms or dystropy in the course of disease, as delirium, anxiety, hallucination, melancholy state and aggressive behavior etc.
(7) dementia irreversibility whether, overemphasized in the former dull-witted notion dull-witted can not healing property, but find that at present some dementia can cure or improve.
3.4 dull-witted classification
Dull-witted at present classification does not still have unified standard, involves the different parts of CNS and produce different neural mental deficiency patterns according to pathological changes to be divided into:
(1) cortex dementia, pathological changes is mainly involved cerebral cortex, as Alzheimer.
(2) dull-witted under the cortex, pathological changes is mainly involved under the cortex that comprises white matter, relates to Basal ganglia, thalamus, brain stem, ventricles of the brain white matter on every side, and positions such as cerebellum are as dementia in Parkinson disease.
(3) Combination dementia, pathological changes is mainly involved structure under cerebral cortex and the cortex.
(2) test case standard
1, cerebral palsy patient
1.1 include the case standard in
(1) tcm diagnosis meets caused by liver and kidney deficiency, asthenia of both the spleen and kidney, phlegm stagnation in collateral person.
(2) Western medicine diagnose meets non-carrying out property brain injury.
(3) infant is based on the inpatient.
1.2 get rid of the case standard
(1) the kentrokiness obstacle due to the PD
1. baby's myelopathic muscular atrophy.
2. alba dysplasia.
(2) the normal temporary Motor development of children's is slow.
2, hyperkinetic syndrome patient
2.1 include the case standard in
(1) tcm diagnosis meets deficiency of kidney-YIN, and deficiency of both the heart and spleen, phlegm-fire are disturbed refreshing person.
(2) Western medicine diagnose meets ADHD person.
2.2 get rid of the case standard
Childhood hyperkinetic syndrome diagnosis scale is lower than person below 15 minutes.
3, dementia patients
3.1 include the case standard in
(1) tcm diagnosis meets deficiency of marrow-reservoir, asthenia of both the spleen and kidney, the turbid illiteracy key of expectorant, congestion internal resistance, stagnation of QI blood deficiency.
(2) the Western medicine diagnose core symptom is the low and personality disorder of memory disorder and cognitive competence.
3.2 get rid of the case standard
(1) forgetful, be non-pathologic, with aging physiological phenomenon together.
(2) depression, such patient often has hypomnesis, indifferent, absent minded, symptoms such as lassitude.
The orientation force, faculty of understanding, the attention disorders that occur when (3) delirium is " clouding of consciousness ", psychomotor excitement or inhibition and cognitive obviously obstacle situation.
(4) the limitation cognitive defect does not often influence intelligence, memory and personality.
Two, Therapeutic Method
Take random packet own control relative method, relatively symptom, sign and the results change before and after the infant treatment.
(1) CP children
(1) treatment group: 300 examples, the kidney-tonifying and brain tonic capsule of embodiment 1 preparation, each 3-6 grain, every day 3 times, ante cibum is oral.
(2) matched group: 100 examples, ganglioside merges cerebrolysin, each 1, every day 1 time.
(2) hyperkinetic syndrome infant
(1) treatment group: 200 examples, the kidney-tonifying and brain tonic capsule of embodiment 1 preparation, each 3-6 grain, every day 3 times, ante cibum is oral.
(2) matched group: 100 examples, methylphenidate, each 1, every day 2 times.
(3) dementia patients
(1) treatment group: 89 examples, the kidney-tonifying and brain tonic capsule of embodiment 1 preparation, each 3-6 grain, every day 3 times, ante cibum is oral.
(2) matched group: 50 examples, aricept, each 10mg, every day 1 time.
