NO20075091L - Fremgangsmate for rensing av antistoffer - Google Patents
Fremgangsmate for rensing av antistofferInfo
- Publication number
- NO20075091L NO20075091L NO20075091A NO20075091A NO20075091L NO 20075091 L NO20075091 L NO 20075091L NO 20075091 A NO20075091 A NO 20075091A NO 20075091 A NO20075091 A NO 20075091A NO 20075091 L NO20075091 L NO 20075091L
- Authority
- NO
- Norway
- Prior art keywords
- procedure
- ion exchange
- purifying antibodies
- immunoglobulin
- purification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
En fremgangsmåte for rensing av immunglobuliner ved ionebytterkromatografi er beskrevet. Den kromatografiske metoden anvender en svak ionebytteresin og en ett trinns elueringsmetode for rensing av et immunglobulin. I tillegg er en fremgangsmåte for bestemmelse av saltkonsentrasjonen for ett trinns eluering av et immunglobulin fra en ionebytteresin beskrevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05011302 | 2005-05-25 | ||
PCT/EP2006/004863 WO2006125599A2 (en) | 2005-05-25 | 2006-05-23 | Method for the purification of antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20075091L true NO20075091L (no) | 2008-01-23 |
NO345362B1 NO345362B1 (no) | 2020-12-28 |
Family
ID=34936911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20075091A NO345362B1 (no) | 2005-05-25 | 2007-10-09 | Fremgangsmåte for rensing av antistoffer |
Country Status (18)
Country | Link |
---|---|
US (3) | US20090098660A1 (no) |
EP (2) | EP1888636B2 (no) |
JP (1) | JP4852602B2 (no) |
KR (1) | KR100967778B1 (no) |
CN (1) | CN101180317B (no) |
AT (1) | ATE525087T1 (no) |
AU (1) | AU2006251307B2 (no) |
BR (1) | BRPI0610201B8 (no) |
CA (1) | CA2607375C (no) |
DK (1) | DK1888636T4 (no) |
ES (2) | ES2373402T5 (no) |
FI (1) | FI1888636T4 (no) |
IL (2) | IL186338A (no) |
MX (1) | MX2007014269A (no) |
NO (1) | NO345362B1 (no) |
PL (1) | PL1888636T5 (no) |
TW (2) | TWI391399B (no) |
WO (1) | WO2006125599A2 (no) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI391399B (zh) | 2005-05-25 | 2013-04-01 | Hoffmann La Roche | 測定溶離多肽之鹽濃度之方法 |
BRPI0812288A2 (pt) | 2007-06-01 | 2014-11-25 | Hoffmann La Roche | Purificação de imunoglobulina. |
CL2008002053A1 (es) * | 2007-07-17 | 2009-05-22 | Hoffmann La Roche | Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion. |
CL2008002054A1 (es) | 2007-07-17 | 2009-05-29 | Hoffmann La Roche | Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico. |
MX2011001696A (es) * | 2008-08-14 | 2011-03-25 | Merck Sharp & Dohme | Metodos para purificar anticuerpos usando cromatografia de afinidad con proteina a. |
US9884904B2 (en) | 2010-03-10 | 2018-02-06 | Hoffmann-La Roche Inc. | Method for purifying polypeptide solutions |
CA2792717A1 (en) * | 2010-04-14 | 2011-10-20 | F. Hoffmann-La Roche Ag | Immunoglobulin aggregate removal |
RU2610667C2 (ru) * | 2010-10-11 | 2017-02-14 | Эббви Бахамаз Лтд., | Способ очистки белков |
MX357821B (es) | 2010-12-21 | 2018-07-25 | Hoffmann La Roche | Preparación de anticuerpo enriquecida con isoforma y método para obtenerla. |
PL3318571T3 (pl) | 2011-03-16 | 2021-07-05 | F. Hoffmann-La Roche Ag | Chromatografia jonowymienna o ulepszonej selektywności do rozdzielania monomerów, agregatów i fragmentów polipeptydowych przez modulację fazy ruchomej |
SG10201605397PA (en) | 2011-07-01 | 2016-08-30 | Hoffmann La Roche | Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides |
US10481164B2 (en) * | 2012-03-26 | 2019-11-19 | Amgen Inc. | Method for using light scattering in real time to directly monitor and control impurity removal in purification processes |
CN105555795A (zh) * | 2013-09-17 | 2016-05-04 | 株式会社钟化 | 新抗体纯化方法和由该方法得到的抗体、以及使用了阳离子交换基团的新抗体纯化法和由该方法得到的抗体 |
WO2015064971A1 (ko) * | 2013-10-30 | 2015-05-07 | (주)셀트리온 | 양이온 교환 크로마토그래피를 이용한 항체의 아형 분리 방법 |
CN107108720A (zh) | 2014-11-06 | 2017-08-29 | 豪夫迈·罗氏有限公司 | 具有改变的FCRN结合的Fc区变体及其使用方法 |
GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
RU2018121657A (ru) * | 2015-11-18 | 2019-12-19 | Мерк Патент Гмбх | ПРОТИВОПОЛОЖНЫЕ ГРАДИЕНТЫ pH-СОЛЬ ДЛЯ УЛУЧШЕННОГО РАЗДЕЛЕНИЯ БЕЛКОВ |
RU2018121653A (ru) * | 2015-11-18 | 2019-12-19 | Мерк Патент Гмбх | Улучшенное разделение белков при ионообменной хроматографии |
US11155575B2 (en) | 2018-03-21 | 2021-10-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbent, devices and methods |
KR20200138346A (ko) * | 2018-04-03 | 2020-12-09 | 메르크 파텐트 게엠베하 | Cex 크로마토그래피 매질 및 생물제약 공급물로부터의 표적 단백질의 저염 용출 |
CN111068361B (zh) * | 2018-10-22 | 2022-02-11 | 中国石油化工股份有限公司 | 一种己内酰胺离子交换装置及其再生方法 |
CN110066314B (zh) * | 2019-04-01 | 2023-10-27 | 上海药明生物技术有限公司 | 一种高效提高多聚体分离分辨率的亲和纯化工艺 |
TW202128264A (zh) * | 2019-09-25 | 2021-08-01 | 瑞士商赫孚孟拉羅股份公司 | 使用經預測之溶離緩衝鹽濃度的陽離子層析法 |
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US4136094A (en) * | 1977-08-31 | 1979-01-23 | The Regents Of The University Of Minnesota | Preparation of intravenous human and animal gamma globulins and isolation of albumin |
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JPS6042336A (ja) * | 1983-08-18 | 1985-03-06 | Nippon Seiyaku Kk | 免疫グロブリンの製造方法 |
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US6962700B1 (en) * | 2000-09-13 | 2005-11-08 | Atopix Pharmaceuticals Corporation | Method of manufacturing immune globulin |
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DK2332996T3 (en) | 2002-09-11 | 2014-12-15 | Genentech Inc | Purification of anti-Her2 antibodies |
CN1490334A (zh) * | 2002-10-18 | 2004-04-21 | 缪金明 | 基因特异性抗体的亲和纯化方法 |
AU2004215653B2 (en) | 2003-02-28 | 2011-03-17 | Lonza Biologics Plc. | Antibody purification by protein A and ion exchange chromatography |
AR045614A1 (es) | 2003-09-10 | 2005-11-02 | Hoffmann La Roche | Anticuerpos contra el recepctor de la interleuquina- 1 y los usos de los mismos |
BRPI0510883B8 (pt) * | 2004-06-01 | 2021-05-25 | Genentech Inc | composto conjugado de droga e anticorpo, composição farmacêutica, método de fabricação de composto conjugado de droga e anticorpo e usos de uma formulação, de um conjugado de droga e anticorpo e um agente quimioterapêutico e de uma combinação |
TWI391399B (zh) | 2005-05-25 | 2013-04-01 | Hoffmann La Roche | 測定溶離多肽之鹽濃度之方法 |
-
2006
- 2006-05-19 TW TW098127045A patent/TWI391399B/zh active
- 2006-05-19 TW TW095118030A patent/TWI320788B/zh active
- 2006-05-23 EP EP06753791.0A patent/EP1888636B2/en active Active
- 2006-05-23 FI FIEP06753791.0T patent/FI1888636T4/fi active
- 2006-05-23 AU AU2006251307A patent/AU2006251307B2/en active Active
- 2006-05-23 JP JP2008512752A patent/JP4852602B2/ja active Active
- 2006-05-23 MX MX2007014269A patent/MX2007014269A/es active IP Right Grant
- 2006-05-23 US US11/920,288 patent/US20090098660A1/en not_active Abandoned
- 2006-05-23 ES ES06753791T patent/ES2373402T5/es active Active
- 2006-05-23 CN CN200680017966XA patent/CN101180317B/zh active Active
- 2006-05-23 WO PCT/EP2006/004863 patent/WO2006125599A2/en active Application Filing
- 2006-05-23 ES ES10175706T patent/ES2389641T5/es active Active
- 2006-05-23 PL PL06753791.0T patent/PL1888636T5/pl unknown
- 2006-05-23 CA CA2607375A patent/CA2607375C/en active Active
- 2006-05-23 EP EP10175706.0A patent/EP2261252B2/en active Active
- 2006-05-23 BR BRPI0610201A patent/BRPI0610201B8/pt active IP Right Grant
- 2006-05-23 AT AT06753791T patent/ATE525087T1/de active
- 2006-05-23 KR KR1020077027285A patent/KR100967778B1/ko active IP Right Grant
- 2006-05-23 DK DK06753791.0T patent/DK1888636T4/da active
-
2007
- 2007-10-07 IL IL186338A patent/IL186338A/en active IP Right Grant
- 2007-10-09 NO NO20075091A patent/NO345362B1/no unknown
-
2010
- 2010-07-14 IL IL206993A patent/IL206993A0/en active IP Right Grant
-
2014
- 2014-05-06 US US14/271,058 patent/US9631007B2/en active Active
-
2017
- 2017-03-14 US US15/458,368 patent/US11034754B2/en active Active
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