BRPI0514691A - composto ou um sal farmaceuticamente aceitável do mesmo, processo para preparar o mesmo, composição farmacêutica, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo - Google Patents
composto ou um sal farmaceuticamente aceitável do mesmo, processo para preparar o mesmo, composição farmacêutica, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmoInfo
- Publication number
- BRPI0514691A BRPI0514691A BRPI0514691-7A BRPI0514691A BRPI0514691A BR PI0514691 A BRPI0514691 A BR PI0514691A BR PI0514691 A BRPI0514691 A BR PI0514691A BR PI0514691 A BRPI0514691 A BR PI0514691A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- pharmaceutical composition
- preparing
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
COMPOSTO OU UM SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO, PROCESSO PARA PREPARAR O MESMO, COMPOSIçãO FARMACêUTICA, E, USO DE UM COMPOSTO OU UM SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO A invenção refere-se a compostos químicos de fórmula (I): ou sais farmaceuticamente aceitáveis do mesmo, que possuem atividade inibitória de Raf B e são, portanto, úteis para sua atividade anti-câncer e, assim, nos métodos de tratamento do corpo humano ou animal. A invenção também refere-se a processos para a manufatura de ditos compostos químicos, a composições farmacêuticas contendo-os e a seu uso na manufatura de medicamentos de uso na produção de um efeito anti-câncer em um animal de sangue quente, tal como o homem.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60576204P | 2004-08-31 | 2004-08-31 | |
PCT/GB2005/003334 WO2006024834A1 (en) | 2004-08-31 | 2005-08-26 | Quinazolinone derivatives and their use as b-raf inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0514691A true BRPI0514691A (pt) | 2008-06-17 |
Family
ID=35159914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0514691-7A BRPI0514691A (pt) | 2004-08-31 | 2005-08-26 | composto ou um sal farmaceuticamente aceitável do mesmo, processo para preparar o mesmo, composição farmacêutica, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo |
Country Status (17)
Country | Link |
---|---|
US (1) | US20090118261A1 (pt) |
EP (1) | EP1789399A1 (pt) |
JP (1) | JP2008511599A (pt) |
KR (1) | KR20070048798A (pt) |
CN (1) | CN101048388A (pt) |
AR (1) | AR055249A1 (pt) |
AU (2) | AU2005278959A1 (pt) |
BR (1) | BRPI0514691A (pt) |
CA (1) | CA2577275A1 (pt) |
IL (1) | IL181212A0 (pt) |
MX (1) | MX2007002434A (pt) |
NO (1) | NO20071246L (pt) |
NZ (1) | NZ553087A (pt) |
TW (1) | TW200621730A (pt) |
UY (1) | UY29093A1 (pt) |
WO (1) | WO2006024834A1 (pt) |
ZA (1) | ZA200701635B (pt) |
Families Citing this family (127)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2009520784A (ja) * | 2005-12-22 | 2009-05-28 | アストラゼネカ アクチボラグ | キナゾリン誘導体、その製造方法および抗癌剤としてのその使用 |
US20090170849A1 (en) * | 2006-04-05 | 2009-07-02 | Astrazeneca Ab | Quinazolinone derivatives having b-raf inhibitory activity |
WO2007113557A1 (en) * | 2006-04-05 | 2007-10-11 | Astrazeneca Ab | Substituted quinazolines with anti-cancer activity |
CN101421253A (zh) * | 2006-04-18 | 2009-04-29 | 阿斯利康(瑞典)有限公司 | 喹唑啉-4-酮衍生物、其制备方法及含有它们的药用组合物 |
CA2649994A1 (en) * | 2006-04-26 | 2007-11-08 | Cancer Research Technology Limited | Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds |
FR2903107B1 (fr) * | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
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WO2008020203A1 (en) * | 2006-08-17 | 2008-02-21 | Astrazeneca Ab | Pyridinylquinaz0linamine derivatives and their use as b-raf inhibitors |
WO2008120004A1 (en) * | 2007-04-02 | 2008-10-09 | Astrazeneca Ab | Combination of a mek- inhibitor and a b-raf inhibitor for the treatment of cancer |
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GB0005357D0 (en) * | 2000-03-06 | 2000-04-26 | Smithkline Beecham Plc | Compounds |
SI1499311T1 (sl) * | 2002-03-29 | 2010-03-31 | Novartis Vaccines & Diagnostic | Substituirani benzazoli in njihova uporaba kot inhibitorji Raf kinaze |
GB0222514D0 (en) | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
US20090170849A1 (en) * | 2006-04-05 | 2009-07-02 | Astrazeneca Ab | Quinazolinone derivatives having b-raf inhibitory activity |
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- 2005-08-26 CN CNA2005800363659A patent/CN101048388A/zh active Pending
- 2005-08-26 BR BRPI0514691-7A patent/BRPI0514691A/pt not_active IP Right Cessation
- 2005-08-26 KR KR1020077007257A patent/KR20070048798A/ko not_active Application Discontinuation
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- 2005-08-26 WO PCT/GB2005/003334 patent/WO2006024834A1/en active Application Filing
- 2005-08-26 NZ NZ553087A patent/NZ553087A/en not_active IP Right Cessation
- 2005-08-26 US US11/574,031 patent/US20090118261A1/en not_active Abandoned
- 2005-08-26 JP JP2007528983A patent/JP2008511599A/ja active Pending
- 2005-08-26 AU AU2005278959A patent/AU2005278959A1/en not_active Abandoned
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- 2005-08-30 AR ARP050103626A patent/AR055249A1/es unknown
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IL181212A0 (en) | 2007-07-04 |
ZA200701635B (en) | 2008-11-26 |
WO2006024834A1 (en) | 2006-03-09 |
EP1789399A1 (en) | 2007-05-30 |
NZ553087A (en) | 2010-12-24 |
TW200621730A (en) | 2006-07-01 |
MX2007002434A (es) | 2007-05-04 |
AU2005278959A1 (en) | 2006-03-09 |
US20090118261A1 (en) | 2009-05-07 |
UY29093A1 (es) | 2006-03-31 |
CA2577275A1 (en) | 2006-03-09 |
AU2010201848A1 (en) | 2010-05-27 |
CN101048388A (zh) | 2007-10-03 |
KR20070048798A (ko) | 2007-05-09 |
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