AU6704794A - Protection of human bone marrow from high dose antifolate therapy using mutated human dihydrofolate reductase dna - Google Patents
Protection of human bone marrow from high dose antifolate therapy using mutated human dihydrofolate reductase dnaInfo
- Publication number
- AU6704794A AU6704794A AU67047/94A AU6704794A AU6704794A AU 6704794 A AU6704794 A AU 6704794A AU 67047/94 A AU67047/94 A AU 67047/94A AU 6704794 A AU6704794 A AU 6704794A AU 6704794 A AU6704794 A AU 6704794A
- Authority
- AU
- Australia
- Prior art keywords
- protection
- bone marrow
- high dose
- human
- dihydrofolate reductase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 101000908713 Homo sapiens Dihydrofolate reductase Proteins 0.000 title 1
- 230000003432 anti-folate effect Effects 0.000 title 1
- 229940127074 antifolate Drugs 0.000 title 1
- 210000001185 bone marrow Anatomy 0.000 title 1
- 239000004052 folic acid antagonist Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
- C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4928493A | 1993-04-13 | 1993-04-13 | |
US049284 | 1993-04-13 | ||
PCT/US1994/004129 WO1994024277A1 (en) | 1993-04-13 | 1994-04-13 | Protection of human bone marrow from high dose antifolate therapy using mutated human dihydrofolate reductase dna |
Publications (1)
Publication Number | Publication Date |
---|---|
AU6704794A true AU6704794A (en) | 1994-11-08 |
Family
ID=21959029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU67047/94A Abandoned AU6704794A (en) | 1993-04-13 | 1994-04-13 | Protection of human bone marrow from high dose antifolate therapy using mutated human dihydrofolate reductase dna |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU6704794A (en) |
WO (1) | WO1994024277A1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997033988A1 (en) | 1996-03-12 | 1997-09-18 | Sloan-Kettering Institute For Cancer Research | Double mutants of dihydrofolate reductase and methods of using same |
US6887467B1 (en) | 1996-03-12 | 2005-05-03 | Sloan-Kettering Institute For Cancer Research | Double mutants of dihydrofolate reductase and methods of using same |
DE60034953T2 (en) * | 1999-08-19 | 2008-01-24 | Omniscience Pharmaceuticals, Tempe | gene cloning |
WO2008144912A1 (en) * | 2007-05-25 | 2008-12-04 | Université de Montréal | Antifolate agent-resistant dihydrofolate reductases |
DK3309248T3 (en) | 2013-05-29 | 2021-08-02 | Cellectis | Method for manipulating T cells for immunotherapy using an RNA-guided CAS nuclease system |
PT3105317T (en) | 2014-02-14 | 2019-02-27 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
CA2943008C (en) | 2014-03-19 | 2021-03-30 | Cellectis | Cd123 specific chimeric antigen receptors for cancer immunotherapy |
AU2016212159A1 (en) | 2015-01-26 | 2017-07-13 | Cellectis | Anti-HSP70 specific Chimeric Antigen Receptors (CARs) for cancer immunotherapy |
WO2017025323A1 (en) | 2015-08-11 | 2017-02-16 | Cellectis | Cells for immunotherapy engineered for targeting cd38 antigen and for cd38 gene inactivation |
WO2018073391A1 (en) | 2016-10-19 | 2018-04-26 | Cellectis | Targeted gene insertion for improved immune cells therapy |
WO2018073394A1 (en) | 2016-10-19 | 2018-04-26 | Cellectis | Cell death inducing chimeric antigen receptors |
US11767512B2 (en) | 2017-04-13 | 2023-09-26 | Cellectis | Sequence specific reagents targeting CCR5 in primary hematopoietic cells |
WO2019002633A1 (en) | 2017-06-30 | 2019-01-03 | Cellectis | Cellular immunotherapy for repetitive administration |
WO2019016360A1 (en) | 2017-07-21 | 2019-01-24 | Cellectis | Engineered immune cells resistant to tumor microoenvironment |
WO2019020733A1 (en) | 2017-07-26 | 2019-01-31 | Cellectis | Methods of antigen-dependent chimeric antigen receptor (car) immune cell selection |
US20200237823A1 (en) | 2017-10-19 | 2020-07-30 | Cellectis | Targeted gene integration of nk inhibitors genes for improved immune cells therapy |
WO2019149743A1 (en) | 2018-01-30 | 2019-08-08 | Cellectis | Combination comprising allogeneic immune cells deficient for an antigen present on both t-cells and pathological cells and therapeutic antibody against said antigen |
MX2022007833A (en) | 2019-12-23 | 2022-09-23 | Cellectis | New mesothelin specific chimeric antigen receptors (car) for solid tumors cancer immunotherapy. |
CA3216563A1 (en) | 2021-04-30 | 2022-11-03 | Beatriz Aranda-Orgilles | New anti-muc1 cars and gene edited immune cells for solid tumors cancer immunotherapy |
EP4341300A1 (en) | 2021-05-21 | 2024-03-27 | Cellectis S.A. | Enhancing efficacy of t-cell-mediated immunotherapy by modulating cancer-associated fibroblasts in solid tumors |
WO2024003334A1 (en) | 2022-06-30 | 2024-01-04 | Cellectis S.A. | Enhancing safety of t-cell-mediated immunotherapy |
WO2024094775A1 (en) | 2022-11-03 | 2024-05-10 | Cellectis S.A. | Enhancing efficacy and safety of t-cell-mediated immunotherapy |
CN117305261B (en) * | 2023-11-30 | 2024-02-23 | 北京智源人工智能研究院 | Dihydrofolate reductase kink and mutant thereof |
-
1994
- 1994-04-13 WO PCT/US1994/004129 patent/WO1994024277A1/en active Application Filing
- 1994-04-13 AU AU67047/94A patent/AU6704794A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1994024277A1 (en) | 1994-10-27 |
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