CL2018000150A1 - Compuestos útiles como inmunomoduladores (divisional de solicitud 201600508) - Google Patents
Compuestos útiles como inmunomoduladores (divisional de solicitud 201600508)Info
- Publication number
- CL2018000150A1 CL2018000150A1 CL2018000150A CL2018000150A CL2018000150A1 CL 2018000150 A1 CL2018000150 A1 CL 2018000150A1 CL 2018000150 A CL2018000150 A CL 2018000150A CL 2018000150 A CL2018000150 A CL 2018000150A CL 2018000150 A1 CL2018000150 A1 CL 2018000150A1
- Authority
- CL
- Chile
- Prior art keywords
- immunomodulators
- divisional application
- useful compounds
- compounds
- useful
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000002955 immunomodulating agent Substances 0.000 title abstract 2
- 229940121354 immunomodulator Drugs 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/396—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
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- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract
<p>LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS ÚTILES COMO INMUNOMODULADORES, ASÍ COMO TAMBIÉN A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN TALES COMPUESTOS. ESTOS COMPUESTOS SON ÚTILES EN EL TRATAMIENTO, PREVENCIÓN O DISMINUCIÓN DEL PROGRESO DE ENFERMEDADES O TRASTORNOS VIROLÓGICOS Y CÁNCER.</p>
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EP2928474B1 (en) | 2012-12-07 | 2018-11-14 | ChemoCentryx, Inc. | Diazole lactams |
US9850225B2 (en) | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
CN107709314A (zh) | 2015-06-11 | 2018-02-16 | 巴斯利尔药物国际股份公司 | 外排泵抑制剂及其治疗性用途 |
US10745382B2 (en) | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
TW201718581A (zh) | 2015-10-19 | 2017-06-01 | 英塞特公司 | 作為免疫調節劑之雜環化合物 |
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CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
MA44075A (fr) * | 2015-12-17 | 2021-05-19 | Incyte Corp | Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1 |
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EP3190103A1 (en) | 2016-01-08 | 2017-07-12 | Rijksuniversiteit Groningen | Inhibitors of the pd-1/pd-l1 protein/protein interaction |
CN109310677A (zh) | 2016-04-07 | 2019-02-05 | 凯莫森特里克斯股份有限公司 | 通过联合施用ccr1拮抗剂与pd-1抑制剂或pd-l1拮抗剂降低肿瘤负荷 |
AR108396A1 (es) * | 2016-05-06 | 2018-08-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
WO2017202276A1 (zh) | 2016-05-23 | 2017-11-30 | 中国医学科学院药物研究所 | 苯醚类衍生物、及其制法和药物组合物与用途 |
US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
LT3472167T (lt) | 2016-06-20 | 2022-11-10 | Incyte Corporation | Heterocikliniai junginiai kaip imunomoduliatoriai |
CN109415366B (zh) * | 2016-06-23 | 2022-02-22 | 豪夫迈·罗氏有限公司 | [1,2,3]***并[4,5-d]嘧啶衍生物 |
CN109803651B (zh) | 2016-06-27 | 2022-05-31 | 凯莫森特里克斯股份有限公司 | 免疫调节剂化合物 |
NZ750414A (en) * | 2016-07-05 | 2023-02-24 | Guangzhou Maxinovel Pharmaceuticals Co Ltd | Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof |
US10590105B2 (en) * | 2016-07-08 | 2020-03-17 | Bristol-Meyers Squibb Company | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators |
US20180016260A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
DK3490986T3 (da) | 2016-07-28 | 2022-03-07 | Idorsia Pharmaceuticals Ltd | Piperidin-cxcr7-receptormodulatorer |
CN109195602B (zh) * | 2016-08-03 | 2022-01-07 | 上海齐鲁制药研究中心有限公司 | 用作免疫调节剂的对称或半对称化合物 |
MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
US10144706B2 (en) | 2016-09-01 | 2018-12-04 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
CR20190172A (es) * | 2016-09-06 | 2019-06-13 | Incelldx Inc | Methods of detecting per cell pd-l1 expression and uses thereof |
US11726089B2 (en) | 2016-09-06 | 2023-08-15 | Incelldx, Inc. | Methods of assaying neoplastic and neoplasia-related cells and uses thereof |
CN117402852A (zh) | 2016-10-14 | 2024-01-16 | 精密生物科学公司 | 对乙肝病毒基因组中的识别序列特异性的工程化大范围核酸酶 |
WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
JP7106572B2 (ja) * | 2016-12-20 | 2022-07-26 | ブリストル-マイヤーズ スクイブ カンパニー | 免疫調節剤として有用な化合物 |
WO2018119221A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Pyridine derivatives as immunomodulators |
US20180177784A1 (en) * | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
ES2934230T3 (es) | 2016-12-22 | 2023-02-20 | Incyte Corp | Derivados de benzooxazol como inmunomoduladores |
EP3558989B1 (en) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
KR102641030B1 (ko) * | 2016-12-22 | 2024-02-29 | 인사이트 코포레이션 | Pd-l1 내재화 유도제로서의 테트라하이드로 이미다조[4,5-c]피리딘 유도체 |
WO2018121560A1 (zh) * | 2016-12-29 | 2018-07-05 | 深圳微芯生物科技有限责任公司 | 脲类化合物、其制备方法及其应用 |
WO2018127711A1 (en) * | 2017-01-06 | 2018-07-12 | Crescendo Biologics Limited | Single Domain Antibodies to Programmed Cell Death (PD-1) |
JP7150745B2 (ja) * | 2017-03-27 | 2022-10-11 | ブリストル-マイヤーズ スクイブ カンパニー | 免疫調節剤としての置換イソキノリン誘導体 |
JOP20180040A1 (ar) * | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
US11130740B2 (en) | 2017-04-25 | 2021-09-28 | Arbutus Biopharma Corporation | Substituted 2,3-dihydro-1H-indene analogs and methods using same |
CA3060597A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Phenyl derivatives as pge2 receptor modulators |
AU2018269667B2 (en) | 2017-05-18 | 2022-02-03 | Idorsia Pharmaceuticals Ltd | N-substituted indole derivatives |
EP3625228B1 (en) | 2017-05-18 | 2021-07-07 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives as pge2 receptor modulators |
ES2929309T3 (es) | 2017-05-18 | 2022-11-28 | Idorsia Pharmaceuticals Ltd | Derivados de benzofurano y benzotiofeno como moduladores del receptor PGE2 |
WO2018210992A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives |
KR20200041834A (ko) | 2017-06-01 | 2020-04-22 | 젠코어 인코포레이티드 | Cd123 및 cd3에 결합하는 이중특이성 항체 |
WO2018223004A1 (en) | 2017-06-01 | 2018-12-06 | Xencor, Inc. | Bispecific antibodies that bind cd20 and cd3 |
WO2019008156A1 (en) | 2017-07-07 | 2019-01-10 | Rijksuniversiteit Groningen | INHIBITORS OF PROTEIN / PROTEIN INTERACTION PD-1 / PD-L1 |
WO2019008152A1 (en) | 2017-07-07 | 2019-01-10 | Rijksuniversiteit Groningen | 3-CYANOTHIOPHENE DERIVATIVES AS INHIBITORS OF PROTEIN / PROTEIN INTERACTION PD-1 / PD-L1 |
WO2019008154A1 (en) | 2017-07-07 | 2019-01-10 | Rijksuniversiteit Groningen | 3- (AZOLYLMETHOXY) BIPHENYL DERIVATIVES AS INHIBITORS OF PROTEIN / PROTEIN INTERACTION PD-1 / PD-L1 |
CN111225896B (zh) * | 2017-07-28 | 2024-03-26 | 凯莫森特里克斯股份有限公司 | 免疫调节剂化合物 |
CN111225665B (zh) | 2017-08-08 | 2023-12-08 | 凯莫森特里克斯股份有限公司 | 大环免疫调节剂 |
WO2019034725A1 (en) | 2017-08-17 | 2019-02-21 | Idorsia Pharmaceuticals Ltd | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND / OR TRYPTOPHAN DIOXYGENASE |