Three, parameters for observation on effect
1, functions such as patient's motion, language
2, tcm symptom, picture of the tongue, pulse condition
Four, hyperkinetic syndrome infant efficacy evaluation point system
1, hyperactivity, play while doing when doing one's assignment: light 1 minute, in 2 minutes, weigh 3 fens
2, easily excited and impulsion: light 1 minute, in 2 minutes, weigh 3 fens
3, bother other people and other misconducts: light 1 minute, in 2 minutes, weigh 3 fens
4, do things having a beginning but no end: light 1 minute, in 2 minutes, weigh 3 fens
5, do not listen advice, possessiveness poor: light 1 minute, in 2 minutes, weigh 3 fens
6, attention time of concentration short, easily shift: light 1 minute, in 2 minutes, weigh 3 fens
7, requirement must be met immediately: light 1 minute, in 2 minutes, weigh 3 fens
8, shout well: light 1 minute, in 2 minutes, weigh 3 fens
9, mood change is fast: light 1 minute, in 2 minutes, weigh 3 fens
10, temper tantrum: light 1 minute, in 2 minutes, weigh 3 fens
Five, curative effect judging standard
1, patients with cerebral palsy
(1) be almost recovered: intelligence, communication are normal, and limb activity is normal, and life can be taken care of oneself
(2) produce effects: intelligence is clearly better, and muscular tension reduces, and muscular strength can be walked
(3) effective: language and mobility take a favorable turn
(4) invalid: with the same before the treatment
2, hyperkinetic syndrome patient
(1) be almost recovered: attention, possessiveness are consistent with normal children
(2) produce effects: attention, possessiveness all are clearly better
(3) effective: attention increases before the treatment, and activity alleviates
(4) invalid: with the same before the treatment
3, dementia patients
(1) the basic healing: memory, cognitive competence are consistent with the normal person
(2) produce effects: memory, cognitive competence obviously improve
(3) effective: memory is than take a turn for the better in the past
(4) invalid: with the same before the treatment
Six, therapeutic outcome
1, CP children general curative effect
2, the general curative effect of hyperkinetic syndrome infant
3, the general curative effect of dementia patients
Seven, model case
1. the long tinkling of pieces of jade of Lee, woman, 7 years old, the Huangzhong County, Qinghai under in April, 2008 my institute during generaI investigation of Qinghai, sees that it can not solely stand solely to walk, two lower limb are pushed together and intersect, and tentative diagnosis is " cerebral palsy-two lower limb spasm paralysiss ", gives 4 of kidney-tonifying and brain tonic capsules, 3/, effect was remarkable, and infant can be stood up after one month, satisfy row operative treatment after May, my institute was in hospital, with rehabilitation+Drug therapy, existing infant can solely be stood, and holds up away.
2. Xiao Ji boat, man, 3 years old half, people from Linxia, Gansu, because of can not solely standing solely to walk, the biped point be pushed together and lands when holding up the station, comes my institute to go to a doctor at the beginning of 2008 3 months, tentative diagnosis is " cerebral palsy-two lower limb spasm paralysiss ", give 3 of kidney-tonifying and brain tonic capsules, 3/, come my the institute rehabilitation+Drug therapy behind the back row operative treatment of being admitted to hospital behind the first quarter moon once more, existing infant can solely stand and hold up away, and biped is smashed.Now continue rehabilitation and Drug therapy.
3. Wang Yuandong, the man, 8 years old, the Baiyin people, on March 6th, 2008 came me to examine tentative diagnosis by gate: " hyperkinetic syndrome ", my the Yang Hui ground director of institute gives the kidney-tonifying and brain tonic capsule, two week back infant mothers come my institute to get it filled, and tell effectively, and the hyperkinetic syndrome shape obviously reduces, attention has also been concentrated, and diet and sleep all take a turn for the better.
4. Yang Yun ice, the woman, 8 years old, people from Zhangye, Gansu, mother told and how moving begin to occur from one grade, do nose, and absent minded during second grade, it is having a beginning but no end to do things, and action is many, and mood change is fast.Come me institute to go to a doctor on May 31st, 2008, it is normal to look into electroencephalogram, transcranial doppler: bilateral blood flow of middle cerebral artery speed speeds, and haves a medical check-up: red tongue greasy fur, deep pulse number.Tentative diagnosis: " hyperkinetic syndrome ", give the kidney-tonifying and brain tonic capsule, to treat after 1 month and obviously improve with examining now, attention before is clearly better.
5. Wang Zhi justice, the man, 76 years old, people from Lanzhou, Gansu, in December, 2008 is repeatedly wandered away because of hypomnesis, emotional instability, it is mischievous to run chaotically.Go to a doctor, the CT brain paralysis that withers shows cerebral blood supply insufficiency through looking into cranium Doppler on inspection, comprehensive diagnos is dull-witted, gives 6 of kidney-tonifying and brain tonic capsules, 3 times/day, cooperate Chinese herbal treatment further consultation in January, effect is obvious, does not run chaotically day and night again, give the kidney-tonifying and brain tonic capsule again, the bimester of treatment after further consultation, be emotionally stable, memory has clear improvement, expression has also been enriched many, also talkative, advises it to take medicine and consolidates curative effect.
