CN104667199A

CN104667199A - Pharmaceutical preparation for treating mental anxiety and application of pharmaceutical preparation

Info

Publication number: CN104667199A
Application number: CN201510139681.4A
Authority: CN
Inventors: 王继委; 孙辉
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-03-29
Filing date: 2015-03-29
Publication date: 2015-06-03

Abstract

The invention relates to a pharmaceutical preparation for treating mental anxiety, which is prepared from the following raw materials: david woodbetony rhizome, rhizoma acori graminei, polygala roots, herba epimedii, poria cocos, fructus psoraleae, radix paeoniae rubra, cortex magnoliae officinalis, arisaema cum bile, centella, acanthopanax roots, semen euryales, rhodobryum roseum, hemerocallis citrina baroni, caulis spatholobi, radix paeoniae alba, tuber fleeceflower stem, fructus aurantii immaturus, parasitic loranthus, dendrobium nobile, rhizoma anemarrhenae, rhizoma sparganii, rhizoma alismatis, gardenia, radix curcumae and spine date seeds. The pharmaceutical preparation can treat both symptoms and root causes of mental anxiety, has no side effect, and is low in cost, simple and convenient to prepare, and wide in application prospect.

Description

A kind of pharmaceutical preparation and application thereof being used for the treatment of Anxiety Treated with Integrated

Technical field

The invention belongs to traditional Chinese medicine preparation technical field, concrete, relate to a kind of pharmaceutical preparation and the application thereof that are used for the treatment of Anxiety Treated with Integrated.

Background technology

Anxiety neurosis, is also called anxiety neurosis, is modal one in this large class disease of neurosis, with anxiety experience for principal character.Chronic anxiety (generalized anxiety disorder) and acute anxiety attack (panic disorder) two kinds of forms can be divided into.Main manifestations is: the anxiety without clear and definite objective objects is worried, is on tenterhooks, and also has vegetative nerve symptom (cardiopalmus, hand shaking, perspiration, frequent micturition etc.).The clinical manifestation of anxiety neurosis is: 1 chronic anxiety (generalized anxiety disorder) (1) emotional symptoms is not when having obvious inducement, the excessive worry that not being inconsistent with real situation often appears in patient, anxiety are feared, this anxiety fears usually do not have clear and definite object and content.Patient feels oneself to be in a kind of nervous, on tenterhooks always, frightened, fear, in worried inner experience.(2) vegetative nerve symptom dizzy, uncomfortable in chest, nervous, rapid breathing, xerostomia, frequent micturition, urgent micturition, perspire, the symptom of the body aspect such as to tremble.(3) mobility's uneasiness is on tenterhooks, and feels restless, irritated, is difficult to get down.(panic attack, panic disorder) (1) the dying sense of 2 acute anxiety attack or sense out of control are in normal daily life, and patient is almost the same with normal person.And once outbreak (what have has certain trigger situation, as enclosed space etc.), extremely frightened psychology appears suddenly in patient, experience dying sense or sense out of control.(2) autonomic nervous system symptom occurs as uncomfortable in chest, nervous, dyspnea simultaneously, perspires, shakes all over.(3) general lasting a few minutes to a few hours outbreak starts suddenly, Clear consciousness during outbreak.