CN109400522B (zh) * | 2017-08-18 | 2023-04-28 | 上海轶诺药业有限公司 | 一种具有pd-l1抑制活性的化合物、其制备方法及用途 |
MX2020003242A (es) | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Compuestos heterociclicos como inhibidores de pad. |
CN111712242B (zh) * | 2017-09-25 | 2023-11-24 | 凯莫森特里克斯股份有限公司 | 使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗 |
CN109665968B (zh) * | 2017-10-16 | 2022-02-22 | 四川科伦博泰生物医药股份有限公司 | 并环化合物及其制备方法和用途 |
IL272667B (en) | 2017-10-18 | 2022-09-01 | Jubilant Epipad LLC | Imidazo-pyridine compounds as pad inhibitors |
CN109721527B (zh) * | 2017-10-27 | 2024-03-12 | 广州丹康医药生物有限公司 | 一种新型抗pd-l1化合物、其应用及含其的组合物 |
US11629135B2 (en) * | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
ES2939112T3 (es) | 2017-11-10 | 2023-04-19 | Armo Biosciences Inc | Composiciones y métodos de uso de interleucina-10 en combinación con inhibidores de vías de puntos de control inmunitario |
WO2019102494A1 (en) | 2017-11-24 | 2019-05-31 | Jubilant Biosys Limited | Heterocyclic compounds as prmt5 inhibitors |
US11203610B2 (en) | 2017-12-20 | 2021-12-21 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
CN111566120B (zh) | 2017-12-20 | 2023-09-29 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸 |
CN109956898B (zh) * | 2017-12-22 | 2021-03-26 | 上海海雁医药科技有限公司 | 免疫调节剂及其制法与医药上的用途 |
SG11202005962YA (en) * | 2017-12-29 | 2020-07-29 | Guangzhou Maxinovel Pharmaceuticals Co Ltd | Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application |
US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
AU2019205784A1 (en) | 2018-01-08 | 2020-07-30 | Chemocentryx, Inc. | Methods of treating solid tumors with CCR2 antagonists |
CA3087565A1 (en) | 2018-01-09 | 2019-07-18 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
AR114564A1 (es) | 2018-01-10 | 2020-09-23 | Idorsia Pharmaceuticals Ltd | DERIVADOS DE 2,4,6,7-TETRAHIDRO-PIRAZOLO[3,4-D]PIRIMIDIN-ONA COMO MODULADORES DEL RECEPTOR C5a Y COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE |
EP3740493B1 (en) | 2018-01-15 | 2021-12-01 | Idorsia Pharmaceuticals Ltd | Inhibteurs de l'indoleamine 2,3-dioxygénase et/ou du tryptophane dioxygénase |
US11685729B2 (en) | 2018-01-19 | 2023-06-27 | Idorsia Pharmaceuticals Ltd. | C5a receptor modulators |
CA3087886A1 (en) | 2018-01-19 | 2019-07-25 | Idorsia Pharmaceuticals Ltd | C5a receptor modulators |
EP3743425A1 (en) | 2018-01-23 | 2020-12-02 | Bristol-Myers Squibb Company | 2,8-diacyl-2,8-diazaspiro[5.5]undecane compounds useful as immunomodulators |
MX2020007881A (es) | 2018-01-26 | 2022-06-02 | Idorsia Pharmaceuticals Ltd | Formas cristalinas del antagonista del receptor cxcr7 acido (3s,4s)-1-ciclopropilmetil-4-{[5-(2,4-difluoro-fenil)-isoxazol-3- carbonil]-amino}-piperidin-3-carboxilico (1-pirimidin-2-il-ciclopr opil)-amida. |
CN110092779B (zh) * | 2018-01-29 | 2022-07-12 | 广州丹康医药生物有限公司 | 一种取代的苯基化合物及其应用 |
CN110092740B (zh) * | 2018-01-29 | 2022-10-14 | 广州丹康医药生物有限公司 | 一种稠环化合物及其应用 |
WO2019149183A1 (zh) | 2018-02-05 | 2019-08-08 | 上海和誉生物医药科技有限公司 | 一种联芳基衍生物、其制备方法和在药学上的应用 |
BR112020016466A2 (pt) | 2018-02-13 | 2020-12-15 | Gilead Sciences, Inc. | Composto, composição farmacêutica, métodos para inibir pd-1, pd-l1 e/ou a interação de pd-1/pd-l1, para tratar câncer e para aprimorar a função de células-t em pacientes com hepatite b crônica (chb), e, kit para tratar ou prevenir câncer ou uma doença ou condição. |
GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
WO2019165043A2 (en) | 2018-02-22 | 2019-08-29 | Chemocentryx, Inc. | Indane-amines as pd-l1 antagonists |
CA3091142C (en) | 2018-02-26 | 2023-04-11 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
US11578054B2 (en) | 2018-03-01 | 2023-02-14 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
CN110240587B (zh) * | 2018-03-08 | 2022-01-04 | 中国科学院上海药物研究所 | 一类芳基二氟苄基醚类化合物、制备方法及用途 |
CN112105610B (zh) | 2018-03-13 | 2024-01-26 | 朱比连特普罗德尔有限责任公司 | 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物 |
WO2019174533A1 (zh) * | 2018-03-13 | 2019-09-19 | 广东东阳光药业有限公司 | Pd-1/pd-l1类小分子抑制剂及其在药物中的应用 |
EP4212529A1 (en) | 2018-03-30 | 2023-07-19 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | 2,2,─環二核苷酸 |
KR20200140867A (ko) | 2018-04-06 | 2020-12-16 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | 3'3'-사이클릭 다이뉴클레오티드 |
TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
US10899735B2 (en) | 2018-04-19 | 2021-01-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
CN112752756A (zh) | 2018-05-11 | 2021-05-04 | 因赛特公司 | 作为PD-L1免疫调节剂的四氢-咪唑并[4,5-c]吡啶衍生物 |
KR20210018253A (ko) | 2018-05-31 | 2021-02-17 | 오노 야꾸힝 고교 가부시키가이샤 | 면역 체크포인트 저해약의 유효성 판정 바이오마커 |
KR20210016426A (ko) | 2018-06-01 | 2021-02-15 | 노파르티스 아게 | Cd123 및 cd3에 결합하는 이중특이적 항체의 투약 |
CN112533629A (zh) | 2018-06-19 | 2021-03-19 | 阿尔莫生物科技股份有限公司 | 结合使用il-10药剂与嵌合抗原受体细胞疗法的组合物和方法 |
CA3103286C (en) | 2018-07-13 | 2023-05-09 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
CN109305934A (zh) * | 2018-08-07 | 2019-02-05 | 成都海博锐药业有限公司 | 苯醚类衍生物及可药用盐、医药上的用途 |
CN108997172B (zh) * | 2018-08-08 | 2020-12-15 | 中国人民解放军总医院 | 抗肿瘤化合物 |
CN110872275A (zh) * | 2018-08-31 | 2020-03-10 | 深圳微芯生物科技股份有限公司 | 作为免疫调节剂的联苯化合物及其用途 |
TW202028212A (zh) | 2018-10-11 | 2020-08-01 | 日商小野藥品工業股份有限公司 | Sting促效化合物 |
AU2019366355B2 (en) * | 2018-10-24 | 2022-10-13 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
TWI721624B (zh) | 2018-10-31 | 2021-03-11 | 美商基利科學股份有限公司 | 經取代之6-氮雜苯并咪唑化合物 |
PE20211655A1 (es) | 2018-10-31 | 2021-08-24 | Gilead Sciences Inc | Compuestos de 6-azabencimidazol sustituidos como inhibidores de hpk1 |
EP3875458A4 (en) | 2018-11-02 | 2022-08-24 | Shanghai Maxinovel Pharmaceuticals Co., Ltd. | DIPHENYLIKE COMPOUNDS, INTERMEDIATE PRODUCTS THEREOF, PREPARATION PROCESS THEREOF, PHARMACEUTICAL COMPOSITION THEREOF AND USES THEREOF |
CN109456284A (zh) * | 2018-11-13 | 2019-03-12 | 南方医科大学 | 一种含取代联苯的查尔酮及其应用 |
CN109438263A (zh) * | 2018-11-28 | 2019-03-08 | 南方医科大学 | 一种含取代联苯的萘及其应用 |
CN109503546A (zh) * | 2019-01-10 | 2019-03-22 | 南方医科大学 | 一种间苯二酚二苯甲醚及其应用 |
JP7411667B2 (ja) | 2019-02-05 | 2024-01-11 | ヴェンタナ メディカル システムズ, インク. | ステージivの結腸直腸がんにおける免疫細胞浸潤の評価のための方法及びシステム |
CN112313220B (zh) * | 2019-02-21 | 2023-11-03 | 厦门宝太生物科技股份有限公司 | Pd-l1拮抗剂化合物 |
US20220152078A1 (en) | 2019-03-07 | 2022-05-19 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
JP7350872B2 (ja) | 2019-03-07 | 2023-09-26 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. | 3’3’-環状ジヌクレオチドおよびそのプロドラッグ |
US11766447B2 (en) | 2019-03-07 | 2023-09-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
EP3943083A4 (en) | 2019-03-22 | 2023-06-07 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | SMALL MOLECULE PD-1/PD-L1 INHIBITOR, PHARMACEUTICAL COMPOSITION THEREOF WITH PD-L1 ANTIBODY, AND USES THEREOF |
