BRPI0608353A2 - derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfundidos - Google Patents

derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfundidos

Info

Publication number
BRPI0608353A2
BRPI0608353A2 BRPI0608353-6A BRPI0608353A BRPI0608353A2 BR PI0608353 A2 BRPI0608353 A2 BR PI0608353A2 BR PI0608353 A BRPI0608353 A BR PI0608353A BR PI0608353 A2 BRPI0608353 A2 BR PI0608353A2
Authority
BR
Brazil
Prior art keywords
benzofuran
indene
indole
benzothiophene
cycloalkyl fused
Prior art date
Application number
BRPI0608353-6A
Other languages
English (en)
Inventor
Annmarie Louise Sabb
Robert Lewis Vogel
Gary Paul Stack
Reinhardt Bernhard Baudy
Jean Yi-Ching Sze
Yanfang Li
Charles John Stanton Iii
Antonia Nikitenko
Deborah Ann Evrard
Amedeo Arturo Failli
Lalitha Krishnan
Anita Wai-Yin Chan
Jianxin Ren
Charles Guinosso
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0608353A2 publication Critical patent/BRPI0608353A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Abstract

DERIVADOS DE INDOL, BENZOTIOFENO, BENZOFURANO E INDENO CICLOALQUILFUNDIDOS. A presente invenção provê derivados de indol, benzotioteno, benzofurano e indeno cicloalquilfundidos e métodos para usá-los, por exemplo, tratar, impedir e/ou melhorar doenças do sistema nervoso central antagonizando os receptores de 5-HT~ 1A~ e modulando os níveis de serotonina.
BRPI0608353-6A 2005-02-17 2006-02-16 derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfundidos BRPI0608353A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65366605P 2005-02-17 2005-02-17
PCT/US2006/005521 WO2006089053A2 (en) 2005-02-17 2006-02-16 Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives

Publications (1)

Publication Number Publication Date
BRPI0608353A2 true BRPI0608353A2 (pt) 2009-12-01

Family

ID=36609274

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608353-6A BRPI0608353A2 (pt) 2005-02-17 2006-02-16 derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfundidos

Country Status (13)

Country Link
US (2) US7297704B2 (pt)
EP (1) EP1856126A2 (pt)
JP (1) JP2008530229A (pt)
CN (1) CN101120002A (pt)
AR (1) AR052674A1 (pt)
AU (1) AU2006214233A1 (pt)
BR (1) BRPI0608353A2 (pt)
CA (1) CA2597616A1 (pt)
GT (1) GT200600078A (pt)
MX (1) MX2007009783A (pt)
PA (1) PA8663501A1 (pt)
TW (1) TW200640931A (pt)
WO (1) WO2006089053A2 (pt)

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CN116514761A (zh) 2016-07-29 2023-08-01 赛诺维信制药公司 化合物、组合物及其用途
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MX2020008537A (es) 2018-02-16 2021-01-08 Sunovion Pharmaceuticals Inc Sales, formas cristalinas y metodos de produccion de las mismas.
KR20210139376A (ko) 2019-03-14 2021-11-22 선오비온 파마슈티컬스 인코포레이티드 이소크로마닐 화합물의 염, 및 이의 결정성 형태, 제조방법, 치료 용도 및 약제학적 조성물
EP4065553A4 (en) 2020-01-17 2023-06-14 Daegu-Gyeongbuk Medical Innovation Foundation NEW COMPOUND, METHOD FOR PREPARATION AND USE
KR20230003503A (ko) 2020-04-14 2023-01-06 선오비온 파마슈티컬스 인코포레이티드 신경학적 및 정신의학적 장애의 치료를 위한 (S)-(4,5-디히드로-7H-티에노[2,3-c]피란-7-일)-N-메틸메탄아민
CN113512430B (zh) * 2021-08-17 2023-05-02 烟台显华科技集团股份有限公司 负介电各向异性液晶组合物及液晶显示器件
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US20080081910A1 (en) 2008-04-03
TW200640931A (en) 2006-12-01
US7297704B2 (en) 2007-11-20
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WO2006089053A3 (en) 2007-01-11
MX2007009783A (es) 2007-08-22
PA8663501A1 (es) 2006-11-09
CN101120002A (zh) 2008-02-06
AU2006214233A1 (en) 2006-08-24
US20060205759A1 (en) 2006-09-14
EP1856126A2 (en) 2007-11-21
CA2597616A1 (en) 2006-08-24

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