BR112015011112A2 - composto oligomérico, oligômero, composição farmacêutica, uso do composto oligomérico, método de síntese de um composto oligomérico e método de tratamento de uma doença. - Google Patents

composto oligomérico, oligômero, composição farmacêutica, uso do composto oligomérico, método de síntese de um composto oligomérico e método de tratamento de uma doença.

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Publication number
BR112015011112A2
BR112015011112A2 BR112015011112-2A BR112015011112A BR112015011112A2 BR 112015011112 A2 BR112015011112 A2 BR 112015011112A2 BR 112015011112 A BR112015011112 A BR 112015011112A BR 112015011112 A2 BR112015011112 A2 BR 112015011112A2
Authority
BR
Brazil
Prior art keywords
oligomeric compound
oligomer
disease
synthesis
treating
Prior art date
Application number
BR112015011112-2A
Other languages
English (en)
Inventor
Albaek Nanna
Frydenlund Hansen Henrik
Ørum Henrik
Ravn Jacob
Kammler Susanne
Original Assignee
Roche Innovation Center Copenhagen A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Innovation Center Copenhagen A/S filed Critical Roche Innovation Center Copenhagen A/S
Publication of BR112015011112A2 publication Critical patent/BR112015011112A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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BR112015011112-2A 2012-11-15 2013-11-14 composto oligomérico, oligômero, composição farmacêutica, uso do composto oligomérico, método de síntese de um composto oligomérico e método de tratamento de uma doença. BR112015011112A2 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP12192773 2012-11-15
EP12192773.5 2012-11-15
EP13153296 2013-01-30
EP13153296.2 2013-01-30
EP13157237 2013-02-28
EP13157237.2 2013-02-28
EP13174092.0 2013-06-27
EP13174092 2013-06-27
PCT/EP2013/073858 WO2014076195A1 (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Publications (1)

Publication Number Publication Date
BR112015011112A2 true BR112015011112A2 (pt) 2018-11-06

Family

ID=49584733

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112015011112-2A BR112015011112A2 (pt) 2012-11-15 2013-11-14 composto oligomérico, oligômero, composição farmacêutica, uso do composto oligomérico, método de síntese de um composto oligomérico e método de tratamento de uma doença.
BR112015010116A BR112015010116A2 (pt) 2012-11-15 2013-11-14 COMPOSTOS CONJUGADOS ANTI-SENTIDO ANTI-ApoB

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Application Number Title Priority Date Filing Date
BR112015010116A BR112015010116A2 (pt) 2012-11-15 2013-11-14 COMPOSTOS CONJUGADOS ANTI-SENTIDO ANTI-ApoB

Country Status (22)

Country Link
US (4) US20150291958A1 (pt)
EP (3) EP2920304B1 (pt)
JP (3) JP6452614B2 (pt)
KR (2) KR102112892B1 (pt)
CN (3) CN117126846A (pt)
AU (2) AU2013346767B2 (pt)
BR (2) BR112015011112A2 (pt)
CA (2) CA2889596C (pt)
DK (2) DK2920304T3 (pt)
ES (1) ES2724853T3 (pt)
HK (2) HK1210213A1 (pt)
HR (1) HRP20190826T1 (pt)
IL (2) IL238448B (pt)
MX (2) MX2015005792A (pt)
MY (1) MY173826A (pt)
NZ (1) NZ708171A (pt)
PL (1) PL2920304T3 (pt)
RU (3) RU2653438C2 (pt)
SG (2) SG10201804331TA (pt)
SI (1) SI2920304T1 (pt)
WO (2) WO2014076196A1 (pt)
ZA (1) ZA201503375B (pt)

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