BR112015009850A2 - compostos de piridila substituídos por heteroarila úteis como moduladores de quinase - Google Patents
compostos de piridila substituídos por heteroarila úteis como moduladores de quinaseInfo
- Publication number
- BR112015009850A2 BR112015009850A2 BR112015009850A BR112015009850A BR112015009850A2 BR 112015009850 A2 BR112015009850 A2 BR 112015009850A2 BR 112015009850 A BR112015009850 A BR 112015009850A BR 112015009850 A BR112015009850 A BR 112015009850A BR 112015009850 A2 BR112015009850 A2 BR 112015009850A2
- Authority
- BR
- Brazil
- Prior art keywords
- kinase modulators
- substituted pyridyl
- compounds useful
- heteroaryl substituted
- pyridyl compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
resumo patente de invenção: "compostos de piridila substituídos por heteroarila úteis como moduladores de quinase". compostos tendo a seguinte fórmula: ou um estereoisômero ou um seu sal farmaceuticamente aceitável, em que r2 é um grupo heteroarila monocíclica, e r1, r3, r4, r5 e r6 são como definidos aqui, são úteis como moduladores de quinase, incluindo inibição de irak-4. 1/1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261723848P | 2012-11-08 | 2012-11-08 | |
US201361774824P | 2013-03-08 | 2013-03-08 | |
PCT/US2013/068875 WO2014074675A1 (en) | 2012-11-08 | 2013-11-07 | Heteroaryl substituted pyridyl compounds useful as kinase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015009850A2 true BR112015009850A2 (pt) | 2017-07-11 |
Family
ID=49667571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015009850A BR112015009850A2 (pt) | 2012-11-08 | 2013-11-07 | compostos de piridila substituídos por heteroarila úteis como moduladores de quinase |
Country Status (21)
Country | Link |
---|---|
US (3) | US9657009B2 (pt) |
EP (1) | EP2917206B1 (pt) |
JP (1) | JP6204484B2 (pt) |
KR (1) | KR20150079963A (pt) |
CN (1) | CN104781254B (pt) |
AU (1) | AU2013341200A1 (pt) |
BR (1) | BR112015009850A2 (pt) |
CA (1) | CA2890983A1 (pt) |
CL (1) | CL2015001249A1 (pt) |
CO (1) | CO7400871A2 (pt) |
EA (1) | EA024940B1 (pt) |
ES (1) | ES2615302T3 (pt) |
HK (1) | HK1213895A1 (pt) |
IL (1) | IL238609A0 (pt) |
MX (1) | MX2015005562A (pt) |
PE (1) | PE20150953A1 (pt) |
PH (1) | PH12015501005A1 (pt) |
SG (1) | SG11201503397YA (pt) |
TN (1) | TN2015000175A1 (pt) |
TW (1) | TW201427953A (pt) |
WO (1) | WO2014074675A1 (pt) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
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BR112015009850A2 (pt) | 2012-11-08 | 2017-07-11 | Bristol Myers Squibb Co | compostos de piridila substituídos por heteroarila úteis como moduladores de quinase |
TW201422606A (zh) | 2012-11-08 | 2014-06-16 | 必治妥美雅史谷比公司 | 可作爲激酶調節劑之經雙環雜環取代之吡啶化合物 |
CA3012242C (en) | 2012-12-21 | 2021-11-02 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
NO2865735T3 (pt) | 2013-07-12 | 2018-07-21 | ||
UY35935A (es) * | 2014-01-03 | 2015-06-30 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Compuestos de nicotinamida sustituida con heteroarilo como inhibidores de quinasa y moduladores de irak-4 |
TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
NO2717902T3 (pt) | 2014-06-20 | 2018-06-23 | ||
UY36749A (es) | 2015-06-24 | 2016-12-30 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Compuestos de aminopiridina sustituida con heteroarilo como inhibidores de quinasa y moduladores de irak-4, y composiciones farmacéuticas que los contienen |
EP3313844B1 (en) | 2015-06-24 | 2020-08-26 | Bristol-Myers Squibb Company | Heteroaryl substituted aminopyridine compounds |
JP6843775B2 (ja) | 2015-06-24 | 2021-03-17 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | ヘテロアリール置換のアミノピリジン化合物 |
UY36875A (es) | 2015-09-02 | 2017-03-31 | Glaxosmithkline Intellectual Property (No 2) Ltd | Composiciones inhibidoras de bromodominios para el tratamiento de diversas enfermedades |
JP6795588B2 (ja) | 2015-09-22 | 2020-12-02 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited | ブロモドメイン阻害薬としての使用のためのピリジノンジカルボキサミド |
CN108290866B (zh) | 2015-10-05 | 2020-12-18 | 葛兰素史克知识产权第二有限公司 | 作为溴结构域抑制剂的2-氧代-1,2-二氢吡啶-3,5-二甲酰胺化合物 |
ES2916582T3 (es) | 2015-11-26 | 2022-07-01 | Novartis Ag | Derivados de diaminopiridina |
CN108884070B (zh) | 2016-04-07 | 2021-07-02 | 葛兰素史克知识产权第二有限公司 | 作为溴结构域抑制剂的吡啶基衍生物 |
WO2017202742A1 (en) * | 2016-05-24 | 2017-11-30 | Glaxosmithkline Intellectual Property (No.2) Limited | Pyridine dicarboxamide derivatives as bromodomain inhibitors |
JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
JOP20190192A1 (ar) | 2017-03-01 | 2019-08-08 | Glaxosmithkline Ip No 2 Ltd | مشتقات بيرازول بوصفها مثبطات برومودومين |
GB201703282D0 (en) | 2017-03-01 | 2017-04-12 | Glaxosmithkline Intellectual Property (No 2) Ltd | Compounds |
ES2889926T3 (es) | 2017-05-11 | 2022-01-14 | Bristol Myers Squibb Co | Tienopiridinas y benzotiofenos útiles como inhibidores de IRAK4 |
CN110785418A (zh) | 2017-06-21 | 2020-02-11 | 豪夫迈·罗氏有限公司 | 作为irak4调节剂的异二氢吲哚酮衍生物 |
WO2018234345A1 (en) | 2017-06-21 | 2018-12-27 | F. Hoffmann-La Roche Ag | PYRAZOLO [1,5A] PYRIMIDINE DERIVATIVES AS MODULATORS OF IRAK4 |
EP3684366A4 (en) | 2017-09-22 | 2021-09-08 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES OF THE LATEST |
AU2018338314A1 (en) | 2017-09-22 | 2020-04-09 | Kymera Therapeutics, Inc | Protein degraders and uses thereof |
WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
US10874743B2 (en) * | 2017-12-26 | 2020-12-29 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
EP3737675A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND THEIR USES |
EP3737666A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | PROTEIN DEGRADANTS AND USES THEREOF |
US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
TW202136268A (zh) | 2018-07-13 | 2021-10-01 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
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WO2020051572A1 (en) * | 2018-09-07 | 2020-03-12 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Brd4-jak2 inhibitors |
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BR112022011651A2 (pt) | 2019-12-17 | 2022-08-23 | Kymera Therapeutics Inc | Degradadores de irak e usos dos mesmos |
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US6825190B2 (en) | 2001-06-15 | 2004-11-30 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
AUPR688101A0 (en) | 2001-08-08 | 2001-08-30 | Luminis Pty Limited | Protein domains and their ligands |
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AU2011226073B2 (en) * | 2010-03-10 | 2015-05-28 | Astrazeneca Ab | 4-Phenyl pyridine analogues as protein kinase inhibitors. |
AU2012249240A1 (en) | 2011-04-29 | 2013-11-07 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitors |
CN104254533B (zh) | 2012-01-13 | 2017-09-08 | 百时美施贵宝公司 | 用作激酶抑制剂的噻唑或噻二唑取代的吡啶基化合物 |
WO2013106614A1 (en) | 2012-01-13 | 2013-07-18 | Bristol-Myers Squibb Company | Triazolyl-substituted pyridyl compounds useful as kinase inhibitors |
US9242975B2 (en) | 2012-01-13 | 2016-01-26 | Bristol-Myers Squibb Company | Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors |
BR112015009850A2 (pt) | 2012-11-08 | 2017-07-11 | Bristol Myers Squibb Co | compostos de piridila substituídos por heteroarila úteis como moduladores de quinase |
AU2013341185B2 (en) * | 2012-11-08 | 2017-07-13 | Bristol-Myers Squibb Company | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNalpha responses |
UY35935A (es) | 2014-01-03 | 2015-06-30 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Compuestos de nicotinamida sustituida con heteroarilo como inhibidores de quinasa y moduladores de irak-4 |
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2013
- 2013-11-07 BR BR112015009850A patent/BR112015009850A2/pt not_active IP Right Cessation
- 2013-11-07 SG SG11201503397YA patent/SG11201503397YA/en unknown
- 2013-11-07 EP EP13795914.4A patent/EP2917206B1/en active Active
- 2013-11-07 PE PE2015000613A patent/PE20150953A1/es not_active Application Discontinuation
- 2013-11-07 KR KR1020157014808A patent/KR20150079963A/ko not_active Application Discontinuation
- 2013-11-07 CA CA2890983A patent/CA2890983A1/en not_active Abandoned
- 2013-11-07 CN CN201380058618.7A patent/CN104781254B/zh active Active
- 2013-11-07 JP JP2015541886A patent/JP6204484B2/ja active Active
- 2013-11-07 ES ES13795914.4T patent/ES2615302T3/es active Active
- 2013-11-07 EA EA201590920A patent/EA024940B1/ru not_active IP Right Cessation
- 2013-11-07 MX MX2015005562A patent/MX2015005562A/es unknown
- 2013-11-07 AU AU2013341200A patent/AU2013341200A1/en not_active Abandoned
- 2013-11-07 WO PCT/US2013/068875 patent/WO2014074675A1/en active Application Filing
- 2013-11-07 TW TW102140575A patent/TW201427953A/zh unknown
- 2013-11-07 US US14/441,705 patent/US9657009B2/en active Active
-
2015
- 2015-05-04 IL IL238609A patent/IL238609A0/en unknown
- 2015-05-06 PH PH12015501005A patent/PH12015501005A1/en unknown
- 2015-05-07 TN TNP2015000175A patent/TN2015000175A1/fr unknown
- 2015-05-08 CL CL2015001249A patent/CL2015001249A1/es unknown
- 2015-06-03 CO CO15127843A patent/CO7400871A2/es unknown
-
2016
- 2016-02-22 HK HK16101951.7A patent/HK1213895A1/zh unknown
-
2017
- 2017-04-06 US US15/480,682 patent/US10023562B2/en active Active
-
2018
- 2018-06-15 US US16/009,389 patent/US10544133B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US10544133B2 (en) | 2020-01-28 |
IL238609A0 (en) | 2015-06-30 |
US9657009B2 (en) | 2017-05-23 |
ES2615302T3 (es) | 2017-06-06 |
HK1213895A1 (zh) | 2016-07-15 |
JP2016501186A (ja) | 2016-01-18 |
TW201427953A (zh) | 2014-07-16 |
CN104781254B (zh) | 2016-12-14 |
EA201590920A1 (ru) | 2015-09-30 |
US20180370956A1 (en) | 2018-12-27 |
US10023562B2 (en) | 2018-07-17 |
CA2890983A1 (en) | 2014-05-15 |
WO2014074675A1 (en) | 2014-05-15 |
AU2013341200A1 (en) | 2015-07-02 |
JP6204484B2 (ja) | 2017-09-27 |
CL2015001249A1 (es) | 2015-07-31 |
EP2917206B1 (en) | 2016-12-21 |
PH12015501005A1 (en) | 2015-07-27 |
TN2015000175A1 (en) | 2016-10-03 |
SG11201503397YA (en) | 2015-05-28 |
KR20150079963A (ko) | 2015-07-08 |
EP2917206A1 (en) | 2015-09-16 |
US20150284382A1 (en) | 2015-10-08 |
US20170210730A1 (en) | 2017-07-27 |
CN104781254A (zh) | 2015-07-15 |
MX2015005562A (es) | 2015-07-23 |
EA024940B1 (ru) | 2016-11-30 |
CO7400871A2 (es) | 2015-09-30 |
PE20150953A1 (es) | 2015-06-20 |
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Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2435 DE 05-09-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |