CN105521211A - Traditional Chinese medicinal ointment rubbing agent for promoting growth of premature low-birth-weight children, and preparation method thereof - Google Patents
Traditional Chinese medicinal ointment rubbing agent for promoting growth of premature low-birth-weight children, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal ointment rubbing agent for promoting growth of premature low-birth-weight children, and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicinal ointment rubbing agent comprises, by weight, 18-20 parts of prepared rehmannia root, 9-10 parts of Chinese yam, 9-10 parts of Cornus officinalis, 7-8 parts of Poria cocos, 7-8 parts of Rhizoma Alismatis, 7-8 parts of Cortex Moutan, 9-11 parts of white vaseline, 11-12 parts of stearic acid, 1.8-2.5 parts of lanolin, 6-7 parts of glyceryl monostearate, 14-16 parts of glycerin, 2.5-3.5 parts of tween80, 50-55 parts of water, 2-3 parts of azone and 0.2-0.3 parts of ethyl p-hydroxybenzoate. The traditional Chinese medicinal ointment rubbing agent can effectively promote the growth of premature low-birth-weight children, has the advantages of no side effects and low cost, and is suitable for being used by general poor families.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent promoting pre-term low birth weight upgrowth and development of children and preparation method thereof.
Background technology
The under-weight symptom that pre-term low birth weight and premature labor cause, WHO is defined as " completing the baby alive be born before gestation for 37 weeks " premature labor.According to gestational age, premature labor comprises lower column split: pole early premature labor (<28 week), early motion therapy (28 to 32 week), moderate are to slight premature labor (32 to 37 week).WHO is defined as " birth weight is lower than the neonate of 2.5kg " under-weight, and lower than 1.5kg is very low birth weight infant, lower than below 1kg part being super low birthweight infant.Estimate according to WHO, the whole world has 1,500 ten thousand baby dues too early every year, namely in every 10 babies just more than 1 people.Have in the country of infallible data nearly all, early productive rate is all in continuous growth.In 184 countries, the premature labor ratio of neonate birth is not from 5% to 18% etc.Although the premature labor of more than 60% occurs in Africa and South Asia, premature labor is a real global problem.In low income country, the baby due of average 12% is too early, and by contrast, this ratio is 9% in comparatively high-income countries.The Chinese premature labor quantity with 1172300 occupies the second place of world's premature labor quantity rank, early productive rate about 7.1%.The neonatal under-weight rate in the whole world is 15.5%, and namely about have the under-weight child of 20600000 to be born every year, developing country accounts for wherein 96.5%.
Premature labor is the primary cause of the death of neonatal death, and is the second largest reason of less than five years old death of child after pneumonia.Worldwide have every year and die from premature labor complication more than 1,000,000 babies.The child that many survivals are got off also will face lifelong disability, comprises learning disorder, visual problems, hearing problem etc.Premature infant is due to birth ahead of time, and each histoorgan of health is all with growth shortcoming in various degree, and child more born after the normal gestation period is low for body weight, and the systemic-functions such as breathing, immunity are low.Premature death rate is 12.7% ~ 30.0%, and the lower case fatality rate of body weight is higher, <1000g premature death rate 80% ~ 100%, <1500g person, and its case fatality rate domestic is up to 70% ~ 80%, and foreign data is 33% ~ 70%.
At present, the treatment of newborn low birthweight infant is primarily of doctor trained in Western medicine nutritional support, symptomatic treatment, and kangaroo mother care composition.Western medical treatment and more the carrying out in NICU of Feeding Nursing Care, the hospital stays is longer, and the medical expense produced is huge.The head of a family, bearing huge economic pressures simultaneously, also bears huge stress.Kangaroo mother care is that father and mother and children's carry out contact skin and a kind of therapeutic modality stroked, but it is still not clear the impact of the mortality rate of premature infant and long-term psychomotor development.And adopt the bibliographical information of the newborn low birthweight infant of Chinese traditional treatment less, equally seldom see the method adopting the newborn low birthweight infant of Chinese traditional treatment clinically.This is because the special physiological status of pre-term low birth weight makes traditional form of Chinese drug premature infant more difficult to get access, due drug effect can not be played; Acupuncture have wound property make the head of a family be reluctant infant accept this treatment; Child massage and doctor trained in Western medicine kangaroo mother care and comforting touches to be had certain similar, makes a lot of head of a family in NICU, select kangaroo mother care to touch and can not do child massage more in addition with comforting.Therefore seek economic security, the method that what easy effect was grand can promote pre-term low birth weight to grow up healthy and sound is a medical circle difficult problem urgently to be resolved hurrily always.
