PE20170698A1 - Derivados de nucleosidos sustituidos con 4'-vinilo como inhibidores de la replicacion del arn del virus respiratorio sincitial - Google Patents
Derivados de nucleosidos sustituidos con 4'-vinilo como inhibidores de la replicacion del arn del virus respiratorio sincitialInfo
- Publication number
- PE20170698A1 PE20170698A1 PE2017000521A PE2017000521A PE20170698A1 PE 20170698 A1 PE20170698 A1 PE 20170698A1 PE 2017000521 A PE2017000521 A PE 2017000521A PE 2017000521 A PE2017000521 A PE 2017000521A PE 20170698 A1 PE20170698 A1 PE 20170698A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitors
- rna replication
- vinyl
- derivatives
- respiratory syncitial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
Se refiere a compuestos de formula I, donde: Y es H o P(=X)(R)(R'); R es OR1 o NHC(R2a)(R2b)C(=O)OR3; R' es -OR3, -OP(=O)(OH)OP(=O)(OH)OH, entre otros; R1 es H, alquilo inferior, entre otros; R2a y R2b son independientemente H, alquilo inferior, entre otros; R3 es H, alquilo inferior, entre otros; Rw, Rx y Ry son independientemente H, OH o F; Rz es H u OH; la base es uracilo, citosina, guanina, entre otros. Son compuestos preferidos: fosforamidato de 4'-viniluridin-5´-(O-fenil-N-(S)-1-(isopropoxicarbonil)etilo); fosforamidato de 4'-viniluridin-5´-(O-1-naftil-N-(S)-1-(isopropoxicarbonil)etilo); entre otros. Tambien se refiere a una composicion y a un metodo de tratamiento. Dichos compuestos son inhibidores de la replicacion del ARN del virus respiratorio sincitial (VRS), siendo utiles en el tratamiento de enfermedades respiratorias estacionales
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462055704P | 2014-09-26 | 2014-09-26 | |
PCT/US2015/052144 WO2016049415A1 (en) | 2014-09-26 | 2015-09-25 | 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20170698A1 true PE20170698A1 (es) | 2017-06-05 |
Family
ID=55582038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017000521A PE20170698A1 (es) | 2014-09-26 | 2015-09-25 | Derivados de nucleosidos sustituidos con 4'-vinilo como inhibidores de la replicacion del arn del virus respiratorio sincitial |
Country Status (20)
Country | Link |
---|---|
US (1) | US10358458B2 (es) |
EP (1) | EP3197457B1 (es) |
JP (1) | JP6671355B2 (es) |
KR (1) | KR102573609B1 (es) |
CN (1) | CN107073002B (es) |
AU (1) | AU2015320511B2 (es) |
BR (1) | BR112017006264A2 (es) |
CA (1) | CA2962770C (es) |
CL (1) | CL2017000707A1 (es) |
CO (1) | CO2017003994A2 (es) |
CR (1) | CR20170157A (es) |
EA (1) | EA031726B1 (es) |
IL (1) | IL251368B (es) |
MA (1) | MA40149A1 (es) |
MX (1) | MX2017003788A (es) |
PE (1) | PE20170698A1 (es) |
PH (1) | PH12017500558A1 (es) |
SG (2) | SG10201810361TA (es) |
WO (1) | WO2016049415A1 (es) |
ZA (1) | ZA201702858B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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BR112017006264A2 (pt) | 2014-09-26 | 2017-12-12 | Riboscience Llc | derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório |
SG11202110742TA (en) * | 2019-04-02 | 2021-10-28 | Aligos Therapeutics Inc | Compounds targeting prmt5 |
WO2021155277A1 (en) * | 2020-01-31 | 2021-08-05 | Octagon Therapeutics, Inc. | Modulation of immune cells |
CN112194694B (zh) * | 2020-09-29 | 2022-03-25 | 佛山科学技术学院 | 尿苷酸双苯丙酸酯基氨基磷酸酯化合物、其药物组合物及其制备方法和应用 |
WO2024103016A1 (en) * | 2022-11-11 | 2024-05-16 | Rome Therapeutics, Inc. | 4'-halomethyl-cytidine phosphoramidates and related compounds and their use in treating medical conditions |
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JP2001524936A (ja) | 1996-10-16 | 2001-12-04 | アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド | プリンl―ヌクレオシド類およびその用途 |
WO1998030223A1 (en) * | 1997-01-17 | 1998-07-16 | Icn Pharmaceuticals, Inc. | Cytokine related treatments of disease |
EP1103559A1 (en) * | 1997-01-17 | 2001-05-30 | ICN Pharmaceuticals, Inc. | Autoimmune nucleosides |
UA72612C2 (en) | 2000-07-06 | 2005-03-15 | Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells | |
GB0114286D0 (en) | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
EP1435974A4 (en) | 2001-09-28 | 2006-09-06 | Idenix Cayman Ltd | METHOD AND COMPOSITIONS FOR TREATING HEPATITIS C VIRUS WITH 4'-MODIFIED NUCLEOSIDES |
