BR112018006939A2 - sais farmacêuticos, formas físicas, e composições de inibidores de pirrol-pirimidina quinase, e métodos para a produção dos mesmos - Google Patents

sais farmacêuticos, formas físicas, e composições de inibidores de pirrol-pirimidina quinase, e métodos para a produção dos mesmos

Info

Publication number
BR112018006939A2
BR112018006939A2 BR112018006939A BR112018006939A BR112018006939A2 BR 112018006939 A2 BR112018006939 A2 BR 112018006939A2 BR 112018006939 A BR112018006939 A BR 112018006939A BR 112018006939 A BR112018006939 A BR 112018006939A BR 112018006939 A2 BR112018006939 A2 BR 112018006939A2
Authority
BR
Brazil
Prior art keywords
methods
compositions
producing
pyrrole
kinase inhibitors
Prior art date
Application number
BR112018006939A
Other languages
English (en)
Inventor
Weng Bojie
Liu Jia
Wu Jian
Dai Kongen
Mao Long
Xu Wanhong
Xu Xiao
Wang Xiaobo
Mo Xiaopeng
Chen Yile
Bao Yimei
Hua Yuning
Original Assignee
Acea Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acea Therapeutics Inc filed Critical Acea Therapeutics Inc
Publication of BR112018006939A2 publication Critical patent/BR112018006939A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

a presente invenção refere-se a métodos para a produção de certos derivados de pirrol-pirimidina, os quais são úteis no tratamento de transtornos proliferativos e outras doenças relacionadas à desregulação de quinases (como, entre outros, egfr (incluindo her), alk, pdgfr, blk, bmx/etk, btk, flt3(d835y), itk, jak1, jak2, jak3, tec e txk) e/ou as respectivas vias, sais, polimorfos e formas amorfas dos referidos compostos, a intermediários sintéticos para preparar os referidos compostos e composições farmacêuticas compreendendo os referidos compostos e métodos para a produção de tais composições.
BR112018006939A 2015-10-09 2016-06-30 sais farmacêuticos, formas físicas, e composições de inibidores de pirrol-pirimidina quinase, e métodos para a produção dos mesmos BR112018006939A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2015091536 2015-10-09
PCT/CN2016/087857 WO2017059702A1 (en) 2015-10-09 2016-06-30 Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same

Publications (1)

Publication Number Publication Date
BR112018006939A2 true BR112018006939A2 (pt) 2018-10-16

Family

ID=58487279

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018006939A BR112018006939A2 (pt) 2015-10-09 2016-06-30 sais farmacêuticos, formas físicas, e composições de inibidores de pirrol-pirimidina quinase, e métodos para a produção dos mesmos

Country Status (14)

Country Link
US (1) US10533011B2 (pt)
EP (1) EP3359159B1 (pt)
JP (1) JP6889494B2 (pt)
KR (1) KR20180067584A (pt)
CN (1) CN107949388B (pt)
AR (1) AR106301A1 (pt)
AU (1) AU2016334141B2 (pt)
BR (1) BR112018006939A2 (pt)
CA (1) CA3001744A1 (pt)
HK (1) HK1253537A1 (pt)
MX (1) MX2018004332A (pt)
RU (1) RU2018115334A (pt)
TW (1) TW201722431A (pt)
WO (1) WO2017059702A1 (pt)

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CN111848631B (zh) * 2020-08-28 2022-04-19 四川大学华西医院 一种靶向EGFR突变的吡咯并[2,3-d]嘧啶衍生物及其制备方法和用途
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Also Published As

Publication number Publication date
AU2016334141A1 (en) 2018-04-26
JP6889494B2 (ja) 2021-06-18
JP2018530610A (ja) 2018-10-18
US20180312510A1 (en) 2018-11-01
AU2016334141B2 (en) 2019-12-19
AR106301A1 (es) 2018-01-03
KR20180067584A (ko) 2018-06-20
EP3359159B1 (en) 2023-06-07
HK1253537A1 (zh) 2019-06-21
TW201722431A (zh) 2017-07-01
MX2018004332A (es) 2019-01-10
RU2018115334A3 (pt) 2019-11-29
RU2018115334A (ru) 2019-11-11
CA3001744A1 (en) 2017-04-13
EP3359159A1 (en) 2018-08-15
EP3359159A4 (en) 2019-06-05
US10533011B2 (en) 2020-01-14
CN107949388B (zh) 2021-10-26
CN107949388A (zh) 2018-04-20
WO2017059702A1 (en) 2017-04-13

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2626 DE 04-05-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021