WO2007011698A3 - Humanized antibody conjugates and related methods, assays, reagents, and kits - Google Patents
Humanized antibody conjugates and related methods, assays, reagents, and kits Download PDFInfo
- Publication number
- WO2007011698A3 WO2007011698A3 PCT/US2006/027312 US2006027312W WO2007011698A3 WO 2007011698 A3 WO2007011698 A3 WO 2007011698A3 US 2006027312 W US2006027312 W US 2006027312W WO 2007011698 A3 WO2007011698 A3 WO 2007011698A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- humanized antibody
- kits
- reagents
- antibody conjugates
- related methods
- Prior art date
Links
- 229940127121 immunoconjugate Drugs 0.000 title abstract 3
- 238000003556 assay Methods 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
- C07K16/109—Hepatitis C virus; Hepatitis G virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The invention provides synthetically and recombinantly-derived humanized antibody conjugates and related methods, diagnostic assays, reagents, and kits. In one embodiment, the invention provides humanized antibody conjugates comprising a human immunoglobulin fragment which is bound by a cross-linking functional group to a non-human antibody fragment (e.g., a non-human monoclonal antibody fragment) comprising an antigen-binding amino acid sequence.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06787249A EP1922412A4 (en) | 2005-07-15 | 2006-07-14 | Humanized antibody conjugates and related methods, assays, reagents, and kits |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69961805P | 2005-07-15 | 2005-07-15 | |
US60/699,618 | 2005-07-15 | ||
US70836105P | 2005-08-31 | 2005-08-31 | |
US60/708,361 | 2005-08-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007011698A2 WO2007011698A2 (en) | 2007-01-25 |
WO2007011698A3 true WO2007011698A3 (en) | 2007-06-28 |
Family
ID=37669378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/027312 WO2007011698A2 (en) | 2005-07-15 | 2006-07-14 | Humanized antibody conjugates and related methods, assays, reagents, and kits |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1922412A4 (en) |
WO (1) | WO2007011698A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7858752B2 (en) | 2006-12-05 | 2010-12-28 | Abbott Laboratories | Recombinant antibodies against hepatitis C virus and methods of obtaining and using same |
JP2010519916A (en) * | 2007-03-06 | 2010-06-10 | リボバックス バイオテクノロジーズ ソシエテ アノニム | Antibodies specific for rubella virus |
CN103383393B (en) * | 2013-06-28 | 2015-11-25 | 英科隆生物技术(杭州)有限公司 | A kind of quality-control product of alternative patient's positive blood |
CN108445224A (en) * | 2018-02-26 | 2018-08-24 | 王贤俊 | A kind of cardic fatty acid binding protein antibody fragment compounded latex particle and preparation method thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4929543A (en) * | 1987-05-14 | 1990-05-29 | Boehringer Mannheim Gmbh | Process for the determination of an antibody in human body fluids |
US5614367A (en) * | 1989-01-10 | 1997-03-25 | Boehringer Mannheim Gmbh | Diagnostic test using chimeric antibodies |
US6015662A (en) * | 1996-01-23 | 2000-01-18 | Abbott Laboratories | Reagents for use as calibrators and controls |
US6207815B1 (en) * | 1988-10-19 | 2001-03-27 | The Dow Chemical Company | Family of high affinity, modified antibodies for cancer treatment |
US6303755B1 (en) * | 1996-07-11 | 2001-10-16 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-FCA receptor antibodies |
US6630292B2 (en) * | 2000-04-25 | 2003-10-07 | Fuji Photo Film B.V. | Method for producing a silver halide photographic emulsion |
US6849259B2 (en) * | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5681566A (en) * | 1988-10-24 | 1997-10-28 | 3I Research Exploitation Limited | Antibody conjugates with two or more covalently linked FC regions |
-
2006
- 2006-07-14 EP EP06787249A patent/EP1922412A4/en not_active Withdrawn
- 2006-07-14 WO PCT/US2006/027312 patent/WO2007011698A2/en active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4929543A (en) * | 1987-05-14 | 1990-05-29 | Boehringer Mannheim Gmbh | Process for the determination of an antibody in human body fluids |
US6207815B1 (en) * | 1988-10-19 | 2001-03-27 | The Dow Chemical Company | Family of high affinity, modified antibodies for cancer treatment |
US5614367A (en) * | 1989-01-10 | 1997-03-25 | Boehringer Mannheim Gmbh | Diagnostic test using chimeric antibodies |
US6015662A (en) * | 1996-01-23 | 2000-01-18 | Abbott Laboratories | Reagents for use as calibrators and controls |
US6303755B1 (en) * | 1996-07-11 | 2001-10-16 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-FCA receptor antibodies |
US6630292B2 (en) * | 2000-04-25 | 2003-10-07 | Fuji Photo Film B.V. | Method for producing a silver halide photographic emulsion |
US6849259B2 (en) * | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
Non-Patent Citations (1)
Title |
---|
See also references of EP1922412A4 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007011698A2 (en) | 2007-01-25 |
EP1922412A4 (en) | 2009-07-15 |
EP1922412A2 (en) | 2008-05-21 |
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