Embodiment 2
Take by weighing: Radix Polygoni Multiflori Preparata 60g, Carapax et Plastrum Testudinis 60g, Radix Achyranthis Bidentatae 60g, Fructus Corni 48g, Radix Polygalae 48g,
Herba Cistanches 32g, Rhizoma Acori Graminei 20g, Radix Ginseng 24g, Cornu Cervi Pantotrichum 24g, Fructus Alpiniae Oxyphyllae 24g,
Cordyceps 18g, Radix Rehmanniae Preparata 48g, Os Draconis 24g, RHIIZOMA DIOSCOREAE frOm Henan of China 36g and Fructus Schisandrae Chinensis 24g.
Preparation method is with embodiment 1.
Embodiment 3
Take by weighing: Radix Polygoni Multiflori Preparata 40g, Carapax et Plastrum Testudinis 40g, Radix Achyranthis Bidentatae 40g, Fructus Corni 32g, Radix Polygalae 32g,
Herba Cistanches 48g, Rhizoma Acori Graminei 30g, Radix Ginseng 36g, Cornu Cervi Pantotrichum 36, Fructus Alpiniae Oxyphyllae 36g,
Cordyceps 12g, Radix Rehmanniae Preparata 32g, Os Draconis 16g, RHIIZOMA DIOSCOREAE frOm Henan of China 24g and Fructus Schisandrae Chinensis 16g.
Preparation method is with embodiment 1.
Claims (4)
1. treat cerebral palsy, hyperkinetic syndrome and dull-witted medicine for one kind, it is characterized in that it is the medicament of being made by the following weight parts proportion raw material:
Radix Polygoni Multiflori Preparata 40-60 part, Carapax et Plastrum Testudinis 40-60 part, Radix Achyranthis Bidentatae 40-60 part, Fructus Corni 32-48 part, Radix Polygalae 32-48 part, Herba Cistanches 32-48 part, Rhizoma Acori Graminei 20-30 part, Radix Ginseng 24-36 part, Cornu Cervi Pantotrichum 24-36, Fructus Alpiniae Oxyphyllae 24-36 part, Cordyceps 12-18 part, Radix Rehmanniae Preparata 32-48 part, Os Draconis 16-24 part, RHIIZOMA DIOSCOREAE frOm Henan of China 24-36 part and Fructus Schisandrae Chinensis 16-24 part.
2. treatment cerebral palsy according to claim 1, hyperkinetic syndrome and dull-witted medicine is characterized in that the weight portion proportioning of each raw material is:
20 parts of 50 parts of Radix Polygoni Multiflori Preparata, 50 parts of Carapax et Plastrum Testudiniss, 50 parts of Radix Achyranthis Bidentataes, 40 parts of Fructus Corni, 40 parts of Radix Polygalaes, 40 parts of Herba Cistanches, 25 parts of Rhizoma Acori Graminei, 30 parts of Radix Ginsengs, 30 parts in Cornu Cervi Pantotrichum, 30 parts of Fructus Alpiniae Oxyphyllae, 15 parts of Cordyceps, 40 parts of Radix Rehmanniae Preparata, 20 parts of Os Draconis, 30 parts of RHIIZOMA DIOSCOREAE frOm Henan of China and Fructus Schisandrae Chinensis.
3. medicine of treatment cerebral palsy according to claim 1 and 2, hyperkinetic syndrome and dementia and preparation method thereof is characterized in that step is as follows: Rhizoma Acori Graminei, the medicinal steam distillation of Fructus Alpiniae Oxyphyllae two flavors are extracted volatile oil, and aqueous solution filters, and device storage in addition is standby; Radix Ginseng, Cordyceps are ground into fine powder, and the Cornu Cervi Pantotrichum file is ground into fine powder; The medicinal residues of ten flavor medicines such as all the other Radix Polygoni Multiflori Preparata and Rhizoma Acori Graminei, Fructus Alpiniae Oxyphyllae decoct twice with 30% ethanol, and decocting liquid filters, with the filtrate merging of Rhizoma Acori Graminei, Fructus Alpiniae Oxyphyllae, leave standstill, filter, filtrate decompression is condensed into thick paste, the fine powder that adds Radix Ginseng, Cordyceps, Cornu Cervi Pantotrichum three flavor medicines, mixing is granulated drying, cooling, evenly spray into volatile oil, incapsulate, promptly.
4. medicine of treatment cerebral palsy according to claim 3, hyperkinetic syndrome and dementia and preparation method thereof is characterized in that: the fineness of each material medicine is a 80-100 purpose pulverulent mixture in the capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101618573A CN101810814B (en) | 2010-04-28 | 2010-04-28 | Medicament for curing cerebral palsy, hyperkinetic syndrome and dementia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101618573A CN101810814B (en) | 2010-04-28 | 2010-04-28 | Medicament for curing cerebral palsy, hyperkinetic syndrome and dementia and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101810814A true CN101810814A (en) | 2010-08-25 |
| CN101810814B CN101810814B (en) | 2011-08-10 |
Family
ID=42618276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101618573A Active CN101810814B (en) | 2010-04-28 | 2010-04-28 | Medicament for curing cerebral palsy, hyperkinetic syndrome and dementia and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101810814B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008676A (en) * | 2010-11-29 | 2011-04-13 | 宋兆普 | Chinese medicinal powder for treating cerebral palsy |
| CN103479900A (en) * | 2013-06-24 | 2014-01-01 | 陈英娣 | Traditional Chinese medicine used for treating athetosis |
| CN104623315A (en) * | 2015-02-11 | 2015-05-20 | 郭如英 | Blood-nourishing yin-replenishing medicine for treating mental retardation and preparation method of medicine |
| CN106729402A (en) * | 2016-12-27 | 2017-05-31 | 王勤 | It is a kind of to treat medicine of encephalatrophy disease and preparation method thereof |
| CN106729437A (en) * | 2017-01-24 | 2017-05-31 | 崔建科 | It is a kind of to treat Chinese medicine composition of cerebellar atrophy and its preparation method and application |
| CN108042750A (en) * | 2018-01-29 | 2018-05-18 | 宋信东 | Children's intelligence development spirit |
| CN109925463A (en) * | 2017-12-18 | 2019-06-25 | 南宁多灵生物科技有限公司 | A kind of pharmaceutical composition of brain tonic and intelligence development |
| CN111743992A (en) * | 2020-06-23 | 2020-10-09 | 西安岐奥丰医疗发展有限公司 | Ginseng and pilose antler brain-strengthening capsule and preparation method thereof |
| CN116726138A (en) * | 2023-08-11 | 2023-09-12 | 中国人民解放军总医院第六医学中心 | Traditional Chinese medicine composition for treating senile parkinsonism and complications, and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1114893A (en) * | 1993-10-14 | 1996-01-17 | 赫连锁 | "Yuanshen" pill-medicine for treatment of encephalatrophy |
| CN1123690A (en) * | 1995-07-28 | 1996-06-05 | 黄斌 | Naoxuekang capsule for curing cerebrovascular disease and its production |
| CN1339316A (en) * | 2001-10-19 | 2002-03-13 | 戚晓峰 | Medicine for curing child brain paralysis |
| CN101474361A (en) * | 2009-01-19 | 2009-07-08 | 河南百年康鑫药业有限公司 | Chinese medicine for treating cerebropathy |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59509782D1 (en) * | 1995-08-23 | 2001-12-06 | Siemens Building Tech Ag | Fire alarm |
| JP4400804B2 (en) * | 1999-09-22 | 2010-01-20 | 本田技研工業株式会社 | Air cleaner device |
-
2010
- 2010-04-28 CN CN2010101618573A patent/CN101810814B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1114893A (en) * | 1993-10-14 | 1996-01-17 | 赫连锁 | "Yuanshen" pill-medicine for treatment of encephalatrophy |
| CN1123690A (en) * | 1995-07-28 | 1996-06-05 | 黄斌 | Naoxuekang capsule for curing cerebrovascular disease and its production |
| CN1339316A (en) * | 2001-10-19 | 2002-03-13 | 戚晓峰 | Medicine for curing child brain paralysis |
| CN101474361A (en) * | 2009-01-19 | 2009-07-08 | 河南百年康鑫药业有限公司 | Chinese medicine for treating cerebropathy |
Non-Patent Citations (3)
| Title |
|---|
| 《山东中医杂志》 20010420 赵法文等 血管性痴呆中医药治疗进展 , 第04期 2 * |
| 《山东中医杂志》 20070605 邓家刚等 老年性痴呆复方用药规律探讨 , 第06期 2 * |
| 《湖北中医杂志》 20010910 崔金涛等 中医药治疗老年痴呆病近况 , 第09期 2 * |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008676A (en) * | 2010-11-29 | 2011-04-13 | 宋兆普 | Chinese medicinal powder for treating cerebral palsy |
| CN102008676B (en) * | 2010-11-29 | 2011-12-28 | 宋兆普 | Chinese medicinal powder for treating cerebral palsy |
| CN103479900A (en) * | 2013-06-24 | 2014-01-01 | 陈英娣 | Traditional Chinese medicine used for treating athetosis |
| CN103479900B (en) * | 2013-06-24 | 2015-02-04 | 张伟 | Traditional Chinese medicine used for treating athetosis |
