MX363068B - Conjugados de oligonucleotido. - Google Patents

Conjugados de oligonucleotido.

Info

Publication number
MX363068B
MX363068B MX2015005794A MX2015005794A MX363068B MX 363068 B MX363068 B MX 363068B MX 2015005794 A MX2015005794 A MX 2015005794A MX 2015005794 A MX2015005794 A MX 2015005794A MX 363068 B MX363068 B MX 363068B
Authority
MX
Mexico
Prior art keywords
oligonucleotide conjugates
cleavable
oligonucleotides
conjugate
enhance
Prior art date
Application number
MX2015005794A
Other languages
English (en)
Other versions
MX2015005794A (es
Inventor
Albaek Nanna
Frydenlund Hansen Henrik
Kammler Susanne
Ravn Jacob
Ørum Henrik
Original Assignee
Roche Innovation Ct Copenhagen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Innovation Ct Copenhagen As filed Critical Roche Innovation Ct Copenhagen As
Publication of MX2015005794A publication Critical patent/MX2015005794A/es
Publication of MX363068B publication Critical patent/MX363068B/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/3517—Marker; Tag
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Abstract

La invención se refiere al campo de terapéuticos de oligonucleótido, y en particular al uso de una escisión, por ejemplo una región fosfodiéster unida covalentemente a un conjugado, un grupo objetivo o grupo de bloqueo para aumentar las propiedades de los oligonucleótidos, por ejemplo para mejorar el índice terapéutico.
MX2015005794A 2012-11-15 2013-11-14 Conjugados de oligonucleotido. MX363068B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12192773 2012-11-15
EP13153296 2013-01-30
EP13157237 2013-02-28
EP13174092 2013-06-27
PCT/EP2013/073858 WO2014076195A1 (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Publications (2)

Publication Number Publication Date
MX2015005794A MX2015005794A (es) 2016-01-12
MX363068B true MX363068B (es) 2019-03-07

Family

ID=49584733

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015005794A MX363068B (es) 2012-11-15 2013-11-14 Conjugados de oligonucleotido.
MX2015005792A MX2015005792A (es) 2012-11-15 2013-11-14 Compuestos de conjugado antisentido anti apob.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2015005792A MX2015005792A (es) 2012-11-15 2013-11-14 Compuestos de conjugado antisentido anti apob.

Country Status (22)

Country Link
US (4) US10077443B2 (es)
EP (3) EP2920307B1 (es)
JP (3) JP2016503300A (es)
KR (2) KR20150083920A (es)
CN (3) CN104837996A (es)
AU (2) AU2013346767B2 (es)
BR (2) BR112015010116A2 (es)
CA (2) CA2889044A1 (es)
DK (2) DK2920307T3 (es)
ES (1) ES2724853T3 (es)
HK (2) HK1210213A1 (es)
HR (1) HRP20190826T1 (es)
IL (2) IL238448B (es)
MX (2) MX363068B (es)
MY (1) MY173826A (es)
NZ (1) NZ708171A (es)
PL (1) PL2920304T3 (es)
RU (3) RU2015119411A (es)
SG (2) SG11201503821YA (es)
SI (1) SI2920304T1 (es)
WO (2) WO2014076196A1 (es)
ZA (1) ZA201503375B (es)

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