ATE478861T1 - Multizyklische verbindung und verwendungsverfahren - Google Patents
Multizyklische verbindung und verwendungsverfahrenInfo
- Publication number
- ATE478861T1 ATE478861T1 AT07751460T AT07751460T ATE478861T1 AT E478861 T1 ATE478861 T1 AT E478861T1 AT 07751460 T AT07751460 T AT 07751460T AT 07751460 T AT07751460 T AT 07751460T AT E478861 T1 ATE478861 T1 AT E478861T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- disease states
- modulating
- influencing
- kinases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77650706P | 2006-02-24 | 2006-02-24 | |
| US11/709,994 US7868177B2 (en) | 2006-02-24 | 2007-02-21 | Multi-cyclic compounds and method of use |
| PCT/US2007/004700 WO2007100646A1 (en) | 2006-02-24 | 2007-02-22 | Multi-cyclic compounds and method of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478861T1 true ATE478861T1 (de) | 2010-09-15 |
Family
ID=38242083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07751460T ATE478861T1 (de) | 2006-02-24 | 2007-02-22 | Multizyklische verbindung und verwendungsverfahren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7868177B2 (de) |
| EP (1) | EP1994030B1 (de) |
| AT (1) | ATE478861T1 (de) |
| AU (1) | AU2007221294B2 (de) |
| CA (1) | CA2643177C (de) |
| DE (1) | DE602007008694D1 (de) |
| ES (1) | ES2347489T3 (de) |
| WO (1) | WO2007100646A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005245386B2 (en) * | 2004-05-07 | 2008-11-27 | Amgen Inc. | Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer |
| US7560551B2 (en) * | 2006-01-23 | 2009-07-14 | Amgen Inc. | Aurora kinase modulators and method of use |
| WO2008057280A1 (en) | 2006-10-27 | 2008-05-15 | Amgen Inc. | Multi-cyclic compounds and methods of use |
| GB0801416D0 (en) * | 2008-01-25 | 2008-03-05 | Piramed Ltd | Pharmaceutical compounds |
| AR074343A1 (es) * | 2008-11-14 | 2011-01-12 | Amgen Inc | Derivados de piridina y pirimidina como inhibidores de la fosfodiesterasa 10 |
| TWI396689B (zh) | 2008-11-14 | 2013-05-21 | Amgen Inc | 作為磷酸二酯酶１０抑制劑之吡衍生物 |
| RU2012120784A (ru) * | 2009-11-12 | 2013-12-20 | Селвита С.А. | Соединение, способ его получения, фармацевтическая композиция, применение соединения, способ модулирования или регулирования сериновых/треониновых киназ и средство, модулирующее сериновые/треониновые киназы |
| US8604217B2 (en) | 2009-11-12 | 2013-12-10 | Selvita S.A. | Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent |
| EP2550266B1 (de) | 2010-03-24 | 2018-05-09 | Amitech Therapeutics Solutions, Inc. | Heterozyklische verbindungen zur kinasehemmung |
| JP5580492B2 (ja) * | 2011-03-01 | 2014-08-27 | エヌファルマコン，エルエルシー | Ｎ−（４−メトキシフェニル）−１−フェニル−１ｈ−ピラゾール−３−アミンおよび関連化合物の使用 |
| CN104302640A (zh) | 2012-03-16 | 2015-01-21 | 埃克希金医药品有限公司 | 3,5-二氨基吡唑激酶抑制剂 |
| MX368263B (es) | 2013-05-07 | 2019-09-26 | Galapagos Nv | Compuestos novedosos y composiciones farmaceuticas de los mismos para el tratamiento de fibrosis quistica. |
| SG11201600891UA (en) | 2013-08-08 | 2016-03-30 | Galapagos Nv | Thieno[2,3-c]pyrans as cftr modulators |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| EP3145505A4 (de) | 2014-05-19 | 2018-02-28 | Northeastern University | Inhibitoren der amidase von n-acylethanolamin-hydrolysierender säure (naaa) und verwendung davon |
| MY191736A (en) | 2014-12-23 | 2022-07-13 | Axikin Pharmaceuticals Inc | 3,5-diaminopyrazole kinase inhibitors |
| EP3351533A4 (de) | 2015-09-18 | 2019-03-06 | Kaken Pharmaceutical Co., Ltd. | Biarylderivat sowie medikament damit |
| US10894784B2 (en) | 2015-12-18 | 2021-01-19 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| AR111281A1 (es) * | 2017-03-17 | 2019-06-26 | Genentech Inc | Compuestos de pirimidinil-piridiloxi-naftil y métodos para tratar enfermedades y trastornos relacionados con ire1 |
| US10689357B2 (en) | 2018-05-08 | 2020-06-23 | Northeastern University | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof |
| EP3843741A4 (de) * | 2018-08-30 | 2022-11-30 | The Regents of the University of California | Ire1-kinasehemmer und verwendungen davon |
| US20220048888A1 (en) | 2018-09-12 | 2022-02-17 | Genentech, Inc. | Pyrimidinyl-heteroaryloxy-naphthyl compounds and methods of use |
| JP7320600B2 (ja) | 2018-09-12 | 2023-08-03 | ジェネンテック， インコーポレイテッド | フェノキシ－ピリジル－ピリミジン化合物及び使用方法 |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2020142612A1 (en) | 2019-01-03 | 2020-07-09 | Genentech, Inc. | Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases. |
| TWI756636B (zh) | 2019-02-18 | 2022-03-01 | 美商建南德克公司 | 嘧啶并嘧啶化合物及使用方法 |
| JP2022536655A (ja) | 2019-06-11 | 2022-08-18 | ジェネンテック， インコーポレイテッド | キナゾリニル化合物及び使用方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997017329A1 (fr) * | 1995-11-07 | 1997-05-15 | Kirin Beer Kabushiki Kaisha | Derives de quinoline et derives de quinazoline inhibant l'autophosphorylation d'un recepteur de facteur de croissance originaire de plaquettes, et compositions pharmaceutiques les contenant |
| CZ306810B6 (cs) | 1999-02-10 | 2017-07-19 | Astrazeneca Ab | Použití chinazolinového derivátu jako inhibitoru angiogeneze |
| SK18102002A3 (sk) * | 2000-06-28 | 2003-07-01 | Astrazeneca Ab | Substituované chinazolínové deriváty, ich použitie a kompozícia obsahujúca tieto deriváty |
| ES2318649T3 (es) | 2000-10-20 | 2009-05-01 | EISAI R&D MANAGEMENT CO., LTD. | Procedimiento de preparacion de derivados de 4-fenoxi quinolinas. |
| CN100415720C (zh) | 2001-06-22 | 2008-09-03 | 麒麟医药株式会社 | 喹啉衍生物和喹唑啉衍生物以及含有这些化合物的药物组合物 |
| HU229477B1 (en) | 2001-12-24 | 2014-01-28 | Astrazeneca Ab | Substituted quinazoline derivatives as inhibitors of aurora kinases |
| AU2003299517A1 (en) | 2002-05-23 | 2004-05-25 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| GB0219054D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
| US7262200B2 (en) | 2002-10-25 | 2007-08-28 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
| AU2004278413B2 (en) | 2003-09-30 | 2008-07-31 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| DE10349587A1 (de) | 2003-10-24 | 2005-05-25 | Merck Patent Gmbh | Benzimidazolylderivate |
| AU2005245386B2 (en) | 2004-05-07 | 2008-11-27 | Amgen Inc. | Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer |
| US7989461B2 (en) * | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
-
2007
- 2007-02-21 US US11/709,994 patent/US7868177B2/en not_active Expired - Fee Related
- 2007-02-22 DE DE602007008694T patent/DE602007008694D1/de active Active
- 2007-02-22 AT AT07751460T patent/ATE478861T1/de not_active IP Right Cessation
- 2007-02-22 CA CA2643177A patent/CA2643177C/en not_active Expired - Fee Related
- 2007-02-22 AU AU2007221294A patent/AU2007221294B2/en not_active Ceased
- 2007-02-22 EP EP07751460A patent/EP1994030B1/de active Active
- 2007-02-22 WO PCT/US2007/004700 patent/WO2007100646A1/en active Application Filing
- 2007-02-22 ES ES07751460T patent/ES2347489T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2643177C (en) | 2011-06-14 |
| ES2347489T3 (es) | 2010-10-29 |
| AU2007221294B2 (en) | 2011-08-25 |
| US7868177B2 (en) | 2011-01-11 |
| WO2007100646A1 (en) | 2007-09-07 |
| AU2007221294A1 (en) | 2007-09-07 |
| EP1994030A1 (de) | 2008-11-26 |
| DE602007008694D1 (de) | 2010-10-07 |
| EP1994030B1 (de) | 2010-08-25 |
| US20070213325A1 (en) | 2007-09-13 |
| CA2643177A1 (en) | 2007-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |