PE20190975A1 - Novela cd47 anticuerpos monoclonales y sus usos - Google Patents

Novela cd47 anticuerpos monoclonales y sus usos

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Publication number
PE20190975A1
PE20190975A1 PE2019000860A PE2019000860A PE20190975A1 PE 20190975 A1 PE20190975 A1 PE 20190975A1 PE 2019000860 A PE2019000860 A PE 2019000860A PE 2019000860 A PE2019000860 A PE 2019000860A PE 20190975 A1 PE20190975 A1 PE 20190975A1
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PE
Peru
Prior art keywords
monoclonal antibody
seq
amino acid
refers
acid sequence
Prior art date
Application number
PE2019000860A
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English (en)
Inventor
Zhengyi Wang
Lei Fang
Bingshi Guo
Jingwu Zang
Original Assignee
I Mab
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62018879&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20190975(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by I Mab filed Critical I Mab
Publication of PE20190975A1 publication Critical patent/PE20190975A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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Abstract

Se refiere a un anticuerpo monoclonal aislado o su fragmento inmunologicamente activo del mismo, que se une al CD47 humano, comprendiendo una secuencia de cadena pesada variable (VH) identica en al menos un 95% a una secuencia de aminoacidos seleccionada de un grupo (SEC ID NO: 1, SEC ID NO: 3, entre otras); una secuencia de cadena ligera variable (VL) identica en al menos en 95% a una secuencia de aminoacidos seleccionada de otro grupo (SEC ID NO: 2, SEC ID NO: 4, entre otras). Dicho anticuerpo monoclonal evita que el CD47 humano interactue con la proteina alfa reguladora de senal (SIRPalfa) y promueve la fagocitosis mediada por macrofagos de una celula que expresa CD47. Tambien se refiere a una composicion farmaceutica que comprende al anticuerpo monoclonal aislado o su fragmento, o un anticuerpo monoclonal biespecifico, y un vehiculo farmaceuticamente aceptable; metodos de preparacion y su uso para el tratamiento del cancer, enfermedad fibrotica o una enfermedad relacionada con la inhibicion de la fagocitosis o agregacion plaquetaria.
PE2019000860A 2016-10-20 2017-10-20 Novela cd47 anticuerpos monoclonales y sus usos PE20190975A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/102720 2016-10-20
CNPCT/CN2017/076462 2017-03-13
CNPCT/CN2017/000329 2017-04-27

Publications (1)

Publication Number Publication Date
PE20190975A1 true PE20190975A1 (es) 2019-07-09

Family

ID=62018879

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019000860A PE20190975A1 (es) 2016-10-20 2017-10-20 Novela cd47 anticuerpos monoclonales y sus usos

Country Status (17)

Country Link
US (3) US20200140565A1 (es)
EP (2) EP4124343A1 (es)
JP (3) JP7043074B2 (es)
KR (3) KR102136742B1 (es)
CN (3) CN108738313B (es)
AU (4) AU2017332960B2 (es)
BR (1) BR112019008010A2 (es)
CA (1) CA2999058C (es)
CL (1) CL2019001088A1 (es)
CO (1) CO2019005033A2 (es)
IL (2) IL258352A (es)
MX (1) MX2019004691A (es)
PE (1) PE20190975A1 (es)
PH (1) PH12019500862A1 (es)
SG (1) SG11201903514VA (es)
WO (1) WO2018075857A1 (es)
ZA (1) ZA201902118B (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7043074B2 (ja) * 2016-10-20 2022-03-29 アイ－マブ バイオファーマ ユーエス リミテッド 新規なｃｄ４７モノクローナル抗体およびこの使用
WO2018205936A1 (zh) * 2017-05-08 2018-11-15 上海津曼特生物科技有限公司 双特异性重组蛋白及其应用
AU2018312222A1 (en) 2017-08-02 2020-02-27 Phanes Therapeutics, Inc. Anti-CD47 antibodies and uses thereof
WO2019086573A1 (en) 2017-11-01 2019-05-09 Hummingbird Bioscience Holdings Pte. Ltd. Cd47 antigen-binding molecules
US20210095019A1 (en) * 2017-11-10 2021-04-01 I-Mab Fusion Proteins Containing CD47 Antibodies and Cytokines
EP3717515A2 (en) 2017-12-01 2020-10-07 Seattle Genetics, Inc. Cd47 (masked) antibodies and uses thereof for treating cancer
WO2019242505A1 (zh) 2018-06-17 2019-12-26 上海健信生物医药科技有限公司 靶向cldn18.2的抗体、双特异性抗体、adc和car及其应用
TWI830774B (zh) * 2018-08-31 2024-02-01 大陸商南京聖和藥業股份有限公司 抗cd47抗體及其應用
BR112021005585A2 (pt) * 2018-09-27 2021-06-29 Celgene Corporation proteínas de ligação a sirpa e métodos de uso das mesmas
EP3860609A4 (en) * 2018-10-01 2022-08-03 Secura Bio, Inc. COMBINATION THERAPIES
AU2019370754A1 (en) * 2018-10-31 2021-02-04 I-Mab Biopharma Us Limited Novel CD47 antibodies and methods of using same
CN110582515A (zh) * 2018-11-12 2019-12-17 天境生物科技(上海)有限公司 包含cd47抗体和细胞因子的融合蛋白
CN109517073A (zh) * 2018-11-30 2019-03-26 北京泽勤生物医药有限公司 一种靶向***的融合肽及其应用
CN111303295A (zh) * 2018-12-11 2020-06-19 宜明昂科生物医药技术（上海）有限公司 一种重组嵌合膜蛋白细胞株及其应用
US20200400662A1 (en) 2019-06-07 2020-12-24 ALX Oncology Inc. Methods and reagents for reducing the interference of drugs that bind cd47 in serological assays
CN112062848B (zh) * 2019-06-10 2022-06-17 山东博安生物技术股份有限公司 抗cd47单克隆抗体及其应用
KR20220047277A (ko) 2019-07-16 2022-04-15 길리애드 사이언시즈, 인코포레이티드 Hiv 백신, 및 이의 제조 및 사용 방법
CN110470828B (zh) * 2019-07-30 2023-11-10 山东第一医科大学(山东省医学科学院) 一种脑卒中标志物免疫传感器的制备方法和检测方法
AU2020365113A1 (en) 2019-10-18 2022-04-07 Forty Seven, Inc. Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia
CN114599681B (zh) * 2019-10-25 2024-01-09 上海药明生物技术有限公司 新型抗cd47抗体及其用途
MX2022005123A (es) 2019-10-31 2022-05-30 Forty Seven Inc Tratamiento basado en anti-cd47 y anti-cd20 para cancer hematologico.
AU2020396548A1 (en) 2019-12-05 2022-07-14 Sorrento Therapeutics, Inc. Compositions and methods comprising an anti-CD47 antibody in combination with a tumor targeting antibody
CN113004406B (zh) * 2019-12-20 2022-04-26 广东菲鹏制药股份有限公司 抗cd47抗体及其应用
CA3165735A1 (en) 2019-12-24 2021-07-01 Carna Biosciences, Inc. Diacylglycerol kinase modulating compounds
BR112022014623A2 (pt) 2020-02-14 2022-09-13 Jounce Therapeutics Inc Anticorpos e proteínas de fusão que se ligam a ccr8 e usos dos mesmos
EP4143239A1 (en) * 2020-04-30 2023-03-08 I-Mab Biopharma US Limited Pharmaceutical compositions containing anti-cd47 antibodies
CN114230662A (zh) * 2020-09-09 2022-03-25 安源医药科技（上海）有限公司 抗cd47抗体及其用途
KR20230114745A (ko) * 2020-10-14 2023-08-01 아이-맵 바이오파마 컴파니 리미티드 신규 항-cd47 항체 및 이의 용도
EP4253415A1 (en) * 2020-11-12 2023-10-04 Mabwell (Shanghai) Bioscience Co., Ltd. Antibody and preparation method therefor
