BR112015023098A2 - agentes de infrarregulação do receptor de andrógeno e usos dos mesmos - Google Patents

agentes de infrarregulação do receptor de andrógeno e usos dos mesmos

Info

Publication number
BR112015023098A2
BR112015023098A2 BR112015023098A BR112015023098A BR112015023098A2 BR 112015023098 A2 BR112015023098 A2 BR 112015023098A2 BR 112015023098 A BR112015023098 A BR 112015023098A BR 112015023098 A BR112015023098 A BR 112015023098A BR 112015023098 A2 BR112015023098 A2 BR 112015023098A2
Authority
BR
Brazil
Prior art keywords
androgen receptor
regulating agents
receptor down
agents
downregulation
Prior art date
Application number
BR112015023098A
Other languages
English (en)
Inventor
Godbole Abhijit
Kwegyir-Afful Andrew
K Gediya Lalji
Purushottamachar Puranik
Vasaitis Tadas
C O Njar Vincent
Original Assignee
Univ Jefferson
Univ Of Maryland Eastern Shore
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson, Univ Of Maryland Eastern Shore, Univ Maryland filed Critical Univ Jefferson
Publication of BR112015023098A2 publication Critical patent/BR112015023098A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Abstract

resumo “agentes de infrarregulação do receptor de andrógeno e usos dos mesmos” a presente invenção refere-se ao design e síntese de novos compostos esteroidais que causam a infrarregulação do receptor de andrógeno (ar), tanto de comprimento total quanto a variante de splicing. os compostos são agentes potenciais para o tratamento de todas as formas de câncer da próstata e outras doenças que dependem do ar funcional.
BR112015023098A 2013-03-14 2014-03-14 agentes de infrarregulação do receptor de andrógeno e usos dos mesmos BR112015023098A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361782383P 2013-03-14 2013-03-14
PCT/US2014/029667 WO2014153215A1 (en) 2013-03-14 2014-03-14 Androgen receptor down-regulating agents and uses thereof

Publications (1)

Publication Number Publication Date
BR112015023098A2 true BR112015023098A2 (pt) 2017-07-18

Family

ID=51583862

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015023098A BR112015023098A2 (pt) 2013-03-14 2014-03-14 agentes de infrarregulação do receptor de andrógeno e usos dos mesmos

Country Status (13)

Country Link
US (2) US9884067B2 (pt)
EP (2) EP4066841A1 (pt)
JP (1) JP2016514165A (pt)
KR (1) KR20150127720A (pt)
CN (1) CN105682662A (pt)
AU (1) AU2014236135A1 (pt)
BR (1) BR112015023098A2 (pt)
CA (1) CA2904170A1 (pt)
IL (1) IL240820A0 (pt)
MX (1) MX2015012274A (pt)
RU (1) RU2015137617A (pt)
SG (1) SG11201507093WA (pt)
WO (1) WO2014153215A1 (pt)

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US20100048912A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
SG11201507093WA (en) * 2013-03-14 2015-10-29 Univ Maryland Baltimore Office Of Technology Transfer Androgen receptor down-regulating agents and uses thereof
WO2014165815A2 (en) * 2013-04-04 2014-10-09 University Of Maryland, Baltimore Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity
RU2016104643A (ru) 2013-08-12 2017-09-19 Токай Фармасьютикалз, Инк. Биомаркёры для лечения неопластических заболеваний с применением нацеленных на андроген методов лечения
US10675289B2 (en) 2014-10-02 2020-06-09 University Of Maryland, Baltimore Methods of treating pancreatic cancer
CN105713063A (zh) * 2014-12-02 2016-06-29 重庆安格龙翔医药科技有限公司 一种阿比特龙乙酸酯的制备方法
WO2017066697A1 (en) 2015-10-14 2017-04-20 Dou Qingping Treatments and diagnostics for cancers
CN112851741B (zh) * 2016-02-19 2022-10-25 深圳市塔吉瑞生物医药有限公司 一种取代的甾体类化合物及其应用
CN107365343A (zh) * 2016-05-12 2017-11-21 四川海思科制药有限公司 一种苯并咪唑雄甾衍生物及其制备方法和医药用途
WO2017223320A1 (en) * 2016-06-22 2017-12-28 University Of Maryland, Baltimore Method for production of novel galeterone analogs and uses thereof
WO2019023651A2 (en) 2017-07-28 2019-01-31 Massachusetts Institute Of Technology MODULATORS OF THE SMALL MOLECULE ANDROGEN RECEPTOR
CN107857790A (zh) * 2017-12-14 2018-03-30 中国药科大学 一种新型甾体类雄激素受体抑制剂、制备方法及其医药用途
CN116444599A (zh) * 2022-01-07 2023-07-18 中国科学院上海药物研究所 甾体类化合物及制备方法和用途

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