CN102973561A - Drug composite for improving sleep and preparation method thereof - Google Patents

Abstract

The invention discloses a drug composite for improving sleep and a preparation method thereof. The drug composite contains the following components in parts by weight: 40 parts of melatonins and 40 parts of vitamins B6.The drug composite disclosed by the invention is a health-care product capsule taking affinal drug and diet raw materials as components, is anticipated to achieve the effect of improving the sleep, takes the melatonins and the vitamins B6 as main raw materials, is processed by adopting a scientific and reasonable production process and has the advantages of finite function, controllable quality and safe taking. The preparation method of the drug composite, which is disclosed by the invention, is simple and completes the preparation through conventional equipment.

Description

A kind of pharmaceutical composition for improving sleep and preparation method thereof

Technical field

The invention belongs to health product technology field, relate to a kind of pharmaceutical composition of health product, particularly a kind of pharmaceutical composition for improving sleep and preparation method thereof.

Background technology

The expection of developing drugs combination product reaches the health care that improves sleep.This product is with melatonin, vitamin B ₆Be primary raw material, theoretical according to Traditional health care, adopt scientific and reasonable production technology to process, this product function is clear and definite, and is quality controllable, takes safety.

Sleep or awakening are normal physiological process, but it is not the activity of the artificial complete Autonomous Control of energy, but a passive process.It can just come by people's will in fact unlike some activity of human body, end and then ending.The bad people that sleeps usually is difficult to induce make and oneself enters sleep and worried.Emotional symptoms shows as agitation, anxiety, emotional lability, worries too much, the nervous emotional symptoms such as frightened, fidgety, restless.The sleep disorder main manifestations for insomnia, the symptoms such as dream is many, easy fatigues, lassitude, hypomnesis, absent minded, thinking bradykinesia.When people are in the sleep state, can make people's brain and health obtain having a rest, rest and reorganize and recover.Help the daily working and learning of people.Science improves sleep quality, is the work guarantees of learning life of people.Yet various bad reasons have caused the not high of sleep quality in people's life.

Summary of the invention

Purpose of the present invention aims to provide a kind of pharmaceutical composition for improving sleep and preparation method thereof, and this drug regimen is a kind of take the integration of edible and medicinal herbs raw material as main health product capsule, and this product is with melatonin, vitamin B ₆Be main composition, two kinds of composition synergism are regulated circadian rhythm, recover damaging cells, improve the physical function state, improve sleep quality, reach the health care that improves sleep, take the crowd and can not produce dependency.

Technical scheme of the present invention is: design a kind of pharmaceutical composition for improving sleep, it is characterized in that composition and weight proportion thereof that it contains are 40 parts of melatonin, vitamin B ₆40 parts.

The preparation method of described a kind of pharmaceutical composition for improving sleep is characterized in that it may further comprise the steps:

1) takes by weighing raw material by following weight ratio: 40 parts of melatonin, vitamin B ₆30 parts;

2) get above-mentioned raw materials, add 20 parts anhydrous glucose, cross 80 mesh sieves, batching;

3) with step 2) the batching mix homogeneously in the mixer of packing into, for subsequent use;

4) capsule filling machine on the said mixture is carried out filling, get final product;

5) inner packing;

6) outer package, product inspection, warehouse-in.

Advantage of the present invention is: melatonin is the human brain depths as body of gland---a kind of amine bormones of " pinus " secretion of size as the strobile among the present invention, also is " melatonin ".Melatonin levels is on the low side in the human body has substantial connection with poor sleeping quality, replenishes melatonin in good time and helps to adjust human boby biorhythm, effectively improves at ordinary times sleep state and jet lag, thereby promotes health.Melatonin can improve the physical function state, improves sleep quality.Regulate circadian rhythm, recover damaging cells, the slow down aging process.Keep skin, reduce the pigmentation that Exposure to Sunlight causes, smooth away wrinkles and mottle.Endocrine regulation improves immunity, keeps the function immunologic function.Vitamin B6 (Vitamin B6) claim again pyridoxin.Be a kind of water soluble vitamins, participate in protein synthesis and catabolism, participate in all amino acid metabolisms, as relevant with the metabolism of haemachrome, relevant with the synthetic nicotinic acid of tryptophan.When human sleep was dull, GABA content can rise very highly, and vitamin B6 can make GABA improve, people's sound sleep of more easily falling asleep.So allow excited brain cell have a rest, except with the melatonin, must add that vitamin B6 begins to bring into play good function.Vitamin B6 can suitably digest, absorb protein and fat: help the tryptophan transfer in the essential amino acid to be changed to nicotinic acid; Prevent the disease of various nerves, skin; Alleviate vomiting: promote the synthetic of nucleic acid, prevent the aging of histoorgan.Reduce because taking the symptoms such as xerostomia that resist melancholy agent causes and dysuria.

This prescription not only can improve sleep, can also enhancing immunity, other diseases there is auxiliary therapeutic action.It is theoretical that pharmaceutical composition of the present invention is used Traditional health care, with melatonin, vitamin B ₆Be main composition, synergism is regulated circadian rhythm, recovers damaging cells, improves the physical function state, improves sleep quality, reaches the health care that improves sleep.No dependence, safety, effectively.

The specific embodiment

The invention will be further described below in conjunction with specific embodiment, but not as limitation of the present invention.The part that is not described in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.

Embodiment 1

Described pharmaceutical composition provided by the invention adopts following steps to make:

1) takes by weighing raw material by following weight ratio: 40 parts of melatonin, vitamin B ₆30 parts;

2) get above-mentioned raw materials, add 20 parts anhydrous glucose, cross 80 mesh sieves, batching;

3) with step 2) the batching mix homogeneously in the mixer of packing into, for subsequent use;

4) capsule filling machine on the said mixture is carried out filling, get final product;

5) inner packing;

6) outer package, product inspection, warehouse-in.

The embodiment of the invention 1 is used for improving the clinical observation of drug regimen (capsule) the treatment sleep disorder of sleeping

1 data and method

1.1 physical data

Sleep disorder patient 120 examples that selection is received treatment voluntarily, male 78 examples, women 42 examples, 25 ~ 67 years old age, average 46 years old, the course of disease 1 ~ 10 year.Be divided at random treatment group 1, treatment group 2, each 30 example for the treatment of group 3 and matched group, each is organized the patient age symptom and consists of without significant difference.Has comparability (P〉0.05).

1.2 Therapeutic Method

The treatment group Primary Care is consistent, and matched group is not taken medicine.The treatment group 1 usefulness embodiment of the invention 1, every day three times, one time 2.Treatment group 2 usefulness compound Semen Ziziphi Spinosae capsules (three friendly Pharma Inc.s produce by Beijing) are oral, and each 1,1 time every night; Treatment group 3 usefulness Chiba board Semen Ziziphi Spinosae gastrodia capsules, each 1, one day three times.

2 results

2.1 curative effect determinate standard

The Drug efficacy evaluation index is assessed with Sleep Dysfunction Rating Scale in Patients with Insomnia (SDRS), the observation project comprise sleep fully, sleep quality, sleep length, insomnia frequency, insomnia degree and wake up after the index such as uncomfortable.With the SDRS total points the treatment before and after subtract minute rate as the curative effect index.Subtract a minute rate=(total points after baseline total points-treatment)/baseline total points.Subtracting minute rate is clinical recovery (containing 80%) more than 80%, and 50%-79% is produce effects, and 30%-49% is invalid for taking a turn for the better less than 30%.

2.2 therapeutic outcome

?	Cure	Produce effects	Take a turn for the better	Invalid	Effective percentage
						Contrast	?	?	?	30	0
Treatment group 1	10	7	10	3	90%
						Treatment group 2	10	14	1	5	84%
Treatment group 3	8	10	6	6	80%

3 discuss

Insomnia is the result that the plyability cause of disease acts on human body, certain with individual body constitution and the character trait of its morbidity has very large dependency, modern society particularly, because the continuous quickening of rhythm of life, the pressure of work, family and society is more and more heavier, and Nervous and Mental Factors and bad living habit, environmental pollution factors etc. have occupied very important status in the pathogenic factor of insomnia.The insomnia pathogenesis also is multi-source, and main pathogenesis shows as negative and positive and do not hand in the modern clinic, YANG failing to enter YIN, although relate to the vital organs of the human body, dirty the most relevant with conscience two, show as void, fire, expectorant, the stasis of blood at pathology.How dirty impaired the Different types of etiopathogenises such as improper diet and overtiredness, internal damage by the excessive seven emotions can simultaneously or successively be attacked body, makes disorder of QI and blood,, thus the patient cause of disease is compound often, syndrome is complicated.Adopt medicine composition, with melatonin, vitamin B ₆Be main composition, regulate circadian rhythm, recover damaging cells, improve the physical function state, improve sleep quality, to reach the purpose of prevention, treatment, control.And then illustrate that embodiment 1 affiliated prescription is reliably effective in this invention.

Claims (2)

1. one kind is used for improving the pharmaceutical composition of sleeping, and it is characterized in that: the composition that it contains and weight proportion thereof are: 40 parts of melatonin, vitamin B ₆40 parts.

2. the preparation method of a kind of pharmaceutical composition for improving sleep according to claim 1, it may further comprise the steps:

1) takes by weighing raw material by following weight ratio: 40 parts of melatonin, vitamin B ₆30 parts;

2) get above-mentioned raw materials, add 20 parts anhydrous glucose, cross 80 mesh sieves, batching;

3) with step 2) the batching mix homogeneously in the mixer of packing into, for subsequent use;

4) capsule filling machine on the said mixture is carried out filling, get final product;

5) inner packing;

6) outer package, product inspection, warehouse-in.