CL2016002681A1 - 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h)-onas como inhibidores de proteínas bet. - Google Patents

1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h)-onas como inhibidores de proteínas bet.

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Publication number
CL2016002681A1
CL2016002681A1 CL2016002681A CL2016002681A CL2016002681A1 CL 2016002681 A1 CL2016002681 A1 CL 2016002681A1 CL 2016002681 A CL2016002681 A CL 2016002681A CL 2016002681 A CL2016002681 A CL 2016002681A CL 2016002681 A1 CL2016002681 A1 CL 2016002681A1
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CL
Chile
Prior art keywords
pyridin
ones
inhibitors
pyrazolo
pyrrolo
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CL2016002681A
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English (en)
Inventor
Andrew P Combs
Thomas P Maduskuie Jr
Nikoo Falahatpisheh
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Incyte Corp
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Publication of CL2016002681A1 publication Critical patent/CL2016002681A1/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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Abstract

<p>COMPUESTOS DERIVADOS DE 1H-PIRROLO[2,3-c]PIRIDIN-7(6H)-ONAS Y PIRAZOLO[3,4-c]PIRIDIN-7(6H)-ONAS O SUS SALES, COMO INHIBIDORES DE PROTEÍNAS BET; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE, UTIL PARA EL TRATAMIENTO DE UN TRASTORNO PROLIFERATIVO TAL COMO CANCER, ALERGIA, ARTRITIS, EPOC, PSORIASIS, ENTRE OTRAS.  </p>
CL2016002681A 2014-04-23 2016-10-21 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h)-onas como inhibidores de proteínas bet. CL2016002681A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461983289P 2014-04-23 2014-04-23

Publications (1)

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CL2016002681A1 true CL2016002681A1 (es) 2017-02-03

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CL2016002681A CL2016002681A1 (es) 2014-04-23 2016-10-21 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h)-onas como inhibidores de proteínas bet.

Country Status (36)

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US (7) US9540368B2 (es)
EP (3) EP3674302B1 (es)
JP (2) JP6572237B2 (es)
KR (2) KR102430144B1 (es)
CN (1) CN106414442B (es)
AR (1) AR100160A1 (es)
AU (3) AU2015249810B2 (es)
BR (1) BR112016024626B1 (es)
CA (1) CA2946731C (es)
CL (1) CL2016002681A1 (es)
CR (2) CR20200231A (es)
CY (2) CY1122948T1 (es)
DK (2) DK3674302T3 (es)
EA (2) EA039678B1 (es)
EC (1) ECSP16088983A (es)
ES (2) ES2784846T3 (es)
FI (1) FI3674302T3 (es)
HR (2) HRP20230340T1 (es)
HU (2) HUE061770T2 (es)
IL (3) IL248415B (es)
LT (2) LT3674302T (es)
MA (1) MA39985B1 (es)
ME (1) ME03763B (es)
MX (2) MX2016013851A (es)
MY (1) MY180775A (es)
NZ (3) NZ763740A (es)
PE (1) PE20170144A1 (es)
PH (1) PH12016502115A1 (es)
PL (2) PL3674302T3 (es)
PT (2) PT3134403T (es)
RS (2) RS60139B1 (es)
SG (2) SG10201809353TA (es)
SI (2) SI3674302T1 (es)
TW (2) TWI735002B (es)
UA (1) UA119870C2 (es)
WO (1) WO2015164480A1 (es)

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JP7254075B2 (ja) 2017-11-06 2023-04-07 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック キサンチン誘導体及びｂｅｔタンパク質のブロモドメインの阻害剤としてのその使用
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