BRPI1012589A2 - anticorpos bi-específicos anti-erbb-3/anti-c-met - Google Patents
anticorpos bi-específicos anti-erbb-3/anti-c-metInfo
- Publication number
- BRPI1012589A2 BRPI1012589A2 BRPI1012589A BRPI1012589A BRPI1012589A2 BR PI1012589 A2 BRPI1012589 A2 BR PI1012589A2 BR PI1012589 A BRPI1012589 A BR PI1012589A BR PI1012589 A BRPI1012589 A BR PI1012589A BR PI1012589 A2 BRPI1012589 A2 BR PI1012589A2
- Authority
- BR
- Brazil
- Prior art keywords
- erbb
- met
- bispecific antibodies
- antibodies anti
- bispecific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09005110 | 2009-04-07 | ||
| PCT/EP2010/002005 WO2010115552A1 (en) | 2009-04-07 | 2010-03-30 | Bispecific anti-erbb-3/anti-c-met antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1012589A2 true BRPI1012589A2 (pt) | 2016-03-22 |
Family
ID=40942420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1012589A BRPI1012589A2 (pt) | 2009-04-07 | 2010-03-30 | anticorpos bi-específicos anti-erbb-3/anti-c-met |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20100256339A1 (pt) |
| EP (1) | EP2417159A1 (pt) |
| JP (1) | JP5587975B2 (pt) |
| KR (1) | KR20110124369A (pt) |
| CN (1) | CN102378768A (pt) |
| AR (1) | AR076196A1 (pt) |
| AU (1) | AU2010233994A1 (pt) |
| BR (1) | BRPI1012589A2 (pt) |
| CA (1) | CA2757531A1 (pt) |
| CL (1) | CL2011002482A1 (pt) |
| CO (1) | CO6420355A2 (pt) |
| CR (1) | CR20110466A (pt) |
| EC (1) | ECSP11011387A (pt) |
| IL (1) | IL215062A0 (pt) |
| MX (1) | MX2011010166A (pt) |
| PE (1) | PE20120550A1 (pt) |
| RU (1) | RU2011144312A (pt) |
| SG (1) | SG175081A1 (pt) |
| TW (1) | TW201039851A (pt) |
| WO (1) | WO2010115552A1 (pt) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| CA2755640C (en) | 2009-03-20 | 2018-05-22 | Genentech, Inc. | Bispecific antibody with a single antigen-binding domain specific for both her3 and egfr |
| BRPI1014089A2 (pt) | 2009-04-02 | 2016-04-19 | Roche Glycart Ag | anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples |
| WO2010115589A1 (en) | 2009-04-07 | 2010-10-14 | Roche Glycart Ag | Trivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| WO2011028952A1 (en) * | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| RU2573915C2 (ru) | 2009-09-16 | 2016-01-27 | Дженентек, Инк. | Содержащие суперспираль и/или привязку белковые комплексы и их применение |
| US8859737B2 (en) * | 2009-12-22 | 2014-10-14 | Roche Glycart Ag | Anti-HER3 antibodies and uses thereof |
| TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
| CA2806252C (en) | 2010-07-29 | 2019-05-14 | Xencor, Inc. | Antibodies with modified isoelectric points |
| KR101612999B1 (ko) * | 2010-08-24 | 2016-04-15 | 로슈 글리카트 아게 | 활성화가능 이중특이적 항체 |
| CN103068846B9 (zh) | 2010-08-24 | 2016-09-28 | 弗·哈夫曼-拉罗切有限公司 | 包含二硫键稳定性Fv片段的双特异性抗体 |
| ES2616961T3 (es) * | 2010-11-01 | 2017-06-14 | Symphogen A/S | Composición de anticuerpos pan-HER |
| WO2012085111A1 (en) | 2010-12-23 | 2012-06-28 | F. Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| ES2549638T3 (es) | 2011-02-28 | 2015-10-30 | F. Hoffmann-La Roche Ag | Proteínas de unión a antígeno |
| RU2013141078A (ru) | 2011-02-28 | 2015-04-10 | Ф. Хоффманн-Ля Рош Аг | Одновалентные антигенсвязывающие белки |
| ES2857734T3 (es) * | 2011-08-23 | 2021-09-29 | Roche Glycart Ag | Moléculas de unión a antígeno activadoras de linfocitos T biespecíficas |
| ES2686327T3 (es) * | 2011-08-23 | 2018-10-17 | Roche Glycart Ag | Moléculas de unión a antígeno biespecíficas |
| US20130078250A1 (en) * | 2011-08-23 | 2013-03-28 | Oliver Ast | Bispecific t cell activating antigen binding molecules |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| CN104105711B (zh) | 2012-02-10 | 2018-11-30 | 弗·哈夫曼-拉罗切有限公司 | 单链抗体及其他异多聚体 |
| CN114133454A (zh) | 2012-03-14 | 2022-03-04 | 瑞泽恩制药公司 | 多特异性抗原结合分子及其用途 |
| KR20150030744A (ko) | 2012-06-27 | 2015-03-20 | 에프. 호프만-라 로슈 아게 | 표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Ｆｃ－영역 접합체의 제조 방법 및 그의 용도 |
| MX354862B (es) | 2012-06-27 | 2018-03-23 | Hoffmann La Roche | Método para la producción de entidades dirigidas altamente selectivas hechas a la medida y biespecíficas que contienen dos entidades de unión diferentes. |
| EA201500503A1 (ru) | 2012-11-08 | 2015-10-30 | Ф.Хоффманн-Ля Рош Аг | Анти-her3/her4 антигенсвязывающие белки, связывающиеся с бета-шпилькой her3 и бета-шпилькой her4 |
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- 2010-03-30 SG SG2011072642A patent/SG175081A1/en unknown
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- 2010-03-30 JP JP2012503896A patent/JP5587975B2/ja not_active Expired - Fee Related
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- 2010-03-30 MX MX2011010166A patent/MX2011010166A/es not_active Application Discontinuation
- 2010-03-30 EP EP10711590A patent/EP2417159A1/en not_active Withdrawn
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- 2010-03-30 AU AU2010233994A patent/AU2010233994A1/en not_active Abandoned
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| TW201039851A (en) | 2010-11-16 |
| KR20110124369A (ko) | 2011-11-16 |
| CN102378768A (zh) | 2012-03-14 |
| RU2011144312A (ru) | 2013-05-20 |
| PE20120550A1 (es) | 2012-05-21 |
| IL215062A0 (en) | 2011-11-30 |
| AR076196A1 (es) | 2011-05-26 |
| EP2417159A1 (en) | 2012-02-15 |
| US20140135482A1 (en) | 2014-05-15 |
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| US20100256339A1 (en) | 2010-10-07 |
| WO2010115552A1 (en) | 2010-10-14 |
| AU2010233994A1 (en) | 2011-09-22 |
| JP5587975B2 (ja) | 2014-09-10 |
| AU2010233994A8 (en) | 2012-07-12 |
| SG175081A1 (en) | 2011-11-28 |
| CL2011002482A1 (es) | 2012-03-30 |
| CO6420355A2 (es) | 2012-04-16 |
| MX2011010166A (es) | 2011-10-11 |
| ECSP11011387A (es) | 2011-11-30 |
| CR20110466A (es) | 2011-09-21 |
| JP2012522524A (ja) | 2012-09-27 |
| CA2757531A1 (en) | 2010-10-14 |
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