BRPI0511089A - tieno[3,2-b]piridina-6-carbonitrilas como inibidores de cinase de proteìna - Google Patents
tieno[3,2-b]piridina-6-carbonitrilas como inibidores de cinase de proteìnaInfo
- Publication number
- BRPI0511089A BRPI0511089A BRPI0511089-0A BRPI0511089A BRPI0511089A BR PI0511089 A BRPI0511089 A BR PI0511089A BR PI0511089 A BRPI0511089 A BR PI0511089A BR PI0511089 A BRPI0511089 A BR PI0511089A
- Authority
- BR
- Brazil
- Prior art keywords
- pyridine
- protein kinase
- kinase inhibitors
- carbonitriles
- thieno
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
Abstract
TIENO¢3,2-b!PIRIDINA-6-CARBONITRILAS COMO INIBIDORES DE CINASE DE PROTEìNA. A presente invenção refere-se a prover compostos da fórmula II: em que: R¬ 1¬, R¬ 2¬ e X são R¬ 1¬ como definido mais abaixo no relatório, úteis no tratamento de câncer, acidente vascular cerebral, infarto do miocardio, dor neuropática, osteoporose, doença de rim policístico, doença auto-imune, artritre reumatóide, e rejeição de transplante. A invenção também provê processos para a produção dos ditos compostos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/845,710 US7276519B2 (en) | 2002-11-25 | 2004-05-14 | Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors |
PCT/US2005/016150 WO2005113560A2 (en) | 2004-05-14 | 2005-05-10 | THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AS PROTEIN KINASE INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0511089A true BRPI0511089A (pt) | 2007-12-26 |
Family
ID=35149207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0511089-0A BRPI0511089A (pt) | 2004-05-14 | 2005-05-10 | tieno[3,2-b]piridina-6-carbonitrilas como inibidores de cinase de proteìna |
Country Status (20)
Country | Link |
---|---|
US (2) | US7276519B2 (pt) |
EP (1) | EP1756117A2 (pt) |
JP (1) | JP2007537262A (pt) |
KR (1) | KR20070015575A (pt) |
CN (1) | CN1950379A (pt) |
AR (1) | AR050248A1 (pt) |
AU (1) | AU2005245820A1 (pt) |
BR (1) | BRPI0511089A (pt) |
CA (1) | CA2564530A1 (pt) |
CR (1) | CR8787A (pt) |
EC (1) | ECSP067087A (pt) |
GT (1) | GT200500109A (pt) |
MX (1) | MXPA06012900A (pt) |
NO (1) | NO20065489L (pt) |
PA (1) | PA8633201A1 (pt) |
PE (1) | PE20060355A1 (pt) |
RU (1) | RU2006137476A (pt) |
TW (1) | TW200602348A (pt) |
WO (1) | WO2005113560A2 (pt) |
ZA (1) | ZA200609422B (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101087787A (zh) | 2004-12-23 | 2007-12-12 | 霍夫曼-拉罗奇有限公司 | 苯甲酰胺衍生物,它们的制备及作为药剂的应用 |
CN101830899A (zh) * | 2004-12-23 | 2010-09-15 | 霍夫曼-拉罗奇有限公司 | 杂环氨基甲酸酯衍生物,它们的制备及作为药剂的应用 |
AR056200A1 (es) * | 2005-09-27 | 2007-09-26 | Wyeth Corp | Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa |
EP1965796A2 (en) * | 2005-12-20 | 2008-09-10 | Gilead Colorado, Inc. | 4,7-dihydrothieno[2,3-b]pyridine compounds and pharmaceutical compositions |
WO2007146824A2 (en) * | 2006-06-08 | 2007-12-21 | Array Biopharma Inc. | Quinoline compounds and methods of use |
TW200900408A (en) * | 2007-03-02 | 2009-01-01 | Kyowa Hakko Kogyo Kk | Fused pyridine derivative |
WO2009041591A1 (ja) * | 2007-09-28 | 2009-04-02 | Kyowa Hakko Kirin Co., Ltd. | 縮環ピリジン誘導体 |
AR070317A1 (es) * | 2008-02-06 | 2010-03-31 | Osi Pharm Inc | Furo (3,2-c) piridina y tieno (3,2-c) piridinas |
CN102232071B (zh) * | 2008-09-26 | 2016-03-23 | 财团法人卫生研究院 | 作为蛋白激酶抑制剂的稠合多环化合物 |
TW201204733A (en) | 2010-06-25 | 2012-02-01 | Kowa Co | Novel condensed pyridine or condensed pyrimidine derivative, and medicinal agent comprising same |
PT2812337T (pt) * | 2012-02-09 | 2016-12-14 | Merck Patent Gmbh | Derivados de furo[3,2-b]piridina como inibidores de tbk1 e ikk |
KR102427777B1 (ko) | 2012-06-26 | 2022-08-01 | 델 마 파마슈티컬스 | 디안하이드로갈락티톨, 디아세틸디안하이드로갈락티톨, 디브로모둘시톨, 또는 그의 유사체 또는 유도체를 이용하여 유전학적 다형성이 있는 환자에 있어서 티로신-키나아제-억제제 내성 악성종양, ahi1 조절곤란 또는 돌연변이를 치료하는 방법 |
DE102013008118A1 (de) | 2013-05-11 | 2014-11-13 | Merck Patent Gmbh | Arylchinazoline |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0126970A3 (en) | 1983-04-27 | 1985-11-06 | Beecham Group Plc | Anxiolytic and anti-depressant thienopyridine derivatives |
AR004010A1 (es) * | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
CZ20001709A3 (cs) | 1997-11-11 | 2001-12-12 | Pfizer Products Inc. | Deriváty thienopyrimidu a thienopyridinu, farmaceutické kompozice a způsoby léčení na jejich bázi |
BR9914164A (pt) * | 1998-09-29 | 2001-06-26 | American Cyanamid Co | Composto, método para o tratamento, inibição do crescimento de, ou erradiacação de um neoplasma, e de doença de rim policìstico, em um mamìfero em necessidade do mesmo, composição farmacêutica, e, processo para preparar um composto |
JP3270834B2 (ja) * | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
PT1171440E (pt) | 1999-04-21 | 2004-07-30 | Wyeth Corp | 3-ciano-¬1,7|,¬1,5|, e ¬1,8|-naftiridinas substituidas inibidoras de tirosina quinases |
JP2003519127A (ja) | 1999-12-29 | 2003-06-17 | ワイス | 三環系タンパクキナーゼ阻害薬 |
AR035851A1 (es) | 2000-03-28 | 2004-07-21 | Wyeth Corp | 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas |
ES2223827T3 (es) | 2000-06-06 | 2005-03-01 | Pfizer Products Inc. | Derivados de tiofeno utiles como agentes anticancerigenos. |
US20020004511A1 (en) | 2000-06-28 | 2002-01-10 | Luzzio Michael Joseph | Thiophene derivatives useful as anticancer agents |
WO2002036570A1 (en) * | 2000-11-02 | 2002-05-10 | Astrazeneca Ab | 4-substituted quinolines as antitumor agents |
CN1523991A (zh) | 2001-08-10 | 2004-08-25 | ��˹��ŵ�� | 单独的c-Src抑制剂或其与STI571的组合用于治疗白血病的用途 |
CL2003002287A1 (es) * | 2002-11-25 | 2005-01-14 | Wyeth Corp | COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS |
GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
CN101796055B (zh) * | 2005-05-20 | 2013-09-04 | 梅特希尔基因公司 | Vegf受体和hgf受体信号的抑制剂 |
AR056200A1 (es) * | 2005-09-27 | 2007-09-26 | Wyeth Corp | Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa |
-
2004
- 2004-05-14 US US10/845,710 patent/US7276519B2/en not_active Expired - Fee Related
-
2005
- 2005-05-10 BR BRPI0511089-0A patent/BRPI0511089A/pt not_active IP Right Cessation
- 2005-05-10 MX MXPA06012900A patent/MXPA06012900A/es unknown
- 2005-05-10 GT GT200500109A patent/GT200500109A/es unknown
- 2005-05-10 JP JP2007513251A patent/JP2007537262A/ja active Pending
- 2005-05-10 WO PCT/US2005/016150 patent/WO2005113560A2/en active Application Filing
- 2005-05-10 AU AU2005245820A patent/AU2005245820A1/en not_active Withdrawn
- 2005-05-10 KR KR1020067023726A patent/KR20070015575A/ko not_active Application Discontinuation
- 2005-05-10 CN CNA2005800147166A patent/CN1950379A/zh active Pending
- 2005-05-10 EP EP05742281A patent/EP1756117A2/en not_active Withdrawn
- 2005-05-10 CA CA002564530A patent/CA2564530A1/en not_active Abandoned
- 2005-05-10 RU RU2006137476/04A patent/RU2006137476A/ru not_active Application Discontinuation
- 2005-05-12 TW TW094115389A patent/TW200602348A/zh unknown
- 2005-05-12 PE PE2005000531A patent/PE20060355A1/es not_active Application Discontinuation
- 2005-05-13 AR ARP050101971A patent/AR050248A1/es not_active Application Discontinuation
- 2005-05-13 PA PA20058633201A patent/PA8633201A1/es unknown
-
2006
- 2006-11-13 ZA ZA200609422A patent/ZA200609422B/en unknown
- 2006-11-28 NO NO20065489A patent/NO20065489L/no unknown
- 2006-12-05 CR CR8787A patent/CR8787A/es not_active Application Discontinuation
- 2006-12-14 EC EC2006007087A patent/ECSP067087A/es unknown
-
2007
- 2007-09-24 US US11/903,754 patent/US20080070913A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA06012900A (es) | 2007-01-26 |
TW200602348A (en) | 2006-01-16 |
KR20070015575A (ko) | 2007-02-05 |
RU2006137476A (ru) | 2008-06-20 |
PA8633201A1 (es) | 2006-05-16 |
US20080070913A1 (en) | 2008-03-20 |
AR050248A1 (es) | 2006-10-11 |
EP1756117A2 (en) | 2007-02-28 |
AU2005245820A1 (en) | 2005-12-01 |
CR8787A (es) | 2007-10-02 |
US7276519B2 (en) | 2007-10-02 |
CA2564530A1 (en) | 2005-12-01 |
GT200500109A (es) | 2005-12-23 |
US20040242883A1 (en) | 2004-12-02 |
WO2005113560A2 (en) | 2005-12-01 |
JP2007537262A (ja) | 2007-12-20 |
NO20065489L (no) | 2006-11-28 |
WO2005113560A3 (en) | 2006-01-12 |
PE20060355A1 (es) | 2006-05-11 |
ZA200609422B (en) | 2008-07-30 |
CN1950379A (zh) | 2007-04-18 |
ECSP067087A (es) | 2007-01-26 |
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Legal Events
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B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |