CN104524188A - Medicament for treating vascular dementia and preparation method of medicament - Google Patents

Abstract

The invention discloses a medicament for treating vascular dementia and preparation method of the medicament. The medicament for treating the vascular dementia is characterized by being prepared from the following medicinal raw materials in parts by weight: 8-15 parts of pearl powder, 10-20 parts of mythic fungus, 8-15 parts of fruit of Chinese wolfberry, 8-15 parts of common cnidium fruit, 8-14 parts of rhizoma polygonati, 8-14 parts of raw eucommia ulmoides, 8-15 parts of loranthus parasiticus, 8-15 parts of achyranthes root, 7-14 parts of fructus psoralea, 7-14 parts of white chrysanthemum, 8-15 parts of rose flower, 10-12 parts of rehmannia root, 8-15 parts of radix puerariae, 8-15 parts of angelica sinensis and 25-40 parts of salvia miltiorrhiza. The medicament has the efficacies of tonifying liver and spleen, inducing resuscitation and promoting mentality, is capable of obviously improving the cognitive function of the vascular dementia, improving the disposing capacity of a patient and obviously improving the traditional Chinese medicine syndrome and is accurate in curative effect.

Description

A kind of medicine for the treatment of vascular dementia and preparation method thereof

Technical field

The invention belongs to a kind of Chinese medicine preparation and preparation method, particularly belong to a kind of medicine for the treatment of vascular dementia and preparation method thereof.

Background technology

Vascular dementia is the disordered brain function caused by various cerebrovascular disease and acquired, the persistence intelligence damage syndrome that produce, with the mental decline of the aspects such as cognition, memory, speech, emotion, personality, action or disappear for main manifestations, be one of modal type in alzheimer disease.Along with aged tendency of population, the sickness rate of vascular dementia rises year by year, the work of old people, life, social activity and quality of life are had a strong impact on, and cause white elephant to family, society, become one of important diseases threatening senior health and fitness, more and more cause the attention of medical circle, also become whole society's question of common concern.At present, less to the medicine of vascular dementia, and lack specific medicament, make the treatment of dementia become a difficult medical problem.Therefore, the present invention is that research is a kind of by obviously improving brain function to treat the medicine of dementia, Chinese medicine dementia has to obtain the munificent advantage in sky, the medicine that the present invention treats vascular dementia has tonifying liver, kidney, effect of inducing resuscitation Fructus Alpiniae Oxyphyllae, can significantly improve the cognitive function of vascular dementia, improve the behavioral competence of patient, tcm syndrome is clearly better; Significantly improve the quality of life of patient, be worth further genralrlization.

Summary of the invention

The object of this invention is to provide a kind of medicine for the treatment of vascular dementia, another object of the present invention is to provide the preparation method of this medicine.

Technical scheme of the present invention is, a kind of medicine for the treatment of vascular dementia, it is characterized in that, be made up of the raw material of following portions by weight proportioning: Margarita powder 8-15, Ganoderma 10-20, Fructus Lycii 8-15, Fructus Cnidii 8-15, Rhizoma Polygonati 8-14, Cortex Eucommiae 8-14, Herba Taxilli 8-15, Radix Achyranthis Bidentatae 8-15, Fructus Psoraleae 7-14, Flos Chrysanthemi 7-14, Flos Rosae Rugosae 8-15, Radix Rehmanniae 10-20, Radix Puerariae 8-15, Radix Angelicae Sinensis 8-15, Radix Salviae Miltiorrhizae 25-40.

The parts by weight proportioning of preferred each raw material is: Margarita powder 12, Ganoderma 15, Fructus Lycii 10, Fructus Cnidii 10, Rhizoma Polygonati 12, Cortex Eucommiae 12, Herba Taxilli 13, Radix Achyranthis Bidentatae 13, Fructus Psoraleae 10, Flos Chrysanthemi 10, Flos Rosae Rugosae 12, Radix Rehmanniae 15, Radix Puerariae 12, Radix Angelicae Sinensis 12, Radix Salviae Miltiorrhizae 32.

The medicine that the present invention treats vascular dementia can be made as decoction, powder, pill, unguentum, syrup, tablet, granule or powder preparation to be taken after being infused in boiling water, granule, capsule by process of Chinese medicine preparation conveniently.

The preferred formulation dosage form that the present invention treats the medicine of vascular dementia is tablet, capsule or pill.

Treat a preparation method for the medicine of vascular dementia, it is characterized in that: the preparation method of described capsule, mainly comprises the steps:

A, to take Margarita powder respectively according to described parts by weight proportioning, Ganoderma, Fructus Lycii, Fructus Cnidii, Rhizoma Polygonati, Cortex Eucommiae, Herba Taxilli, Radix Achyranthis Bidentatae, Fructus Psoraleae, Flos Chrysanthemi, Flos Rosae Rugosae, Radix Rehmanniae, Radix Puerariae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae are for subsequent use;

It is the extractum of 1.30-1.36g/cm3 that B, Fructus Lycii steps A prepared, Ganoderma, Cortex Eucommiae, Rhizoma Polygonati decocting extract relative density when concentration of liquid medicine becomes temperature 80 DEG C;

C. Margarita powder steps A prepared, Fructus Cnidii, Herba Taxilli, Radix Achyranthis Bidentatae, Fructus Psoraleae, Flos Chrysanthemi, Flos Rosae Rugosae, Radix Rehmanniae, Radix Puerariae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae co-grinding cross 100 mesh sieves;

D, by above-mentioned B, C two after step gained extractum and fine powder mixing, cross that 14 mesh sieves are concentrated makes granule, dry, by gained granule filling capsule, each capsule is 0.35g.

Instructions of taking: oral capsule of the present invention a time four, every day three times.

Inventor thinks: vascular dementia is brain inner blood circulatory disturbance mainly, causes brain function and reduces so that dull-witted generation.Belonging to the category such as " dementia ", " literary composition silly ", " staying disease ", " forgetful " in the traditional Chinese medical science, is with mentally disabled, slow-witted and stupid, a kind of abnormal state of mind disease for main manifestations such as forgetful.Primary disease is more common in old people, and because the reasons such as body deficiency due to old age, internal injury caused by excess of seven emotions, prolonged illness consume cause insufficiency of vital energy and blood, deficiency of the kidney essence consumption, brains lose supports, or blood stasis, the stagnation of QI, stagnation of phlegm form in brain.Chinese medicine thinks pathogenesis mainly due to deficiency of kidney essence, the turbid illiteracy key of expectorant, obstruction of collaterals by blood stasis, and mechanism of qi is uncomfortable etc. causes clear YANG failing to ascend, turbid YIN failing to descend, and the mind is failed to understand, refreshing machine does not turn, and god is without pathological changes such as institute keep.Its sick position is at brain, relevant to the heart, liver, spleen, lung, kidney, and its morbidity and the deficiency of vital energy, blood stasis, expectorant is turbid, marrow is withered etc., and factor is relevant.Primary disease belongs to the card of deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive, lose with deficiency of qi and blood, brains support, marrow of suffering from a deficiency of the kidney is empty for this, the stagnation of QI, blood stasis, expectorant are turbid is mark.Deficiency of kidney-QI, water liquid dysfunction of the spleen in transportation and transformation, the expectorant stasis of blood is detained brains, the clear key of mist and cause dementia.