Summary of the invention
The object of the invention is to solve the deficiencies in the prior art, a kind of Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent promoting pre-term low birth weight upgrowth and development of children and preparation method thereof is provided.Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease of the present invention agent can effectively promote pre-term low birth weight upgrowth and development of children, without any side effects, and cost is lower, is applicable to vast underprivileged home and uses.
For achieving the above object, the technical solution used in the present invention is as follows:
Promote a Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent for pre-term low birth weight upgrowth and development of children, comprise the following raw material according to weight parts:
Radix Rehmanniae Preparata 18-20 part, Rhizoma Dioscoreae 9-10 part, Fructus Corni 9-10 part, Poria 7-8 part, Rhizoma Alismatis 7-8 part, Cortex Moutan 7-8 part, white vaseline 9-11 part, stearic acid 11-12 part, lanoline 1.8-2.5 part, glyceryl monostearate 6-7 part, glycerol 14-16 part, Tween 80 2.5-3.5 part, water 50-55 part (consumption of water is the substrate aqueous phase water yield used when preparing herein), azone 2-3 part, ethylparaben 0.2-0.3 part.
Further, the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of preferably described promoted pre-term low birth weight upgrowth and development of children, is characterized in that, comprise the following raw material according to weight parts:
19.2 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 9.6 parts, Fructus Corni 9.6 parts, 7.2 parts, Poria, Rhizoma Alismatis 7.2 parts, Cortex Moutan 7.2 parts, white vaseline 10 parts, stearic acid 11.25 parts, lanoline 2 parts, glyceryl monostearate 6.35 parts, glycerol 15 parts, Tween 80 3 parts, 52.4 parts, water, azone 2.6 parts, ethylparaben 0.26 part.Herein, the consumption of water is the substrate aqueous phase water yield used when preparing, and does not comprise volatile oil is drawn, water consumption time prepared by extractum.
The present invention also provides a kind of above-mentioned preparation method promoting the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of pre-term low birth weight upgrowth and development of children, it is characterized in that, comprises the steps:
Step (1), volatile oil is drawn: adopt the volatile oil in steam distillation extraction Cortex Moutan, and be separated Cortex Moutan volatile oil;
Step (2), prepared by extractum: after being mixed with Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria, Rhizoma Alismatis by the remaining solidliquid mixture of step (1) removing Cortex Moutan volatile oil, carry out decocting, then the decocting liquid obtained is concentrated into paste, obtains extractum;
Step (3), prepared by substrate oil phase: white vaseline, stearic acid, lanoline and glyceryl monostearate are mixed, then heating in water bath is to molten condition, and insulation, is then stirred to mix homogeneously, obtains substrate oil phase, for subsequent use;
Step (4), prepared by substrate aqueous phase: after glycerol, Tween 80 and water (herein, the consumption of water is consumption disclosed in above-mentioned raw materials) being mixed together, and heating in water bath is to 79-81 DEG C, and insulation, is then stirred to mix homogeneously, obtains substrate aqueous phase;
Step (5), matrix composition: after the substrate aqueous phase that substrate oil phase step (3) obtained and step (4) obtain mixes, heating in water bath is to 79-81 DEG C, and insulation, is then stirred to profit and mixes uniformly emulsion, obtain substrate;
Step (6), step (2) is obtained extractum join in the substrate that step (5) obtains, heating in water bath is to 79-81 DEG C, insulation, then be stirred to mix homogeneously, and then add the obtained Cortex Moutan volatile oil of azone, ethylparaben and step (1) wherein, continue to be stirred to mix homogeneously, naturally cool to room temperature, namely obtain the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent that can promote pre-term low birth weight upgrowth and development of children.
Further, when preferably steam distillation extracts the volatile oil in Cortex Moutan, the mass ratio of Cortex Moutan and water is 1:9-11.
Further, preferably the quality of the concentrated extractum obtained of step (2) be Cortex Moutan, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria and Rhizoma Alismatis gross mass 0.4-0.6 doubly.
Further, preferably step (3) and the stirring described in step (4) adopt pestle of pounding medicine in a mortar to carry out large contact surface stirring.
Further, preferably step (5) and the stirring described in step (6) adopt mechanical agitation, and speed is 180-240 rev/min.
Further, the preparation method of the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of preferably described promoted pre-term low birth weight upgrowth and development of children, comprises the steps:
Step (1), volatile oil is drawn: adopt the volatile oil in steam distillation extraction Cortex Moutan, and be separated Cortex Moutan volatile oil; During extraction, the mass ratio of Cortex Moutan and water is 1:10; Step (2), prepared by extractum: after being mixed with Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria, Rhizoma Alismatis by the remaining solidliquid mixture of step (1) removing Cortex Moutan volatile oil, decocting 2 times, 2 hours first times, second time 1 hour, each water consumption be Cortex Moutan, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria and Rhizoma Alismatis gross mass 25-30 doubly, merge decocting liquid, then the decocting liquid obtained is concentrated into paste, obtains extractum; The quality of extractum be Cortex Moutan, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria and Rhizoma Alismatis gross mass 0.5 times;
Step (3), substrate oil phase prepare: by white vaseline, stearic acid, lanoline and glyceryl monostearate mix, then heating in water bath is to molten condition, insulation, then adopt glass pound medicine in a mortar pestle stir 10min, obtain substrate oil phase, for subsequent use;
Step (4), substrate aqueous phase prepare: after glycerol, Tween 80 and water are mixed together, heating in water bath to 80 DEG C, insulation, then adopt glass pound medicine in a mortar pestle stir 10min, obtain substrate aqueous phase;
Step (5), matrix composition: after the substrate aqueous phase that substrate oil phase step (3) obtained and step (4) obtain mixes, heating in water bath to 80 DEG C, insulation, then stirs 30min with the clockwise direction of 180-240 rev/min, obtains substrate;
Step (6), step (2) is obtained extractum join in the substrate that step (5) obtains, heating in water bath to 80 DEG C, insulation, then stir 30min with the clockwise direction of 180-240 rev/min, and then add the obtained Cortex Moutan volatile oil of azone, ethylparaben and step (1) wherein, continue to stir 5min with the clockwise direction of 180-240 rev/min, naturally cool to room temperature, namely obtain the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent that can promote pre-term low birth weight upgrowth and development of children.
Cortex Moutan volatile oil is when preserving, and also can dissolve in ethanol, the dehydrated alcohol adopted and the mass ratio of Cortex Moutan are preferably 1:11-12, directly can add like this, can not have an impact to product when step (6) uses.
Compared with prior art, its beneficial effect is in the present invention:
(1) Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease of the present invention agent can effectively promote pre-term low birth weight upgrowth and development of children, without any side effects, and cost is lower, adopts the present invention's treatment to be only the 5-10% of modern Western medicine medical expense, is applicable to vast family and uses;
(2) instant invention overcomes the problem of traditional form of Chinese drug premature infant more difficult to get access, Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease of the present invention agent is treated preterm children as massage medium, not only there is comparatively considerable economic benefit, also there is certain social benefit.
(3) children's's a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease obtains prosperity and development in Tang and Song Dynasty time, and the present invention again develops traditional Chinese medicine therapy mode and in conjunction with modern science and technology, creatively reform, has great scientific research and explore meaning.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
It will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.Unreceipted concrete technology or condition person in embodiment, according to the technology described by the document in this area or condition or carry out according to product description.Agents useful for same or the unreceipted production firm person of instrument, being can by buying the conventional products obtained.
Embodiment 1
Promote a Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent for pre-term low birth weight upgrowth and development of children, comprise the following raw material according to weight parts:
18 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 9 parts, Fructus Corni 9 parts, 7 parts, Poria, Rhizoma Alismatis 7 parts, Cortex Moutan 7 parts, white vaseline 9 parts, stearic acid 11 parts, lanoline 1.8 parts, glyceryl monostearate 6 parts, glycerol 14 parts, Tween 80 2.5 parts, 50 parts, water, azone 2 parts, ethylparaben 0.2 part.
The present embodiment can promote the preparation method of the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of pre-term low birth weight upgrowth and development of children, comprises the steps:
Step (1), volatile oil is drawn: adopt the volatile oil in steam distillation extraction Cortex Moutan, and be separated Cortex Moutan volatile oil; When steam distillation extracts the volatile oil in Cortex Moutan, the mass ratio of Cortex Moutan and water is 1:9;
Step (2), prepared by extractum: after being mixed with Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria, Rhizoma Alismatis by the remaining solidliquid mixture of step (1) removing Cortex Moutan volatile oil, carry out decocting, then the decocting liquid obtained is concentrated into paste, obtains extractum; The quality of described extractum be Cortex Moutan, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria and Rhizoma Alismatis gross mass 0.4 times;
Step (3), prepared by substrate oil phase: white vaseline, stearic acid, lanoline and glyceryl monostearate are mixed, then heating in water bath is to molten condition, insulation, then adopts pestle of pounding medicine in a mortar to carry out being stirred to mix homogeneously, obtains substrate oil phase, for subsequent use;
Step (4), prepared by substrate aqueous phase: after glycerol, Tween 80 and water being mixed together, heating in water bath to 79 DEG C, insulation, then adopts pestle of pounding medicine in a mortar to carry out being stirred to mix homogeneously, obtains substrate aqueous phase;
Step (5), matrix composition: after the substrate aqueous phase that substrate oil phase step (3) obtained and step (4) obtain mixes, heating in water bath to 79 DEG C, insulation, is then stirred to profit with the speed of 180 revs/min and mixes uniformly emulsion, obtain substrate;
Step (6), step (2) is obtained extractum join in the substrate that step (5) obtains, heating in water bath to 79 DEG C, insulation, then be stirred to mix homogeneously with the speed of 180 revs/min, and then add the obtained Cortex Moutan volatile oil of azone, ethylparaben and step (1) wherein, continue to be stirred to mix homogeneously with the speed of 180 revs/min, naturally cool to room temperature, namely obtain the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent that can promote pre-term low birth weight upgrowth and development of children.
Embodiment 2
Promote a Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent for pre-term low birth weight upgrowth and development of children, comprise the following raw material according to weight parts:
20 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 10 parts, Fructus Corni 10 parts, 8 parts, Poria, Rhizoma Alismatis 8 parts, Cortex Moutan 8 parts, white vaseline 11 parts, stearic acid 12 parts, lanoline 2.5 parts, glyceryl monostearate 7 parts, glycerol 16 parts, Tween 80 3.5 parts, 55 parts, water, azone 3 parts, ethylparaben 0.3 part.
The present embodiment promotes the preparation method of the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of pre-term low birth weight upgrowth and development of children, comprises the steps:
Step (1), volatile oil is drawn: adopt the volatile oil in steam distillation extraction Cortex Moutan, and be separated Cortex Moutan volatile oil; When steam distillation extracts the volatile oil in Cortex Moutan, the mass ratio of Cortex Moutan and water is 1:9-11;
Step (2), prepared by extractum: after being mixed with Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria, Rhizoma Alismatis by the remaining solidliquid mixture of step (1) removing Cortex Moutan volatile oil, carry out decocting, then the decocting liquid obtained is concentrated into paste, obtains extractum; The quality of described extractum be Cortex Moutan, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria and Rhizoma Alismatis gross mass 0.6 times;
Step (3), prepared by substrate oil phase: white vaseline, stearic acid, lanoline and glyceryl monostearate are mixed, then heating in water bath is to molten condition, insulation, then adopts pestle of pounding medicine in a mortar to carry out being stirred to mix homogeneously, obtains substrate oil phase, for subsequent use;
Step (4), prepared by substrate aqueous phase: after glycerol, Tween 80 and water being mixed together, heating in water bath to 81 DEG C, insulation, then adopts pestle of pounding medicine in a mortar to carry out being stirred to mix homogeneously, obtains substrate aqueous phase;
Step (5), matrix composition: after the substrate aqueous phase that substrate oil phase step (3) obtained and step (4) obtain mixes, heating in water bath to 81 DEG C, insulation, is then stirred to profit with the speed of 240 revs/min and mixes uniformly emulsion, obtain substrate;
Step (6), step (2) is obtained extractum join in the substrate that step (5) obtains, heating in water bath to 81 DEG C, insulation, then be stirred to mix homogeneously with the speed of 240 revs/min, and then add the obtained Cortex Moutan volatile oil of azone, ethylparaben and step (1) wherein, continue to be stirred to mix homogeneously with the speed of 240 revs/min, naturally cool to room temperature, namely obtain the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent that can promote pre-term low birth weight upgrowth and development of children.
Embodiment 3
Promote a Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent for pre-term low birth weight upgrowth and development of children, it is characterized in that, comprise the following raw material according to weight parts:
19.2 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 9.6 parts, Fructus Corni 9.6 parts, 7.2 parts, Poria, Rhizoma Alismatis 7.2 parts, Cortex Moutan 7.2 parts, white vaseline 10 parts, stearic acid 11.25 parts, lanoline 2 parts, glyceryl monostearate 6.35 parts, glycerol 15 parts, Tween 80 3 parts, 52.4 parts, water, azone 2.6 parts, ethylparaben 0.26 part.
The present embodiment can promote the preparation method of the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of pre-term low birth weight upgrowth and development of children, comprises the steps:
Step (1), volatile oil is drawn: adopt the volatile oil in steam distillation extraction Cortex Moutan, and be separated Cortex Moutan volatile oil, then Cortex Moutan volatile oil is dissolved in dehydrated alcohol, for subsequent use; During extraction, the mass ratio of Cortex Moutan and water is 1:10;
Step (2), prepared by extractum: after being mixed with Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria, Rhizoma Alismatis by the remaining solidliquid mixture of step (1) removing Cortex Moutan volatile oil, decocting 2 times, 2 hours first times, second time 1 hour, each water consumption be Cortex Moutan, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria and Rhizoma Alismatis gross mass 26.7 times, merge decocting liquid, then the decocting liquid obtained is concentrated into paste, obtains extractum; The quality of extractum be Cortex Moutan, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria and Rhizoma Alismatis gross mass 0.5 times;
Step (3), substrate oil phase prepare: by white vaseline, stearic acid, lanoline and glyceryl monostearate mix, then heating in water bath is to molten condition, insulation, then adopt glass pound medicine in a mortar pestle stir 10min, obtain substrate oil phase, for subsequent use;
Step (4), substrate aqueous phase prepare: after glycerol, Tween 80 and water are mixed together, heating in water bath to 80 DEG C, insulation, then adopt glass pound medicine in a mortar pestle stir 10min, obtain substrate aqueous phase;
Step (5), matrix composition: after the substrate aqueous phase that substrate oil phase step (3) obtained and step (4) obtain mixes, heating in water bath to 80 DEG C, insulation, then stirs 30min with the clockwise direction of 200 revs/min, obtains substrate;
Step (6), step (2) is obtained extractum join in the substrate that step (5) obtains, heating in water bath to 80 DEG C, insulation, then stir 30min with the clockwise direction of 200 revs/min, and then add the obtained Cortex Moutan volatile oil of azone, ethylparaben and step (1) wherein, continue to stir 5min with the clockwise direction of 200 revs/min, naturally cool to room temperature, namely obtain the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent that can promote pre-term low birth weight upgrowth and development of children.
Performance Detection
One, safety testing (comprising acute toxicity test, Skin Irritation Test, skin anaphylactic test)
1. acute toxicity test
Carry out acute toxicity test to the finished product of the embodiment of the present invention 1 ~ 10, extracting waste healthy guinea pig 50 (male and female half and half, about body weight 0.3kg), is divided into 5 groups at random.Within first 24 hours, take off with the hair of razor by family's rabbit back spinal column both sides in administration, unhairing scope is equivalent to the 10%(40cm of body surface area
2) left and right.Within after unhairing 24 hours, check that whether skin of unhairing is injured because of unhairing.Get the Cavia porcellus of 20 unhairing male and female half and half at random, with 75% alcohol disinfecting skin then with No. 16 sterilizing syringe needles at unhairing zoning " # " word wound, each 2cm anyhow, the degree of being with oozing of blood, left and right sides skin injury degree is consistent.
Residue 30 Cavia porcellus stochastic averagina are divided into 3 groups, often organize 10, male and female half and half.First group is Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent low dose group of the present invention, and Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent 1g of the present invention is evenly applied to depilation district, and covers with non-stimulated hospital gauze, Medical adhesive plaster is fixed, and continues after 24 hours, removes residual plaster with warm water.Second group is Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease of the present invention agent 4 multiple dose group, and give Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent 4g of the present invention and be evenly applied to depilation district, operation is with first group.3rd group be male and female half and half, 10 of skin injury, operation is with first group.4th group be residue male and female half and half, 10 of skin injury, operation is with second group.5th group is blank group, and be coated with reference substance vaseline 1g, operation is with first group.
Result is presented at low dosage and the high dose outer used time to the behavior of intact skin Cavia porcellus and damaged skin Cavia porcellus, activity, fur gloss, diet, eye and mucosa, breathing, body weight without impact (being P>0.05), dead without Cavia porcellus in 7 days, there is not any acute toxic reaction.
Result shows this finished product and belongs to non-toxic type;
2. irritation test
Extracting waste healthy guinea pig 10 (male and female half and half, body weight 0.3Kg), is divided into 2 groups at random, and often organize 5, wherein one group is intact skin, and another group is damaged skin.Before administration, the hair of family's rabbit back spinal column both sides is taken off by 24h razor, and the depilation every side of area is about 40cm
2.Damaged skin group will to be lost hair or feathers position sterilization skin standardized " # " word cut with No. 16 sterilizing syringe needles, and cut is each about 2cm anyhow, and the degree of being with oozing of blood, left and right sides skin injury degree is consistent.Two groups of rabbit left dorsal all apply the agent of 1g Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease of the present invention, the right side back of the body all applies reference substance 1g(medical ventolin), and cover with gauze, fix with Medical adhesive plaster again, continue after 24 hours, use warm water cleaning medicine, observe and smear position 1h, 24h, 48h, 72h skin wound repair, result shows; The skin irritation such as erythema, edema phenomenon is all there is not when 1h, 24h, 48h, 72h.Prove that Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent single administration of the present invention is to Cavia porcellus intact skin and the equal nonirritant of damaged skin.
3. skin allergy test
Get healthy albino guinea-pig 30 (body weight 220 ~ 250g), be divided into 3 groups at random, often organize 10, male and female half and half, set up Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent test group of the present invention, blank group and positive controls separately.Before administration, the hair of guinea pig back spinal column both sides is taken off by 24h depilatory, the every side 3 × 3cm of depilation area
2.Lose hair or feathers on the left of experimental group every Cavia porcellus district's coating cream 0.2g, and cover with gauze, then fix with Medical adhesive plaster, continues to dismantle for 6 hours.7th day and the 14th day in kind respectively repeats once, blank group coating medical ventolin 0.2g, and positive controls coating quality concentration is 1% 2, the alcoholic solution 0.2ml of 4-dinitrochlorobenzene, the same experimental group of method.After last administration the 14th day, test group every Cavia porcellus repasted deposited 2,4-dinitrochlorobenzene 0.2g in depilation district, right side, fix, remove covering after 6h, at once observe, then again observe skin allergy situation respectively at 24h, 48h, 72h with method.Blank group and positive controls give medical ventolin 0.2g respectively, mass concentration is 0.1% 2, the alcoholic solution 0.2ml of 4-dinitrochlorobenzene, the same experimental group of method.Found that and all do not make guinea pig skin occur the anaphylaxis such as erythema, edema in observation at once, 24h, 48h, 72h experimental group, blank group, sensitization rate is 0%, and positive controls sensitization rate is 100%.Show Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease of the present invention agent to guinea pig skin without sensitization, 2,4-dinitrochlorobenzene has extremely sensitization to guinea pig skin.
Two, clinical research
Select 200 routine infants, infant is all be born before gestation for 37 weeks, and birth weight is the baby alive of 1-2.5kg, and treatment time is the birth infant of latter 42 days to 1 years old.Be divided into matched group and test group of the present invention at random.
Matched group:
Feed, kangaroo mother care according to " premature labor/low birth weight infant feeding recommendations "; And treat according to spleen invigorating provicial commander massage therapy, the medium in massage uses commercially available Johnson & Johnson baby talcum powder, and operating procedure is as follows:
The first step: infant gets dorsal position or the head of a family embraces seat, spleen reinforcing is through 300 times, and the kidney invigorating is through 300 times, and tonifying the lung is through 100 times; Rub tsu san li 100 times; Push away spring 100 times.
Second step: infant gets ventricumbent position, gently to rub spinal column with palm palm-rubbing technique, 3 times from top to bottom; Chiropractic, 3 times from down to up, selectivity rubs fei shu, Pishu and shen shu or muscular tone, even have position that is streak or nodal-like reactant, 30 seconds, every cave; Rub Testudinis tail 30 times, push to seven joint bones 100 times; Straight wiping governor vessel (changqiang-gate of vitality), horizontal wiping lumbosacral region, the degree of being with heat.
3rd step: infant gets dorsal position, frontal scrubing 30 times, pushes away bank palace 30 times, rubs Baihui 10 times, and rub fontanel 30 seconds; Rub the middle part of gastric cavity 1 minute, and rub Shenque 1 minute, and shake abdomen 1 minute, rubs Qihai, Guan Yuan, 30 seconds, every cave.
Test group of the present invention:
On the basis of matched group, for the massage of shen shu, yao yang kuan, Zhiyang, big vertebra, massage medium is changed into Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease of the present invention agent, other positions use Johnson & Johnson's baby talcum powder.
Two groups of identical nursings, introduction on discharge and massage treatment operating procedures.
The Therapeutic Method of matched group and test group of the present invention: treat 1 time every other day, 3 times is weekly for 12 times a course for the treatment of.2 days, interval between the course for the treatment of, treats 3 courses for the treatment of altogether.
Compared with matched group, the average sleep of test group of the present invention is all better than matched group (P<0.05), and body weight and height all have statistical significance (P<0.05) than matched group raising, the mental status is suitable with matched group with diet.
More than show and describe ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (8)
1. promote a Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent for pre-term low birth weight upgrowth and development of children, it is characterized in that, comprise the following raw material according to weight parts:
Radix Rehmanniae Preparata 18-20 part, Rhizoma Dioscoreae 9-10 part, Fructus Corni 9-10 part, Poria 7-8 part, Rhizoma Alismatis 7-8 part, Cortex Moutan 7-8 part, white vaseline 9-11 part, stearic acid 11-12 part, lanoline 1.8-2.5 part, glyceryl monostearate 6-7 part, glycerol 14-16 part, Tween 80 2.5-3.5 part, water 50-55 part, azone 2-3 part, ethylparaben 0.2-0.3 part.
2. the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of promotion pre-term low birth weight upgrowth and development of children according to claim 1, is characterized in that, comprises the following raw material according to weight parts:
19.2 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 9.6 parts, Fructus Corni 9.6 parts, 7.2 parts, Poria, Rhizoma Alismatis 7.2 parts, Cortex Moutan 7.2 parts, white vaseline 10 parts, stearic acid 11.25 parts, lanoline 2 parts, glyceryl monostearate 6.35 parts, glycerol 15 parts, Tween 80 3 parts, 52.4 parts, water, azone 2.6 parts, ethylparaben 0.26 part.
3. the preparation method of the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of the promotion pre-term low birth weight upgrowth and development of children described in claim 1 or 2, is characterized in that, comprise the steps:
Step (1), volatile oil is drawn: adopt the volatile oil in steam distillation extraction Cortex Moutan, and be separated Cortex Moutan volatile oil;
Step (2), prepared by extractum: after being mixed with Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria, Rhizoma Alismatis by the remaining solidliquid mixture of step (1) removing Cortex Moutan volatile oil, carry out decocting, then the decocting liquid obtained is concentrated into paste, obtains extractum;
Step (3), prepared by substrate oil phase: white vaseline, stearic acid, lanoline and glyceryl monostearate are mixed, then heating in water bath is to molten condition, and insulation, is then stirred to mix homogeneously, obtains substrate oil phase, for subsequent use;
Step (4), prepared by substrate aqueous phase: after glycerol, Tween 80 and water being mixed together, and heating in water bath is to 79-81 DEG C, and insulation, is then stirred to mix homogeneously, obtains substrate aqueous phase;
Step (5), matrix composition: after the substrate aqueous phase that substrate oil phase step (3) obtained and step (4) obtain mixes, heating in water bath is to 79-81 DEG C, and insulation, is then stirred to profit and mixes uniformly emulsion, obtain substrate;
Step (6), step (2) is obtained extractum join in the substrate that step (5) obtains, heating in water bath is to 79-81 DEG C, insulation, then be stirred to mix homogeneously, and then add the obtained Cortex Moutan volatile oil of azone, ethylparaben and step (1) wherein, continue to be stirred to mix homogeneously, naturally cool to room temperature, namely obtain the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent that can promote pre-term low birth weight upgrowth and development of children.
4. the preparation method of the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of promotion pre-term low birth weight upgrowth and development of children according to claim 3, is characterized in that, when steam distillation extracts the volatile oil in Cortex Moutan, the mass ratio of Cortex Moutan and water is 1:9-11.
5. the preparation method of the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of promotion pre-term low birth weight upgrowth and development of children according to claim 3, it is characterized in that, the quality of the concentrated extractum obtained of step (2) be Cortex Moutan, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria and Rhizoma Alismatis gross mass 0.4-0.6 doubly.
6. the preparation method of the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of promotion pre-term low birth weight upgrowth and development of children according to claim 3, is characterized in that, step (3) and the stirring described in step (4) adopt pestle of pounding medicine in a mortar to stir.
7. the preparation method of the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of promotion pre-term low birth weight upgrowth and development of children according to claim 3, is characterized in that, step (5) and the stirring described in step (6) adopt mechanical agitation, and speed is 180-240 rev/min.
8. the preparation method of the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent of promotion pre-term low birth weight upgrowth and development of children according to claim 3, is characterized in that, comprise the steps:
Step (1), volatile oil is drawn: adopt the volatile oil in steam distillation extraction Cortex Moutan, and be separated Cortex Moutan volatile oil; During extraction, the mass ratio of Cortex Moutan and water is 1:10;
Step (2), prepared by extractum: after being mixed with Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria, Rhizoma Alismatis by the remaining solidliquid mixture of step (1) removing Cortex Moutan volatile oil, decocting 2 times, 2 hours first times, second time 1 hour, each water consumption be Cortex Moutan, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria and Rhizoma Alismatis gross mass 25-30 doubly, merge decocting liquid, then the decocting liquid obtained is concentrated into paste, obtains extractum; The quality of extractum be Cortex Moutan, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Poria and Rhizoma Alismatis gross mass 0.5 times;
Step (3), substrate oil phase prepare: by white vaseline, stearic acid, lanoline and glyceryl monostearate mix, then heating in water bath is to molten condition, insulation, then adopt glass pound medicine in a mortar pestle stir 10min, obtain substrate oil phase, for subsequent use;
Step (4), substrate aqueous phase prepare: after glycerol, Tween 80 and water are mixed together, heating in water bath to 80 DEG C, insulation, then adopt glass pound medicine in a mortar pestle stir 10min, obtain substrate aqueous phase;
Step (5), matrix composition: after the substrate aqueous phase that substrate oil phase step (3) obtained and step (4) obtain mixes, heating in water bath to 80 DEG C, insulation, then stirs 30min with the clockwise direction of 180-240 rev/min, obtains substrate;
Step (6), step (2) is obtained extractum join in the substrate that step (5) obtains, heating in water bath to 80 DEG C, insulation, then stir 30min with the clockwise direction of 180-240 rev/min, and then add the obtained Cortex Moutan volatile oil of azone, ethylparaben and step (1) wherein, continue to stir 5min with the clockwise direction of 180-240 rev/min, naturally cool to room temperature, namely obtain the Chinese medicine a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease agent that can promote pre-term low birth weight upgrowth and development of children.
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