CH660306A5 - Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren. - Google Patents

Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren. Download PDF

Info

Publication number: CH660306A5
Authority: CH; Switzerland
Prior art keywords: amino acids; cis; arginine; salt; excess
Prior art date: 1984-10-05

Application number

CH4792/84A

Other languages

German (de)

English (en)

Inventor

Stefania Meola

Original Assignee

Schering Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-05

Filing date

1984-10-05

Publication date

1987-04-15

1984-10-05 Application filed by Schering Spa filed Critical Schering Spa

1984-10-05 Priority to CH4792/84A priority Critical patent/CH660306A5/de

1985-10-02 Priority to JP60219969A priority patent/JPS62223121A/ja

1985-10-03 Priority to AT0287185A priority patent/AT383736B/de

1985-10-03 Priority to DE19853535356 priority patent/DE3535356A1/de

1985-10-04 Priority to GB08524550A priority patent/GB2165152B/en

1985-10-04 Priority to BE2/60807A priority patent/BE903369A/nl

1985-10-04 Priority to NL8502712A priority patent/NL8502712A/nl

1985-10-04 Priority to ES547625A priority patent/ES8609351A1/es

1985-10-04 Priority to IT22367/85A priority patent/IT1201479B/it

1985-10-05 Priority to KR1019850007328A priority patent/KR860003012A/ko

1985-10-07 Priority to FR8514800A priority patent/FR2571255B1/fr

1987-04-15 Publication of CH660306A5 publication Critical patent/CH660306A5/de

Links

150000001413 amino acids Chemical class 0.000 title claims 16
239000008194 pharmaceutical composition Substances 0.000 title claims 6
235000001014 amino acid Nutrition 0.000 claims 15
150000003839 salts Chemical class 0.000 claims 9
239000000203 mixture Substances 0.000 claims 8
239000004475 Arginine Substances 0.000 claims 7
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 7
YMDXZJFXQJVXBF-STHAYSLISA-N fosfomycin Chemical compound C[C@@H]1O[C@@H]1P(O)(O)=O YMDXZJFXQJVXBF-STHAYSLISA-N 0.000 claims 6
150000001875 compounds Chemical class 0.000 claims 5
239000000243 solution Substances 0.000 claims 5
230000003115 biocidal effect Effects 0.000 claims 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 2
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 2
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 2
KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 2
229960003104 ornithine Drugs 0.000 claims 2
238000007911 parenteral administration Methods 0.000 claims 2
238000002560 therapeutic procedure Methods 0.000 claims 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
239000004471 Glycine Substances 0.000 claims 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
239000004472 Lysine Substances 0.000 claims 1
235000004279 alanine Nutrition 0.000 claims 1
125000000129 anionic group Chemical group 0.000 claims 1
230000000844 anti-bacterial effect Effects 0.000 claims 1
239000007864 aqueous solution Substances 0.000 claims 1
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
108010062796 arginyllysine Proteins 0.000 claims 1
230000009286 beneficial effect Effects 0.000 claims 1
229960003237 betaine Drugs 0.000 claims 1
230000036765 blood level Effects 0.000 claims 1
OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
229960001231 choline Drugs 0.000 claims 1
230000003750 conditioning effect Effects 0.000 claims 1
235000018417 cysteine Nutrition 0.000 claims 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
239000007911 effervescent powder Substances 0.000 claims 1
235000019441 ethanol Nutrition 0.000 claims 1
230000002349 favourable effect Effects 0.000 claims 1
238000009472 formulation Methods 0.000 claims 1
230000001771 impaired effect Effects 0.000 claims 1
230000036512 infertility Effects 0.000 claims 1
210000003734 kidney Anatomy 0.000 claims 1
239000007788 liquid Substances 0.000 claims 1
210000004072 lung Anatomy 0.000 claims 1
OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 1
229930182817 methionine Natural products 0.000 claims 1
238000000034 method Methods 0.000 claims 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
239000008203 oral pharmaceutical composition Substances 0.000 claims 1
210000000056 organ Anatomy 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
230000002035 prolonged effect Effects 0.000 claims 1
238000001228 spectrum Methods 0.000 claims 1
235000020357 syrup Nutrition 0.000 claims 1
239000006188 syrup Substances 0.000 claims 1
230000001225 therapeutic effect Effects 0.000 claims 1
230000002110 toxicologic effect Effects 0.000 claims 1
231100000723 toxicological property Toxicity 0.000 claims 1
230000010415 tropism Effects 0.000 claims 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CH4792/84A 1984-10-05 1984-10-05 Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren. CH660306A5 (de)

Priority Applications (11)

Application Number	Priority Date	Filing Date	Title
CH4792/84A CH660306A5 (de)	1984-10-05	1984-10-05	Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren.
JP60219969A JPS62223121A (ja)	1984-10-05	1985-10-02	（−）シス−１，２−エポキシプロピルホスホン酸のアミノ酸塩を基体とした水溶性医薬組成物
AT0287185A AT383736B (de)	1984-10-05	1985-10-03	Verfahren zur herstellung von wasserloeslichen pharmazeutischen zusammensetzungen
DE19853535356 DE3535356A1 (de)	1984-10-05	1985-10-03	Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren
GB08524550A GB2165152B (en)	1984-10-05	1985-10-04	Hydrosoluble antibiotic pharmaceutical compositions
BE2/60807A BE903369A (nl)	1984-10-05	1985-10-04	Water-oplosbare farmaceutische preparaten, welke zouten van (-)cis-1,2-epoxypropylfosfonzuur met aminozuren bevatten
NL8502712A NL8502712A (nl)	1984-10-05	1985-10-04	Water-oplosbare farmaceutische preparaten, welke zouten van (-)cis-1,2-epoxypropylfosfonzuur met aminozuren bevatten.
ES547625A ES8609351A1 (es)	1984-10-05	1985-10-04	Procedimiento para la preparacion de composiciones farmaceuticas hidrosolubles a base de sales del acido (-) cis-1, 2-epoxi-propilfosfonico.
IT22367/85A IT1201479B (it)	1984-10-05	1985-10-04	Composizioni farmaceutiche idrosolubili a base di sali dell'acido (-cis)-1,2-epossipropilfosfonico con amminoacidi
KR1019850007328A KR860003012A (ko)	1984-10-05	1985-10-05	(-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물
FR8514800A FR2571255B1 (fr)	1984-10-05	1985-10-07	Compositions pharmaceutiques hydrosolubles a base de sels de l'acide (-)cis-1,2-epoxypropylphosphonique avec des amino-acides

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH4792/84A CH660306A5 (de)	1984-10-05	1984-10-05	Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren.

Publications (1)

Publication Number	Publication Date
CH660306A5 true CH660306A5 (de)	1987-04-15

Family

ID=4282621

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH4792/84A CH660306A5 (de)	1984-10-05	1984-10-05	Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren.

Country Status (11)

Country	Link
JP (1)	JPS62223121A (nl)
KR (1)	KR860003012A (nl)
AT (1)	AT383736B (nl)
BE (1)	BE903369A (nl)
CH (1)	CH660306A5 (nl)
DE (1)	DE3535356A1 (nl)
ES (1)	ES8609351A1 (nl)
FR (1)	FR2571255B1 (nl)
GB (1)	GB2165152B (nl)
IT (1)	IT1201479B (nl)
NL (1)	NL8502712A (nl)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH310498A (de) *	1951-11-14	1955-10-31	Waldhof Zellstoff Fab	Verfahren zur Stabilisierung von Alkalisalzen von Adenosinpolyphosphorsäuren.
DE1767212B1 (de) *	1967-04-13	1971-05-06	Sumitomo Chemical Co	Verfahren zur Herstellung injizierbarer Arzneimittel
US3639590A (en) *	1967-07-25	1972-02-01	Merck & Co Inc	Antibacterial composition containing (-) (cis-1 2-epoxypropyl) phosphoric acid
BE756953A (fr) *	1969-10-02	1971-04-01	Merck & Co Inc	Potentialisation d'antibiotiques
IT1161974B (it) *	1978-02-02	1987-03-18	Italchemi Spa	Derivti dell acido cis.i 2 epossipropilfosfonico loro procedimento di preparazione e composizioni farmaceutiche che li contengono
DE2813814A1 (de) *	1978-03-31	1979-10-18	Boehringer Mannheim Gmbh	Hochwirksame, enteral resorbierbare pharmazeutische praeparate
IT1112282B (it) *	1978-07-19	1986-01-13	Zambon Spa	Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato
IT1097578B (it) *	1978-07-31	1985-08-31	Italchemi Spa	Metodo per la preparazione di sali dell'acido (-)
US4235900A (en) *	1978-11-15	1980-11-25	E. R. Squibb & Sons, Inc.	Cephradine compositions

1984
- 1984-10-05 CH CH4792/84A patent/CH660306A5/de not_active IP Right Cessation
1985
- 1985-10-02 JP JP60219969A patent/JPS62223121A/ja active Pending
- 1985-10-03 AT AT0287185A patent/AT383736B/de not_active IP Right Cessation
- 1985-10-03 DE DE19853535356 patent/DE3535356A1/de not_active Withdrawn
- 1985-10-04 GB GB08524550A patent/GB2165152B/en not_active Expired
- 1985-10-04 NL NL8502712A patent/NL8502712A/nl not_active Application Discontinuation
- 1985-10-04 ES ES547625A patent/ES8609351A1/es not_active Expired
- 1985-10-04 BE BE2/60807A patent/BE903369A/nl not_active IP Right Cessation
- 1985-10-04 IT IT22367/85A patent/IT1201479B/it active
- 1985-10-05 KR KR1019850007328A patent/KR860003012A/ko not_active IP Right Cessation
- 1985-10-07 FR FR8514800A patent/FR2571255B1/fr not_active Expired

Also Published As

Publication number	Publication date
ATA287185A (de)	1987-01-15
BE903369A (nl)	1986-02-03
FR2571255B1 (fr)	1988-09-16
KR860003012A (ko)	1986-05-19
GB8524550D0 (en)	1985-11-06
IT1201479B (it)	1989-02-02
DE3535356A1 (de)	1986-04-24
IT8522367A0 (it)	1985-10-04
NL8502712A (nl)	1986-05-01
JPS62223121A (ja)	1987-10-01
ES8609351A1 (es)	1986-09-01
GB2165152B (en)	1988-03-16
FR2571255A1 (fr)	1986-04-11
GB2165152A (en)	1986-04-09
ES547625A0 (es)	1986-09-01
AT383736B (de)	1987-08-10

Legal Events

Date	Code	Title	Description
1987-08-14	PUE	Assignment	Owner name: ISTITUTO GENTILI S.P.A.
1990-06-29	PL	Patent ceased

Publication	Publication Date	Title
DE2043933C3 (de)	1978-05-18	N-(ß-Naphthylaminomethyl)-aminocarbonsäuren sowie diese enthaltende Arzneimittel
DE602005002495T2 (de)	2008-06-12	Injizierbare Formulierung mit Natriumdiclofenac, Beta-Cyclodextrin und einem Polysorbat
EP0152836B1 (de)	1990-06-20	Mittel zur oralen Hygiene
DE1802394C2 (de)	1984-06-28	Arzneimittel mit antihypertensiver Wirkung, die [(2,6-Dichlorbenzyliden)-amino]-guanidin oder ein Säureadditionssalz davon enthalten
DE10334820B4 (de)	2020-02-06	Pharmazeutische Zusammensetzungen mit antibiotischer Aktivität
DE3000743C2 (de)	1985-07-11	Arzneipräparat auf der Basis eines Salzes der Acetylsalicylsäure und einer basischen Aminosäure
DE68915269T2 (de)	1994-09-29	Polyvalentes entzündungshemmendes mittel.
CH676549A5 (nl)	1991-02-15
DE2820794C2 (de)	1980-01-17	Salze der (-Hcis)-l^-Epoxypropylphosphonsäure, Verfahren zu ihrer Herstellung und diese enthaltendes pharmazeutisches Präparat
DE3619426A1 (de)	1987-12-17	Mittel zur erhoehung der widerstandskraft gegen erkaeltungskrankheiten bei patienten mit eingeschraenkter lungenfunktion
DE181050T1 (de)	1986-12-18	1-beta-d-ribofuranosyl-1,2,4-triazol-3-carboxamid fuer die verwendung in medizinischer behandlung von menschen.
DE3700379C2 (nl)	1989-08-17
DE3440621A1 (de)	1985-05-23	Pharmazeutische zusammensetzung zur bekaempfung von vireninfektionen und deren verwendung
CH660306A5 (de)	1987-04-15	Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren.
CH660305A5 (de)	1987-04-15	Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren.
DE3011274A1 (de)	1980-10-09	Synergistische strahlenschuetzende pharmazeutische praeparate sowie deren herstellung
DE1936723C2 (de)	1983-12-22	Salze von Chinarindenalkoloiden und Verfahren zu ihrer Herstellung
DE19853483A1 (de)	1999-05-27	Verwendung von Biphosphonaten zur Herstellung von pharmazeutischen Darreichungsformen zur intramuskulären Verwendung
DE1043587B (de)	1958-11-13	Verfahren zur Herstellung eines Appetitzueglers
DE2236876B2 (de)	1980-06-04	N-Substituierte Aminocarbonsäuren und diese Verbindungen enthaltende Arzneimittel
DE951228C (de)	1956-10-25	Verfahren zur Stabilisierung eines adrenocorticotropen Praeparates
DE3520325C2 (nl)	1988-08-04
DE3780702T2 (de)	1992-12-10	Verwendung von etodolac zur senkung des blutgehalts an harnsaeure.
DE69328357T2 (de)	2000-08-10	Komplex von 2-aminoäthansulfonsäure und zink
EP0098475A2 (de)	1984-01-18	Pharmazeutische Zusammensetzung, ihre Herstellung und Verwendung