EA201492116A1 - Композиции и способы для модулирования экспрессии mecp2 - Google Patents

Композиции и способы для модулирования экспрессии mecp2

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Publication number
EA201492116A1
EA201492116A1 EA201492116A EA201492116A EA201492116A1 EA 201492116 A1 EA201492116 A1 EA 201492116A1 EA 201492116 A EA201492116 A EA 201492116A EA 201492116 A EA201492116 A EA 201492116A EA 201492116 A1 EA201492116 A1 EA 201492116A1
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Eurasian Patent Office
Prior art keywords
expression
mecp2
methods
modulating
compositions
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EA201492116A
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English (en)
Inventor
Артур М. Криг
Ромеш Субраманиан
Джеймс Максвиджен
Джинни Т. Ли
Original Assignee
Рана Терапьютикс, Инк.
ДЗЕ ДЖЕНЕРАЛ ХОСПИТАЛ КОРПОРЕЙШН д/б/а МАССАЧУСЕТС ДЖЕНЕРАЛ ХОСПИТАЛ
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Publication of EA201492116A1 publication Critical patent/EA201492116A1/ru

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Abstract

Аспекты настоящего изобретения относятся к одноцепочечным олигонуклеотидам для активации или усиления экспрессии МЕСР2. Дополнительные аспекты относятся к композициям и наборам, содержащим одноцепочечные олигонуклеотиды для активации или усиления экспрессии МЕСР2. Также предложены способы модуляции экспрессии МЕСР2 с использованием одноцепочечных олигонуклеотидов. Дополнительные аспекты настоящего изобретения относятся к способам отбора олигонуклеотида-кандидата для активации или усиления экспрессии МЕСР2.
EA201492116A 2012-05-16 2013-05-16 Композиции и способы для модулирования экспрессии mecp2 EA201492116A1 (ru)

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US201261648051P 2012-05-16 2012-05-16
PCT/US2013/041394 WO2013173608A1 (en) 2012-05-16 2013-05-16 Compositions and methods for modulating mecp2 expression

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EA201492116A1 true EA201492116A1 (ru) 2015-05-29

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US (3) US20150152410A1 (ru)
EP (1) EP2850190B1 (ru)
JP (1) JP2015518712A (ru)
CN (1) CN104583402A (ru)
AU (1) AU2013262709A1 (ru)
CA (1) CA2873779A1 (ru)
EA (1) EA201492116A1 (ru)
WO (1) WO2013173608A1 (ru)

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