ATE239741T1 - Derivate der phosphonsäure zur inhibierung von carboxypeptidase b - Google Patents
Derivate der phosphonsäure zur inhibierung von carboxypeptidase bInfo
- Publication number
- ATE239741T1 ATE239741T1 AT00960970T AT00960970T ATE239741T1 AT E239741 T1 ATE239741 T1 AT E239741T1 AT 00960970 T AT00960970 T AT 00960970T AT 00960970 T AT00960970 T AT 00960970T AT E239741 T1 ATE239741 T1 AT E239741T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- alkyl group
- hydrogen atom
- acid derivatives
- phosphonic acid
- Prior art date
Links
- 102000003670 Carboxypeptidase B Human genes 0.000 title abstract 2
- 108090000087 Carboxypeptidase B Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 229940042400 direct acting antivirals phosphonic acid derivative Drugs 0.000 title 1
- 150000003007 phosphonic acid derivatives Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4018—Esters of cycloaliphatic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26099399 | 1999-09-14 | ||
| JP2000084145 | 2000-03-24 | ||
| PCT/JP2000/006248 WO2001019836A1 (fr) | 1999-09-14 | 2000-09-13 | Derives d'acides phosphoniques presentant une activite inhibitrice de carboxypeptidase b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE239741T1 true ATE239741T1 (de) | 2003-05-15 |
Family
ID=26544854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00960970T ATE239741T1 (de) | 1999-09-14 | 2000-09-13 | Derivate der phosphonsäure zur inhibierung von carboxypeptidase b |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6576627B1 (de) |
| EP (2) | EP1152004B1 (de) |
| JP (1) | JP3400798B2 (de) |
| KR (1) | KR100681632B1 (de) |
| CN (1) | CN1187360C (de) |
| AT (1) | ATE239741T1 (de) |
| AU (1) | AU780542B2 (de) |
| BR (1) | BR0014615A (de) |
| CA (1) | CA2381801C (de) |
| DE (1) | DE60002558T2 (de) |
| ES (1) | ES2202171T3 (de) |
| MX (1) | MXPA02002671A (de) |
| TW (1) | TWI223651B (de) |
| WO (1) | WO2001019836A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9901572D0 (sv) * | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
| SE0103272D0 (sv) | 2001-09-28 | 2001-09-28 | Astrazeneca Ab | Chemical compounds |
| US6713496B2 (en) | 2002-01-22 | 2004-03-30 | Pfizer Inc | 3-(imidazolyl)-2-alkoxypropanoic acids |
| BR0307033A (pt) | 2002-01-22 | 2004-12-07 | Pfizer | ácidos 3-(imidazolil)-2-aminopropanóicos para o uso como inibidores tafi-a para o tratamento de doenças trombóticas |
| CN1332964C (zh) | 2002-03-21 | 2007-08-22 | 舍林股份公司 | 血浆羧肽酶b抑制剂 |
| EP1380290A1 (de) * | 2002-07-09 | 2004-01-14 | Universitair Medisch Centrum Utrecht | Cross-Beta-Strukturweg und seine therapeutische Relevanz |
| JPWO2004035594A1 (ja) * | 2002-10-01 | 2006-02-16 | 明治製菓株式会社 | カルボキシペプチダーゼｂ阻害剤の製造用中間体 |
| EP2386861A3 (de) | 2005-07-13 | 2012-07-18 | Crossbeta Biosciences B.V. | Cross-Beta-Struktur-bindende Verbindungen |
| US8114832B2 (en) | 2005-07-13 | 2012-02-14 | Crossbeta Biosciences B.V. | Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition |
| US7820323B1 (en) | 2006-09-07 | 2010-10-26 | The United States Of America As Represented By The Secretary Of The Army | Metal borate synthesis process |
| US7833660B1 (en) | 2006-09-07 | 2010-11-16 | The United States Of America As Represented By The Secretary Of The Army | Fluorohaloborate salts, synthesis and use thereof |
| NZ592764A (en) | 2008-10-29 | 2012-08-31 | Taisho Pharmaceutical Co Ltd | Compound having tafia inhibitory activity |
| JP5996532B2 (ja) | 2010-07-15 | 2016-09-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 有害生物防除剤としての新規複素環式化合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE212739C (de) | ||||
| US4560680A (en) | 1982-03-15 | 1985-12-24 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
| US4452791A (en) | 1982-03-15 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
| US4616005A (en) | 1982-06-23 | 1986-10-07 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives |
| JPS63215686A (ja) * | 1987-03-03 | 1988-09-08 | Mitsubishi Kasei Corp | アミノエチルホスフイン酸誘導体 |
| US5030732A (en) * | 1988-03-03 | 1991-07-09 | Merck & Co., Inc. | Aminoethylphosphinic acid derivatives |
| CA2300135A1 (en) | 1997-08-14 | 1999-02-25 | Department Of The Army, U.S. Government | Treatment or prophylaxis of retinal pathology and spinal cord injury |
| US6121252A (en) | 1998-03-30 | 2000-09-19 | Guilford Pharmaceuticals Inc. | Phosphinic acid derivatives |
| US6444657B1 (en) * | 1998-12-31 | 2002-09-03 | Guilford Pharmaceuticals Inc. | Methods for treating certain diseases using naaladase inhibitors |
| SE9901572D0 (sv) * | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
| AR023819A1 (es) | 1999-05-03 | 2002-09-04 | Astrazeneca Ab | FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION |
| SE9901573D0 (sv) | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
-
2000
- 2000-09-13 CN CNB008127913A patent/CN1187360C/zh not_active Expired - Fee Related
- 2000-09-13 US US09/926,125 patent/US6576627B1/en not_active Expired - Fee Related
- 2000-09-13 EP EP00960970A patent/EP1152004B1/de not_active Expired - Lifetime
- 2000-09-13 BR BR0014615-3A patent/BR0014615A/pt not_active IP Right Cessation
- 2000-09-13 KR KR1020027003321A patent/KR100681632B1/ko not_active IP Right Cessation
- 2000-09-13 CA CA002381801A patent/CA2381801C/en not_active Expired - Fee Related
- 2000-09-13 AU AU73112/00A patent/AU780542B2/en not_active Ceased
- 2000-09-13 AT AT00960970T patent/ATE239741T1/de not_active IP Right Cessation
- 2000-09-13 DE DE60002558T patent/DE60002558T2/de not_active Expired - Lifetime
- 2000-09-13 ES ES00960970T patent/ES2202171T3/es not_active Expired - Lifetime
- 2000-09-13 WO PCT/JP2000/006248 patent/WO2001019836A1/ja active IP Right Grant
- 2000-09-13 EP EP01125712A patent/EP1174434A1/de not_active Withdrawn
- 2000-09-13 MX MXPA02002671A patent/MXPA02002671A/es active IP Right Grant
- 2000-09-13 JP JP2001523413A patent/JP3400798B2/ja not_active Expired - Fee Related
- 2000-09-14 TW TW089118781A patent/TWI223651B/zh not_active IP Right Cessation
-
2002
- 2002-10-07 US US10/265,400 patent/US6737416B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1152004B1 (de) | 2003-05-07 |
| CN1373766A (zh) | 2002-10-09 |
| EP1152004A1 (de) | 2001-11-07 |
| ES2202171T3 (es) | 2004-04-01 |
| DE60002558D1 (de) | 2003-06-12 |
| BR0014615A (pt) | 2002-06-18 |
| AU780542B2 (en) | 2005-03-24 |
| KR20020026268A (ko) | 2002-04-06 |
| CA2381801C (en) | 2009-12-08 |
| US20030119787A1 (en) | 2003-06-26 |
| US6737416B2 (en) | 2004-05-18 |
| TWI223651B (en) | 2004-11-11 |
| CN1187360C (zh) | 2005-02-02 |
| US6576627B1 (en) | 2003-06-10 |
| MXPA02002671A (es) | 2002-07-30 |
| EP1174434A1 (de) | 2002-01-23 |
| DE60002558T2 (de) | 2004-04-08 |
| CA2381801A1 (en) | 2001-03-22 |
| KR100681632B1 (ko) | 2007-02-09 |
| JP3400798B2 (ja) | 2003-04-28 |
| EP1152004A4 (de) | 2002-01-23 |
| AU7311200A (en) | 2001-04-17 |
| WO2001019836A1 (fr) | 2001-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE396988T1 (de) | Chinolin- und chianzolinderivate zur behandlung von tumoren | |
| PT976748E (pt) | Derivados de pirrolidina com actividade inibidora de fosfolipase a2 | |
| DE60012751D1 (de) | Verwendung von ep4 rezeptorliganden zur behandlung von neuropathischen schmerz | |
| NO20004485D0 (no) | Sykloalkenderivater, deres fremstilling og anvendelse | |
| NO20014925D0 (no) | Farmasöytiske forbindelser | |
| ATE239741T1 (de) | Derivate der phosphonsäure zur inhibierung von carboxypeptidase b | |
| ID24846A (id) | Turunan-turunan bifenilamidina | |
| ATE513821T1 (de) | Thiadiazolin-derivate zur behandlung von krebs | |
| DE69623497T2 (de) | 1-methylcarbapenem-derivate | |
| DE69814800T2 (de) | Epoxysuccinamid-derivate oder ihre salze | |
| DE69828197D1 (de) | Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut | |
| DK0900797T3 (da) | Et 1-methylcarbapenemderivat |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |