EA201790209A1 - Новые 2,5-замещенные пиримидины в качестве ингибиторов pde - Google Patents

Новые 2,5-замещенные пиримидины в качестве ингибиторов pde

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Publication number
EA201790209A1
EA201790209A1 EA201790209A EA201790209A EA201790209A1 EA 201790209 A1 EA201790209 A1 EA 201790209A1 EA 201790209 A EA201790209 A EA 201790209A EA 201790209 A EA201790209 A EA 201790209A EA 201790209 A1 EA201790209 A1 EA 201790209A1
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EA
Eurasian Patent Office
Prior art keywords
new
substituted pyrimidines
pde inhibitors
medicines
indices
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Application number
EA201790209A
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English (en)
Inventor
Инго Конетцки
Тобиас Кран
Флориан Якоб
Антонио Нарди
Кристиан Хесслингер
Андре Вельберс
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Грюненталь Гмбх
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Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201790209A1 publication Critical patent/EA201790209A1/ru

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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

Изобретение относится к новым замещенным конденсированным пиримидиновым соединениям общей формулы (I)в которой химические группировки, заместители и индексы являются такими, как определено в описании, и к их применению в качестве лекарственных средств, в частности в качестве лекарственных средств для лечения состояний и заболеваний, которые можно лечить путем ингибирования фермента PDE4.
EA201790209A 2014-07-16 2015-07-16 Новые 2,5-замещенные пиримидины в качестве ингибиторов pde EA201790209A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14002451 2014-07-16
PCT/EP2015/001475 WO2016008592A1 (en) 2014-07-16 2015-07-16 Novel 2,5-substituted pyrimidines as pde inhibitors

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EA201790209A1 true EA201790209A1 (ru) 2017-07-31

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US (1) US9315490B2 (ru)
EP (2) EP3169680A1 (ru)
JP (1) JP6726655B2 (ru)
KR (1) KR20170032420A (ru)
CN (1) CN106488916A (ru)
AR (1) AR101197A1 (ru)
AU (1) AU2015291477B2 (ru)
BR (1) BR112017000826A2 (ru)
CA (1) CA2955062A1 (ru)
CL (1) CL2017000105A1 (ru)
CO (1) CO2017001523A2 (ru)
EA (1) EA201790209A1 (ru)
EC (1) ECSP17010482A (ru)
IL (1) IL250025A0 (ru)
MX (1) MX366840B (ru)
PE (1) PE20170119A1 (ru)
TW (1) TW201609708A (ru)
WO (1) WO2016008592A1 (ru)
ZA (1) ZA201701132B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR101198A1 (es) * 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b
AR101196A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos
WO2017144633A1 (en) * 2016-02-25 2017-08-31 Asceneuron S. A. Glycosidase inhibitors
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