Motherland's medical science is thought, anxiety neurosis belongs to " strongly fragrant disease " category.Strongly fragrant disease be due to feelings will do not relax, caused by depression and stagnation of QI, to feel depressed, full vexed, the distending pain over the hypochondrium of irritable emotion, chest, or irritability is easily cried, or is a class disease of main clinical manifestation if any diseases such as foreign body infractions in pharynx.By Chinese medical discrimination, anxiety neurosis is mainly divided into following several types: depression of liver-QI: spirit depressing, irritable emotion, and chest is full vexed, distending pain over the hypochondrium, migratory pain, the vexed belch of gastral cavity, and anorexia, defecates uncomfortable, greasy and thin fur, stringy pulse; Stagnated QI transforming into fire: being irritable and irascible, fullness and distention in the chest and hypochondrium, bitter taste and dryness in the mouth, or headache, conjunctival congestion, tinnitus, or noisy acid regurgitation, constipation, red tongue, yellow fur, wiry and frequent pulse; Blood stasis: spirit depressing, irascible temperament, headache, insomnia, forgetful, or pain in chest and hypochondrium, or there is sense of feeling cold or generate heat in health portion, purplish tongue, or have petechia, ecchymosis, stringy pulse or puckery; Mental disorder pent-up: spirit depressing, the vexed plug of chest, side of body rib distension, if any thing infraction in pharynx, can not swallow, not out, tongue is greasy in vain, stringy and rolling pulse.Assertive evidence that is " Medical Treasures of the Golden Chamber the miscellaneous internal diseases in woman arteries and veins is demonstrate,proved and controls " said " married woman pharynx in if any processing a small slice of meat, BANXIA HOUPU TANG master it " disease.This disease is called " globus hystericus " by " all gas method for the treatment of of Yizong Jinjian "; The mind is deluded and confused: absentminded, malaise, suspicious easily frightened, and sad melancholy is kind cries, being happy and angry uncertainly, or stretches oneself and yawn constantly, or dances for joy, and scolding is scolded and shouted, pale tongue, stringy pulse.Be more common in women, often bring out because of direct stimulation.Clinical manifestation is varied, but same patient per outbreak mostly is the repetition of same several symptom.This kind of syndrome is called " hysteria " by " Medical Treasures of the Golden Chamber the miscellaneous internal diseases in woman arteries and veins is demonstrate,proved and controls "; Deficiency of both the heart and spleen: kind doubting of thinking much, dizziness and fatigue, cardiopalmus is timid, insomnia, forgetful, poor appetite, lustreless complexion, pale tongue, white and thin fur, thready pulse; The heart-yin virtual loss: irritable emotion, cardiopalmus, forgetful, insomnia, dreaminess, dysphoria with feverish sensation in the chest palms and soles, night sweat, pharyngoxerosis, red tongue with a little fluid, thready and rapid pulse; Deficiency and exhaustion of liver-YIN: irritable emotion, being irritable and getting angry easily, dizzy, tinnitus, order does photophobia, fuzzy viewing, or headache and swollen, flushing conjunctival congestion, dry tongue is red, stringy and thready pulse or number.

In clinical treatment, ancient Chinese medicine doctor is thought along with course advancement, and disease there will be the change of various card, the dialectical pathological change that will disclose a certain moment essence in disease progression exactly, and it is a dynamic idea.Anxiety neurosis is divided three types by Huang Yuedong: insufficiency of heart-QI blood stasis type, heart qi stagnation and blood stasis type and phlegm stagnation fire type.Liu Zhengxue etc. think to be main mainly with the anxiety neurosis of caused by hepatic stagnation qi stagnation and liver-qi and blood stagnation clinically.Zhang Chuanru thinks that the clinical pattern of syndrome of primary disease is simulataneous insufficiency and excessive, and the liver heart combination of syndromes, incoordination between the liver and stomach, insufficiency of the spleen stagnant, deficiency of kidney essence, respectively lay particular stress on.Yu Yihong is summarized as two types: simple type (deficiency of heart-yin causes nutrient blood to be lost), is mingled with type (dyspepsia phlegm-fire stops in stomach, disturbing the mind upwards).Sun Suming etc. think this onset of disease, and mostly be stagnation of QI unconsciousness due to blockage of phlegm, liver-spleen disharmony, gods are become deaf, real how empty few: after prolonged illness, deficiency of both QI and blood, cloudy essence consumption wound, and marrow brain cervical carcinoma with cachexia is empty how real few.Feng Hui is then by its point four type: caused by hepatic stagnation qi stagnation, expectorant heat disturb type, type of deficiency of heart-QI and gallbladder-QI and type of hyperactivity of fire caused by deficiency of YIN.Also be dispersed in ancient Chinese medicine doctor ancient books and records to the record of primary disease, as Xu Ling tire experience: " the frightened expectorant of the lower liver and gall of we, controlling epilepsy must imitate ".Become the deteriorated case of disease involving both the exterior and the interior, deficient and excessive syndromes appearing together.Golden Mirror of Medicine was once called, and " being demonstrate,prove also, is the heresy that negative and positive are mixed; The side of being also, also attacks and mends mixed medicine.Bavin, Gui Xiewei pathogenic factor in the exterior to the greatest extent, Radix Et Rhizoma Rhei attacks sunken interior-heat, Radix Ginseng, Rhizoma Zingiberis Recens, Fructus Jujubae tonify deficiency and stomach function regulating; Poria, Rhizoma Pinelliae diuretic and sending down the abnormal ascending QI, Os Draconis, Concha Ostreae, Plumbum preparatium puckery heavy, relieving convulsion getting into the frame of mind for work and calm the nerves bright, this is for controlling mixed disease also with mixed medicine ", etc.