The present invention is with Margarita, Ganoderma altogether for monarch drug, and Margarita enters the heart, Liver Channel, salty sweet, cold, nontoxic; Have the effects such as arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation, modern study also shows that Margarita is improving the effect all in body immunity, slow down aging, freckle removing and whitening, supplement calcium etc. with uniqueness, arresting convulsion of calming the nerves in addition, heat clearing away YIN nourishing, improving eyesight, removing toxic substances; Relieving palpitation is calmed the frightened, and is applicable to palpitation with fear palpitation with a distress feeling, epilepsy infantile convulsion.The flat sweet in the mouth of Ganoderma property, GUIXIN, lung, liver, kidney channel.Tool invigorating QI and tranquilization, effect of relieving cough and asthma, is mainly used in treating dizzy sleeplessness, shortness of breath and palpitation, the diseases such as asthenia cough with asthma.The modern evidence provided according to pharmacological experiment study and clinical trial shows: Ganoderma has improves microcirculation, reduces blood viscosity, prevents thrombosis effect; The sedation of Ganoderma, analgesic activity and scavenging activated oxygen thereof and the effect etc. of raising body to the tolerance of anoxia have effect to treatment of vascular dementia.Margarita, Ganoderma are share, and the void can mending internal organs supports lean intelligence, again can heat-clearing and toxic substances removing, and in order to clear key, reach tonify deficiency and to dispel reality, treating both the principal and secondary aspects of a disease, improves body immunity further, improves microcirculation, reduces blood viscosity; Thus effect of inducing resuscitation, tranquilizing the mind improves further; Fructus Lycii, returns liver, kidney channel, cures mainly nourishing the liver and kidney, replenishing vital essence to improve eyesight, and for asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Flos Chrysanthemi: return lung, Liver Channel.Cure mainly dispelling wind and heat pathogens, suppressing the hyperactive liver improving eyesight, heat-clearing and toxic substances removing.Radix Rehmanniae, enters the heart, liver, kidney channel, and clearing away heat and promoting production of body fluid YIN nourishing, nourishes blood.Rhizoma Polygonati, sweet in the mouth is flat.Return lung, spleen, kidney channel, cure mainly nourishing kidney lung moistening, invigorating the spleen and replenishing QI.It is ministerial drug altogether that four medicines share, and have enriching yin and nourishing kidney, the function of heat clearing away suppressing the hyperactive liver, the smart of Liver and kidney must be mended, brains must fill; Share with monarch drug and strengthen its empty foster lean intelligence further, heat-clearing and toxic substances removing, in order to clear key, effect of inducing resuscitation, tranquilizing the mind.Fructus Psoraleae warming the kidney to activate YANG, controlling nocturnal emission with astringent drugs reducing urination, warm spleen antidiarrheal, helping inspiration to relieve asthma; Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening; Radix Achyranthis Bidentatae returns liver, kidney channel, invigorating the liver and kidney, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards; Fructus Cnidii, acrid in the mouth, hardship, warm in nature." not Lu " warming the middle warmer and descending qi, make the dirty heat of married woman's, man is cloudy strong, has made us son.Cover and can dehumidify with hardship, temperature energy cold expelling, pungently can moisten kidney, and sweet energy strengthening the spleen, modern pharmacological research Fructus Cnidii can improve gonadal hormone, has certain curative effect to old hormonoprivia.Five medicines share, and are adjuvant drug, temperature compensation Liver and kidney, bone and muscle strengthening, and the raw marrow Fructus Alpiniae Oxyphyllae of supplementing the brain, also principal drug assistance strengthens the effect of supporting lean intelligence altogether.Radix Angelicae Sinensis, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, removing heat from blood is subsided a swelling, and relieving restlessness clears away heart-fire.The two be also adjuvant drug, has blood circulation promoting and enriching, an effect of the blood stasis dispelling that stimulates the menstrual flow, and share and strengthens its blood stasis dispelling that stimulates the menstrual flow further, promotion brain blood circulation, effect of calm the nerves arresting convulsion, slow down aging with monarch drug.Radix Puerariae, the property of medicine is sweet, pungent, cool, returns spleen, stomach two warp, cures mainly expelling pathogenic factors from muscles for reducing heat, rash, yang invigorating antidiarrheal of promoting the production of body fluid.Modern pharmacological research shows, the compositions such as the puerarin of the main isoflavone-containing class of Radix Puerariae and triterpenes Pueraria lobota soap alcohol.The symptom such as headache, dizziness, tinnitus that Radix Puerariae total flavones daidzein and puerarin cause hypertension has obvious curative effect.Radix Puerariae total flavones makes cerebral blood flow increase, and cerebral vascular resistance declines, and is significantly improved the microcirculation disturbance that topical drops norepinephrine causes.To hypertensive arteriosclerosis patient intramuscular injection, then cerebral vascular resistance can be made to reduce, the blood flow angle of incidence is shortened, and has gentle improvement brain blood circulation effect.Radix Puerariae is for making medicine, and it has the effect of sending up the lucid YANG, and all medicines can be led to arrive top, mountain peak brain, and the institute of through slight illness, better plays tonifying the kidney to regenerate bone marrow, Health of brain.Flos Rosae Rugosae, sweet and slightly bitter taste, warm in nature, dispersing the stagnated live-QI to relieve the stagnation of QI of regulating the flow of vital energy, promoting blood circulation to remove blood stasis.The property of medicine is gentle, can the conscience blood vessels of replenishing vital QI with drugs of warm nature people, strongly fragrant gas in Shu Fati, emotion of releiving, and plays calmness, pacifies, antidepressant effect.Obvious mitigation is had to gerontal patient's Hypoemotivity.With Radix Puerariae altogether for making medicine, the up head of priming.All medicines share plays tonifying both YIN and YANG, blood circulation promoting and blood stasis dispelling, clearing away heat and relieving the wind syndrome, inducing resuscitation altogether, the effect of Fructus Alpiniae Oxyphyllae of calming the nerves.

Observation of curative effect:

One, data and method

﹙ mono-﹚ physical data

In research process of the present invention, screen the 78 routine Patients with Vascular Dementia that my institute's traditional Chinese medical science clinic is medical altogether, all patients all have history of cerebrovascular, dementia symptom maintains more than 6 months, there is the focal sign of nervous system, Mini-mental Status Examination (MMSE) scoring≤24 points (more than middle school), ≤ 20 points (primary school's degree), ≤ 17 points (illiteracy), all meet the diagnostic criteria [2] about dementia in American Psychiatric Association " mental sickness diagnostic and statistical manual " the 4th edition (DSM-IV), simultaneously with reference to the VD diagnostic criteria that neurological branch of Chinese Medical Association formulates, and be defined as light moderate dementia according to clinical dementia hierarchical table (CDR) standard.Matched group and observation group is divided at random by medical sequencing.Matched group 39 example, wherein man 20 example, female 19 example, the age (70.81 ± 3.19) year, the course of disease (1.32 ± 0.21) year; Observation group 39 example, wherein man 21 example, female 18 example, the age (71.13 ± 3.41) year, the course of disease (1.29 ± 0.34) year.Two groups of patients are in the index such as sex, age, the course of disease, coincident with severity degree of condition, Mini-mental Status Examination (MMSE) scoring, blessed behavior rating scale (BBS), vascular dementia Chinese medicine syndrome integral table (SDS-VD), without significant difference (P>0.05), there is comparability.

﹙ bis-﹚ Therapeutic Method

Observation group gives capsule for treating of the present invention, each 4 oral, 3 times/d is oral; Matched group gives piracetam (piracetam, 0.4g/ sheet, people from Yichang good fortune Pharmaceutical) 0.8g, and 3 times/d is oral; Nimodipine (30mg/ sheet, Shandong Xinhua Pharmaceutical) 30mg3 time/d is oral, and 90d is 1 course for the treatment of.The Primary Care of two groups of patient's cerebrovascular is identical, all gives medicament for resisting platelet aggregation, and for the patient of the diseases such as complicated hypertension, diabetes, infection, conventional use controls blood pressure, blood sugar lowering, anti-infective therapy.

﹙ tri-﹚ clinical efficacy assessment method

Select Mini-mental Status Examination (MMSE), Blessed-Roth behavior rating scale, vascular dementia Chinese medicine syndrome integral table (SDSVD) as evaluation index, evaluate respectively with before treatment and after treating 90d.

﹙ tetra-﹚ statistical method

Use SPSS11.0 statistical analysis software, before and after two groups of treatments, MMSE, Blessed-Roth and SDSVD scoring adopts t inspection.

Two, result

Before and after observation group and treatment of control group, MMSE, Blessed-Roth and SDSVD scoring is compared (see table 1), after observation group treatment 90d, cognitive competence, behavioral competence, TCM syndrome evaluation obviously improve before all comparatively treating, MMSE mark improves 3.9 points, BBS mark reduces by 2.6 points, and SDSVD mark reduces by 4.75 points; After treatment of control group 90d, cognitive competence, behavioral competence, TCM syndrome evaluation are improved before all comparatively treating, and MMSE mark improves 2.1 points, and BBS mark reduces by 1.05 points, and tcm syndrome comparation and assessment are without significant change.After observation group treatment 90d, the indexs such as cognitive competence, behavioral competence, TCM syndrome evaluation are obviously better than matched group (P<0.01).Table 1 is that before and after observation group and treatment of control group, MMSE, BBS and SDSVD mark Comparative indices

