CA2477764A1 - Mimetiques du glucocorticoide, procedes de fabrication de ces mimetiques, compositions pharmaceutiques et leurs utilisations - Google Patents

Mimetiques du glucocorticoide, procedes de fabrication de ces mimetiques, compositions pharmaceutiques et leurs utilisations Download PDF

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Publication number
CA2477764A1
CA2477764A1 CA002477764A CA2477764A CA2477764A1 CA 2477764 A1 CA2477764 A1 CA 2477764A1 CA 002477764 A CA002477764 A CA 002477764A CA 2477764 A CA2477764 A CA 2477764A CA 2477764 A1 CA2477764 A1 CA 2477764A1
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Prior art keywords
fluoro
trifluoro
hydroxy
methoxyphenyl
methyl
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Abandoned
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CA002477764A
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Inventor
Younes Bekkali
Mario G. Cardozo
Thomas M. Kirrane
Daniel Kuzmich
John Robert Proudfoot
Hidenori Takahashi
David Thomson
Ji Wang
Renee Zindell
Christian Hanke Justus Joachim Harcken
Hossein Razavi
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Boehringer Ingelheim Pharmaceuticals Inc
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Individual
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Publication of CA2477764A1 publication Critical patent/CA2477764A1/fr
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/577—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Abstract

L'invention concerne des composés ou un tautomère, un promédicament, un solvate ou sel de ces composés, lesquels sont représentés par la formule (IA) ou la formule (IB) dans lesquelles R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ et R?6¿ sont tels que définis dans le descriptif pour la formule (IA) ou la formule (IB). L'invention concerne également des compositions pharmaceutiques contenant ces composés ainsi que des méthodes permettant de moduler la fonction du récepteur du glucocorticoïde et des méthodes permettant de traiter, à l'aide de ces composés, des états pathologiques médiés par la fonction du récepteur du glucocorticoïde ou caractérisés par des processus inflammatoires, allergiques ou prolifératifs chez un patient.
CA002477764A 2002-03-26 2003-03-21 Mimetiques du glucocorticoide, procedes de fabrication de ces mimetiques, compositions pharmaceutiques et leurs utilisations Abandoned CA2477764A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36780102P 2002-03-26 2002-03-26
US60/367,801 2002-03-26
PCT/US2003/008589 WO2003082787A1 (fr) 2002-03-26 2003-03-21 Mimetiques du glucocorticoide, procedes de fabrication de ces mimetiques, compositions pharmaceutiques et leurs utilisations

Publications (1)

Publication Number Publication Date
CA2477764A1 true CA2477764A1 (fr) 2003-10-09

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Country Link
US (1) US7268152B2 (fr)
EP (1) EP1490317A1 (fr)
JP (1) JP2005521717A (fr)
AU (1) AU2003230700A1 (fr)
CA (1) CA2477764A1 (fr)
WO (1) WO2003082787A1 (fr)

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US7268152B2 (en) 2007-09-11
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