CN113677402A (zh) | 2019-03-28 | 2021-11-19 | 百时美施贵宝公司 | ***的方法 |
EP3946628A1 (en) | 2019-03-28 | 2022-02-09 | Bristol-Myers Squibb Company | Methods of treating tumor |
CN111747927B (zh) * | 2019-03-29 | 2023-08-18 | 广州丹康医药生物有限公司 | 作为免疫调节剂的化合物及其应用 |
WO2020204714A1 (en) | 2019-04-02 | 2020-10-08 | Immunetune B.V. | Immune-stimulatory compositions and use thereof |
TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
WO2020225077A1 (en) | 2019-05-03 | 2020-11-12 | Idorsia Pharmaceuticals Ltd | Pyrimido[4,5-b]indol derivatives as pdhk1 inhibitors |
JP2022532178A (ja) * | 2019-05-10 | 2022-07-13 | 上海海雁医薬科技有限公司 | 置換フェニルプロペニルピリジン誘導体、その調製方法及びその医学的使用 |
WO2020232256A1 (en) | 2019-05-15 | 2020-11-19 | Chemocentryx, Inc. | Triaryl compounds for treatment of pd-l1 diseases |
TWI826690B (zh) | 2019-05-23 | 2023-12-21 | 美商基利科學股份有限公司 | 經取代之烯吲哚酮化物及其用途 |
EP3977132A1 (en) | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
WO2020243563A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Multi-tumor gene signatures for suitability to immuno-oncology therapy |
JP2022534982A (ja) | 2019-05-30 | 2022-08-04 | ブリストル-マイヤーズ スクイブ カンパニー | 細胞局在化シグネチャーおよびその使用 |
CN112028870B (zh) * | 2019-06-04 | 2021-11-05 | 中国科学院上海药物研究所 | 一种具有苄氧基芳环结构的化合物,其制备方法和用途 |
EP3980413B1 (en) * | 2019-06-07 | 2023-07-19 | Janssen Sciences Ireland Unlimited Company | Heterocyclic immunomodulators as pdl1 checkpoint inhibitor |
WO2020248908A1 (zh) * | 2019-06-10 | 2020-12-17 | 中国科学院广州生物医药与健康研究院 | 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 |
WO2020249801A1 (en) | 2019-06-12 | 2020-12-17 | Technical University Of Denmark | Dissacharide formulations for controlled drug release |
SG11202112875UA (en) | 2019-06-20 | 2021-12-30 | Chemocentryx Inc | Compounds for treatment of pd-l1 diseases |
CN112121169B (zh) * | 2019-06-24 | 2023-10-24 | 广州再极医药科技有限公司 | 用于治疗具有高间质压力的肿瘤受试者的癌症的小分子抑制剂 |
US20220265658A1 (en) | 2019-07-09 | 2022-08-25 | Idorsia Pharmaceuticals Ltd. | Pharmaceutical composition comprising a tetrahydropyrazolopyrimidinone compound |
US11872217B2 (en) | 2019-07-10 | 2024-01-16 | Chemocentryx, Inc. | Indanes as PD-L1 inhibitors |
CA3146406A1 (en) | 2019-07-11 | 2021-01-14 | Idorsia Pharmaceuticals Ltd | Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase |
WO2021025554A1 (en) | 2019-08-02 | 2021-02-11 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Combination comprising an activator of the glucocorticoid receptor and an inhibitor of ifg-1 signaling for carcinoma treatment |
WO2021025031A1 (ja) | 2019-08-05 | 2021-02-11 | 小野薬品工業株式会社 | 免疫チェックポイント阻害薬の有効性判定バイオマーカー |
US11753406B2 (en) | 2019-08-09 | 2023-09-12 | Incyte Corporation | Salts of a PD-1/PD-L1 inhibitor |
WO2021034804A1 (en) | 2019-08-19 | 2021-02-25 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
CN111909108B (zh) * | 2019-09-02 | 2023-05-02 | 中国药科大学 | 联苯类化合物及其制备方法和医药用途 |
US20220348653A1 (en) | 2019-09-22 | 2022-11-03 | Bristol-Myers Squibb Company | Quantitative Spatial Profiling for LAG-3 Antagonist Therapy |
CN112574183B (zh) * | 2019-09-29 | 2022-07-08 | 南京华威医药科技集团有限公司 | 一种pd-1抑制剂及其制备方法和用途 |
CN114286822A (zh) | 2019-09-30 | 2022-04-05 | 南京明德新药研发有限公司 | 作为pd-1/pd-l1小分子抑制剂的化合物及其应用 |
