BRPI0510410A - compostos orgánicos - Google Patents
compostos orgánicosInfo
- Publication number
- BRPI0510410A BRPI0510410A BRPI0510410-6A BRPI0510410A BRPI0510410A BR PI0510410 A BRPI0510410 A BR PI0510410A BR PI0510410 A BRPI0510410 A BR PI0510410A BR PI0510410 A BRPI0510410 A BR PI0510410A
- Authority
- BR
- Brazil
- Prior art keywords
- organic compounds
- compounds
- medicaments
- modification
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
COMPOSTOS ORGáNICOS. A presente invenção refere-se a novos compostos heterocíclicos da fórmula geral (I) em que R, R¬ 1¬, R¬ 2¬, W, X, Y, Z e n têm os significados definidos na descrição, a um processo para sua preparação e ao uso desses compostos como medicamentos, em particular, como inibidores de aldosterona síntase.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH9162004 | 2004-05-28 | ||
PCT/EP2005/052417 WO2005118557A2 (en) | 2004-05-28 | 2005-05-27 | Heterocyclic compounds and their use as aldosterone synthase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0510410A true BRPI0510410A (pt) | 2007-10-23 |
Family
ID=35033774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0510410-6A BRPI0510410A (pt) | 2004-05-28 | 2005-05-27 | compostos orgánicos |
Country Status (10)
Country | Link |
---|---|
US (2) | US7612088B2 (pt) |
EP (2) | EP2261225A1 (pt) |
JP (1) | JP2008500998A (pt) |
CN (2) | CN1956987A (pt) |
AR (1) | AR049388A1 (pt) |
BR (1) | BRPI0510410A (pt) |
CA (1) | CA2568165A1 (pt) |
IL (1) | IL179405A0 (pt) |
TW (1) | TW200611898A (pt) |
WO (1) | WO2005118557A2 (pt) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080076784A1 (en) * | 2004-05-28 | 2008-03-27 | Peter Herold | Bicyclic, Nitrogen-Containing Heterocycles and Aromatase Inhibitors |
AR056888A1 (es) * | 2005-12-09 | 2007-10-31 | Speedel Experimenta Ag | Derivados de heterociclil imidazol |
EP1842543A1 (en) | 2006-04-05 | 2007-10-10 | Speedel Pharma AG | Pharmaceutical composition coprising an aldosterone synthase inhibitor and a mineralcorticoid receptor antagonist |
TW200813071A (en) | 2006-04-12 | 2008-03-16 | Speedel Experimenta Ag | Spiro-imidazo compounds |
TW200808813A (en) | 2006-04-12 | 2008-02-16 | Speedel Experimenta Ag | Imidazo compounds |
TW200808812A (en) | 2006-04-12 | 2008-02-16 | Speedel Experimenta Ag | Imidazo compounds |
US20100240641A1 (en) * | 2006-05-26 | 2010-09-23 | Julien Papillon | Aldosterone Synthase and/or 11B-hydroxylase Inhibitors |
EP1886695A1 (en) * | 2006-06-27 | 2008-02-13 | Speedel Experimenta AG | Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist |
JP2010505842A (ja) * | 2006-10-04 | 2010-02-25 | シェーリング コーポレイション | トロンビン受容体拮抗薬としての二環式誘導体および三環式誘導体 |
US9216221B2 (en) | 2008-11-07 | 2015-12-22 | University Of Sheffield | Medicament and method of diagnosis for treating subclinical Cushing's syndrome |
JP5466759B2 (ja) | 2009-05-28 | 2014-04-09 | ノバルティス アーゲー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
CN103896796B (zh) | 2009-05-28 | 2016-04-27 | 诺华股份有限公司 | 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物 |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
AU2012282109B2 (en) | 2011-07-08 | 2016-06-23 | Novartis Ag | Method of treating atherosclerosis in high triglyceride subjects |
WO2014013477A1 (en) | 2012-07-20 | 2014-01-23 | Koninklijke Philips N.V. | Lighting device for obtaining a predetermined light distribution at a target area |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
NZ710574A (en) | 2013-02-14 | 2017-11-24 | Novartis Ag | Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors |
EA201690278A1 (ru) | 2013-07-25 | 2016-06-30 | Новартис Аг | Циклические полипептиды для лечения сердечной недостаточности |
CA2918077A1 (en) | 2013-07-25 | 2015-01-29 | Novartis Ag | Bioconjugates of synthetic apelin polypeptides |
EP3043784B9 (en) | 2013-09-09 | 2019-11-20 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
CA2931085C (en) | 2013-12-16 | 2021-10-19 | Peloton Therapeutics, Inc. | Cyclic sulfone and sulfoximine analogs and uses thereof |
MA41580A (fr) | 2015-01-23 | 2017-11-29 | Novartis Ag | Conjugués d'acides gras de l'apeline synthétique présentant une demi-vie améliorée |
WO2016144825A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
US10155726B2 (en) | 2015-03-11 | 2018-12-18 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
WO2016145032A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
WO2016145045A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Compositions for use in treating glioblastoma |
WO2016168510A1 (en) | 2015-04-17 | 2016-10-20 | Peloton Therapeutics, Inc. | Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
US9796697B2 (en) | 2015-06-12 | 2017-10-24 | Peloton Therapeutics, Inc. | Tricyclic inhibitors of HIF-2-alpha and uses thereof |
JOP20190086A1 (ar) | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
BR112019018700A2 (pt) | 2017-03-10 | 2020-04-07 | Embera Neurotherapeutics Inc | composições farmacêuticas e seus usos |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
US20230089867A1 (en) | 2018-11-27 | 2023-03-23 | Novartis Ag | Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder |
UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
EP3887388A1 (en) | 2018-11-27 | 2021-10-06 | Novartis AG | Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders |
WO2023084449A1 (en) | 2021-11-12 | 2023-05-19 | Novartis Ag | Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder |
AR127698A1 (es) | 2021-11-23 | 2024-02-21 | Novartis Ag | Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4617307A (en) * | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
DE3609596A1 (de) * | 1986-03-21 | 1987-10-01 | Hoechst Ag | 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
GB8820730D0 (en) * | 1988-09-02 | 1988-10-05 | Erba Carlo Spa | Substituted 5 6 7 8-tetrahydroimidazo/1.5-a/pyridines & process for their preparation |
US5057521A (en) * | 1988-10-26 | 1991-10-15 | Ciba-Geigy Corporation | Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism |
CA2026792A1 (en) * | 1989-11-01 | 1991-05-02 | Michael N. Greco | (6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives |
DE69330557T2 (de) | 1992-01-27 | 2002-06-20 | Janssen Pharmaceutica Nv | Pyrroloimidazolyl und imidazopyridinyl substituierte 1h-benzimidazolderivate als aromatase inhibitoren |
JPH0971586A (ja) * | 1995-09-07 | 1997-03-18 | Yamanouchi Pharmaceut Co Ltd | 新規な二環性縮合イミダゾール誘導体 |
WO2002102250A1 (en) * | 1999-10-22 | 2002-12-27 | Glaxo Group Limited | $g(in vivo) imaging |
JP2003171294A (ja) * | 2001-12-04 | 2003-06-17 | Nof Corp | 血栓抑制剤および組成物 |
ATE335744T1 (de) * | 2002-08-07 | 2006-09-15 | Novartis Pharma Gmbh | Organische verbindungen als mittel zur behandlung von aldosteronbedingten zuständen |
-
2005
- 2005-05-27 CA CA002568165A patent/CA2568165A1/en not_active Abandoned
- 2005-05-27 CN CNA2005800169574A patent/CN1956987A/zh active Pending
- 2005-05-27 AR ARP050102197A patent/AR049388A1/es unknown
- 2005-05-27 EP EP10176099A patent/EP2261225A1/en not_active Withdrawn
- 2005-05-27 WO PCT/EP2005/052417 patent/WO2005118557A2/en not_active Application Discontinuation
- 2005-05-27 TW TW094117478A patent/TW200611898A/zh unknown
- 2005-05-27 JP JP2007513940A patent/JP2008500998A/ja active Pending
- 2005-05-27 EP EP05752794A patent/EP1749006A2/en not_active Withdrawn
- 2005-05-27 BR BRPI0510410-6A patent/BRPI0510410A/pt not_active IP Right Cessation
- 2005-05-27 US US11/597,620 patent/US7612088B2/en not_active Expired - Fee Related
- 2005-05-27 CN CNA2005800172990A patent/CN1997643A/zh active Pending
-
2006
- 2006-11-20 IL IL179405A patent/IL179405A0/en unknown
-
2009
- 2009-09-18 US US12/585,584 patent/US20100029694A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2005118557A3 (en) | 2006-02-23 |
IL179405A0 (en) | 2007-05-15 |
JP2008500998A (ja) | 2008-01-17 |
CN1956987A (zh) | 2007-05-02 |
US20070208035A1 (en) | 2007-09-06 |
TW200611898A (en) | 2006-04-16 |
EP1749006A2 (en) | 2007-02-07 |
CN1997643A (zh) | 2007-07-11 |
US20080318978A2 (en) | 2008-12-25 |
WO2005118557A2 (en) | 2005-12-15 |
AR049388A1 (es) | 2006-07-26 |
CA2568165A1 (en) | 2005-12-15 |
US7612088B2 (en) | 2009-11-03 |
EP2261225A1 (en) | 2010-12-15 |
US20100029694A1 (en) | 2010-02-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0510410A (pt) | compostos orgánicos | |
BRPI0510412A (pt) | compostos orgánicos | |
BRPI0510409A (pt) | heterociclos bicìclicos contendo nitrogênio como inibidores da aromatase | |
BRPI0508969A (pt) | compostos orgánicos | |
BRPI0512938A (pt) | derivados da quinazolinediona como inibidores parp | |
BRPI0717970C1 (pt) | composto inibidor de 11betahsd1, composição farmacêutica, e, uso do composto | |
BRPI0506843A (pt) | composto, composição farmacêutica, processo para a preparação de um composto, e, uso de um composto | |
BRPI0510273A (pt) | derivados de tetraazabenzo[e]azuleno e análogos destes | |
BRPI0518758A2 (pt) | compostos de acetamida como fungicidas | |
BRPI0408347B8 (pt) | derivados de pirimidina, seu uso, e composição e combinação farmacêuticas | |
BRPI0514841A (pt) | inibidores de piridila da sinalização de hedgehog, processo de preparação dos mesmos e composição compreendendo os referidos inibidores | |
BRPI0512797A (pt) | derivados de quinazolinona como inibidores de parp | |
BR0314379A (pt) | Quinazolinonas espirocondensadas e a sua utilização como inibidores de fosfodiesterase | |
BRPI0712631B8 (pt) | compostos, processos para a preparação de um composto, composição farmacêutica, uso de um composto e combinações | |
TW200611897A (en) | Organic compounds | |
BRPI0712889A8 (pt) | composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica. | |
BR0314113A (pt) | Derivados de amino propanol | |
BRPI0206433B8 (pt) | composto, composição farmacêutica, e, uso de um composto | |
ECSP099370A (es) | Derivados de hidantoína usados como inhibidores de mmp | |
BRPI0720525B8 (pt) | inibidores de mapk/erk quinase | |
BRPI0607019A2 (pt) | compostos que inibem a atividade de beta -secretase e métodos de uso dos mesmos | |
BRPI0512986A (pt) | novos derivados de hidantoìna | |
BRPI0508364A (pt) | derivados de 4-benzimidazol-2-ilpiridazin-3-ona | |
ECSP088140A (es) | Nuevos análogos de piridina | |
BRPI0414948A (pt) | derivados de pirazolo-e-imidazo pirimidina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |