BR112016011170A8 - derivados de heteroaril ácido butanoico, seus usos, combinação e composição farmacêutica - Google Patents

derivados de heteroaril ácido butanoico, seus usos, combinação e composição farmacêutica Download PDF

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BR112016011170A8
BR112016011170A8 BR112016011170A BR112016011170A BR112016011170A8 BR 112016011170 A8 BR112016011170 A8 BR 112016011170A8 BR 112016011170 A BR112016011170 A BR 112016011170A BR 112016011170 A BR112016011170 A BR 112016011170A BR 112016011170 A8 BR112016011170 A8 BR 112016011170A8
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butanoic acid
derivatives
combination
pharmaceutical composition
heteroaryl
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BR112016011170A
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BR112016011170B1 (pt
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Bollbuck Birgit
Market Christian
Roehn Till
Miltz Wofgang
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Novartis Ag
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/42—Oxazoles
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    • A—HUMAN NECESSITIES
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    • A61K31/4245—Oxadiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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Abstract

a presente invenção refere-se a novos derivados de heteroaril ácido butanoico que são bons candidatos de fármaco, especialmente com relação a leucotrieno a4 hidrolase (lta4h). a presente invenção também se refere a composições farmacêuticas compreendendo referidos novos derivados de heteroaril ácido butanoico, métodos de uso de referidos compostos no tratamento de várias doenças e distúrbios, e processos para preparação de referidos novos compostos.
BR112016011170-2A 2013-12-20 2014-12-18 Derivados de ácido heteroaril butanóico, seus usos, combinação e composição farmacêutica BR112016011170B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP13199138 2013-12-20
EP13199138.2 2013-12-20
EP14181155.4 2014-08-15
EP14181155 2014-08-15
PCT/IB2014/067086 WO2015092740A1 (en) 2013-12-20 2014-12-18 Heteroaryl butanoic acid derivatives as lta4h inhibitors

Publications (2)

Publication Number Publication Date
BR112016011170A8 true BR112016011170A8 (pt) 2020-04-28
BR112016011170B1 BR112016011170B1 (pt) 2023-01-10

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BR112016011170-2A BR112016011170B1 (pt) 2013-12-20 2014-12-18 Derivados de ácido heteroaril butanóico, seus usos, combinação e composição farmacêutica

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US (4) US9981926B2 (pt)
EP (1) EP3083564B1 (pt)
JP (1) JP6500024B2 (pt)
KR (2) KR102423640B1 (pt)
CN (1) CN105829286B (pt)
AP (1) AP2016009301A0 (pt)
AU (1) AU2014369180B2 (pt)
BR (1) BR112016011170B1 (pt)
CA (1) CA2927564C (pt)
CL (1) CL2016001255A1 (pt)
CR (1) CR20160279A (pt)
CU (1) CU24360B1 (pt)
CY (1) CY1120715T1 (pt)
DK (1) DK3083564T3 (pt)
EA (1) EA034436B1 (pt)
EC (1) ECSP16062173A (pt)
ES (1) ES2690790T3 (pt)
GT (1) GT201600132A (pt)
HR (1) HRP20181506T1 (pt)
HU (1) HUE039615T2 (pt)
IL (1) IL245011B (pt)
LT (1) LT3083564T (pt)
MX (1) MX2016008247A (pt)
MY (1) MY180165A (pt)
NZ (1) NZ719169A (pt)
PE (1) PE20160899A1 (pt)
PH (1) PH12016500814B1 (pt)
PL (1) PL3083564T3 (pt)
PT (1) PT3083564T (pt)
RS (1) RS57642B1 (pt)
SG (1) SG11201602787YA (pt)
SI (1) SI3083564T1 (pt)
SV (1) SV2016005230A (pt)
TN (1) TN2016000127A1 (pt)
UA (1) UA117498C2 (pt)
UY (1) UY36178A (pt)
WO (1) WO2015092740A1 (pt)
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WO2017175185A1 (en) 2016-04-08 2017-10-12 Novartis Ag Heteroaryl butanoic acid derivatives as lta4h inhibitors
MX2020011114A (es) 2018-05-15 2021-01-29 Alkahest Inc Tratamiento de enfermedades asociadas con el envejecimiento con moduladores de la leucotrieno a4 hidrolasa.
CN112424207B (zh) 2018-07-25 2024-03-19 诺华股份有限公司 Nlrp3炎性小体抑制剂
AR115866A1 (es) * 2018-07-31 2021-03-03 Novartis Ag Formas cristalinas de un inhibidor de lta4h
WO2020095983A1 (ja) * 2018-11-07 2020-05-14 中外製薬株式会社 Ｏ－置換セリン誘導体の製造方法
WO2020144604A1 (en) * 2019-01-11 2020-07-16 Novartis Ag Lta4h inhibitors for the treatment of hidradenitis suppurativa
US10610280B1 (en) 2019-02-02 2020-04-07 Ayad K. M. Agha Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
TW202122078A (zh) 2019-09-06 2021-06-16 瑞士商諾華公司 使用lta4h抑制劑治療肝臟疾病之方法
WO2022034529A1 (en) 2020-08-14 2022-02-17 Novartis Ag Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
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