CL2017000707A1 - Derivados de nucleosidos sustituidos de 4'-vinilo como inhibidores de la replicación del arn del virus sincicial respiratorio - Google Patents

Derivados de nucleosidos sustituidos de 4'-vinilo como inhibidores de la replicación del arn del virus sincicial respiratorio

Info

Publication number
CL2017000707A1
CL2017000707A1 CL2017000707A CL2017000707A CL2017000707A1 CL 2017000707 A1 CL2017000707 A1 CL 2017000707A1 CL 2017000707 A CL2017000707 A CL 2017000707A CL 2017000707 A CL2017000707 A CL 2017000707A CL 2017000707 A1 CL2017000707 A1 CL 2017000707A1
Authority
CL
Chile
Prior art keywords
inhibitors
respiratory syncytial
syncytial virus
virus rna
rna replication
Prior art date
Application number
CL2017000707A
Other languages
English (en)
Inventor
Mark Smith
Klaus G Klumpp
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of CL2017000707A1 publication Critical patent/CL2017000707A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

<p>LA SOLICITUD DA A CONOCER COMPUESTOS DE FÓRMULA I, EN LA QUE LOS SUSTITUYENTES VARIABLES SON TAL COMO SE DEFINEN EN EL PRESENTE DOCUMENTO. LOS COMPUESTOS DE FÓRMULA I Y LAS COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN COMPUESTOS DE FÓRMULA I SON ÚTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR VRS.</p>
CL2017000707A 2014-09-26 2017-03-24 Derivados de nucleosidos sustituidos de 4'-vinilo como inhibidores de la replicación del arn del virus sincicial respiratorio CL2017000707A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462055704P 2014-09-26 2014-09-26

Publications (1)

Publication Number Publication Date
CL2017000707A1 true CL2017000707A1 (es) 2017-12-15

Family

ID=55582038

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000707A CL2017000707A1 (es) 2014-09-26 2017-03-24 Derivados de nucleosidos sustituidos de 4'-vinilo como inhibidores de la replicación del arn del virus sincicial respiratorio

Country Status (20)

Country Link
US (1) US10358458B2 (es)
EP (1) EP3197457B1 (es)
JP (1) JP6671355B2 (es)
KR (1) KR102573609B1 (es)
CN (1) CN107073002B (es)
AU (1) AU2015320511B2 (es)
BR (1) BR112017006264A2 (es)
CA (1) CA2962770C (es)
CL (1) CL2017000707A1 (es)
CO (1) CO2017003994A2 (es)
CR (1) CR20170157A (es)
EA (1) EA031726B1 (es)
IL (1) IL251368B (es)
MA (1) MA40149A1 (es)
MX (1) MX2017003788A (es)
PE (1) PE20170698A1 (es)
PH (1) PH12017500558A1 (es)
SG (2) SG11201702430WA (es)
WO (1) WO2016049415A1 (es)
ZA (1) ZA201702858B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20170157A (es) 2014-09-26 2017-07-03 Riboscience Llc Derivados de nucleósidos sustituidos con 4´-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial
EP3947388A4 (en) * 2019-04-02 2022-12-21 Aligos Therapeutics, Inc. LINKS DIRECTED AGAINST PRMT5
EP4096673A4 (en) * 2020-01-31 2024-06-12 Octagon Therapeutics Inc. MODULATION OF IMMUNE CELLS
CN112194694B (zh) * 2020-09-29 2022-03-25 佛山科学技术学院 尿苷酸双苯丙酸酯基氨基磷酸酯化合物、其药物组合物及其制备方法和应用
WO2024103016A1 (en) * 2022-11-11 2024-05-16 Rome Therapeutics, Inc. 4'-halomethyl-cytidine phosphoramidates and related compounds and their use in treating medical conditions

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CR20170157A (es) 2014-09-26 2017-07-03 Riboscience Llc Derivados de nucleósidos sustituidos con 4´-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial

Also Published As

Publication number Publication date
MX2017003788A (es) 2017-08-07
CA2962770A1 (en) 2016-03-31
IL251368B (en) 2020-05-31
BR112017006264A2 (pt) 2017-12-12
SG11201702430WA (en) 2017-04-27
AU2015320511B2 (en) 2020-11-12
CO2017003994A2 (es) 2017-07-11
US20160264611A1 (en) 2016-09-15
ZA201702858B (en) 2018-08-29
WO2016049415A1 (en) 2016-03-31
KR102573609B1 (ko) 2023-08-31
JP2017529375A (ja) 2017-10-05
EP3197457B1 (en) 2022-11-09
EP3197457A4 (en) 2018-08-01
EA201790632A1 (ru) 2017-09-29
PH12017500558A1 (en) 2017-08-30
PE20170698A1 (es) 2017-06-05
KR20170062499A (ko) 2017-06-07
AU2015320511A1 (en) 2017-05-04
EP3197457A1 (en) 2017-08-02
CR20170157A (es) 2017-07-03
EA031726B1 (ru) 2019-02-28
MA40149A1 (fr) 2019-04-30
US10358458B2 (en) 2019-07-23
NZ730923A (en) 2020-09-25
CN107073002B (zh) 2019-10-15
JP6671355B2 (ja) 2020-03-25
SG10201810361TA (en) 2018-12-28
CN107073002A (zh) 2017-08-18
IL251368A0 (en) 2017-05-29
CA2962770C (en) 2023-08-22

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