BRPI0417605A - derivados de 3-cicloalquilaminopirrolidina como moduladores de receptores de quimiocina - Google Patents

derivados de 3-cicloalquilaminopirrolidina como moduladores de receptores de quimiocina

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Publication number
BRPI0417605A
BRPI0417605A BRPI0417605-7A BRPI0417605A BRPI0417605A BR PI0417605 A BRPI0417605 A BR PI0417605A BR PI0417605 A BRPI0417605 A BR PI0417605A BR PI0417605 A BRPI0417605 A BR PI0417605A
Authority
BR
Brazil
Prior art keywords
receptor modulators
chemokine receptor
chemokine
ccr2
useful
Prior art date
Application number
BRPI0417605-7A
Other languages
English (en)
Inventor
Chu-Biao Xue
Brian Metcalf
Amy Qi Han
Darius J Robinson
Changsheng Zheng
Anlai Wang
Yingxin Zhang
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of BRPI0417605A publication Critical patent/BRPI0417605A/pt
Publication of BRPI0417605B1 publication Critical patent/BRPI0417605B1/pt
Publication of BRPI0417605B8 publication Critical patent/BRPI0417605B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

"DERIVADOS DE 3-CICLOALQUILAMINOPIRROLIDINA COMO MODULADORES DE RECEPTORES DE QUIMIOCINA". A presente invenção está relacionada com derivados de 3-cicloalquilaminopirrolidina de fórmula 1: (na qual R¬ 1¬, R¬ 2¬, R¬ 3¬, R¬ 4¬, R¬ 5¬, R¬ 6¬, R¬ 7¬, X, Y, e Z são como definido nesta) que são úteis como moduladores da atividade dos receptores de quimiocina. Em particular, esses compostos são úteis como moduladores de receptores de quimiocinas e mais especificamente como moduladores dos receptores CCR2 e/ou CCRS. os compostos e composições da invenção podem se ligar aos receptores de quimiocina, por exemplo, os receptores CCR2 e/ou CCR5, e são úteis para o tratamento de doenças associadas a quimiocina, por exemplo, atividade de CCR2 e/ou CCR5, tais como arteriosclerose, restenose, lúpus, rejeição ao transplante de órgãos e artrite reumatóide.
BRPI0417605A 2003-12-18 2004-12-16 “n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende”. BRPI0417605B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53127003P 2003-12-18 2003-12-18
US60/531.270 2003-12-18
PCT/US2004/042321 WO2005060665A2 (en) 2003-12-18 2004-12-16 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors

Publications (3)

Publication Number Publication Date
BRPI0417605A true BRPI0417605A (pt) 2007-03-27
BRPI0417605B1 BRPI0417605B1 (pt) 2020-05-12
BRPI0417605B8 BRPI0417605B8 (pt) 2021-05-25

Family

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Application Number Title Priority Date Filing Date
BRPI0417605A BRPI0417605B8 (pt) 2003-12-18 2004-12-16 “n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende”.

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US (5) US7576089B2 (pt)
EP (1) EP1696919B1 (pt)
JP (1) JP4740151B2 (pt)
KR (2) KR100859027B1 (pt)
CN (2) CN1893945A (pt)
AP (1) AP2439A (pt)
AU (1) AU2004305079B2 (pt)
BR (1) BRPI0417605B8 (pt)
CA (1) CA2550596C (pt)
CR (1) CR8455A (pt)
DK (1) DK1696919T3 (pt)
EA (1) EA013631B1 (pt)
EC (1) ECSP066615A (pt)
ES (1) ES2439894T3 (pt)
GE (1) GEP20084505B (pt)
HK (1) HK1166321A1 (pt)
IL (1) IL175953A (pt)
IS (1) IS2956B (pt)
MA (1) MA28391B1 (pt)
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NI (1) NI200600136A (pt)
NO (1) NO336486B1 (pt)
NZ (1) NZ547316A (pt)
OA (1) OA13338A (pt)
TN (1) TNSN06188A1 (pt)
UA (1) UA82917C2 (pt)
WO (1) WO2005060665A2 (pt)
ZA (1) ZA200604875B (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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