CL2018003205A1 - Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf y un resto de unión a pd1. - Google Patents
Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf y un resto de unión a pd1.Info
- Publication number
- CL2018003205A1 CL2018003205A1 CL2018003205A CL2018003205A CL2018003205A1 CL 2018003205 A1 CL2018003205 A1 CL 2018003205A1 CL 2018003205 A CL2018003205 A CL 2018003205A CL 2018003205 A CL2018003205 A CL 2018003205A CL 2018003205 A1 CL2018003205 A1 CL 2018003205A1
- Authority
- CL
- Chile
- Prior art keywords
- tnf family
- ligand trimer
- antigen binding
- binding molecules
- binding moiety
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Abstract
SE DESCRIBEN NUEVAS MOLÉCULAS DE UNIÓN A ANTÍGENO QUE CONTIENEN TRÍMERO DE LIGANDO DE LA FAMILIA DE TNF QUE COMPRENDEN (A) AL MENOS UN RESTO CAPAZ DE UNIRSE ESPECÍFICAMENTE A PD1 Y (B) UN PRIMER Y UN SEGUNDO POLIPÉPTIDO QUE ESTÁN UNIDOS ENTRE SÍ MEDIANTE UN ENLACE DISULFURO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16169487.2A EP3243832A1 (en) | 2016-05-13 | 2016-05-13 | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2018003205A1 true CL2018003205A1 (es) | 2019-01-18 |
Family
ID=56014831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018003205A CL2018003205A1 (es) | 2016-05-13 | 2018-11-12 | Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf y un resto de unión a pd1. |
Country Status (22)
Country | Link |
---|---|
US (2) | US20190185566A1 (es) |
EP (2) | EP3243832A1 (es) |
JP (1) | JP6801006B2 (es) |
KR (1) | KR20190004802A (es) |
CN (1) | CN109563146B (es) |
AR (1) | AR108453A1 (es) |
AU (1) | AU2017264548A1 (es) |
BR (1) | BR112018073289A2 (es) |
CA (1) | CA3023393A1 (es) |
CL (1) | CL2018003205A1 (es) |
CO (1) | CO2018012083A2 (es) |
CR (1) | CR20180538A (es) |
IL (1) | IL262843A (es) |
MA (1) | MA44973A (es) |
MX (1) | MX2018013675A (es) |
PE (1) | PE20190436A1 (es) |
PH (1) | PH12018502367A1 (es) |
RU (1) | RU2018143439A (es) |
SG (1) | SG11201810076WA (es) |
TW (1) | TW201805306A (es) |
WO (1) | WO2017194641A1 (es) |
ZA (1) | ZA201807581B (es) |
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KR20180040138A (ko) | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | 항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법 |
KR102146319B1 (ko) | 2015-10-02 | 2020-08-25 | 에프. 호프만-라 로슈 아게 | Pd1 및 tim3에 특이적인 이중특이성 항체 |
IL300122A (en) | 2015-11-18 | 2023-03-01 | Merck Sharp ַ& Dohme Llc | Substances that bind to PD1 and/or LAG3 |
EP3559034B1 (en) | 2016-12-20 | 2020-12-02 | H. Hoffnabb-La Roche Ag | Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists |
BR112019013189A2 (pt) | 2017-01-03 | 2019-12-10 | Hoffmann La Roche | moléculas de ligação ao antígeno biespecífica, polinucleotídeo, célula hospedeira, método de produção da molécula de ligação ao antígeno biespecífica, composição farmacêutica, uso, métodos para inibir o crescimento de células tumorais em um indivíduo e para tratar o câncer ou uma doença infecciosa |
SI3565828T1 (sl) | 2017-01-05 | 2022-04-29 | Kahr Medical Ltd. | SIRP1 alfa-41BBL fuzijski protein in postopki za njegovo uporabo |
WO2018127918A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A sirp alpha-cd70 fusion protein and methods of use thereof |
US11566060B2 (en) | 2017-01-05 | 2023-01-31 | Kahr Medical Ltd. | PD1-CD70 fusion protein and methods of use thereof |
US11702458B2 (en) | 2017-01-05 | 2023-07-18 | Kahr Medical Ltd. | PD1-41BBL fusion protein and methods of use thereof |
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KR102346336B1 (ko) * | 2017-04-05 | 2022-01-04 | 에프. 호프만-라 로슈 아게 | Pd1 및 lag3에 특이적으로 결합하는 이중특이적 항체 |
AR114284A1 (es) * | 2018-04-13 | 2020-08-12 | Hoffmann La Roche | Moléculas de unión a antígeno dirigidas a her2 que comprenden 4-1bbl |
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US8686119B2 (en) | 2011-07-24 | 2014-04-01 | Curetech Ltd. | Variants of humanized immunomodulatory monoclonal antibodies |
EP2844667B1 (en) * | 2012-04-30 | 2018-05-30 | Biocon Limited | Targeted/immunomodulatory fusion proteins and methods for making same |
RS61400B1 (sr) | 2013-05-02 | 2021-02-26 | Anaptysbio Inc | Antitela usmerena protiv programirane smrti-1 (pd-1) |
CA2934028A1 (en) * | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
UA117289C2 (uk) | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифічне антитіло |
EP3224275B1 (en) * | 2014-11-14 | 2020-03-04 | F.Hoffmann-La Roche Ag | Antigen binding molecules comprising a tnf family ligand trimer |
EP3150636A1 (en) * | 2015-10-02 | 2017-04-05 | F. Hoffmann-La Roche AG | Tetravalent multispecific antibodies |
KR102146319B1 (ko) * | 2015-10-02 | 2020-08-25 | 에프. 호프만-라 로슈 아게 | Pd1 및 tim3에 특이적인 이중특이성 항체 |
WO2017194442A1 (en) * | 2016-05-11 | 2017-11-16 | F. Hoffmann-La Roche Ag | Antigen binding molecules comprising a tnf family ligand trimer and a tenascin binding moiety |
-
2016
- 2016-05-13 EP EP16169487.2A patent/EP3243832A1/en not_active Ceased
-
2017
- 2017-05-11 MA MA044973A patent/MA44973A/fr unknown
- 2017-05-11 MX MX2018013675A patent/MX2018013675A/es unknown
- 2017-05-11 RU RU2018143439A patent/RU2018143439A/ru not_active Application Discontinuation
- 2017-05-11 CN CN201780038363.6A patent/CN109563146B/zh active Active
- 2017-05-11 JP JP2018559781A patent/JP6801006B2/ja active Active
- 2017-05-11 CR CR20180538A patent/CR20180538A/es unknown
- 2017-05-11 BR BR112018073289-3A patent/BR112018073289A2/pt not_active Application Discontinuation
- 2017-05-11 EP EP17725542.9A patent/EP3455248B1/en active Active
- 2017-05-11 WO PCT/EP2017/061241 patent/WO2017194641A1/en unknown
- 2017-05-11 SG SG11201810076WA patent/SG11201810076WA/en unknown
- 2017-05-11 AU AU2017264548A patent/AU2017264548A1/en not_active Abandoned
- 2017-05-11 PE PE2018002326A patent/PE20190436A1/es unknown
- 2017-05-11 CA CA3023393A patent/CA3023393A1/en not_active Abandoned
- 2017-05-11 AR ARP170101253A patent/AR108453A1/es unknown
- 2017-05-11 KR KR1020187036101A patent/KR20190004802A/ko not_active Application Discontinuation
- 2017-05-12 TW TW106115699A patent/TW201805306A/zh unknown
-
2018
- 2018-11-07 IL IL262843A patent/IL262843A/en unknown
- 2018-11-08 CO CONC2018/0012083A patent/CO2018012083A2/es unknown
- 2018-11-09 PH PH12018502367A patent/PH12018502367A1/en unknown
- 2018-11-12 ZA ZA2018/07581A patent/ZA201807581B/en unknown
- 2018-11-12 CL CL2018003205A patent/CL2018003205A1/es unknown
- 2018-11-13 US US16/189,041 patent/US20190185566A1/en not_active Abandoned
-
2022
- 2022-01-28 US US17/649,321 patent/US20230123178A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MX2018013675A (es) | 2019-04-01 |
CR20180538A (es) | 2019-01-10 |
CO2018012083A2 (es) | 2018-11-22 |
MA44973A (fr) | 2021-04-07 |
EP3455248A1 (en) | 2019-03-20 |
JP2019524053A (ja) | 2019-09-05 |
TW201805306A (zh) | 2018-02-16 |
WO2017194641A1 (en) | 2017-11-16 |
PE20190436A1 (es) | 2019-03-27 |
PH12018502367A1 (en) | 2019-09-09 |
RU2018143439A (ru) | 2020-06-15 |
CA3023393A1 (en) | 2017-11-16 |
EP3455248B1 (en) | 2021-06-30 |
ZA201807581B (en) | 2021-05-26 |
JP6801006B2 (ja) | 2020-12-16 |
KR20190004802A (ko) | 2019-01-14 |
CN109563146A (zh) | 2019-04-02 |
BR112018073289A2 (pt) | 2019-03-19 |
IL262843A (en) | 2018-12-31 |
RU2018143439A3 (es) | 2020-08-03 |
CN109563146B (zh) | 2022-10-14 |
EP3243832A1 (en) | 2017-11-15 |
SG11201810076WA (en) | 2018-12-28 |
US20190185566A1 (en) | 2019-06-20 |
US20230123178A1 (en) | 2023-04-20 |
AR108453A1 (es) | 2018-08-22 |
AU2017264548A1 (en) | 2018-11-22 |
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