MX2022000050A - Compuestos heterocíclicos como inhibidores de bromodominio extraterminal (bet). - Google Patents
Compuestos heterocíclicos como inhibidores de bromodominio extraterminal (bet).Info
- Publication number
- MX2022000050A MX2022000050A MX2022000050A MX2022000050A MX2022000050A MX 2022000050 A MX2022000050 A MX 2022000050A MX 2022000050 A MX2022000050 A MX 2022000050A MX 2022000050 A MX2022000050 A MX 2022000050A MX 2022000050 A MX2022000050 A MX 2022000050A
- Authority
- MX
- Mexico
- Prior art keywords
- heterocyclic compounds
- bet inhibitors
- inhibitors
- bet
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Se proporcionan nuevos inhibidores de bromodominio y dominio extraterminal (BET) y métodos terapéuticos para tratar afecciones y enfermedades utilizando estos nuevos inhibidores de BET.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962870020P | 2019-07-02 | 2019-07-02 | |
US202063017547P | 2020-04-29 | 2020-04-29 | |
PCT/US2020/040566 WO2021003310A1 (en) | 2019-07-02 | 2020-07-01 | Heterocyclic compounds as bet inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022000050A true MX2022000050A (es) | 2022-05-24 |
Family
ID=74065335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022000050A MX2022000050A (es) | 2019-07-02 | 2020-07-01 | Compuestos heterocíclicos como inhibidores de bromodominio extraterminal (bet). |
Country Status (12)
Country | Link |
---|---|
US (2) | US11584756B2 (es) |
EP (1) | EP3997070A4 (es) |
JP (1) | JP7465945B2 (es) |
KR (1) | KR20220028072A (es) |
CN (1) | CN114286818A (es) |
AU (1) | AU2020299592A1 (es) |
BR (1) | BR112021026668A2 (es) |
CA (1) | CA3145827A1 (es) |
CL (1) | CL2021003513A1 (es) |
IL (1) | IL289439A (es) |
MX (1) | MX2022000050A (es) |
WO (1) | WO2021003310A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20210038921A (ko) * | 2018-07-25 | 2021-04-08 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 브로모도메인 단백질 억제제로서의 설폭시민 화합물과 약학적 조성물 및 이의 의학적 용도 |
CA3116931A1 (en) | 2018-10-30 | 2020-05-07 | Nuvation Bio Inc. | Heterocyclic compounds as bet inhibitors |
WO2021222466A1 (en) * | 2020-04-29 | 2021-11-04 | Nuvation Bio Inc. | Heterocyclic compounds as bet inhibitors |
GB2621505A (en) | 2021-06-29 | 2024-02-14 | Tay Therapeutics Ltd | Pyrrolopyridone derivatives useful in the treatment of cancer |
CN116135858A (zh) * | 2021-11-16 | 2023-05-19 | 中国科学院广州生物医药与健康研究院 | 一种呋喃并吡啶酮类化合物及其应用 |
WO2023133284A2 (en) * | 2022-01-06 | 2023-07-13 | Design Therapeutics, Inc. | Compounds and methods for treating friedreich's ataxia |
CN114907335A (zh) * | 2022-02-25 | 2022-08-16 | 陕西维世诺新材料有限公司 | 2-(苯并噻吩-2-基)苯并[d]惡唑衍生物、制备方法及应用 |
CN115028646B (zh) * | 2022-05-31 | 2023-06-30 | 山东第一医科大学(山东省医学科学院) | 一种含氮杂环类化合物、制备方法及在抗肿瘤制剂中的应用 |
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IL118631A (en) | 1995-06-27 | 2002-05-23 | Tanabe Seiyaku Co | History of pyridazinone and processes for their preparation |
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WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
ES2625945T3 (es) | 2012-11-14 | 2017-07-21 | Glaxosmithkline Llc | Tieno[3,2-c]piridin-4(5H)-onas como inhibidores de bet |
US9266891B2 (en) | 2012-11-16 | 2016-02-23 | Boehringer Ingelheim International Gmbh | Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors |
EP2961747B1 (en) | 2013-02-27 | 2017-11-15 | Bristol-Myers Squibb Company | Carbazole compounds useful as bromodomain inhibitors |
BR112015022861A8 (pt) * | 2013-03-11 | 2019-11-26 | Abbvie Inc | inibidores de bromodomínio |
WO2014164596A1 (en) | 2013-03-11 | 2014-10-09 | The Regents Of The University Of Michigan | Bet bromodomain inhibitors and therapeutic methods using the same |
EP2970330B1 (en) | 2013-03-12 | 2019-04-17 | AbbVie Inc. | Tetracyclic bromodomain inhibitors |
SG11201506245QA (en) | 2013-03-14 | 2015-09-29 | Glaxosmithkline Ip No 2 Ltd | 2,3-disubstituted 1 -acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors |
US9670221B2 (en) | 2013-03-14 | 2017-06-06 | Glaxosmithkline Intellectual Property (No. 2) Limited | Furopyridines as bromodomain inhibitors |
SG11201510409QA (en) | 2013-06-21 | 2016-01-28 | Zenith Epigenetics Corp | Novel bicyclic bromodomain inhibitors |
MX2015017963A (es) | 2013-06-28 | 2016-11-10 | Abbvie Inc | Inhibidores de bromodominio. |
ES2930305T3 (es) * | 2013-10-18 | 2022-12-09 | Celgene Quanticel Res Inc | Inhibidores del bromodominio |
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JP6422164B2 (ja) | 2013-12-26 | 2018-11-14 | 塩野義製薬株式会社 | 含窒素6員環誘導体およびそれらを含有する医薬組成物 |
CA2934788C (en) | 2014-01-09 | 2021-12-07 | Orion Corporation | Bicyclic heterocyclic derivatives as bromodomain inhibitors |
JP2017511801A (ja) | 2014-02-28 | 2017-04-27 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | BETブロモドメイン阻害剤としての9H−ピリミド[4,5−b]インドールおよび関連類似体 |
MX2016013851A (es) | 2014-04-23 | 2017-07-14 | Incyte Corp | 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet). |
AU2015314184B2 (en) | 2014-09-12 | 2018-09-13 | Glaxosmithkline Intellectual Property (No.2) Limited | Tetrahydroquinoline derivatives as bromodomain inhibitors |
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JP6795588B2 (ja) | 2015-09-22 | 2020-12-02 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited | ブロモドメイン阻害薬としての使用のためのピリジノンジカルボキサミド |
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KR20210038921A (ko) | 2018-07-25 | 2021-04-08 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 브로모도메인 단백질 억제제로서의 설폭시민 화합물과 약학적 조성물 및 이의 의학적 용도 |
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WO2021222466A1 (en) | 2020-04-29 | 2021-11-04 | Nuvation Bio Inc. | Heterocyclic compounds as bet inhibitors |
-
2020
- 2020-07-01 WO PCT/US2020/040566 patent/WO2021003310A1/en active Application Filing
- 2020-07-01 MX MX2022000050A patent/MX2022000050A/es unknown
- 2020-07-01 BR BR112021026668A patent/BR112021026668A2/pt active Search and Examination
- 2020-07-01 KR KR1020227003392A patent/KR20220028072A/ko active IP Right Grant
- 2020-07-01 JP JP2022500105A patent/JP7465945B2/ja active Active
- 2020-07-01 AU AU2020299592A patent/AU2020299592A1/en active Pending
- 2020-07-01 CN CN202080060057.4A patent/CN114286818A/zh active Pending
- 2020-07-01 US US16/918,997 patent/US11584756B2/en active Active
- 2020-07-01 EP EP20834516.5A patent/EP3997070A4/en active Pending
- 2020-07-01 CA CA3145827A patent/CA3145827A1/en active Pending
-
2021
- 2021-12-27 IL IL289439A patent/IL289439A/en unknown
- 2021-12-27 CL CL2021003513A patent/CL2021003513A1/es unknown
-
2023
- 2023-01-09 US US18/152,049 patent/US20230339964A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20220028072A (ko) | 2022-03-08 |
IL289439A (en) | 2022-02-01 |
BR112021026668A2 (pt) | 2022-02-15 |
US11584756B2 (en) | 2023-02-21 |
EP3997070A1 (en) | 2022-05-18 |
CN114286818A (zh) | 2022-04-05 |
AU2020299592A1 (en) | 2022-02-17 |
CA3145827A1 (en) | 2021-01-07 |
WO2021003310A1 (en) | 2021-01-07 |
US20230339964A1 (en) | 2023-10-26 |
EP3997070A4 (en) | 2023-07-26 |
CL2021003513A1 (es) | 2022-10-28 |
US20210002293A1 (en) | 2021-01-07 |
JP2022538917A (ja) | 2022-09-06 |
JP7465945B2 (ja) | 2024-04-11 |
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