BRPI0417605B8 - n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende. - Google Patents
n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende.Info
- Publication number
- BRPI0417605B8 BRPI0417605B8 BRPI0417605A BRPI0417605A BRPI0417605B8 BR PI0417605 B8 BRPI0417605 B8 BR PI0417605B8 BR PI0417605 A BRPI0417605 A BR PI0417605A BR PI0417605 A BRPI0417605 A BR PI0417605A BR PI0417605 B8 BRPI0417605 B8 BR PI0417605B8
- Authority
- BR
- Brazil
- Prior art keywords
- ylpyridin
- oxoethyl
- pyrrolidin
- benzamide
- pyrimidin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A—HUMAN NECESSITIES
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53127003P | 2003-12-18 | 2003-12-18 | |
US60/531.270 | 2003-12-18 | ||
PCT/US2004/042321 WO2005060665A2 (en) | 2003-12-18 | 2004-12-16 | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0417605A BRPI0417605A (pt) | 2007-03-27 |
BRPI0417605B1 BRPI0417605B1 (pt) | 2020-05-12 |
BRPI0417605B8 true BRPI0417605B8 (pt) | 2021-05-25 |
Family
ID=34710216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BRPI0417605A BRPI0417605B8 (pt) | 2003-12-18 | 2004-12-16 | n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende. |
Country Status (28)
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US (5) | US7576089B2 (pt) |
EP (1) | EP1696919B1 (pt) |
JP (1) | JP4740151B2 (pt) |
KR (2) | KR100859027B1 (pt) |
CN (2) | CN1893945A (pt) |
AP (1) | AP2439A (pt) |
AU (1) | AU2004305079B2 (pt) |
BR (1) | BRPI0417605B8 (pt) |
CA (1) | CA2550596C (pt) |
CR (1) | CR8455A (pt) |
DK (1) | DK1696919T3 (pt) |
EA (1) | EA013631B1 (pt) |
EC (1) | ECSP066615A (pt) |
ES (1) | ES2439894T3 (pt) |
GE (1) | GEP20084505B (pt) |
HK (1) | HK1166321A1 (pt) |
IL (1) | IL175953A (pt) |
IS (1) | IS2956B (pt) |
MA (1) | MA28391B1 (pt) |
MX (1) | MXPA06007000A (pt) |
NI (1) | NI200600136A (pt) |
NO (1) | NO336486B1 (pt) |
NZ (1) | NZ547316A (pt) |
OA (1) | OA13338A (pt) |
TN (1) | TNSN06188A1 (pt) |
UA (1) | UA82917C2 (pt) |
WO (1) | WO2005060665A2 (pt) |
ZA (1) | ZA200604875B (pt) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0316732B8 (pt) * | 2002-11-27 | 2021-05-25 | Incyte Corp | composto derivado de 3-aminopirrolidina e sua composição farmacêutica |
WO2005101838A2 (en) * | 2004-04-13 | 2005-10-27 | Incyte Corporation | Piperazinylpiperidine derivatives as chemokine receptor antagonists |
BRPI0510665A (pt) | 2004-05-11 | 2007-12-04 | Incyte Corp | 3-(4-heteroarilcicloexilamino) ciclopentano-carboxiamidas como moduladores de receptores de quimiocinas |
JP4116670B2 (ja) | 2004-06-28 | 2008-07-09 | インサイト コーポレイション | ケモカイン受容体の調節剤としての3−アミノシクロペンタンカルボキサミド |
JP4116671B2 (ja) | 2004-06-28 | 2008-07-09 | インサイト コーポレイション | ケモカイン受容体の調節剤としての3−アミノシクロペンタンカルボキサミド |
EP1778285A2 (en) * | 2004-07-30 | 2007-05-02 | Pfizer Products Inc. | Treatment of ccr2 mediated diseases or disorders |
EP1802331A2 (en) * | 2004-09-08 | 2007-07-04 | Boys Town National Research Hospital | Treatment of glomerular basement membrane disease involving matrix metalloproteinase-12 |
JP4958785B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体およびステアロイル−CoAデサチュラーゼインヒビターとしてのそれらの使用 |
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