DK1888636T4 - Fremgangsmåde til oprensning af antistoffer - Google Patents

Fremgangsmåde til oprensning af antistoffer Download PDF

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Publication number
DK1888636T4
DK1888636T4 DK06753791.0T DK06753791T DK1888636T4 DK 1888636 T4 DK1888636 T4 DK 1888636T4 DK 06753791 T DK06753791 T DK 06753791T DK 1888636 T4 DK1888636 T4 DK 1888636T4
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DK
Denmark
Prior art keywords
purification
ion exchange
antibodies
procedure
immunoglobulin
Prior art date
Application number
DK06753791.0T
Other languages
English (en)
Other versions
DK1888636T3 (da
Inventor
Roberto Falkenstein
Burkard Kolb
Maria Smida
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34936911&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1888636(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1888636T3 publication Critical patent/DK1888636T3/da
Publication of DK1888636T4 publication Critical patent/DK1888636T4/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK06753791.0T 2005-05-25 2006-05-23 Fremgangsmåde til oprensning af antistoffer DK1888636T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05011302 2005-05-25
PCT/EP2006/004863 WO2006125599A2 (en) 2005-05-25 2006-05-23 Method for the purification of antibodies

Publications (2)

Publication Number Publication Date
DK1888636T3 DK1888636T3 (da) 2011-11-14
DK1888636T4 true DK1888636T4 (da) 2022-07-18

Family

ID=34936911

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06753791.0T DK1888636T4 (da) 2005-05-25 2006-05-23 Fremgangsmåde til oprensning af antistoffer

Country Status (18)

Country Link
US (3) US20090098660A1 (da)
EP (2) EP1888636B2 (da)
JP (1) JP4852602B2 (da)
KR (1) KR100967778B1 (da)
CN (1) CN101180317B (da)
AT (1) ATE525087T1 (da)
AU (1) AU2006251307B2 (da)
BR (1) BRPI0610201B8 (da)
CA (1) CA2607375C (da)
DK (1) DK1888636T4 (da)
ES (2) ES2373402T5 (da)
FI (1) FI1888636T4 (da)
IL (2) IL186338A (da)
MX (1) MX2007014269A (da)
NO (1) NO345362B1 (da)
PL (1) PL1888636T5 (da)
TW (2) TWI391399B (da)
WO (1) WO2006125599A2 (da)

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TWI391399B (zh) 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法
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CL2008002054A1 (es) 2007-07-17 2009-05-29 Hoffmann La Roche Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico.
MX2011001696A (es) * 2008-08-14 2011-03-25 Merck Sharp & Dohme Metodos para purificar anticuerpos usando cromatografia de afinidad con proteina a.
US9884904B2 (en) 2010-03-10 2018-02-06 Hoffmann-La Roche Inc. Method for purifying polypeptide solutions
CA2792717A1 (en) * 2010-04-14 2011-10-20 F. Hoffmann-La Roche Ag Immunoglobulin aggregate removal
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MX357821B (es) 2010-12-21 2018-07-25 Hoffmann La Roche Preparación de anticuerpo enriquecida con isoforma y método para obtenerla.
PL3318571T3 (pl) 2011-03-16 2021-07-05 F. Hoffmann-La Roche Ag Chromatografia jonowymienna o ulepszonej selektywności do rozdzielania monomerów, agregatów i fragmentów polipeptydowych przez modulację fazy ruchomej
SG10201605397PA (en) 2011-07-01 2016-08-30 Hoffmann La Roche Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides
US10481164B2 (en) * 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
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CN107108720A (zh) 2014-11-06 2017-08-29 豪夫迈·罗氏有限公司 具有改变的FCRN结合的Fc区变体及其使用方法
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RU2018121657A (ru) * 2015-11-18 2019-12-19 Мерк Патент Гмбх ПРОТИВОПОЛОЖНЫЕ ГРАДИЕНТЫ pH-СОЛЬ ДЛЯ УЛУЧШЕННОГО РАЗДЕЛЕНИЯ БЕЛКОВ
RU2018121653A (ru) * 2015-11-18 2019-12-19 Мерк Патент Гмбх Улучшенное разделение белков при ионообменной хроматографии
US11155575B2 (en) 2018-03-21 2021-10-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
KR20200138346A (ko) * 2018-04-03 2020-12-09 메르크 파텐트 게엠베하 Cex 크로마토그래피 매질 및 생물제약 공급물로부터의 표적 단백질의 저염 용출
CN111068361B (zh) * 2018-10-22 2022-02-11 中国石油化工股份有限公司 一种己内酰胺离子交换装置及其再生方法
CN110066314B (zh) * 2019-04-01 2023-10-27 上海药明生物技术有限公司 一种高效提高多聚体分离分辨率的亲和纯化工艺
TW202128264A (zh) * 2019-09-25 2021-08-01 瑞士商赫孚孟拉羅股份公司 使用經預測之溶離緩衝鹽濃度的陽離子層析法

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TWI391399B (zh) 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法

Also Published As

Publication number Publication date
CA2607375F (en) 2006-11-30
US20170183394A1 (en) 2017-06-29
US20140243508A1 (en) 2014-08-28
EP2261252A3 (en) 2011-03-23
IL186338A0 (en) 2008-01-20
EP2261252B2 (en) 2020-10-21
JP4852602B2 (ja) 2012-01-11
EP1888636B1 (en) 2011-09-21
IL186338A (en) 2011-01-31
WO2006125599A3 (en) 2007-06-21
FI1888636T4 (fi) 2023-01-31
MX2007014269A (es) 2008-01-24
ATE525087T1 (de) 2011-10-15
KR20080017322A (ko) 2008-02-26
IL206993A0 (en) 2012-01-01
US9631007B2 (en) 2017-04-25
TWI320788B (en) 2010-02-21
ES2389641T5 (es) 2021-06-10
PL1888636T5 (pl) 2023-03-06
BRPI0610201B1 (pt) 2020-12-29
ES2389641T3 (es) 2012-10-30
PL1888636T3 (pl) 2012-02-29
WO2006125599A2 (en) 2006-11-30
EP1888636A2 (en) 2008-02-20
KR100967778B1 (ko) 2010-07-05
BRPI0610201A2 (pt) 2010-06-01
DK1888636T3 (da) 2011-11-14
TW200716669A (en) 2007-05-01
AU2006251307B2 (en) 2011-08-04
CN101180317A (zh) 2008-05-14
CA2607375A1 (en) 2006-11-30
US20090098660A1 (en) 2009-04-16
NO345362B1 (no) 2020-12-28
AU2006251307A1 (en) 2006-11-30
JP2008542218A (ja) 2008-11-27
CA2607375C (en) 2014-01-21
EP2261252A2 (en) 2010-12-15
EP1888636B2 (en) 2022-03-30
EP2261252B1 (en) 2012-07-25
TW200946543A (en) 2009-11-16
BRPI0610201B8 (pt) 2021-05-25
NO20075091L (no) 2008-01-23
TWI391399B (zh) 2013-04-01
CN101180317B (zh) 2013-06-19
ES2373402T3 (es) 2012-02-03
US11034754B2 (en) 2021-06-15
ES2373402T5 (es) 2022-09-14

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