| CN104623315A (en) * | 2015-02-11 | 2015-05-20 | 郭如英 | Blood-nourishing yin-replenishing medicine for treating mental retardation and preparation method of medicine |
| CN106729402A (en) * | 2016-12-27 | 2017-05-31 | 王勤 | It is a kind of to treat medicine of encephalatrophy disease and preparation method thereof |
| CN106729437A (en) * | 2017-01-24 | 2017-05-31 | 崔建科 | It is a kind of to treat Chinese medicine composition of cerebellar atrophy and its preparation method and application |
| CN109925463A (en) * | 2017-12-18 | 2019-06-25 | 南宁多灵生物科技有限公司 | A kind of pharmaceutical composition of brain tonic and intelligence development |
| CN108042750A (en) * | 2018-01-29 | 2018-05-18 | 宋信东 | Children's intelligence development spirit |
| CN111743992A (en) * | 2020-06-23 | 2020-10-09 | 西安岐奥丰医疗发展有限公司 | Ginseng and pilose antler brain-strengthening capsule and preparation method thereof |
| CN116726138A (en) * | 2023-08-11 | 2023-09-12 | 中国人民解放军总医院第六医学中心 | Traditional Chinese medicine composition for treating senile parkinsonism and complications, and preparation method and application thereof |
| CN116726138B (en) * | 2023-08-11 | 2023-11-24 | 中国人民解放军总医院第六医学中心 | Traditional Chinese medicine composition for treating senile parkinsonism and complications, and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101810814B (en) | 2011-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101810814B (en) | Medicament for curing cerebral palsy, hyperkinetic syndrome and dementia and preparation method thereof | |
| CN101496865B (en) | Chinese medicament preparation for treating depression and anxiety as well as preparation method thereof | |
| CN101757573B (en) | Traditional Chinese medicine composition for treating memory loss and preparation method thereof | |
| CN107126485B (en) | Traditional Chinese medicine composition for assisting in improving sleep and preparation method and application thereof | |
| CN103083541A (en) | Drug for treating anemia | |
| CN104873745B (en) | A kind of Chinese medicine that treating insomnia and preparation method | |
| CN104587050B (en) | A kind of Chinese medicinal body slim patch and preparation method thereof | |
| CN102178853B (en) | Chinese medicinal preparation for treating infantile epilepsia and preparation method thereof | |
| CN102973561A (en) | Drug composite for improving sleep and preparation method thereof | |
| CN100586458C (en) | Medicine for treating cerebral apoplexy | |
| CN101810787B (en) | Chinese medicinal composition for treating dysphoria and preparation method thereof | |
| CN101711809A (en) | Medicine composition for treating postpartum melancholia, preparation method and application | |
| CN104147518A (en) | Traditional Chinese medicinal capsule for treating depression and preparation method thereof | |
| CN102961578A (en) | Traditional Chinese medicine health care product for improving sleep and preparation method thereof | |
| CN102716307A (en) | Prepared common monkshood daughter root Chinese medicinal preparation for treating hypersomnia and preparation method thereof | |
| CN105521211A (en) | Traditional Chinese medicinal ointment rubbing agent for promoting growth of premature low-birth-weight children, and preparation method thereof | |
| CN104524188A (en) | Medicament for treating vascular dementia and preparation method of medicament | |
| CN104383420A (en) | Preparation method of pharmaceutical preparation for treating insomnia and dreaminess | |
| CN104383421A (en) | Pharmaceutical preparation for treating insomnia and dreaminess | |
| CN104667199A (en) | Pharmaceutical preparation for treating mental anxiety and application of pharmaceutical preparation | |
| CN101773652B (en) | Chinese medicine composition for treating amnesia and preparation method thereof | |
| CN104547556B (en) | It is a kind of to treat Chinese medicine preparation of children epilepsy and preparation method thereof | |
| CN103494935A (en) | Formula of qi-tonifying liver-replenishing sleep-comforting powder and preparation method | |
| CN103638461B (en) | Treatment anxiety neurosis's medicine pill | |
| CN103585372B (en) | Traditional Chinese medicine preparation for treating cerebral palsy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |