BR112017014547A2 - sistemas de receptor de antígeno quimérico dirigidos por mab para classificação/depleção de células imunes engenheiradas - Google Patents

sistemas de receptor de antígeno quimérico dirigidos por mab para classificação/depleção de células imunes engenheiradas

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Publication number
BR112017014547A2
BR112017014547A2 BR112017014547-2A BR112017014547A BR112017014547A2 BR 112017014547 A2 BR112017014547 A2 BR 112017014547A2 BR 112017014547 A BR112017014547 A BR 112017014547A BR 112017014547 A2 BR112017014547 A2 BR 112017014547A2
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BR
Brazil
Prior art keywords
depletion
chimeric antigen
immune cell
antigen receptor
engineered immune
Prior art date
Application number
BR112017014547-2A
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English (en)
Inventor
Johnson Sasu Barbra
Rajpal Arvind
Duchateau Philippe
Juillerat Alexandre
Valton Julien
Original Assignee
Cellectis
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Filing date
Publication date
Application filed by Cellectis filed Critical Cellectis
Publication of BR112017014547A2 publication Critical patent/BR112017014547A2/pt

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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Abstract

um polipeptídeo que codifica um receptor de antígeno quimérico (car) compreendendo pelo menos um domínio de ligação extracelular que compreende um scfv formado por pelo menos uma cadeia vh e uma cadeia vl específicas para um antígeno, em que o dito domínio de ligação extracelular compreende pelo menos um epitopo específico de mab.
BR112017014547-2A 2015-01-26 2016-01-25 sistemas de receptor de antígeno quimérico dirigidos por mab para classificação/depleção de células imunes engenheiradas BR112017014547A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201570044 2015-01-26
DKPA201570044 2015-01-26
PCT/EP2016/051467 WO2016120216A1 (en) 2015-01-26 2016-01-25 mAb-DRIVEN CHIMERIC ANTIGEN RECEPTOR SYSTEMS FOR SORTING/DEPLETING ENGINEERED IMMUNE CELLS

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