The object of this invention is to provide that a kind for the treatment of both the principal and secondary aspects of a disease, side effect are little, safe ready, cheap Chinese medicine composition.Its objective is to solve treatment Anxiety Treated with Integrated, overcome Western medicine toxic and side effects large, easily repeatedly, the inapparent problem of therapeutic effect, reaches the object for the treatment of both the principal and secondary aspects of a disease in drug withdrawal.

Summary of the invention

The defect that present inventor exists based on the medicine of existing treatment Anxiety Treated with Integrated, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, seek therapeutic regimen, from motherland's medical treasure-house, filter out YIN and YANG balance regulating, invigorating the spleen for dissipating phlegm, dispelling wind to relieve the exterior syndrome, the natural Chinese medicine of clearing heart fire, by theory of Chinese medical science prescription, skim the cream off milk, it is made to play appetite promoting and the spleen strengthening, benefiting qi and nourishing blood, heart tonifying and tranquilizing, nourish blood the effect of reinforcing the kidney, adopt natural Chinese medicines raw material, through systematic study, scientific compatibility, the Chinese medicine composition for Anxiety Treated with Integrated of the present invention is meticulously mixed with in conjunction with Traditional Chinese Medicine technology, Anxiety Treated with Integrated is had to effect of rapid healing.

For achieving the above object, the technical solution used in the present invention is as follows:

Be used for the treatment of a pharmaceutical preparation for Anxiety Treated with Integrated, it is characterized in that being prepared by following raw material and obtaining,

Rhizoma Pedicularis Davidii, Rhizoma Acori Graminei, Radix Polygalae, Herba Epimedii, Poria, Fructus Psoraleae, Radix Paeoniae Rubra, Cortex Magnoliae Officinalis, Arisaema Cum Bile, Herba Centellae, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Rhodobryum roseum Limpr., Radix hemerocalis plicatae, Caulis Spatholobi, the Radix Paeoniae Alba, Caulis Polygoni Multiflori, Fructus Aurantii Immaturus, Herba Taxilli, Herba Dendrobii, the Rhizoma Anemarrhenae, Rhizoma Sparganii, Rhizoma Alismatis, Fructus Gardeniae, Radix Curcumae, Semen Ziziphi Spinosae.

Preferably, prepared by following weight proportioning raw material and obtain,

Rhizoma Pedicularis Davidii 35 parts, Rhizoma Acori Graminei 35 parts, Radix Polygalae 35 parts, Herba Epimedii 35 parts, 30 parts, Poria,

Fructus Psoraleae 30 parts, Radix Paeoniae Rubra 30 parts, Cortex Magnoliae Officinalis 30 parts, Arisaema Cum Bile 25 parts, Herba Centellae 25 parts,

Radix Et Caulis Acanthopanacis Senticosi 25 parts, Semen Euryales 20 parts, Rhodobryum roseum Limpr. 20 parts, Radix hemerocalis plicatae 20 parts, Caulis Spatholobi 20 parts,

The Radix Paeoniae Alba 18 parts, Caulis Polygoni Multiflori 18 parts, Fructus Aurantii Immaturus 18 parts, Herba Taxilli 18 parts, Herba Dendrobii 15 parts,

The Rhizoma Anemarrhenae 15 parts, Rhizoma Sparganii 15 parts, Rhizoma Alismatis 10 parts, Fructus Gardeniae 10 parts, Radix Curcumae 10 parts, Semen Ziziphi Spinosae 5 parts.

Medicine of the present invention can add one or more pharmaceutically acceptable carriers and be mixed and made into any one clinically or pharmaceutically acceptable dosage form, preferred oral preparation.When being applied in the mode of oral administration the patient needing this treatment, conventional solid preparation can be made into, as tablet, capsule, soft capsule etc.

Preferably, its preparation method is:

(1) get Rhizoma Pedicularis Davidii, Rhizoma Acori Graminei, Radix Polygalae, Herba Epimedii, Arisaema Cum Bile, Herba Centellae, Rhodobryum roseum Limpr., Caulis Polygoni Multiflori, Herba Taxilli, Herba Dendrobii, Radix Curcumae mix in described ratio, add the ethanol relative to mixture 4-5 times amount 95%, reflux, extract, 3 times, each 2 hours, extracting solution merges, and is concentrated into the clear paste that density is 1.25g/ml, 80 DEG C of oven dry, be ground into powder, be complex A;

(2) get surplus stock medicine and add 3 times of soak by water twice, 1 hour first time, second time 0.5 hour, merge extracted twice liquid, it is the extractum of 1.25g/ml that extracting solution drying under reduced pressure is obtained density, after 80 DEG C of oven dry, is ground into powder, is complex B;

(3) by complex A and complex B mixing and stirring, sterilization obtains capsule product.

Chinese medicine YIN and YANG balance regulating of the present invention, dispelling wind to relieve the exterior syndrome, benefiting qi and nourishing blood, heart tonifying and tranquilizing, nourishes blood and reinforces the kidney, and have definite curative effect to Anxiety Treated with Integrated, side effect is little.Fill blood, nourish heart kidney.

Usage and dosage: oral, a 0.2g, three times on the one.

Attention: hyperpietic avoids clothes, warm water delivery service.Period in a medicine avoids pungent food and cold and cool food, and avoid emotional stimulation, life is regular.

The Chinese patent medicine excellent results that the present invention is used for Anxiety Treated with Integrated is:

1. Chinese medicine preparation compatibility of the present invention meets Chinese medicine " monarch " principle, be made up of pure Chinese medicine, each component meets pharmaceutical control law regulation, utilize the comprehensive function of each taste Chinese medicine, not containing chemical components, not containing hormone, have no side effect, treating both the exterior and interior, reaches better enriching yin and nourishing kidney, tranquilizing by nourishing the heart effect;

2. this medicament short treating period, total effective rate is high, not easily recurs more.

3. technique of the present invention is simple, reduces production cost, alleviates the financial burden of patient.

Detailed description of the invention

Embodiment 1

Be used for the treatment of a pharmaceutical preparation for Anxiety Treated with Integrated, it is prepared by following weight proportioning raw material and obtains,

Its preparation method is:

(1) get Rhizoma Pedicularis Davidii, Rhizoma Acori Graminei, Radix Polygalae, Herba Epimedii, Arisaema Cum Bile, Herba Centellae, Rhodobryum roseum Limpr., Caulis Polygoni Multiflori, Herba Taxilli, Herba Dendrobii, Radix Curcumae mix in described ratio, add the ethanol relative to mixture 4 times amount 95%, reflux, extract, 3 times, each 2 hours, extracting solution merges, and is concentrated into the clear paste that density is 1.25g/ml, 80 DEG C of oven dry, be ground into powder, be complex A;

(2) get surplus stock medicine and add 3 times of water boiling and extraction twice, 1 hour first time, second time 0.5 hour, merge extracted twice liquid, it is the extractum of 1.25g/ml that extracting solution drying under reduced pressure is obtained density, after 80 DEG C of oven dry, is ground into powder, is complex B;

Usage and dosage: oral, a 0.2g, three times on the one.

Embodiment 2

Acute toxicity testing: application mice 40, male and female half and half, body weight 30 ~ 40g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group group, often organize 20, fasting 12 hours before experiment, the Chinese patent medicine that administration group gives embodiments of the invention 1 preparation is dissolved in gastric infusion in water (gavage unit dosage form is 50g crude drug/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation fortnight after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Therefore Chinese patent medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: respectively by Chinese medicine embodiment 1 capsule of the present invention to mice continuous use 10 weeks and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 10 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Embodiment 3

Clinical data

Case 102 example is all selected from outpatient clinic patient, selected patient all meets the diagnostic criteria of CCMD-3 and DSM-IV generalized anxiety disorder, Manifest Anxiety Scale (HAMARS) score >=18, without physical disease and brain organic disease, get rid of other mental sickness, different by treatment process, be divided into treatment group and matched group:

Treatment group: 51 examples, man 24 example, female 27 example, 35 years old mean age, minimum 27 years old, maximum 54 years old; Average course of disease 9 months.

Matched group: 51 examples, man 23 example, female 28 example, 35 years old mean age, minimum 26 years old, maximum 53 years old; Average course of disease 9 months.

Between two groups, physical data is through statistics (X 2 test and t inspection) process no significant difference (P > 0.05), has comparability.

Therapeutic modality: capsule prepared by the oral embodiment 1 for the treatment of group, every day three times, each 0.2g 15 days is a course for the treatment of, and treatment time is 3 courses for the treatment of.

Matched group takes buspirone (5mg/ sheet), and first week every day, 15 ~ 20mg, divided three clothes; 2nd ~ 6 week every day, 30mg, divided three clothes.After treating 1 first quarter moon (3 courses for the treatment of), statistics curative effect.

The standard of curative effect evaluation: curative effect evaluation clinical efficacy is evaluated by China's existing " mental sickness efficacy assessment standard ", evaluation criteria point level Four: recovery from illness (mental symptom disappears completely), effective (cardinal symptom disappearance), effectively (symptom alleviates or partial disappearance), invalid (symptom is without improvement or increase the weight of).Therapeutic outcome is in table 1:

Table 1

Group	Example time	Recovery from illness	Effective	Effectively	Invalid	Total effective rate (%)
							Treatment group	51	29	11	7	4	92.2%
Matched group	51	20	10	10	11	78.4%

As seen from the above table: cure rate and the total effective rate for the treatment of group are all obviously better than matched group, have significant difference.

Untoward reaction is compared:

Treatment group, dizzy 1 example, weak 2 examples, xerostomia 2 example, 1 example of feeling sick, totally 6 examples, account for 11.7%.

Matched group, dizzy 5 examples, weak 7 examples, xerostomia 3 example, 2 examples of feeling sick, totally 17 examples, account for 33.3%.

Two groups are compared that there were significant differences.

Above-mentioned each Chinese medicinal components that the present invention adopts makes compatibility mutually, its collaborative effect of curing the disease can be played, there is between each composition of raw material of Chinese medicine used drug effect be interweaved and mutually promote and coordinate usefulness, through clinical verification, have good therapeutic effect to Anxiety Treated with Integrated, in the applicant's medical practice for many years, the case Numerous of curing, all obtains good effect, and with low cost, alleviate the burden of patient, have broad application prospects.

Claims

1. be used for the treatment of a pharmaceutical preparation for Anxiety Treated with Integrated, it is characterized in that, described pharmaceutical preparation is prepared by following raw material and obtains,

2. pharmaceutical preparation according to claim 1, is characterized in that, described pharmaceutical preparation is prepared by the raw material of following weight proportioning and obtains,

3. the preparation method of pharmaceutical preparation described in claim 1-2, is characterized in that, described preparation method comprises the steps:

(1) Rhizoma Pedicularis Davidii, Rhizoma Acori Graminei, Radix Polygalae, Herba Epimedii, Arisaema Cum Bile, Herba Centellae, Rhodobryum roseum Limpr., Caulis Polygoni Multiflori, Herba Taxilli, Herba Dendrobii, Radix Curcumae is got according to weight proportion, mixing, add the ethanol relative to mixture 4-5 times weight 95%, reflux, extract, 3 times, each 2 hours, extracting solution merged, be concentrated into the clear paste that density is 1.25g/ml, 80 DEG C of oven dry, are ground into powder, are complex A;

(2) get surplus stock, mix, add 3 times of water boiling and extraction twice, 1 hour first time, second time 0.5 hour, merge extracted twice liquid, then drying under reduced pressure obtains density is the extractum of 1.25g/ml, after 80 DEG C of oven dry, is ground into powder, is complex B;

(3) by complex A and complex B mixing and stirring, sterilization and get final product.

4. the application of pharmaceutical preparation described in claim 1-3.