AR019190A1 - Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos - Google Patents
Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentosInfo
- Publication number
- AR019190A1 AR019190A1 ARP990103182A ARP990103182A AR019190A1 AR 019190 A1 AR019190 A1 AR 019190A1 AR P990103182 A ARP990103182 A AR P990103182A AR P990103182 A ARP990103182 A AR P990103182A AR 019190 A1 AR019190 A1 AR 019190A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- linear
- branched
- hydrogen atom
- alkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0325—Animal model for autoimmune diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0368—Animal model for inflammation
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Abstract
Derivados de 2-aminopiridinas que presentan una actividad inhibidora sobre las enzimas NO-sintasas productoras de monoxido de nitrogeno NO, y/ouna actividad que entrampa las especies reactivas del oxígeno. Estos derivados tienen la formula general (I), en la cual A representa un radical queentrampa radicales libres, y en particular: un radical (II), en la cual: R1, R2 y R3 representan, independientemente entre sí, un átomo de hidrogeno, unhalogeno, el grupo OH o SH, un radical alquilo, alcoxi oaralcoxi, lineal o ramificado, que tiene C1-6, un radical -O-CO-R4, -SR4, -S(O)R4, -SO2R4 oNR5R6 o también R1 y R2 o R2 y R3 juntos forman un ciclo metilendioxi; R4 representa un radical alquilo lineal o ramificado que tiene C1-6, y R5 y R6representan, independientemente entre sí, un átomo de hidrogeno, un radical alquilo lineal o ramificado que tiene C1-6 o un ciclo aromático opcionalmentesustituido por uno o más grupos elegidos entre un átomo de halogeno, el grupo OH y un radical alquilo o alcoxi lineal o ramificado que tiene C1-6, oNR5R6 constituye un heterociclo de 4 a 6 miembros, que contiene 1 o 2 heteroátomos elegidos entre O, S y N, siendo los miembros correspondientes: O-, -S- y-NR7; R7 representa un átomo de hidrogeno o un radicalalquilo lineal o ramificado que tiene C1-6; o un radical (III), en el cual R1, R2, R3 y R4representan independientemente entre sí, un átomo de hidrogeno, un halogeno, el grupo OH, o un radical alcoxi lineal o ramificado que tiene C1-6; otambién un radical (IV), en el cual R8 representa un átomo de hidrogeno, un radical alquilo lineal o ramificado que tiene C1-6, un radical -CO-R9, un radicalarilalquilo opcionalmente sustituido por uno o más radicales alquilo o alcoxi lineales o ramificados quetienen C1-6; R9 representa un radicalalquilo lineal o ramificado que tiene C1-6; X representa un radical -(CH2)m-Q, -(CH2)m-CH=CH-Q-, -(CH2)m-C(=W)-Q-, -(CH2)m-NR11-C(=W)-Q-, -(CH2)m-R11-C(=W)-O-Q-, -(CH2)m-R11-C(=W)-NR12-Q-, -(CH2)m-NH-Z-NH-C(=W)-,-(CH2)m-N-C(R16)-NR12-, -(CH2)m-CH=CH-C(=W)-Q o un radical alquenilo lineal o ramificado
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9808732A FR2780971B1 (fr) | 1998-07-08 | 1998-07-08 | Nouveaux derives de 2-aminopyridines, leur application en tant que medicaments et compositions pharmaceutiques les contenant |
FR9904133A FR2791674A1 (fr) | 1999-04-02 | 1999-04-02 | Nouveaux derives de 2-aminopyridines, leur utilisation en tant que medicaments et compositions pharmaceutiques les contenant |
Publications (1)
Publication Number | Publication Date |
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AR019190A1 true AR019190A1 (es) | 2001-12-26 |
Family
ID=26234430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990103182A AR019190A1 (es) | 1998-07-08 | 1999-06-30 | Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos |
Country Status (19)
Country | Link |
---|---|
US (2) | US6762176B1 (es) |
EP (1) | EP1095020B1 (es) |
JP (1) | JP2002520317A (es) |
AR (1) | AR019190A1 (es) |
AT (1) | ATE303363T1 (es) |
AU (1) | AU756221B2 (es) |
CA (1) | CA2337258A1 (es) |
CZ (1) | CZ299818B6 (es) |
DE (1) | DE69927033T2 (es) |
DK (1) | DK1095020T3 (es) |
ES (1) | ES2249015T3 (es) |
HU (1) | HUP0105073A3 (es) |
IL (2) | IL140525A0 (es) |
MY (1) | MY128840A (es) |
NO (1) | NO318383B1 (es) |
PL (1) | PL345354A1 (es) |
RU (1) | RU2226527C2 (es) |
TW (1) | TW509677B (es) |
WO (1) | WO2000002860A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200507841A (en) * | 2003-03-27 | 2005-03-01 | Glaxo Group Ltd | Antibacterial agents |
US20070254055A1 (en) * | 2003-11-21 | 2007-11-01 | Trustees Of Tufts College | Therapeutic Avenanthramide Compounds |
US20050239892A1 (en) * | 2003-11-21 | 2005-10-27 | Trustees Of Tufts College | Therapeutic avenathramide compounds |
UA87854C2 (en) * | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
RU2442781C2 (ru) * | 2004-10-14 | 2012-02-20 | Абботт ГмбХ унд Ко. КГ | Арилсульфонилметильные или арилсульфонамидные производные ароматических соединений, фармацевтическая композиция на их основе и способ лечения расстройств, восприимчивых к лечению лигандами дофаминовых d3 рецепторов, с их помощью |
US7511035B2 (en) * | 2005-01-25 | 2009-03-31 | Glaxo Group Limited | Antibacterial agents |
EP1856126A2 (en) * | 2005-02-17 | 2007-11-21 | Wyeth a Corporation of the State of Delaware | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
ES2382876T3 (es) | 2005-05-31 | 2012-06-14 | Pfizer, Inc. | Compuestos de ariloxi-N-biciclometil-acetamida sustituidos como antagonistas de VR1 |
WO2008003745A1 (en) * | 2006-07-06 | 2008-01-10 | Bayer Cropscience Sa | N- (4-pyridin-2-ylbutyl) benzamide derivatives and their use as fungicides |
JP2010523476A (ja) | 2007-03-08 | 2010-07-15 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | ミトコンドリアアルデヒドデヒドロゲナーゼ−2モジュレーター及びその使用方法 |
EP2337563B1 (en) | 2008-09-08 | 2014-04-09 | The Board of Trustees of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
EP2349279A4 (en) | 2008-10-28 | 2013-12-25 | Univ Leland Stanford Junior | ALDEHYDE DEHYDROGENASE MODULATORS AND METHOD OF USE THEREOF |
US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
JP6292721B2 (ja) * | 2012-07-12 | 2018-03-14 | コンドリオン アイピー ビー.ブイ.Khondrion Ip B.V. | ミトコンドリア病を治療するためのクロマニル誘導体 |
US9388156B2 (en) | 2012-07-12 | 2016-07-12 | Khondiron IP B.V. | Chromanyl derivatives for treating mitochondrial disease |
NL2010010C2 (en) | 2012-12-19 | 2014-06-23 | Sulfateq B V | Compounds for protection of cells. |
CN105358531B (zh) | 2013-03-14 | 2017-11-14 | 利兰-斯坦福大学初级学院的董事会 | 线粒体醛脱氢酶‑2调节剂和其使用方法 |
BR112017024854B1 (pt) * | 2015-05-22 | 2023-12-26 | Sulfateq B.V | Uso de um composto |
PL3319959T3 (pl) | 2015-07-06 | 2022-02-14 | Alkermes, Inc. | Hetero-haloinhibitory deacetylazy histonowej |
US10421756B2 (en) | 2015-07-06 | 2019-09-24 | Rodin Therapeutics, Inc. | Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase |
JP6756925B2 (ja) | 2017-01-11 | 2020-09-16 | ロダン・セラピューティクス,インコーポレーテッド | ヒストンデアセチラーゼの二環式阻害剤 |
JP7152471B2 (ja) | 2017-08-07 | 2022-10-12 | ロダン・セラピューティクス,インコーポレーテッド | ヒストン脱アセチル化酵素の二環阻害剤 |
CN108558817B (zh) * | 2018-03-30 | 2021-07-09 | 宁波大学 | 一种异香豆素类衍生物及其制备方法和用途 |
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US3037988A (en) * | 1962-06-05 | Benzoylamiivomethylpykidines | ||
DE2830351A1 (de) | 1978-07-11 | 1980-01-24 | Consortium Elektrochem Ind | Acylanilide |
US4180574A (en) | 1978-12-26 | 1979-12-25 | Abbott Laboratories | Certain ovicidal piperazines |
US4386209A (en) * | 1982-04-08 | 1983-05-31 | Reilly Tar & Chemical Corporation | Chichibabin reaction |
JPS62223173A (ja) * | 1986-03-25 | 1987-10-01 | Otsuka Pharmaceut Factory Inc | ピリジルアミノフエノ−ル誘導体及びその製造方法 |
IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicycle compounds and pharmaceuticals containing them |
AU4515696A (en) * | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
GB9506188D0 (en) | 1995-03-27 | 1995-05-17 | Fujisawa Pharmaceutical Co | Amidine derivatives |
CA2197364A1 (en) | 1996-02-15 | 1997-08-16 | Toshikazu Suzuki | Phenol compound and process for preparing the same |
CN1168719C (zh) * | 1996-03-29 | 2004-09-29 | 辉瑞大药厂 | 6-苯基吡啶-2-基胺衍生物以及药物组合物和用途 |
HN1997000027A (es) * | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
FR2764889B1 (fr) * | 1997-06-20 | 2000-09-01 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
FR2761066B1 (fr) * | 1997-03-24 | 2000-11-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
-
1999
- 1999-06-30 AR ARP990103182A patent/AR019190A1/es unknown
- 1999-07-01 MY MYPI99002793A patent/MY128840A/en unknown
- 1999-07-05 HU HU0105073A patent/HUP0105073A3/hu unknown
- 1999-07-05 DE DE69927033T patent/DE69927033T2/de not_active Expired - Fee Related
- 1999-07-05 WO PCT/FR1999/001610 patent/WO2000002860A1/fr active IP Right Grant
- 1999-07-05 JP JP2000559091A patent/JP2002520317A/ja active Pending
- 1999-07-05 CZ CZ20010086A patent/CZ299818B6/cs not_active IP Right Cessation
- 1999-07-05 PL PL99345354A patent/PL345354A1/xx not_active Application Discontinuation
- 1999-07-05 AU AU46223/99A patent/AU756221B2/en not_active Ceased
- 1999-07-05 CA CA002337258A patent/CA2337258A1/fr not_active Abandoned
- 1999-07-05 IL IL14052599A patent/IL140525A0/xx active IP Right Grant
- 1999-07-05 AT AT99929395T patent/ATE303363T1/de not_active IP Right Cessation
- 1999-07-05 US US09/743,043 patent/US6762176B1/en not_active Expired - Fee Related
- 1999-07-05 DK DK99929395T patent/DK1095020T3/da active
- 1999-07-05 ES ES99929395T patent/ES2249015T3/es not_active Expired - Lifetime
- 1999-07-05 RU RU2001103646/04A patent/RU2226527C2/ru not_active IP Right Cessation
- 1999-07-05 EP EP99929395A patent/EP1095020B1/fr not_active Expired - Lifetime
- 1999-08-18 TW TW088111513A patent/TW509677B/zh not_active IP Right Cessation
-
2000
- 2000-12-25 IL IL140525A patent/IL140525A/en not_active IP Right Cessation
-
2001
- 2001-01-03 NO NO20010031A patent/NO318383B1/no not_active IP Right Cessation
-
2003
- 2003-04-02 US US10/405,828 patent/US6727239B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU756221B2 (en) | 2003-01-09 |
DE69927033T2 (de) | 2006-06-14 |
ATE303363T1 (de) | 2005-09-15 |
EP1095020A1 (fr) | 2001-05-02 |
NO318383B1 (no) | 2005-03-14 |
HUP0105073A3 (en) | 2002-10-28 |
US6762176B1 (en) | 2004-07-13 |
NO20010031D0 (no) | 2001-01-03 |
CZ299818B6 (cs) | 2008-12-03 |
ES2249015T3 (es) | 2006-03-16 |
JP2002520317A (ja) | 2002-07-09 |
CA2337258A1 (fr) | 2000-01-20 |
IL140525A0 (en) | 2002-02-10 |
TW509677B (en) | 2002-11-11 |
US6727239B1 (en) | 2004-04-27 |
IL140525A (en) | 2006-08-01 |
EP1095020B1 (fr) | 2005-08-31 |
WO2000002860A1 (fr) | 2000-01-20 |
NO20010031L (no) | 2001-01-05 |
DK1095020T3 (da) | 2006-01-16 |
MY128840A (en) | 2007-02-28 |
AU4622399A (en) | 2000-02-01 |
CZ200186A3 (en) | 2001-05-16 |
HUP0105073A2 (hu) | 2002-04-29 |
RU2226527C2 (ru) | 2004-04-10 |
PL345354A1 (en) | 2001-12-17 |
DE69927033D1 (de) | 2005-10-06 |
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