BR0209342A - Antidepressivos de azaheterociclilmetila derivados de 2,3 dihidro-1,4-dioxino[2,3-f]quinoxalina; método de tratamento usando tais compostos; processo para prepará-los - Google Patents
Antidepressivos de azaheterociclilmetila derivados de 2,3 dihidro-1,4-dioxino[2,3-f]quinoxalina; método de tratamento usando tais compostos; processo para prepará-losInfo
- Publication number
- BR0209342A BR0209342A BR0209342-1A BR0209342A BR0209342A BR 0209342 A BR0209342 A BR 0209342A BR 0209342 A BR0209342 A BR 0209342A BR 0209342 A BR0209342 A BR 0209342A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- treatment
- azaheterocyclylmethyl
- dioxino
- antidepressants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
"ANTIDEPRESSIVOS DE AZAHETEROCICLILMETILA DERIVADOS DE 2,3-DIHIDRO-1,4-DIOXINO[2,3-f]QUINOXALINA; MéTODO DE TRATAMENTO USANDO TAIS COMPOSTOS; PROCESSO PARA PREPARá-LOS". Compostos da fórmula (I) são úteis para o tratamento de depressão e outras doenças tais como desordem compulsiva obsessiva, ataques de pânico, desordem de ansiedade generalizada, desordem de ansiedade social, disfunção sexual, desordens alimentares, obesidade, desordens de vício provocadas por abuso de etanol ou cocaína e doenças relacionadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28643801P | 2001-04-26 | 2001-04-26 | |
PCT/US2002/012859 WO2002088144A2 (en) | 2001-04-26 | 2002-04-23 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO[2,3-f]QUINOXALINE |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0209342A true BR0209342A (pt) | 2004-06-15 |
Family
ID=23098606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0209342-1A BR0209342A (pt) | 2001-04-26 | 2002-04-23 | Antidepressivos de azaheterociclilmetila derivados de 2,3 dihidro-1,4-dioxino[2,3-f]quinoxalina; método de tratamento usando tais compostos; processo para prepará-los |
Country Status (13)
Country | Link |
---|---|
US (1) | US6617327B2 (pt) |
EP (1) | EP1381614B1 (pt) |
JP (1) | JP2004527563A (pt) |
CN (1) | CN1250553C (pt) |
AT (1) | ATE334989T1 (pt) |
AU (1) | AU2002256334A1 (pt) |
BR (1) | BR0209342A (pt) |
CA (1) | CA2445581A1 (pt) |
DE (1) | DE60213576T2 (pt) |
DK (1) | DK1381614T3 (pt) |
ES (1) | ES2269678T3 (pt) |
MX (1) | MXPA03009826A (pt) |
WO (1) | WO2002088144A2 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040192730A1 (en) * | 2003-03-13 | 2004-09-30 | Dynogen Pharmaceuticals, Inc. | Methods of using compounds with combined 5-HT1A and SSRI activities as-needed to treat sexual dysfunction |
CN101676285A (zh) | 2004-03-30 | 2010-03-24 | 沃泰克斯药物股份有限公司 | 用作jak和其它蛋白激酶抑制剂的氮杂吲哚 |
EP1856126A2 (en) * | 2005-02-17 | 2007-11-21 | Wyeth a Corporation of the State of Delaware | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
WO2008079346A1 (en) | 2006-12-21 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
RS55341B1 (sr) | 2009-06-17 | 2017-03-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
CN103492381A (zh) | 2010-12-16 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
DK3421468T3 (da) | 2013-11-13 | 2021-01-11 | Vertex Pharma | Fremgangsmåder til fremstilling af inhibitorer af re-plikation af influenzavira |
NZ719729A (en) | 2013-11-13 | 2022-04-29 | Vertex Pharma | Inhibitors of influenza viruses replication |
WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0594593A1 (en) * | 1990-03-15 | 1994-05-04 | PHARMACIA & UPJOHN COMPANY | Therapeutically useful heterocyclic indole compounds |
DE4135474A1 (de) | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
DE4140540A1 (de) | 1991-12-09 | 1993-06-17 | Bayer Ag | Neue azaheterocyclylmethyl-chromane |
US5741789A (en) | 1995-01-17 | 1998-04-21 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
US5756532A (en) | 1995-11-06 | 1998-05-26 | American Home Products Corporation | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives |
GB9526495D0 (en) * | 1995-12-23 | 1996-02-28 | Knoll Ag | Therapeutic agents |
US5869490A (en) | 1996-10-15 | 1999-02-09 | American Home Products Corporation | Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one |
-
2002
- 2002-04-23 JP JP2002585442A patent/JP2004527563A/ja active Pending
- 2002-04-23 US US10/128,722 patent/US6617327B2/en not_active Expired - Fee Related
- 2002-04-23 EP EP02725787A patent/EP1381614B1/en not_active Expired - Lifetime
- 2002-04-23 CN CNB028086791A patent/CN1250553C/zh not_active Expired - Fee Related
- 2002-04-23 DE DE60213576T patent/DE60213576T2/de not_active Expired - Fee Related
- 2002-04-23 DK DK02725787T patent/DK1381614T3/da active
- 2002-04-23 BR BR0209342-1A patent/BR0209342A/pt not_active IP Right Cessation
- 2002-04-23 MX MXPA03009826A patent/MXPA03009826A/es active IP Right Grant
- 2002-04-23 ES ES02725787T patent/ES2269678T3/es not_active Expired - Lifetime
- 2002-04-23 AT AT02725787T patent/ATE334989T1/de not_active IP Right Cessation
- 2002-04-23 AU AU2002256334A patent/AU2002256334A1/en not_active Abandoned
- 2002-04-23 WO PCT/US2002/012859 patent/WO2002088144A2/en active IP Right Grant
- 2002-04-23 CA CA002445581A patent/CA2445581A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1250553C (zh) | 2006-04-12 |
MXPA03009826A (es) | 2005-03-07 |
CN1503801A (zh) | 2004-06-09 |
EP1381614A2 (en) | 2004-01-21 |
DE60213576D1 (de) | 2006-09-14 |
US6617327B2 (en) | 2003-09-09 |
US20020183329A1 (en) | 2002-12-05 |
WO2002088144A2 (en) | 2002-11-07 |
CA2445581A1 (en) | 2002-11-07 |
ES2269678T3 (es) | 2007-04-01 |
AU2002256334A1 (en) | 2002-11-11 |
WO2002088144A3 (en) | 2002-12-19 |
DK1381614T3 (da) | 2006-11-06 |
JP2004527563A (ja) | 2004-09-09 |
EP1381614B1 (en) | 2006-08-02 |
ATE334989T1 (de) | 2006-08-15 |
DE60213576T2 (de) | 2007-10-18 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A(S) 8A E 9A ANUIDADE(S) |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011. |