BR112017012504A2 - derivados de piperidina como inibidores de hdac1/2 - Google Patents

derivados de piperidina como inibidores de hdac1/2

Info

Publication number
BR112017012504A2
BR112017012504A2 BR112017012504-8A BR112017012504A BR112017012504A2 BR 112017012504 A2 BR112017012504 A2 BR 112017012504A2 BR 112017012504 A BR112017012504 A BR 112017012504A BR 112017012504 A2 BR112017012504 A2 BR 112017012504A2
Authority
BR
Brazil
Prior art keywords
hdac1
inhibitors
piperidine derivatives
compounds
methods
Prior art date
Application number
BR112017012504-8A
Other languages
English (en)
Inventor
H. Van Duzer John
Mazitschek Ralph
Original Assignee
Acetylon Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acetylon Pharmaceuticals, Inc. filed Critical Acetylon Pharmaceuticals, Inc.
Publication of BR112017012504A2 publication Critical patent/BR112017012504A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

são fornecidos no presente documento compostos, composições farmacêuticas que compreendem tais compostos e métodos de uso de tais compostos para tratar doenças ou distúrbios associados à atividade de hdac1 e/ou hdac2.
BR112017012504-8A 2014-12-12 2015-12-11 derivados de piperidina como inibidores de hdac1/2 BR112017012504A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462091221P 2014-12-12 2014-12-12
US62/091,221 2014-12-12
US201562238931P 2015-10-08 2015-10-08
US62/238,931 2015-10-08
PCT/US2015/065289 WO2016094824A1 (en) 2014-12-12 2015-12-11 Piperidine derivatives as hdac1/2 inhibitors

Publications (1)

Publication Number Publication Date
BR112017012504A2 true BR112017012504A2 (pt) 2018-01-09

Family

ID=56108272

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017012504-8A BR112017012504A2 (pt) 2014-12-12 2015-12-11 derivados de piperidina como inibidores de hdac1/2

Country Status (17)

Country Link
US (6) US9790180B2 (pt)
EP (2) EP3725787B1 (pt)
JP (1) JP6693957B2 (pt)
KR (1) KR20170095964A (pt)
CN (1) CN107835810A (pt)
AU (2) AU2015360270B9 (pt)
BR (1) BR112017012504A2 (pt)
CA (1) CA2970500C (pt)
CL (1) CL2017001511A1 (pt)
EA (1) EA035120B1 (pt)
ES (1) ES2816641T3 (pt)
HK (1) HK1251566A1 (pt)
IL (1) IL252828A0 (pt)
MX (2) MX2017007623A (pt)
PH (1) PH12017501095A1 (pt)
SG (1) SG11201704759QA (pt)
WO (1) WO2016094824A1 (pt)

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US9145412B2 (en) 2012-11-02 2015-09-29 Acetylon Pharmaceuticals, Inc. Selective HDAC1 and HDAC2 inhibitors
US9403779B2 (en) 2013-10-08 2016-08-02 Acetylon Pharmaceuticals, Inc. Combinations of histone deacetylase inhibitors and either Her2 inhibitors or PI3K inhibitors
CA2932411A1 (en) 2013-12-03 2015-06-11 Acetylon Pharmaceuticals, Inc. Combinations of histone deacetylase inhibitors and immunomodulatory drugs
CN107835810A (zh) * 2014-12-12 2018-03-23 瑞格纳西制药有限公司 作为hdac1/2抑制剂的哌啶衍生物
RU2770061C2 (ru) 2014-12-12 2022-04-14 Джапан Тобакко Инк. Соединения дигидропиримидин-2-она и их медицинское применение
AR105812A1 (es) 2015-06-08 2017-11-15 Acetylon Pharmaceuticals Inc Métodos para la preparación de inhibidores de proteína deacetilasa
WO2016200919A1 (en) 2015-06-08 2016-12-15 Acetylon Pharmaceuticals, Inc. Crystalline forms of a histone deacetylase inhibitor
JP7100018B2 (ja) 2016-08-08 2022-07-12 アセチロン ファーマシューティカルズ インコーポレイテッド ヒストンデアセチラーゼ６阻害剤及びｃｄ２０阻害抗体の薬学的組み合わせならびにその使用
CA3087994A1 (en) 2018-02-28 2019-09-06 Japan Tobacco Inc. 4-methyldihydropyrimidinone compounds and pharmaceutical use thereof
CN110372572A (zh) * 2019-08-23 2019-10-25 苏州汉德创宏生化科技有限公司 一种4,4-二氟哌啶-1-甲酰氯的合成方法
WO2024030659A1 (en) 2022-08-05 2024-02-08 Tango Therapeutics, Inc. An hdac inhibitor for treating cancer with a modified stk11 activity or expression

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Also Published As

Publication number Publication date
EP3292113A4 (en) 2018-07-04
MX2017007623A (es) 2018-09-26
MX2020002487A (es) 2020-07-13
EA035120B1 (ru) 2020-04-29
EA201791259A1 (ru) 2017-11-30
US10239837B2 (en) 2019-03-26
AU2015360270B2 (en) 2019-11-28
US10358421B2 (en) 2019-07-23
EP3725787B1 (en) 2023-11-29
KR20170095964A (ko) 2017-08-23
SG11201704759QA (en) 2017-07-28
CN107835810A (zh) 2018-03-23
CA2970500A1 (en) 2016-06-16
US20210179559A1 (en) 2021-06-17
AU2020200846A1 (en) 2020-02-27
ES2816641T3 (es) 2021-04-05
US20190359569A1 (en) 2019-11-28
US9790180B2 (en) 2017-10-17
HK1251566A1 (zh) 2019-02-01
JP2018502841A (ja) 2018-02-01
EP3292113B1 (en) 2020-07-08
US20230348389A1 (en) 2023-11-02
EP3725787A1 (en) 2020-10-21
US10968180B2 (en) 2021-04-06
JP6693957B2 (ja) 2020-05-13
IL252828A0 (en) 2017-08-31
US11702389B2 (en) 2023-07-18
PH12017501095A1 (en) 2017-10-18
EP3292113A1 (en) 2018-03-14
CA2970500C (en) 2023-08-29
US20160168093A1 (en) 2016-06-16
US20170369441A1 (en) 2017-12-28
US20180022702A1 (en) 2018-01-25
CL2017001511A1 (es) 2018-02-16
AU2015360270B9 (en) 2019-12-05
WO2016094824A1 (en) 2016-06-16
AU2015360270A1 (en) 2017-07-13

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