BR112017006264A2 - derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório - Google Patents

derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório

Info

Publication number
BR112017006264A2
BR112017006264A2 BR112017006264A BR112017006264A BR112017006264A2 BR 112017006264 A2 BR112017006264 A2 BR 112017006264A2 BR 112017006264 A BR112017006264 A BR 112017006264A BR 112017006264 A BR112017006264 A BR 112017006264A BR 112017006264 A2 BR112017006264 A2 BR 112017006264A2
Authority
BR
Brazil
Prior art keywords
vinyl
respiratory syncytial
syncytial virus
virus rna
rna replication
Prior art date
Application number
BR112017006264A
Other languages
English (en)
Inventor
G Klumpp Klaus
Smith Mark
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of BR112017006264A2 publication Critical patent/BR112017006264A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

Abstract

o pedido divulga compostos da fórmula i em que os substituintes variáveis são como definidos aqui. os compostos da fórmula i e composições farmacêuticas compreendendo compostos da fórmula i são úteis para o tratamento de doenças mediadas por rsv.
BR112017006264A 2014-09-26 2015-09-25 derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório BR112017006264A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462055704P 2014-09-26 2014-09-26
PCT/US2015/052144 WO2016049415A1 (en) 2014-09-26 2015-09-25 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication

Publications (1)

Publication Number Publication Date
BR112017006264A2 true BR112017006264A2 (pt) 2017-12-12

Family

ID=55582038

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017006264A BR112017006264A2 (pt) 2014-09-26 2015-09-25 derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório

Country Status (20)

Country Link
US (1) US10358458B2 (pt)
EP (1) EP3197457B1 (pt)
JP (1) JP6671355B2 (pt)
KR (1) KR102573609B1 (pt)
CN (1) CN107073002B (pt)
AU (1) AU2015320511B2 (pt)
BR (1) BR112017006264A2 (pt)
CA (1) CA2962770C (pt)
CL (1) CL2017000707A1 (pt)
CO (1) CO2017003994A2 (pt)
CR (1) CR20170157A (pt)
EA (1) EA031726B1 (pt)
IL (1) IL251368B (pt)
MA (1) MA40149A1 (pt)
MX (1) MX2017003788A (pt)
PE (1) PE20170698A1 (pt)
PH (1) PH12017500558A1 (pt)
SG (2) SG11201702430WA (pt)
WO (1) WO2016049415A1 (pt)
ZA (1) ZA201702858B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20170698A1 (es) 2014-09-26 2017-06-05 Riboscience Llc Derivados de nucleosidos sustituidos con 4'-vinilo como inhibidores de la replicacion del arn del virus respiratorio sincitial
SG11202110742TA (en) * 2019-04-02 2021-10-28 Aligos Therapeutics Inc Compounds targeting prmt5
US20230123911A1 (en) * 2020-01-31 2023-04-20 Octagon Therapeutics, Inc. Modulation of immune cells
CN112194694B (zh) * 2020-09-29 2022-03-25 佛山科学技术学院 尿苷酸双苯丙酸酯基氨基磷酸酯化合物、其药物组合物及其制备方法和应用

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CA2278158A1 (en) * 1997-01-14 1998-07-16 Guangyi Wang Cytokine related treatments of disease
EP1103559A1 (en) * 1997-01-17 2001-05-30 ICN Pharmaceuticals, Inc. Autoimmune nucleosides
UA72612C2 (en) * 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
AU2002330154A1 (en) 2001-09-28 2003-04-07 Centre National De La Recherche Scientifique Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
WO2003026675A1 (en) 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
CN102174038A (zh) * 2003-02-19 2011-09-07 耶鲁大学 用于治疗病毒感染的抗病毒核苷
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JP5485140B2 (ja) 2008-04-10 2014-05-07 浜理薬品工業株式会社 ５−メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法
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JP2015535261A (ja) * 2012-10-29 2015-12-10 コクリスタル ファーマ，インコーポレイテッド ウイルス感染及び癌の治療のためのピリミジンヌクレオチド及びその一リン酸プロドラッグ
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Also Published As

Publication number Publication date
CO2017003994A2 (es) 2017-07-11
IL251368A0 (en) 2017-05-29
WO2016049415A1 (en) 2016-03-31
PH12017500558A1 (en) 2017-08-30
EP3197457B1 (en) 2022-11-09
KR102573609B1 (ko) 2023-08-31
CL2017000707A1 (es) 2017-12-15
SG10201810361TA (en) 2018-12-28
ZA201702858B (en) 2018-08-29
KR20170062499A (ko) 2017-06-07
US20160264611A1 (en) 2016-09-15
CN107073002A (zh) 2017-08-18
JP6671355B2 (ja) 2020-03-25
PE20170698A1 (es) 2017-06-05
EA201790632A1 (ru) 2017-09-29
IL251368B (en) 2020-05-31
US10358458B2 (en) 2019-07-23
CA2962770A1 (en) 2016-03-31
AU2015320511B2 (en) 2020-11-12
JP2017529375A (ja) 2017-10-05
CR20170157A (es) 2017-07-03
MX2017003788A (es) 2017-08-07
EP3197457A1 (en) 2017-08-02
EP3197457A4 (en) 2018-08-01
AU2015320511A1 (en) 2017-05-04
NZ730923A (en) 2020-09-25
MA40149A1 (fr) 2019-04-30
SG11201702430WA (en) 2017-04-27
EA031726B1 (ru) 2019-02-28
CN107073002B (zh) 2019-10-15
CA2962770C (en) 2023-08-22

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2640 DE 10-08-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.