BR112022005826A2 (pt) | 2019-09-30 | 2022-06-21 | Incyte Corp | Compostos de pirido[3,2-d]pirimidina como imunomoduladores |
JP7398556B2 (ja) | 2019-09-30 | 2023-12-14 | ギリアード サイエンシーズ, インコーポレイテッド | Hbvワクチン及びhbvを治療する方法 |
JP2022551972A (ja) | 2019-10-16 | 2022-12-14 | ケモセントリックス,インコーポレイティド | Pd-l1疾患の治療のためのヘテロアリール-ビフェニルアミン |
KR20220084119A (ko) | 2019-10-16 | 2022-06-21 | 케모센트릭스, 인크. | Pd-l1 질환의 치료를 위한 헤테로아릴-바이페닐 아미드 |
MX2022004487A (es) | 2019-10-16 | 2022-05-06 | Corcept Therapeutics Inc | Metodo para normalizar el indice de neutrofilos a linfocitos en pacientes con cancer con un antagonista del receptor de glucocorticoide selectivo. |
US20220280499A1 (en) | 2019-10-21 | 2022-09-08 | Stichting Het Nederlands Kanker Instituue-Antoni van Leeuwenhoek Ziekenhuis | Novel drug combinations for treatment of a carcinoma |
WO2021092380A1 (en) | 2019-11-08 | 2021-05-14 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for melanoma |
BR112022009031A2 (pt) | 2019-11-11 | 2022-10-11 | Incyte Corp | Sais e formas cristalinas de um inibidor de pd-1/pd-l1 |
CN116057068A (zh) | 2019-12-06 | 2023-05-02 | 精密生物科学公司 | 对乙型肝炎病毒基因组中的识别序列具有特异性的优化的工程化大范围核酸酶 |
JP2022552693A (ja) * | 2019-12-26 | 2022-12-19 | アドレイ・ノーティ・バイオファーマ・カンパニー・リミテッド | Pd-l1拮抗薬化合物 |
CN113348170B (zh) | 2020-01-03 | 2023-12-22 | 上海翰森生物医药科技有限公司 | 联苯类衍生物抑制剂、其制备方法和应用 |
CN111187172B (zh) * | 2020-01-20 | 2021-10-29 | 中国药科大学 | 硝基苯醚类化合物、其制备方法和药物组合物与用途 |
WO2021171264A1 (en) | 2020-02-28 | 2021-09-02 | Novartis Ag | Dosing of a bispecific antibody that binds cd123 and cd3 |
CN115551497A (zh) * | 2020-03-11 | 2022-12-30 | 普渡研究基金会 | 具有免疫调节活性的化合物及其治疗用途 |
CN115605493A (zh) | 2020-03-20 | 2023-01-13 | 吉利德科学公司(Us) | 4′-c-取代的-2-卤代-2′-脱氧腺苷核苷的前药及其制备和使用方法 |
CN111303122A (zh) * | 2020-04-07 | 2020-06-19 | 南方医科大学 | 一种泊马度胺衍生物及其用途 |
WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
EP4134134A4 (en) | 2020-04-10 | 2023-12-27 | ONO Pharmaceutical Co., Ltd. | STING AGONIST COMPOUND |
CN111333629B (zh) * | 2020-04-10 | 2021-03-05 | 颜建发 | 苯基-1h-吡唑类衍生物及其在抗肿瘤药物中的应用 |
CN111559981B (zh) * | 2020-04-15 | 2023-08-01 | 杭州庆正鸿科技有限公司 | 一种联苯-嘧啶偶联物及其制备方法和应用 |
EP4143344A1 (en) | 2020-04-27 | 2023-03-08 | Agendia N.V. | Treatment of her2 negative, mammaprint high risk 2 breast cancer |
CN113563260A (zh) * | 2020-04-28 | 2021-10-29 | 药康众拓(江苏)医药科技有限公司 | 苯甲酰胺类化合物、制备方法及用途 |
CN113582971B (zh) * | 2020-04-30 | 2023-10-20 | 北京康辰药业股份有限公司 | 一种小分子免疫抑制剂、其制备方法及其应用 |
CN113943330A (zh) * | 2020-07-17 | 2022-01-18 | 中国科学院上海药物研究所 | 一类含糖结构化合物、其制备方法、药物组合物和用途 |
MX2023002332A (es) | 2020-08-28 | 2023-03-21 | Bristol Myers Squibb Co | Terapia con antagonistas del gen 3 de activacion de linfocitos (lag-3) para carcinoma hepatocelular. |
BR112023003553A2 (pt) | 2020-08-31 | 2023-04-04 | Bristol Myers Squibb Co | Assinatura de localização celular e imunoterapia |
JP2023540612A (ja) | 2020-09-09 | 2023-09-25 | グアンジョウ マキシノベル ファーマシューティカルズ カンパニー リミテッド | 芳香族エチレン系化合物、その製造方法、中間体、医薬組成物及びその使用 |
JP2023541389A (ja) | 2020-09-11 | 2023-10-02 | ナミ セラピューティクス, インコーポレイテッド | がんの処置において有用なpd-1アンタゴニストプロドラッグを含有する製剤化および/または共製剤化リポソーム組成物ならびにその方法 |
IL301907A (en) | 2020-10-23 | 2023-06-01 | Bristol Myers Squibb Co | LAG-3 antagonist therapy for lung cancer |
US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
AR124001A1 (es) | 2020-11-06 | 2023-02-01 | Incyte Corp | Proceso para fabricar un inhibidor pd-1 / pd-l1 y sales y formas cristalinas del mismo |
WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
CN114507227A (zh) * | 2020-11-17 | 2022-05-17 | 中国医学科学院药物研究所 | 苯并异噻唑类化合物、及其制法和药物组合物与用途 |
EP4251772A1 (en) | 2020-11-26 | 2023-10-04 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Personalized tumor markers |
WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
CA3204162A1 (en) | 2021-01-11 | 2022-07-14 | Robert Kastelein | Compositions and methods related to receptor pairing |
CN117677634A (zh) | 2021-03-05 | 2024-03-08 | 利达提斯有限公司 | 三聚体多肽及其在治疗癌症中的用途 |
WO2022199578A1 (zh) * | 2021-03-22 | 2022-09-29 | 南京明德新药研发有限公司 | 氟代乙烯基联苯衍生物及其应用 |
CN113105431B (zh) * | 2021-03-24 | 2022-10-28 | 河北康泰药业有限公司 | 一种蛋白水解靶向嵌合体及其应用 |
KR20240005700A (ko) | 2021-03-29 | 2024-01-12 | 주노 쎄러퓨티크스 인코퍼레이티드 | 체크포인트 억제제 요법 및 car t 세포 요법의 조합을 사용한 투여 및 치료 방법 |
BR112023021790A2 (pt) * | 2021-04-22 | 2023-12-26 | Jubilant Prodel LLC | Composto de fórmula (i); composto selecionado; processo para preparação de compostos de fórmula (i); composição farmacêutica; método para o tratamento e/ou prevenção de uma condição mediada por pd-1/pd-l1 ou um distúrbio proliferativo ou câncer; método para o tratamento ou prevenção de doença ou distúrbio proliferativo ou câncer; uso dos compostos; e; método para o tratamento de câncer |
CN113135895A (zh) * | 2021-04-30 | 2021-07-20 | 中国药科大学 | 一种新型联苯类衍生物及其制备方法与医药用途 |
KR20240004801A (ko) * | 2021-05-05 | 2024-01-11 | 브리스톨-마이어스 스큅 컴퍼니 | 면역조절제로서 유용한 락톤 및 락탐 함유 화합물 |
KR20240006683A (ko) | 2021-05-13 | 2024-01-15 | 길리애드 사이언시즈, 인코포레이티드 | TLR8 조절 화합물과 항-HBV siRNA 치료제의 조합물 |
AU2022291381A1 (en) | 2021-06-11 | 2023-11-30 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-cancer agents |
US11931424B2 (en) | 2021-06-11 | 2024-03-19 | Gilead Sciences, Inc. | Combination MCL-1 inhibitors with anti-body drug conjugates |
WO2022266236A1 (en) * | 2021-06-18 | 2022-12-22 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
CN117355531A (zh) | 2021-06-23 | 2024-01-05 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
CN117377671A (zh) | 2021-06-23 | 2024-01-09 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
EP4359389A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
IT202100016775A1 (it) * | 2021-06-25 | 2022-12-25 | Univ Degli Studi Milano | Derivati triazinici per il trattamento dei tumori e di disturbi neurodegenerativi |
CN114437051A (zh) * | 2021-09-18 | 2022-05-06 | 药康众拓(江苏)医药科技有限公司 | 一类联苯类化合物、其制备方法和用途 |
WO2023057548A1 (en) | 2021-10-07 | 2023-04-13 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
CA3235910A1 (en) | 2021-10-26 | 2023-05-04 | Oliver Allemann | Ccr6 receptor modulators |
CA3236396A1 (en) | 2021-10-28 | 2023-05-04 | Oliver Allemann | Ccr6 receptor modulators |
CA3224890A1 (en) | 2021-10-29 | 2023-05-04 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
WO2023080788A1 (en) | 2021-11-05 | 2023-05-11 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Tryptophan depletion induces production and presentation of tryptophan to phenylalanine substitutions |
WO2023104744A1 (en) | 2021-12-06 | 2023-06-15 | Helmholtz-Zentrum Dresden-Rossendorf E.V. | 3-((3-([1,1'-biphenyl]-3-ylmethoxy)phenoxy)methyl)benzonitrile derivatives and the use thereof |
WO2023147371A1 (en) | 2022-01-26 | 2023-08-03 | Bristol-Myers Squibb Company | Combination therapy for hepatocellular carcinoma |
CN116768870A (zh) * | 2022-03-08 | 2023-09-19 | 中国科学院上海药物研究所 | 具有苄氧基芳基醚结构的化合物及其制备方法和用途 |
WO2023192946A1 (en) | 2022-03-31 | 2023-10-05 | Ventana Medical Systems, Inc. | Methods and systems for predicting response to pd-1 axis directed therapeutics in colorectal tumors with deficient mismatch repair |
US20230326022A1 (en) | 2022-04-08 | 2023-10-12 | Bristol-Myers Squibb Company | Machine Learning Identification, Classification, and Quantification of Tertiary Lymphoid Structures |
WO2023224487A1 (en) | 2022-05-19 | 2023-11-23 | Agendia N.V. | Prediction of response to immune therapy in breast cancer patients |
EP4282448A1 (en) | 2022-05-23 | 2023-11-29 | Danmarks Tekniske Universitet | Porous expanding biocompatible scaffolds |
EP4282435A1 (en) | 2022-05-23 | 2023-11-29 | Danmarks Tekniske Universitet | Formulations of active pharmaceutical ingredients and excipients in icells via hydrophobic ion pairing |
CN115417870B (zh) * | 2022-09-20 | 2024-02-27 | 中国药科大学 | Pd-l1&nampt双靶点抑制剂和用途 |
CN115477609B (zh) * | 2022-09-26 | 2024-03-12 | 浙江师范大学 | 基于疏水标签技术的pd-l1蛋白降解剂及其应用 |
WO2024088036A1 (zh) * | 2022-10-26 | 2024-05-02 | 西安新通药物研究股份有限公司 | 一种非对称性联苯衍生物及其制备方法与医药用途 |
CN117986158A (zh) * | 2024-04-03 | 2024-05-07 | 云南大学 | 取代联苯类化合物、制备方法及应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994018167A1 (en) * | 1993-02-01 | 1994-08-18 | Kaken Pharmaceutical Co., Ltd. | Substituted dibenzylamine derivative |
US6297239B1 (en) * | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
AU2003208105C1 (en) * | 2002-02-07 | 2009-08-13 | J-Pharma Co., Ltd. | Aromatic amino acid derivatives and medicinal compositions |
AU2003281040A1 (en) * | 2002-07-10 | 2004-02-02 | Sumitomo Pharmaceuticals Co., Ltd. | Biaryl derivatives |
EP2385032A1 (en) | 2002-11-08 | 2011-11-09 | Takeda Pharmaceutical Company Limited | GPR40 Receptor function regulator |
TW200815377A (en) | 2006-04-24 | 2008-04-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
US9321730B2 (en) * | 2007-08-21 | 2016-04-26 | The Hong Kong Polytechnic University | Method of making and administering quinoline derivatives as anti-cancer agents |
TW200932219A (en) | 2007-10-24 | 2009-08-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
WO2010059838A2 (en) * | 2008-11-20 | 2010-05-27 | Decode Genetics Ehf | Pde4 inhibitors selective for the long form of pde4 for treating inflammation and avoiding side effects |
US20130022629A1 (en) * | 2010-01-04 | 2013-01-24 | Sharpe Arlene H | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof |
US9850225B2 (en) | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
US10745382B2 (en) | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
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CN105705489B (zh) | 2019-04-26 |
CL2016000508A1 (es) | 2016-11-04 |
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EA029901B1 (ru) | 2018-05-31 |
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AU2014315457B2 (en) | 2018-05-10 |
MX2016002544A (es) | 2016-06-17 |
EP3041822B1 (en) | 2017-08-09 |
US9872852B2 (en) | 2018-01-23 |
JP6417419B2 (ja) | 2018-11-07 |
IL244346B (en) | 2019-10-31 |
CA2923184A1 (en) | 2015-03-12 |
US20160194307A1 (en) | 2016-07-07 |
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