Note: * *: compare with before treatment, P<0.01, has significant difference; *: compare with before treatment, P<0.05, has significant difference; △ △: compare with after treatment of control group, P<0.01, have significant difference.MMSE (Mini-mental Status Examination), SDSVD (vascular dementia Chinese medicine syndrome integral table), BBS (behavior rating scale)

Three, medical record citing;

1, patient aperture so-and-so, man, 67 years old, because hypomnesis was examined over 5 years.Once lacunar infarction was suffered from, hypertension before 5 years; Leave over without obvious sequela after Comprehensive Treatment.Over nearly 5 years, there is hypomnesis, based on nearly hypomnesis, remote memory still can, it is slightly blunt to react, and haves a medical check-up: the clear language profit of patient god, hypomnesis, it is slightly blunt to react, and orientation force, computing power, faculty of understanding still can, structure sound is clear, and loll placed in the middle, neck is soft, heart and lung auscultation is without exception, abdomen is soft, and extremity muscular strength, muscular tension are normal, and bilateral babinski sign is positive.Light red tongue, tongue is white thick greasy, stringy and rolling pulse.Brain MRI: 1, right side temporal lobe deep abnormal signal, considers cyst, 2, infraction ischemia degeneration stove in brain, 3, brain atrophy.After being admitted to hospital, give that Mini-mental Status Examination (MMSE) scoring is 18 points, blessed behavior rating scale (BBS) is marked 10 points, vascular dementia Chinese medicine syndrome integral table (SDS-VD) marks 14 points.On the basis of conventional Comprehensive Treatment, give precious clever Cognex oral, three times on the one, each 4.Control Fructus Alpiniae Oxyphyllae of calming the nerves, to have one's ideas straightened out refreshment, invigorating the liver and kidney is in hospital, leave hospital after 10 days, to follow the doctor's advice the clever Cognex of oral treasure always, January once in outpatient service check, give after 90 days that Mini-mental Status Examination (MMSE) scoring is 22 points, blessed behavior rating scale (BBS) is marked 8 points, vascular dementia Chinese medicine syndrome integral table (SDS-VD) marks 12 points. follow up a case by regular visits to and continue to take medicine for 1 year, stable disease.

2, patient Chen, female, 70 years old, because of unfavorable 6 years of right side limb activity, bradykinesia was examined over 1 year.Once cerebral infarction was suffered from, hypertension before 6 years; Left over right side limb activity after Comprehensive Treatment unfavorable, Long-term taking medicine is treated.Over nearly 1 year, there is bradykinesia, lethargy, hypomnesis, can't take care of oneself.Have a medical check-up: patient god is clear, incomplete motion aphasia, hypomnesis, bradykinesia, orientation force, computing power, faculty of understanding still can, structure sound is clear, loll right avertence, and neck is soft, and heart and lung auscultation is without exception, abdomen is soft, right side myodynamia 2 grades, hypermyotonia, left limb muscular strength 4 grades, muscular tension is normal, and bilateral babinski sign is positive.Red tongue, thick and greasy fur is slightly yellow, deep-thready pulse.Cerebral CT: 1, left side thalamus infraction, 2, meet Arteriosclerosis Disease of Tapetum White Matter become.After being admitted to hospital, give that Mini-mental Status Examination (MMSE) scoring is 16 points, blessed behavior rating scale (BBS) is marked 12 points, vascular dementia Chinese medicine syndrome integral table (SDS-VD) marks 17 points.On the basis of conventional Comprehensive Treatment, give precious clever Cognex oral, three times on the one, each 4.Control with inducing resuscitation, to calm the nerves Fructus Alpiniae Oxyphyllae, blood circulation promoting and blood stasis dispelling, leave hospital after 21 days in hospital, to follow the doctor's advice the clever Cognex of oral treasure always, January once in outpatient service check, give after 90 days that Mini-mental Status Examination (MMSE) scoring is 22 points, blessed behavior rating scale (BBS) is marked 10 points, vascular dementia Chinese medicine syndrome integral table (SDS-VD) marks 15 points. follow up a case by regular visits to and continue to take medicine for 1 year, stable disease.

3, patient Cui so-and-so, man, 81 years old, because absentminded is examined January.Once cerebral infarction was suffered from, hypertension, type 2 diabetes mellitus before 10 years; Left over left limb activity after Comprehensive Treatment unfavorable, hypomnesis, bradykinesia, Long-term taking medicine is treated.There is absentminded in nearly January, bradykinesia is given an irrelevant answer, hypomnesis, can't take care of oneself.Have a medical check-up: patient god is clear, incomplete motion aphasia, hypomnesis, bradykinesia, orientation force, computing power, faculty of understanding all decline, and structure sound is still clear, loll slightly left avertence, and neck is soft, and cardiac auscultation hear sounds is low blunt, without noise hear and, abdomen is soft, left limb muscular strength 3 grades, hypermyotonia, right side myodynamia 4 grades, muscular tension is normal, and bilateral babinski sign is positive.Body of the tongue is light red, has ecchymosis, root of the tongue portion thick, yellow and greasy fur, stringy and thready pulse.Cerebral CT: 1, multiple focus of infarct in brain, 2, brain atrophy, 3, meet Arteriosclerosis Disease of Tapetum White Matter and become.After being admitted to hospital, give that Mini-mental Status Examination (MMSE) scoring is 15 points, blessed behavior rating scale (BBS) is marked 10 points, vascular dementia Chinese medicine syndrome integral table (SDS-VD) marks 14 points.On the basis of conventional Comprehensive Treatment, give precious clever Cognex oral, three times on the one, each 4.Control with inducing resuscitation, to calm the nerves Fructus Alpiniae Oxyphyllae, blood circulation promoting and blood stasis dispelling, clearing away heat and relieving the wind syndrome, leave hospital after 17 days in hospital, the clever Cognex of oral treasure always of following the doctor's advice, irregularly checks in outpatient service, give after 90 days that Mini-mental Status Examination (MMSE) scoring is 18 points, blessed behavior rating scale (BBS) is marked 12 points, vascular dementia Chinese medicine syndrome integral table (SDS-VD) marks 15 points. follow up a case by regular visits to and continue to take medicine for 1 year, stable disease.

Beneficial effect of the present invention is: the prescription drug adopting traditional Chinese medical science composition, and raw material is easy to get, and preparation method is simple, low price; The present invention has tonifying liver, kidney, effect of inducing resuscitation Fructus Alpiniae Oxyphyllae, significantly improves the cognitive function of vascular dementia, and improve the behavioral competence of patient, tcm syndrome is clearly better; Treatment vascular dementia determined curative effect, and curative effect is also stablized; Drug administration of the present invention is convenient, and patient takes rear absorption completely rapidly, has no side effect.It is a kind of newtype drug for the treatment of vascular dementia at present.

Detailed description of the invention

The specific embodiment of the invention is:

Embodiment 1

A, take Margarita powder 8 grams respectively, Ganoderma 10 grams, Fructus Lycii 15 grams, Fructus Cnidii 15 grams, Rhizoma Polygonati 8 grams, Cortex Eucommiae 14 grams, Herba Taxilli 15 grams, Radix Achyranthis Bidentatae 8 grams, Fructus Psoraleae 7 grams, Flos Chrysanthemi 7 grams, Flos Rosae Rugosae 14 grams, Radix Rehmanniae 20 grams, Radix Puerariae 15 grams, Radix Angelicae Sinensis 8 grams, Radix Salviae Miltiorrhizae 25 grams are for subsequent use;

It is the extractum of 1.30-1.36g/cm3 that B, Fructus Lycii steps A prepared, Ganoderma, Cortex Eucommiae, Rhizoma Polygonati decocting extract relative density when concentration of liquid medicine becomes temperature 80 DEG C;

C, Margarita powder steps A prepared, Fructus Cnidii, Herba Taxilli, Radix Achyranthis Bidentatae, Fructus Psoraleae, Flos Chrysanthemi, Flos Rosae Rugosae, Radix Rehmanniae, Radix Puerariae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae co-grinding cross 100 mesh sieves;

D, by above-mentioned B, C two after step gained extractum and fine powder mixing, cross that 14 mesh sieves are concentrated makes granule, dry, by gained granule filling capsule, each capsule is 0.35g.

Embodiment 2

A, take Margarita powder 12 grams respectively, Ganoderma 15 grams, Fructus Lycii 10 grams, Fructus Cnidii 10 grams, Rhizoma Polygonati 12 grams, Cortex Eucommiae 12 grams, Herba Taxilli 13 grams, Radix Achyranthis Bidentatae 13 grams, Fructus Psoraleae 10 grams, Flos Chrysanthemi 10 grams, Flos Rosae Rugosae 12 grams, Radix Rehmanniae 15 grams, Radix Puerariae 12 grams, Radix Angelicae Sinensis 12 grams, Radix Salviae Miltiorrhizae 32 grams are for subsequent use; All the other steps are with embodiment 1.

Embodiment 3

A, take Margarita powder 15 grams respectively, Ganoderma 20 grams, Fructus Lycii 8 grams, Fructus Cnidii 8 grams, Rhizoma Polygonati 14 grams, Cortex Eucommiae 8 grams, Herba Taxilli 8 grams, Radix Achyranthis Bidentatae 15 grams, Fructus Psoraleae 14 grams, Flos Chrysanthemi 14 grams, Flos Rosae Rugosae 8 grams, Radix Rehmanniae 10 grams, Radix Puerariae 8 grams, Radix Angelicae Sinensis 15 grams, Radix Salviae Miltiorrhizae 40 grams are for subsequent use; All the other steps are with embodiment 1.

Claims (5)

1. treat the medicine of vascular dementia for one kind, it is characterized in that, be made up of the raw material of following portions by weight proportioning: Margarita powder 8-15, Ganoderma 10-20, Fructus Lycii 8-15, Fructus Cnidii 8-15, Rhizoma Polygonati 8-14, Cortex Eucommiae 8-14, Herba Taxilli 8-15, Radix Achyranthis Bidentatae 8-15, Fructus Psoraleae 7-14, Flos Chrysanthemi 7-14, Flos Rosae Rugosae 8-15, Radix Rehmanniae 10-20, Radix Puerariae 8-15, Radix Angelicae Sinensis 8-15, Radix Salviae Miltiorrhizae 25-40.

2. a kind of medicine for the treatment of vascular dementia according to claim 1, is characterized in that: the parts by weight proportioning of each raw material is: Margarita powder 12, Ganoderma 15, Fructus Lycii 10, Fructus Cnidii 10, Rhizoma Polygonati 12, Cortex Eucommiae 12, Herba Taxilli 13, Radix Achyranthis Bidentatae 13, Fructus Psoraleae 10, Flos Chrysanthemi 10, Flos Rosae Rugosae 12, Radix Rehmanniae 15, Radix Puerariae 12, Radix Angelicae Sinensis 12, Radix Salviae Miltiorrhizae 32.

3. a kind of medicine for the treatment of vascular dementia according to claim 1 or 2, is characterized in that: described Chinese medicine can be made as decoction, powder, pill, unguentum, syrup, tablet, granule or powder preparation to be taken after being infused in boiling water, granule, capsule by process of Chinese medicine preparation conveniently.

4. a kind of medicine for the treatment of vascular dementia according to claim 3, is characterized in that: the preparation formulation of described medicine is tablet, capsule or pill.

5. a kind of preparation method for the treatment of the medicine of vascular dementia as claimed in claim 4, is characterized in that: the preparation method of described capsule, mainly comprises the steps:

A, to take Margarita powder respectively according to described parts by weight proportioning, Ganoderma, Fructus Lycii, Fructus Cnidii, Rhizoma Polygonati, Cortex Eucommiae, Herba Taxilli, Radix Achyranthis Bidentatae, Fructus Psoraleae, Flos Chrysanthemi, Flos Rosae Rugosae, Radix Rehmanniae, Radix Puerariae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae are for subsequent use;

It is the extractum of 1.30-1.36g/cm3 that B, Fructus Lycii steps A prepared, Ganoderma, Cortex Eucommiae, Rhizoma Polygonati decocting extract relative density when concentration of liquid medicine becomes temperature 80 DEG C;

C, Margarita powder steps A prepared, Fructus Cnidii, Herba Taxilli, Radix Achyranthis Bidentatae, Fructus Psoraleae, Flos Chrysanthemi, Flos Rosae Rugosae, Radix Rehmanniae, Radix Puerariae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae co-grinding cross 100 mesh sieves;

D, by above-mentioned B, C two after step gained extractum and fine powder mixing, cross that 14 mesh sieves are concentrated makes granule, dry, by gained granule filling capsule, each capsule is 0.35g.