WO2022120286A1 (en) 2020-12-06 2022-06-09 ALX Oncology Inc. Multimers for reducing the interference of drugs that bind cd47 in serological assays
KR20220080375A (ko) 2020-12-07 2022-06-14 (주)이노베이션바이오 Cd47에 특이적인 항체 및 이의 용도
AU2022235341A1 (en) 2021-03-12 2023-09-21 Mendus B.V. Methods of vaccination and use of cd47 blockade
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症
US11976072B2 (en) 2021-06-23 2024-05-07 Gilead Sciences, Inc. Diacylglycerol kinase modulating compounds
US11926628B2 (en) 2021-06-23 2024-03-12 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3220923A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
AU2022298639A1 (en) 2021-06-23 2023-12-07 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2023277281A1 (ko) 2021-06-30 2023-01-05 (주)이노베이션바이오 Cd47에 특이적인 인간화 항체 및 이를 포함하는 cd47 관련 질환의 예방 또는 치료용 약학적 조성물
CN115785268A (zh) * 2021-09-13 2023-03-14 三优生物医药(上海)有限公司 抗cd47抗体及其用途
AR127270A1 (es) * 2021-10-09 2024-01-03 Hutchmed Ltd Formulación de anticuerpos anti-cd47
CN115991784A (zh) 2021-10-19 2023-04-21 宝船生物医药科技(上海)有限公司 抗cd47-cldn18.2双特异性抗体及其用途
WO2023076983A1 (en) 2021-10-28 2023-05-04 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
AU2022376954A1 (en) 2021-10-29 2024-05-02 Gilead Sciences, Inc. Cd73 compounds
WO2023122581A2 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
US20230242508A1 (en) 2021-12-22 2023-08-03 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Ｐａｒｐ７抑制劑
WO2023165615A1 (en) * 2022-03-04 2023-09-07 I-Mab Biopharma Co., Ltd. Combination therapies comprising a kras inhibitor for the treatment of cancer
TW202346277A (zh) 2022-03-17 2023-12-01 美商基利科學股份有限公司 Ｉｋａｒｏｓ鋅指家族降解劑及其用途
US20230355796A1 (en) 2022-03-24 2023-11-09 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
WO2023186067A1 (en) * 2022-03-31 2023-10-05 I-Mab Biopharma Co., Ltd. Combination therapies comprising an anti-her2 antibody-drug conjugate for the treatment of cancer
TW202345901A (zh) 2022-04-05 2023-12-01 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
TW202400138A (zh) 2022-04-21 2024-01-01 美商基利科學股份有限公司 Ｋｒａｓ ｇ１２ｄ調節化合物
US20240116928A1 (en) 2022-07-01 2024-04-11 Gilead Sciences, Inc. Cd73 compounds
WO2024015741A1 (en) 2022-07-12 2024-01-18 Gilead Sciences, Inc. Hiv immunogenic polypeptides and vaccines and uses thereof
US20240091351A1 (en) 2022-09-21 2024-03-21 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US20080131431A1 (en) * 2006-05-15 2008-06-05 Viral Logic Systems Technology Corp. CD47 related compositions and methods for treating immunological diseases and disorders
EP2166021A1 (en) * 2008-09-16 2010-03-24 Ganymed Pharmaceuticals AG Monoclonal antibodies for treatment of cancer
DK3789038T3 (da) 2010-05-14 2022-10-17 Univ Leland Stanford Junior Humaniserede og kimære monoklonale antistoffer mod cd47
GB201020995D0 (en) * 2010-12-10 2011-01-26 Bioinvent Int Ab Biological materials and uses thereof
EA034778B1 (ru) * 2012-02-06 2020-03-19 Инхибркс, Инк. Антитела к cd47 и способы их применения
US20140140989A1 (en) 2012-02-06 2014-05-22 Inhibrx Llc Non-Platelet Depleting and Non-Red Blood Cell Depleting CD47 Antibodies and Methods of Use Thereof
US9221908B2 (en) 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
CN107406503B (zh) * 2014-11-18 2021-07-16 詹森药业有限公司 Cd47抗体、方法和用途
SG11201705310TA (en) 2014-12-30 2017-07-28 Celgene Corp Anti-cd47 antibodies and uses thereof
JP7043074B2 (ja) * 2016-10-20 2022-03-29 アイ－マブ バイオファーマ ユーエス リミテッド 新規なｃｄ４７モノクローナル抗体およびこの使用

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