CA2556872C - Modulation of inflammatory and metastatic processes - Google Patents
Modulation of inflammatory and metastatic processes Download PDFInfo
- Publication number
- CA2556872C CA2556872C CA2556872A CA2556872A CA2556872C CA 2556872 C CA2556872 C CA 2556872C CA 2556872 A CA2556872 A CA 2556872A CA 2556872 A CA2556872 A CA 2556872A CA 2556872 C CA2556872 C CA 2556872C
- Authority
- CA
- Canada
- Prior art keywords
- groups
- substituted
- unsubstituted
- benzimidazol
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54639504P | 2004-02-20 | 2004-02-20 | |
US60/546,395 | 2004-02-20 | ||
US54710304P | 2004-02-23 | 2004-02-23 | |
US60/547,103 | 2004-02-23 | ||
US55477104P | 2004-03-19 | 2004-03-19 | |
US60/554,771 | 2004-03-19 | ||
PCT/US2005/005316 WO2005082340A2 (en) | 2004-02-20 | 2005-02-18 | Modulation of inflammatory and metastatic processes |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2556872A1 CA2556872A1 (en) | 2005-09-09 |
CA2556872C true CA2556872C (en) | 2015-05-12 |
Family
ID=34916329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2556872A Expired - Fee Related CA2556872C (en) | 2004-02-20 | 2005-02-18 | Modulation of inflammatory and metastatic processes |
Country Status (10)
Country | Link |
---|---|
US (1) | US7875624B2 (pt) |
EP (1) | EP1718306A2 (pt) |
JP (1) | JP5019884B2 (pt) |
CN (1) | CN1960731B (pt) |
AU (1) | AU2005216904B2 (pt) |
BR (1) | BRPI0507891A (pt) |
CA (1) | CA2556872C (pt) |
IL (1) | IL177574A0 (pt) |
RU (1) | RU2377988C2 (pt) |
WO (1) | WO2005082340A2 (pt) |
Families Citing this family (41)
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GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
MX2007008781A (es) * | 2005-01-21 | 2007-09-11 | Astex Therapeutics Ltd | Compuestos farmaceuticos. |
AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
WO2006081445A2 (en) * | 2005-01-27 | 2006-08-03 | Novartis Vaccines And Diagnostics Inc. | Treatment of metastasized tumors |
DK1885187T3 (da) * | 2005-05-13 | 2013-12-09 | Novartis Ag | Fremgangsmåde til behandling af lægemiddelresistent cancer |
JP5545925B2 (ja) * | 2005-05-17 | 2014-07-09 | ノバルティス アーゲー | ヘテロ環化合物の合成方法 |
EP2270000B1 (en) * | 2005-05-23 | 2015-07-29 | Novartis AG | Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts |
GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
AR062545A1 (es) * | 2005-11-29 | 2008-11-19 | Novartis Ag | Formulaciones estables de quinolinonas |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
US20090253687A1 (en) * | 2005-12-28 | 2009-10-08 | Shoji Fukumoto | Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands |
US8138205B2 (en) | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
KR20150004441A (ko) | 2006-07-07 | 2015-01-12 | 칼립시스, 인코포레이티드 | Pde4의 바이사이클릭 헤테로아릴 억제제 |
AU2009214190A1 (en) * | 2008-02-15 | 2009-08-20 | F. Hoffmann-La Roche Ag | 3-alkyl-piperazine derivatives and uses thereof |
AR070924A1 (es) * | 2008-03-19 | 2010-05-12 | Novartis Ag | Formas cristalinas y dos formas solvatadas de sales del acido lactico de 4- amino -5- fluoro-3-(5-(4-metilpiperazin-1-il ) -1h- bencimidazol-2-il) quinolin -2-(1h) - ona |
MX2010014566A (es) * | 2008-07-03 | 2011-02-15 | Novartis Ag | Proceso de granulacion de fundido. |
TWI410418B (zh) | 2009-04-29 | 2013-10-01 | Ind Tech Res Inst | 氮雜薁化合物、藥學組合物與抑制一細胞中蛋白質激酶之活性的方法 |
CN102712601A (zh) * | 2009-11-12 | 2012-10-03 | 赛尔维他股份公司 | 化合物、其制备方法、药物组合物、化合物的用途、用于调节或调控丝氨酸/苏氨酸激酶的方法以及丝氨酸/苏氨酸激酶调节剂 |
EP2558095B1 (en) * | 2010-04-16 | 2018-10-24 | Novartis AG | Organic compound for use in the treatment of liver cancer |
BR112015018282B1 (pt) | 2013-02-01 | 2021-08-24 | Wellstat Therapeutics Corporation | Compostos de amina, composição compreendendo os referidos compostos e usos dos mesmos |
WO2014127214A1 (en) | 2013-02-15 | 2014-08-21 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
EP2958895B1 (en) | 2013-02-20 | 2020-08-19 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
MX363708B (es) | 2013-10-14 | 2019-03-29 | Eisai R&D Man Co Ltd | Compuestos de quinolina selectivamente sustituidos. |
AU2014334554B2 (en) | 2013-10-14 | 2018-12-06 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
CN106061261B (zh) | 2013-11-01 | 2018-04-24 | 卡拉制药公司 | 治疗化合物的结晶形式及其用途 |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
CN104529894B (zh) * | 2015-01-15 | 2017-02-22 | 成都丽凯手性技术有限公司 | 一种喹啉酮类衍生物及其制备方法 |
WO2018048747A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
MX2019002629A (es) | 2016-09-08 | 2019-10-07 | Kala Pharmaceuticals Inc | Formas cristalinas de compuestos terapéuticos y usos de los mismos. |
EP3509423A4 (en) | 2016-09-08 | 2020-05-13 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
GB201705263D0 (en) * | 2017-03-31 | 2017-05-17 | Probiodrug Ag | Novel inhibitors |
KR20200020888A (ko) | 2017-06-27 | 2020-02-26 | 얀센 파마슈티카 엔.브이. | 신규 퀴놀리논 화합물 |
CN108610293B (zh) * | 2018-06-15 | 2020-08-04 | 南京工业大学 | 一种采用微通道反应装置制备多韦替尼中间体的方法 |
JP2021532158A (ja) * | 2018-07-31 | 2021-11-25 | ザ、トラスティーズ オブ プリンストン ユニバーシティ | 転移性癌および化学療法抵抗性癌の治療のためのテトラヒドロキノリノ誘導体 |
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JP2007508332A (ja) | 2003-10-17 | 2007-04-05 | ノボ ノルディスク アクティーゼルスカブ | 併用療法 |
EP1682529A4 (en) | 2003-11-07 | 2010-06-30 | Novartis Vaccines & Diagnostic | METHODS FOR SYNTHESIS OF QUINOLINONE COMPOUNDS |
WO2005054183A2 (en) * | 2003-12-01 | 2005-06-16 | The Scripps Research Institute | Quinolinone based protein kinase inhibitors |
MX2007014612A (es) | 2005-05-18 | 2008-01-17 | M & G Polimeri Italia Spa | Composicion de poliester. |
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2005
- 2005-02-18 EP EP05723338A patent/EP1718306A2/en not_active Withdrawn
- 2005-02-18 RU RU2006133536/15A patent/RU2377988C2/ru not_active IP Right Cessation
- 2005-02-18 BR BRPI0507891-1A patent/BRPI0507891A/pt not_active IP Right Cessation
- 2005-02-18 CN CN2005800095231A patent/CN1960731B/zh not_active Expired - Fee Related
- 2005-02-18 CA CA2556872A patent/CA2556872C/en not_active Expired - Fee Related
- 2005-02-18 US US11/061,386 patent/US7875624B2/en not_active Expired - Fee Related
- 2005-02-18 WO PCT/US2005/005316 patent/WO2005082340A2/en active Application Filing
- 2005-02-18 AU AU2005216904A patent/AU2005216904B2/en not_active Ceased
- 2005-02-18 JP JP2006554253A patent/JP5019884B2/ja not_active Expired - Fee Related
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2006
- 2006-08-17 IL IL177574A patent/IL177574A0/en unknown
Also Published As
Publication number | Publication date |
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RU2377988C2 (ru) | 2010-01-10 |
CN1960731A (zh) | 2007-05-09 |
AU2005216904A1 (en) | 2005-09-09 |
CN1960731B (zh) | 2011-12-07 |
US20050239825A1 (en) | 2005-10-27 |
IL177574A0 (en) | 2006-12-10 |
JP2007523185A (ja) | 2007-08-16 |
RU2006133536A (ru) | 2008-03-27 |
WO2005082340A3 (en) | 2006-05-04 |
AU2005216904B2 (en) | 2010-11-25 |
WO2005082340A2 (en) | 2005-09-09 |
BRPI0507891A (pt) | 2007-07-24 |
CA2556872A1 (en) | 2005-09-09 |
US7875624B2 (en) | 2011-01-25 |
JP5019884B2 (ja) | 2012-09-05 |
EP1718306A2 (en) | 2006-11-08 |
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