JP2005536440A (ja) | 2001-09-28 | 2005-12-02 | イデニクス(ケイマン)リミテツド | 4’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物 |
TWI332507B (en) * | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
BRPI0407374A (pt) * | 2003-02-19 | 2006-01-10 | Univ Yale | Análogos de nucleosìdeo antiviral e métodos para tratar infecções virais, especialmente infecções de hiv |
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EP1928475B1 (en) | 2005-08-15 | 2018-05-23 | Riboscience LLC | Antiviral phosphoramidates of 4'-c-azido-substituted pronucleotides |
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WO2010030858A1 (en) | 2008-09-15 | 2010-03-18 | Enanta Pharmaceuticals, Inc. | 4'-allene-substituted nucleoside derivatives |
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US20130260460A1 (en) | 2010-04-22 | 2013-10-03 | Isis Pharmaceuticals Inc | Conformationally restricted dinucleotide monomers and oligonucleotides |
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US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
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UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
CA2952959C (en) | 2014-06-24 | 2023-03-07 | Alios Biopharma, Inc. | Use of nucleosides and nucleotides to treat filoviridae viral infection |
EP3797782A1 (en) * | 2014-06-24 | 2021-03-31 | Janssen BioPharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof for use in the treatment of viral infections |
TWI673283B (zh) * | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | 2’-氯胺基嘧啶酮及嘧啶二酮核苷類 |
BR112017006264A2 (pt) | 2014-09-26 | 2017-12-12 | Riboscience Llc | derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório |
-
2015
- 2015-09-25 BR BR112017006264A patent/BR112017006264A2/pt not_active IP Right Cessation
- 2015-09-25 EA EA201790632A patent/EA031726B1/ru not_active IP Right Cessation
- 2015-09-25 AU AU2015320511A patent/AU2015320511B2/en active Active
- 2015-09-25 EP EP15844391.1A patent/EP3197457B1/en active Active
- 2015-09-25 KR KR1020177011174A patent/KR102573609B1/ko active IP Right Grant
- 2015-09-25 CN CN201580055281.3A patent/CN107073002B/zh active Active
- 2015-09-25 CA CA2962770A patent/CA2962770C/en active Active
- 2015-09-25 MA MA40149A patent/MA40149A1/fr unknown
- 2015-09-25 US US14/865,135 patent/US10358458B2/en active Active
- 2015-09-25 SG SG10201810361TA patent/SG10201810361TA/en unknown
- 2015-09-25 JP JP2017516420A patent/JP6671355B2/ja active Active
- 2015-09-25 PE PE2017000521A patent/PE20170698A1/es unknown
- 2015-09-25 WO PCT/US2015/052144 patent/WO2016049415A1/en active Application Filing
- 2015-09-25 SG SG11201702430WA patent/SG11201702430WA/en unknown
- 2015-09-25 CR CR20170157A patent/CR20170157A/es unknown
- 2015-09-25 MX MX2017003788A patent/MX2017003788A/es unknown
-
2017
- 2017-03-23 IL IL251368A patent/IL251368B/en active IP Right Grant
- 2017-03-24 PH PH12017500558A patent/PH12017500558A1/en unknown
- 2017-03-24 CL CL2017000707A patent/CL2017000707A1/es unknown
- 2017-04-24 ZA ZA2017/02858A patent/ZA201702858B/en unknown
- 2017-04-25 CO CONC2017/0003994A patent/CO2017003994A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN107073002A (zh) | 2017-08-18 |
IL251368A0 (en) | 2017-05-29 |
KR102573609B1 (ko) | 2023-08-31 |
MA40149A1 (fr) | 2019-04-30 |
SG11201702430WA (en) | 2017-04-27 |
WO2016049415A1 (en) | 2016-03-31 |
CA2962770C (en) | 2023-08-22 |
NZ730923A (en) | 2020-09-25 |
MX2017003788A (es) | 2017-08-07 |
CO2017003994A2 (es) | 2017-07-11 |
EP3197457A1 (en) | 2017-08-02 |
KR20170062499A (ko) | 2017-06-07 |
BR112017006264A2 (pt) | 2017-12-12 |
CL2017000707A1 (es) | 2017-12-15 |
JP6671355B2 (ja) | 2020-03-25 |
CR20170157A (es) | 2017-07-03 |
EP3197457B1 (en) | 2022-11-09 |
EA201790632A1 (ru) | 2017-09-29 |
EP3197457A4 (en) | 2018-08-01 |
AU2015320511A1 (en) | 2017-05-04 |
AU2015320511B2 (en) | 2020-11-12 |
CA2962770A1 (en) | 2016-03-31 |
PH12017500558A1 (en) | 2017-08-30 |
EA031726B1 (ru) | 2019-02-28 |
CN107073002B (zh) | 2019-10-15 |
JP2017529375A (ja) | 2017-10-05 |
US20160264611A1 (en) | 2016-09-15 |
ZA201702858B (en) | 2018-08-29 |
SG10201810361TA (en) | 2018-12-28 |
IL251368B (en) | 2020-05-31 |
US10358458B2 (en) | 2019-07-23 |
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