CH622529A5 - Process for the preparation of anthracycline glycosides and optically active anthracyclinones - Google Patents

Process for the preparation of anthracycline glycosides and optically active anthracyclinones Download PDF

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Publication number
CH622529A5
CH622529A5 CH769276A CH769276A CH622529A5 CH 622529 A5 CH622529 A5 CH 622529A5 CH 769276 A CH769276 A CH 769276A CH 769276 A CH769276 A CH 769276A CH 622529 A5 CH622529 A5 CH 622529A5
Authority
CH
Switzerland
Prior art keywords
mixture
trifluoroacetyl
ivb
formula
daunomycin
Prior art date
Application number
CH769276A
Other languages
German (de)
English (en)
Inventor
Federico Arcamone
Luigi Bernardi
Bianca Patelli
Sergio Penco
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Publication of CH622529A5 publication Critical patent/CH622529A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH769276A 1976-06-14 1976-06-16 Process for the preparation of anthracycline glycosides and optically active anthracyclinones CH622529A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7617955A FR2355028A1 (fr) 1976-06-14 1976-06-14 Procede pour la preparation de glycosides derives d'anthracyclines optiquement actives

Publications (1)

Publication Number Publication Date
CH622529A5 true CH622529A5 (en) 1981-04-15

Family

ID=9174331

Family Applications (1)

Application Number Title Priority Date Filing Date
CH769276A CH622529A5 (en) 1976-06-14 1976-06-16 Process for the preparation of anthracycline glycosides and optically active anthracyclinones

Country Status (11)

Country Link
US (1) US4107423A (fr)
JP (1) JPS532463A (fr)
AT (2) AT344899B (fr)
BE (1) BE842930A (fr)
CA (1) CA1046510A (fr)
CH (1) CH622529A5 (fr)
DE (1) DE2626783C2 (fr)
FR (1) FR2355028A1 (fr)
GB (1) GB1509875A (fr)
NL (2) NL175300C (fr)
SE (2) SE421318B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0288268A2 (fr) * 1987-04-21 1988-10-26 FARMITALIA CARLO ERBA S.r.l. 4-Déméthoxy-4-aminoanthracyclines
DE10155016A1 (de) * 2001-11-07 2003-05-15 Knoell Hans Forschung Ev Neue Chinon-Verbindung, Verfahren zur Herstellung und deren Verwendung

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
IL55431A (en) * 1978-08-24 1982-07-30 Yeda Res & Dev Anthracycline type antibiotics,their preparation and pharmaceutical compositions comprising them
NL8001417A (nl) * 1979-03-17 1980-09-19 Erba Farmitalia Antitumorglycosiden.
GB2056443B (en) * 1979-08-20 1984-01-18 Hoffmann La Roche Cyclic compounds
JPS56135021A (en) * 1980-03-25 1981-10-22 Nippon Kokan Kk <Nkk> Lining for internal surface of welded part of steel pipe
CA1174669A (fr) * 1980-07-18 1984-09-18 Michael J. Broadhurst Glucosides d'anthracycline
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
US4540695A (en) * 1981-08-12 1985-09-10 Sumitomo Chemical Co., Ltd. Aminonaphthacene derivatives and their use
NL8300150A (nl) * 1982-01-26 1983-08-16 Erba Farmitalia Daunorubicine en doxorubicine-analoga, hun bereiding en toepassing.
AU554416B2 (en) * 1982-05-24 1986-08-21 Farmitalia Carlo Erba S.P.A. Anthracycline glycosides
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
US4831019A (en) * 1983-10-31 1989-05-16 Adria Laboratories, Inc. Pharmaceutical preparations of 4-demethoxy-n-trifluoroacetyl anthracyclines
US4496485A (en) * 1983-11-25 1985-01-29 G. D. Searle & Co. Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
EP3222628A1 (fr) 2008-12-23 2017-09-27 Gilead Pharmasset LLC Phosphoramidates nucléosidiques
PT3290428T (pt) 2010-03-31 2021-12-27 Gilead Pharmasset Llc Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
US8846882B2 (en) * 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin
CN104151376B (zh) * 2014-06-23 2017-02-08 天津药物研究院新药评价有限公司 一种抗肿瘤药物及其合成方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3427300A (en) * 1965-11-12 1969-02-11 Merck & Co Inc Anti-inflammatory steroid 2'-acetamido-2'-deoxy-glucoside compounds
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
US3629231A (en) * 1968-05-23 1971-12-21 Biorex Laboratories Ltd Derivatives of glycyrrhetinic acid
FI51808C (fi) * 1968-07-15 1977-04-12 Rhone Poulenc Sa Menetelmä uusien kasvainten naftaseenijohdannaisten valmistamiseksi.
GB1467383A (en) * 1974-06-12 1977-03-16 Farmaceutici Italia Daunomycin analogues
US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0288268A2 (fr) * 1987-04-21 1988-10-26 FARMITALIA CARLO ERBA S.r.l. 4-Déméthoxy-4-aminoanthracyclines
EP0288268A3 (en) * 1987-04-21 1988-12-14 Farmitalia Carlo Erba S.R.L. 4-demethoxy-4-amino-anthracyclines
AU600816B2 (en) * 1987-04-21 1990-08-23 Pharmacia Italia S.P.A. 4-demethoxy-4-amino-anthracyclines
DE10155016A1 (de) * 2001-11-07 2003-05-15 Knoell Hans Forschung Ev Neue Chinon-Verbindung, Verfahren zur Herstellung und deren Verwendung

Also Published As

Publication number Publication date
SE447988B (sv) 1987-01-12
DE2626783C2 (de) 1985-08-14
SE8100471L (sv) 1981-01-26
NL175300C (nl) 1984-10-16
FR2355028A1 (fr) 1978-01-13
JPS532463A (en) 1978-01-11
DE2626783A1 (de) 1977-12-29
AT344899B (de) 1978-08-10
CA1046510A (fr) 1979-01-16
JPS6123200B2 (fr) 1986-06-04
NL930090I2 (nl) 1994-03-16
NL930090I1 (nl) 1993-10-01
ATA636377A (de) 1978-01-15
US4107423A (en) 1978-08-15
AT345461B (de) 1978-09-25
NL175300B (nl) 1984-05-16
FR2355028B3 (fr) 1979-03-02
BE842930A (fr) 1976-10-01
SE7606808L (sv) 1977-12-16
ATA450676A (de) 1977-12-15
NL7606897A (nl) 1977-12-28
SE421318B (sv) 1981-12-14
GB1509875A (en) 1978-05-04

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Legal Events

Date Code Title Description
PFA Name/firm changed

Owner name: FARMITALIA CARLO ERBA S.R.L.

PUE Assignment

Owner name: FARMITALIA CARLO ERBA S.R.L. TRANSFER- PHARMACIA S

SPCF Supplementary protection certificate filed

Free format text: IKS 50838 01-02, 951018

SPCG Supplementary protection certificate granted

Free format text: IKS 50838/920330, 951018, EXPIRES:20010615

PL Patent ceased
PFA Name/firm changed

Owner name: PHARMACIA S.P.A. TRANSFER- PHARMACIA & UPJOHN S.P.

SPCP Certificates - modification of firm

Free format text: PHARMACIA SPA TRANSFER- PHARMACIA & UPJOHN S.P.A.