CL2010000823A1 - Anticuerpo anti-cd-20 con actividad apoptotica; polinucleotido, vector y celula huesped que expresa el anticuerpo; composicion farmaceutica que lo comprende; usos en la preparacion de un medicamento para tratar cancer o una enfermedad autoinmune; metodo para producir dicho anticuerpo (div. sol. n°2246-06). - Google Patents

Anticuerpo anti-cd-20 con actividad apoptotica; polinucleotido, vector y celula huesped que expresa el anticuerpo; composicion farmaceutica que lo comprende; usos en la preparacion de un medicamento para tratar cancer o una enfermedad autoinmune; metodo para producir dicho anticuerpo (div. sol. n°2246-06).

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Publication number
CL2010000823A1
CL2010000823A1 CL2010000823A CL2010000823A CL2010000823A1 CL 2010000823 A1 CL2010000823 A1 CL 2010000823A1 CL 2010000823 A CL2010000823 A CL 2010000823A CL 2010000823 A CL2010000823 A CL 2010000823A CL 2010000823 A1 CL2010000823 A1 CL 2010000823A1
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CL
Chile
Prior art keywords
antibody
vector
pharmaceutical composition
producing
div
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CL2010000823A
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English (en)
Inventor
Ekkehard Mössner
Pablo Umaña
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Roche Glycart Ag
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Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of CL2010000823A1 publication Critical patent/CL2010000823A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N2510/02—Cells for production

Abstract

UN ANTICUERPO ANTI-CD20 MODIFICADO, QUE COMPRENDE UNA REGIÓN VARIABLE DE CADENA PESADA QUE CONTIENE AL MENOS UNA SUSTITUCIÓN EN LA REGIÓN FR1 DE LA REGIÓN VARIABLE DE CADENA PESADA DONDE DICHO FR1 COMPRENDE UNA SECUENCIA DE AMINOÁCIDOS EN LAS POSICIONES KABAT 8 A 13 DE LA SEQ ID NO: 63, Y DONDE DICHO ANTICUERPO MODIFICADO INDUCE MAYORES NIVELES DE APOPTOSIS CUANDO FORMA UN COMPLEJO CON CD20 RESPECTO DEL COMPLEJO CON EL ANTICUERPO MURINO B-LY1, Y DONDE DICHO ANTICUERPO MODIFICADO COMPRENDE: UN PRIMER Y SEGUNDO POLIPÉPTIDOS AISLADOS DEFINIDOS EN EL PLIEGO DE REIVINDICACIONES. UNA CÉLULA HUÉSPED QUE LO PRODUCE. UNA<br /> COMPOSICIÓN FARMACÉUTICA, QUE COMPRENDE A DICHO ANTICUERPO, ÚTIL PARA TRATAR DESÓRDENES QUE RESPONDEN AL AGOTAMIENTO DE CÉLULAS B. UN POLINUCLEÓTIDO AISLADO QUE CODIFICA LA SECUENCIA DE REGIÓN VARIABLE DE CADENA LIVIANA DEL ANTICUERPO, UN VECTOR DE EXPRESIÓN Y UNA CÉLULA HUÉSPED QUE COMPRENDE A DICHO VECTOR. UN MÉTODO PARA PRODUCIR EL ANTICUERPO EN UNA CÉLULA HUÉSPED QUE COMPRENDE CULTIVAR UNA CÉLULA HUÉSPED GENÉTICAMENTE MODIFICADA Y AISLAR DICHO ANTICUERPO.<br />  
CL2010000823A 2005-08-26 2010-07-30 Anticuerpo anti-cd-20 con actividad apoptotica; polinucleotido, vector y celula huesped que expresa el anticuerpo; composicion farmaceutica que lo comprende; usos en la preparacion de un medicamento para tratar cancer o una enfermedad autoinmune; metodo para producir dicho anticuerpo (div. sol. n°2246-06). CL2010000823A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71145405P 2005-08-26 2005-08-26

Publications (1)

Publication Number Publication Date
CL2010000823A1 true CL2010000823A1 (es) 2011-01-07

Family

ID=37865318

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2010000823A CL2010000823A1 (es) 2005-08-26 2010-07-30 Anticuerpo anti-cd-20 con actividad apoptotica; polinucleotido, vector y celula huesped que expresa el anticuerpo; composicion farmaceutica que lo comprende; usos en la preparacion de un medicamento para tratar cancer o una enfermedad autoinmune; metodo para producir dicho anticuerpo (div. sol. n°2246-06).
CL2010000822A CL2010000822A1 (es) 2005-08-26 2010-07-30 Anticuerpo humanizado anti-cd20 el cual induce mayores niveles de apoptosis cuando esta formando un complejo con cd20, en comparacion al anticuerpo parental; composición farmaceutica; uso para tratar desordenes que responden a la eliminación de células b; polinucleotido codificante; vector, célula huésped; método de producción. (divisional solicitud n° 2246-06).

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2010000822A CL2010000822A1 (es) 2005-08-26 2010-07-30 Anticuerpo humanizado anti-cd20 el cual induce mayores niveles de apoptosis cuando esta formando un complejo con cd20, en comparacion al anticuerpo parental; composición farmaceutica; uso para tratar desordenes que responden a la eliminación de células b; polinucleotido codificante; vector, célula huésped; método de producción. (divisional solicitud n° 2246-06).

Country Status (19)

Country Link
US (2) US20070071745A1 (es)
EP (3) EP2395024B1 (es)
JP (3) JP5373396B2 (es)
KR (2) KR101379568B1 (es)
CN (2) CN101291954B (es)
AR (1) AR055137A1 (es)
AU (1) AU2006290433B2 (es)
BR (2) BRPI0615397B1 (es)
CA (1) CA2619298C (es)
CL (2) CL2010000823A1 (es)
HK (1) HK1185357A1 (es)
IL (1) IL189756A (es)
NO (2) NO345919B1 (es)
PH (1) PH12012502376B1 (es)
RU (2) RU2547931C2 (es)
SG (1) SG192479A1 (es)
TW (2) TWI615407B (es)
WO (1) WO2007031875A2 (es)
ZA (1) ZA200802500B (es)

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EP1622942B1 (en) 2003-05-01 2014-11-19 ImClone LLC Fully human antibodies directed against the human insulin-like growth factor-1 receptor
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EP2402374A1 (en) 2005-02-07 2012-01-04 GlycArt Biotechnology AG Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof
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CN101291954B (zh) * 2005-08-26 2013-03-27 罗氏格黎卡特股份公司 具有改变的细胞信号传导活性的修饰的抗原结合分子
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AU2006290433B2 (en) 2012-06-07
TWI478940B (zh) 2015-04-01
PH12012502376A1 (en) 2016-01-11
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CA2619298C (en) 2017-07-04
EP2395023B1 (en) 2019-04-03
NO20210557A1 (no) 2008-05-23
CN101291954A (zh) 2008-10-22
RU2012139197A (ru) 2014-03-20
BRPI0615397A2 (pt) 2011-05-17
EP2395024A3 (en) 2012-02-22
JP2015078191A (ja) 2015-04-23
AU2006290433A1 (en) 2007-03-22
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US20150344584A1 (en) 2015-12-03
NO345919B1 (no) 2021-10-18
AR055137A1 (es) 2007-08-08
EP1931712B1 (en) 2018-12-05
JP5912090B2 (ja) 2016-04-27
BR122020020335B1 (pt) 2023-10-03
RU2008111068A (ru) 2009-10-10
CA2619298A1 (en) 2007-03-22
CL2010000822A1 (es) 2011-01-07
TW201527324A (zh) 2015-07-16
WO2007031875A2 (en) 2007-03-22
CN103204935B (zh) 2014-12-10
IL189756A (en) 2017-08-31
CN101291954B (zh) 2013-03-27
JP6081974B2 (ja) 2017-02-15
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RU2547931C2 (ru) 2015-04-10

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