CL2019002777A1 - Compuestos que inhiben la proteína mcl-1. - Google Patents
Compuestos que inhiben la proteína mcl-1.Info
- Publication number
- CL2019002777A1 CL2019002777A1 CL2019002777A CL2019002777A CL2019002777A1 CL 2019002777 A1 CL2019002777 A1 CL 2019002777A1 CL 2019002777 A CL2019002777 A CL 2019002777A CL 2019002777 A CL2019002777 A CL 2019002777A CL 2019002777 A1 CL2019002777 A1 CL 2019002777A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- mcl
- inhibit
- protein
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Abstract
EN LA PRESENTE SE PROVEEN INHIBIDORES DE LA PROTEÍNA LEUCEMIA DE CÉLULAS MIELOIDES 1 (MCL- 1), MÉTODOS PARA SU PREPARACIÓN, COMPOSICIONES FARMACÉUTICAS RELACIONADAS, Y MÉTODOS DE USO DE ESTO. POR EJEMPLO, EN LA PRESENTE SE PROVEEN COMPUESTOS DE FÓRMULA 1, O UN ESTEREOISOMERO DE ESTOS; Y SALES FARMACÉUTICAMENTE ACEPTABLES DE ESTOS Y COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS COMPUESTOS. LOS COMPUESTOS Y COMPOSICIONES PROVISTAS EN LA PRESENTE PUEDEN USARSE, POR EJEMPLO, EN EL TRATAMIENTO DE ENFERMEDADES O AFECCIONES, COMO CÁNCER.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762479230P | 2017-03-30 | 2017-03-30 | |
| US201762479171P | 2017-03-30 | 2017-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019002777A1 true CL2019002777A1 (es) | 2019-12-20 |
Family
ID=61972255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019002777A CL2019002777A1 (es) | 2017-03-30 | 2019-09-27 | Compuestos que inhiben la proteína mcl-1. |
Country Status (33)
| Country | Link |
|---|---|
| US (5) | US10300075B2 (es) |
| EP (1) | EP3601297B9 (es) |
| JP (2) | JP6453507B2 (es) |
| KR (1) | KR102372322B1 (es) |
| CN (1) | CN110691784B (es) |
| AU (2) | AU2018244349B2 (es) |
| BR (1) | BR112019020459B1 (es) |
| CA (1) | CA3057882A1 (es) |
| CL (1) | CL2019002777A1 (es) |
| CO (1) | CO2019011762A2 (es) |
| CR (1) | CR20190489A (es) |
| DK (1) | DK3601297T5 (es) |
| ES (1) | ES2940641T3 (es) |
| FI (1) | FI3601297T3 (es) |
| HR (1) | HRP20221412T2 (es) |
| HU (1) | HUE060919T2 (es) |
| IL (1) | IL269603B (es) |
| JO (1) | JOP20190229B1 (es) |
| LT (1) | LT3601297T (es) |
| MX (1) | MX2019011693A (es) |
| NZ (1) | NZ757606A (es) |
| PE (1) | PE20200335A1 (es) |
| PH (1) | PH12019502245A1 (es) |
| PL (1) | PL3601297T3 (es) |
| PT (1) | PT3601297T (es) |
| RS (1) | RS63892B9 (es) |
| SA (1) | SA519410222B1 (es) |
| SG (1) | SG11201908945RA (es) |
| SI (1) | SI3601297T1 (es) |
| TW (1) | TWI685493B (es) |
| UA (1) | UA124784C2 (es) |
| UY (1) | UY37656A (es) |
| WO (1) | WO2018183418A1 (es) |
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| KR102611446B1 (ko) | 2017-01-20 | 2023-12-06 | 아르커스 바이오사이언시즈 인코포레이티드 | 암-관련 장애의 치료를 위한 아졸로피리미딘 |
| JOP20180029A1 (ar) | 2017-03-30 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب حلقي غير متجانس |
| JP6453507B2 (ja) | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| PE20200008A1 (es) | 2017-03-30 | 2020-01-06 | Hoffmann La Roche | Isoquinolinas como inhibidores de hpk1 |
| US11364248B2 (en) * | 2017-08-18 | 2022-06-21 | Amgen Inc. | Compounds that inhibit Mcl-1 protein |
| EP3676270A1 (en) | 2017-08-29 | 2020-07-08 | Amgen Inc. | Macrocyclic compounds that inhibit mcl-1 protein |
| US11301560B2 (en) * | 2018-02-09 | 2022-04-12 | Bolster, Inc | Real-time detection and blocking of counterfeit websites |
| US11271966B2 (en) * | 2018-02-09 | 2022-03-08 | Bolster, Inc | Real-time detection and redirecton from counterfeit websites |
| KR20200121337A (ko) | 2018-02-16 | 2020-10-23 | 아르커스 바이오사이언시즈 인코포레이티드 | 아졸로피리미딘 화합물의 투여 |
| US11274105B2 (en) | 2018-03-05 | 2022-03-15 | Amgen Inc. | Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists |
| BR112020021648A2 (pt) | 2018-05-14 | 2021-01-26 | Gilead Sciences, Inc. | inibidores de mcl-1 |
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| CN113166173A (zh) | 2018-11-09 | 2021-07-23 | 普莱鲁德疗法有限公司 | 作为骨髓细胞白血病1(mcl-1)蛋白抑制剂的螺-磺酰胺衍生物 |
| CN112867722B (zh) * | 2019-01-18 | 2022-09-23 | 苏州亚盛药业有限公司 | 作为mcl-1抑制剂的大螺环醚(macrocyclic spiroethers) |
| WO2020151738A1 (en) * | 2019-01-23 | 2020-07-30 | Ascentage Pharma (Suzhou) Co., Ltd. | Macrocyclic fused pyrrazoles as mcl-1 inhibitors |
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| TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症 |
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2018
- 2018-03-27 JP JP2018059341A patent/JP6453507B2/ja active Active
- 2018-03-28 SI SI201830809T patent/SI3601297T1/sl unknown
- 2018-03-28 EP EP18717811.6A patent/EP3601297B9/en active Active
- 2018-03-28 KR KR1020197029091A patent/KR102372322B1/ko active IP Right Grant
- 2018-03-28 CR CR20190489A patent/CR20190489A/es unknown
- 2018-03-28 PE PE2019001963A patent/PE20200335A1/es unknown
- 2018-03-28 UA UAA201910703A patent/UA124784C2/uk unknown
- 2018-03-28 JO JOP/2019/0229A patent/JOP20190229B1/ar active
- 2018-03-28 DK DK18717811.6T patent/DK3601297T5/da active
- 2018-03-28 HR HRP20221412TT patent/HRP20221412T2/hr unknown
- 2018-03-28 AU AU2018244349A patent/AU2018244349B2/en active Active
- 2018-03-28 CA CA3057882A patent/CA3057882A1/en active Pending
- 2018-03-28 SG SG11201908945R patent/SG11201908945RA/en unknown
- 2018-03-28 PL PL18717811.6T patent/PL3601297T3/pl unknown
- 2018-03-28 ES ES18717811T patent/ES2940641T3/es active Active
- 2018-03-28 MX MX2019011693A patent/MX2019011693A/es unknown
- 2018-03-28 LT LTEPPCT/US2018/024723T patent/LT3601297T/lt unknown
- 2018-03-28 FI FIEP18717811.6T patent/FI3601297T3/fi active
- 2018-03-28 NZ NZ757606A patent/NZ757606A/en unknown
- 2018-03-28 WO PCT/US2018/024723 patent/WO2018183418A1/en unknown
- 2018-03-28 RS RS20230036A patent/RS63892B9/sr unknown
- 2018-03-28 PT PT187178116T patent/PT3601297T/pt unknown
- 2018-03-28 BR BR112019020459-8A patent/BR112019020459B1/pt active IP Right Grant
- 2018-03-28 HU HUE18717811A patent/HUE060919T2/hu unknown
- 2018-03-28 US US15/938,001 patent/US10300075B2/en active Active
- 2018-03-28 CN CN201880035818.3A patent/CN110691784B/zh active Active
- 2018-03-30 TW TW107111110A patent/TWI685493B/zh active
- 2018-04-02 UY UY0001037656A patent/UY37656A/es unknown
- 2018-12-11 JP JP2018231352A patent/JP6629419B2/ja active Active
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2019
- 2019-03-11 US US16/297,904 patent/US10500213B2/en active Active
- 2019-08-22 US US16/547,747 patent/US10632128B2/en active Active
- 2019-09-24 IL IL269603A patent/IL269603B/en unknown
- 2019-09-27 CL CL2019002777A patent/CL2019002777A1/es unknown
- 2019-09-27 PH PH12019502245A patent/PH12019502245A1/en unknown
- 2019-09-30 SA SA519410222A patent/SA519410222B1/ar unknown
- 2019-10-24 CO CONC2019/0011762A patent/CO2019011762A2/es unknown
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2020
- 2020-02-06 US US16/783,269 patent/US10821115B2/en active Active
- 2020-09-23 US US17/029,249 patent/US11224601B1/en active Active
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2021
- 2021-01-15 AU AU2021200233A patent/AU2021200233A1/en not_active Abandoned
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