MX2019007103A - Derivados de tiazina condensados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso. - Google Patents
Derivados de tiazina condensados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso.Info
- Publication number
- MX2019007103A MX2019007103A MX2019007103A MX2019007103A MX2019007103A MX 2019007103 A MX2019007103 A MX 2019007103A MX 2019007103 A MX2019007103 A MX 2019007103A MX 2019007103 A MX2019007103 A MX 2019007103A MX 2019007103 A MX2019007103 A MX 2019007103A
- Authority
- MX
- Mexico
- Prior art keywords
- beta
- compounds
- bace
- methods
- secretase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
La presente descripción proporciona una nueva clase de compuestos útiles para la modulación de la actividad de la enzima beta-secretasa (BACE). Los compuestos tienen una fórmula general I: (ver fórmula). En donde las variables A, R1, R2, R2', R3, R4 Y R5 de la fórmula I se definen en el presente documento. La presente divulgación también proporciona composiciones farmacéuticas que comprenden los compuestos, y usos de los compuestos y composiciones para el tratamiento de trastornos y/o afecciones relacionadas con la formación y deposición de placas Aß, como resultado de la actividad biológica de BACE. Dichos trastornos mediados por BACE incluyen, por ejemplo, enfermedad del Alzheimer, déficits cognitivos, trastornos cognitivos y otras afecciones del sistema nervioso central.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662434721P | 2016-12-15 | 2016-12-15 | |
PCT/US2017/066184 WO2018112086A1 (en) | 2016-12-15 | 2017-12-13 | Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019007103A true MX2019007103A (es) | 2019-11-05 |
Family
ID=60888747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019007103A MX2019007103A (es) | 2016-12-15 | 2017-12-13 | Derivados de tiazina condensados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso. |
Country Status (7)
Country | Link |
---|---|
US (1) | US10889581B2 (es) |
EP (1) | EP3555085B1 (es) |
JP (1) | JP7159161B2 (es) |
AU (1) | AU2017378316B2 (es) |
CA (1) | CA3047287A1 (es) |
MX (1) | MX2019007103A (es) |
WO (1) | WO2018112086A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2017376441B2 (en) | 2016-12-15 | 2021-10-14 | Amgen Inc. | Oxazine derivatives as beta-secretase inhibitors and methods of use |
MX2019007104A (es) | 2016-12-15 | 2019-11-05 | Amgen Inc | Derivados de dioxido de 1,4-tiazina y dioxido de 1,2,4-tiadiazina como inhibidores de beta-secretasa y metodos de uso. |
CA3047285A1 (en) | 2016-12-15 | 2018-06-21 | Amgen Inc. | Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use |
CA3047288A1 (en) | 2016-12-15 | 2018-06-21 | Amgen Inc. | Thiazine derivatives as beta-secretase inhibitors and methods of use |
MX2019007103A (es) | 2016-12-15 | 2019-11-05 | Amgen Inc | Derivados de tiazina condensados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso. |
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CA3047285A1 (en) | 2016-12-15 | 2018-06-21 | Amgen Inc. | Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use |
CA3047288A1 (en) | 2016-12-15 | 2018-06-21 | Amgen Inc. | Thiazine derivatives as beta-secretase inhibitors and methods of use |
MX2019007103A (es) | 2016-12-15 | 2019-11-05 | Amgen Inc | Derivados de tiazina condensados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso. |
AU2017376441B2 (en) | 2016-12-15 | 2021-10-14 | Amgen Inc. | Oxazine derivatives as beta-secretase inhibitors and methods of use |
-
2017
- 2017-12-13 MX MX2019007103A patent/MX2019007103A/es unknown
- 2017-12-13 WO PCT/US2017/066184 patent/WO2018112086A1/en unknown
- 2017-12-13 US US16/466,199 patent/US10889581B2/en active Active
- 2017-12-13 AU AU2017378316A patent/AU2017378316B2/en active Active
- 2017-12-13 JP JP2019531735A patent/JP7159161B2/ja active Active
- 2017-12-13 EP EP17822987.8A patent/EP3555085B1/en active Active
- 2017-12-13 CA CA3047287A patent/CA3047287A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2017378316B2 (en) | 2021-04-01 |
WO2018112086A1 (en) | 2018-06-21 |
EP3555085B1 (en) | 2020-12-02 |
AU2017378316A1 (en) | 2019-07-04 |
US10889581B2 (en) | 2021-01-12 |
US20200231585A1 (en) | 2020-07-23 |
CA3047287A1 (en) | 2018-06-21 |
EP3555085A1 (en) | 2019-10-23 |
JP7159161B2 (ja) | 2022-10-24 |
JP2020503295A (ja) | 2020-01-30 |
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