BRPI0610201B8 - método para a purificação de anticorpo monoclonal a partir de agregados do mesmo - Google Patents
método para a purificação de anticorpo monoclonal a partir de agregados do mesmoInfo
- Publication number
- BRPI0610201B8 BRPI0610201B8 BRPI0610201A BRPI0610201A BRPI0610201B8 BR PI0610201 B8 BRPI0610201 B8 BR PI0610201B8 BR PI0610201 A BRPI0610201 A BR PI0610201A BR PI0610201 A BRPI0610201 A BR PI0610201A BR PI0610201 B8 BRPI0610201 B8 BR PI0610201B8
- Authority
- BR
- Brazil
- Prior art keywords
- aggregates
- monoclonal antibody
- ion exchange
- purifying monoclonal
- immunoglobulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
método para a purificação de anticorpos. a presente invenção refere-se a método para a purificação de imunoglobulinas através de cromatografia de troca de íon que é descrito. o método cromatográfico usa uma resina de troca de íon fraca e um processo de eluição de etapa única para a purificação de uma imunoglobulina. adicionalmente um método para a determinação da concentração de sal para a eluição de etapa única de uma imunoglobulina a partir de uma resina de troca de íon é descrito.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05011302.6 | 2005-05-25 | ||
EP05011302 | 2005-05-25 | ||
PCT/EP2006/004863 WO2006125599A2 (en) | 2005-05-25 | 2006-05-23 | Method for the purification of antibodies |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0610201A2 BRPI0610201A2 (pt) | 2010-06-01 |
BRPI0610201B1 BRPI0610201B1 (pt) | 2020-12-29 |
BRPI0610201B8 true BRPI0610201B8 (pt) | 2021-05-25 |
Family
ID=34936911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0610201A BRPI0610201B8 (pt) | 2005-05-25 | 2006-05-23 | método para a purificação de anticorpo monoclonal a partir de agregados do mesmo |
Country Status (18)
Country | Link |
---|---|
US (3) | US20090098660A1 (pt) |
EP (2) | EP2261252B2 (pt) |
JP (1) | JP4852602B2 (pt) |
KR (1) | KR100967778B1 (pt) |
CN (1) | CN101180317B (pt) |
AT (1) | ATE525087T1 (pt) |
AU (1) | AU2006251307B2 (pt) |
BR (1) | BRPI0610201B8 (pt) |
CA (1) | CA2607375C (pt) |
DK (1) | DK1888636T4 (pt) |
ES (2) | ES2373402T5 (pt) |
FI (1) | FI1888636T4 (pt) |
IL (2) | IL186338A (pt) |
MX (1) | MX2007014269A (pt) |
NO (1) | NO345362B1 (pt) |
PL (1) | PL1888636T5 (pt) |
TW (2) | TWI391399B (pt) |
WO (1) | WO2006125599A2 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI391399B (zh) | 2005-05-25 | 2013-04-01 | Hoffmann La Roche | 測定溶離多肽之鹽濃度之方法 |
EP2152745B2 (en) | 2007-06-01 | 2023-03-15 | F. Hoffmann-La Roche AG | Immunoglobulin purification |
AR067537A1 (es) * | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | Purificacion de polipeptidos pegilados |
CL2008002054A1 (es) | 2007-07-17 | 2009-05-29 | Hoffmann La Roche | Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico. |
CA2733782A1 (en) * | 2008-08-14 | 2010-02-18 | Merck Sharp & Dohme Corp. | Methods for purifying antibodies using protein a affinity chromatography |
MX348739B (es) | 2010-03-10 | 2017-06-27 | F Hoffmann-La Roche Ag * | Metodo para purificar soluciones de inmunoglobulina. |
MX2012011737A (es) * | 2010-04-14 | 2012-11-16 | Hoffmann La Roche | Remocion de agregado de inmunoglobulina. |
SG189872A1 (en) * | 2010-10-11 | 2013-06-28 | Abbvie Inc | Processes for purification of proteins |
RU2586515C2 (ru) | 2010-12-21 | 2016-06-10 | Ф.Хоффманн-Ля Рош Аг | Препарат антитела, обогащенного изоформами и способ его получения |
ES2865449T3 (es) | 2011-03-16 | 2021-10-15 | Hoffmann La Roche | Cromatografía de intercambio iónico con selectividad mejorada para la separación de monómeros, agregados y fragmentos polipeptídicos por modulación de la fase móvil |
JP6292718B2 (ja) * | 2011-07-01 | 2018-03-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 凝集ポリペプチドから単量体ポリペプチドを分離するための方法 |
US10481164B2 (en) * | 2012-03-26 | 2019-11-19 | Amgen Inc. | Method for using light scattering in real time to directly monitor and control impurity removal in purification processes |
JPWO2015041218A1 (ja) * | 2013-09-17 | 2017-03-02 | 株式会社カネカ | 新規抗体精製方法及びそれから得られる抗体(NovelAntibodyPurificationMethodandAntibodyobtainedtherefrom)、並びに陽イオン交換基を用いた新規抗体精製法及びそれから得られる抗体(NovelAntibodyPurificationmethodusingCationExchangerandAntibodyobtainedtherefrom) |
WO2015064971A1 (ko) * | 2013-10-30 | 2015-05-07 | (주)셀트리온 | 양이온 교환 크로마토그래피를 이용한 항체의 아형 분리 방법 |
SI3215528T1 (sl) | 2014-11-06 | 2019-11-29 | Hoffmann La Roche | Variante regije Fc s spremenjeno vezavo FcRn in postopki uporabe |
GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
US20180327447A1 (en) * | 2015-11-18 | 2018-11-15 | Merck Patent Gmbh | Improved protein separation in ion exchange chromatography |
AU2016356482A1 (en) * | 2015-11-18 | 2018-06-28 | Merck Patent Gmbh | Opposite pH-salt gradients for improved protein separations |
WO2019183334A1 (en) | 2018-03-21 | 2019-09-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbents, devices and methods |
CA3095850A1 (en) * | 2018-04-03 | 2019-10-10 | Merck Patent Gmbh | Cex chromatography media and low salt elution of target proteins from biopharmaceutical feeds |
CN111068361B (zh) * | 2018-10-22 | 2022-02-11 | 中国石油化工股份有限公司 | 一种己内酰胺离子交换装置及其再生方法 |
CN110066314B (zh) * | 2019-04-01 | 2023-10-27 | 上海药明生物技术有限公司 | 一种高效提高多聚体分离分辨率的亲和纯化工艺 |
TW202128264A (zh) * | 2019-09-25 | 2021-08-01 | 瑞士商赫孚孟拉羅股份公司 | 使用經預測之溶離緩衝鹽濃度的陽離子層析法 |
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AR045614A1 (es) | 2003-09-10 | 2005-11-02 | Hoffmann La Roche | Anticuerpos contra el recepctor de la interleuquina- 1 y los usos de los mismos |
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2006
- 2006-05-19 TW TW098127045A patent/TWI391399B/zh active
- 2006-05-19 TW TW095118030A patent/TWI320788B/zh active
- 2006-05-23 AU AU2006251307A patent/AU2006251307B2/en active Active
- 2006-05-23 PL PL06753791.0T patent/PL1888636T5/pl unknown
- 2006-05-23 EP EP10175706.0A patent/EP2261252B2/en active Active
- 2006-05-23 FI FIEP06753791.0T patent/FI1888636T4/fi active
- 2006-05-23 ES ES06753791T patent/ES2373402T5/es active Active
- 2006-05-23 EP EP06753791.0A patent/EP1888636B2/en active Active
- 2006-05-23 WO PCT/EP2006/004863 patent/WO2006125599A2/en active Application Filing
- 2006-05-23 US US11/920,288 patent/US20090098660A1/en not_active Abandoned
- 2006-05-23 CN CN200680017966XA patent/CN101180317B/zh active Active
- 2006-05-23 KR KR1020077027285A patent/KR100967778B1/ko active IP Right Grant
- 2006-05-23 CA CA2607375A patent/CA2607375C/en active Active
- 2006-05-23 BR BRPI0610201A patent/BRPI0610201B8/pt active IP Right Grant
- 2006-05-23 AT AT06753791T patent/ATE525087T1/de active
- 2006-05-23 JP JP2008512752A patent/JP4852602B2/ja active Active
- 2006-05-23 MX MX2007014269A patent/MX2007014269A/es active IP Right Grant
- 2006-05-23 ES ES10175706T patent/ES2389641T5/es active Active
- 2006-05-23 DK DK06753791.0T patent/DK1888636T4/da active
-
2007
- 2007-10-07 IL IL186338A patent/IL186338A/en active IP Right Grant
- 2007-10-09 NO NO20075091A patent/NO345362B1/no unknown
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2010
- 2010-07-14 IL IL206993A patent/IL206993A0/en active IP Right Grant
-
2014
- 2014-05-06 US US14/271,058 patent/US9631007B2/en active Active
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2017
- 2017-03-14 US US15/458,368 patent/US11034754B2/en active Active
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/05/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |