SG10201804331TA - Oligonucleotide conjugates - Google Patents

Oligonucleotide conjugates

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Publication number
SG10201804331TA
SG10201804331TA SG10201804331TA SG10201804331TA SG10201804331TA SG 10201804331T A SG10201804331T A SG 10201804331TA SG 10201804331T A SG10201804331T A SG 10201804331TA SG 10201804331T A SG10201804331T A SG 10201804331TA SG 10201804331T A SG10201804331T A SG 10201804331TA
Authority
SG
Singapore
Prior art keywords
oligonucleotide conjugates
oligonucleotide
cleavable
oligonucleotides
conjugate
Prior art date
Application number
SG10201804331TA
Inventor
Nanna Albæk
Henrik Frydenlund Hansen
Susanne Kammler
Jacob Ravn
HENRIK øRUM
Original Assignee
Roche Innovation Ct Copenhagen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Roche Innovation Ct Copenhagen As filed Critical Roche Innovation Ct Copenhagen As
Publication of SG10201804331TA publication Critical patent/SG10201804331TA/en

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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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Abstract

OLIGONUCLEOTIDE CONJUGATES The invention relates to the field of oligonucleotide therapeutics, and in particular to the use of a cleavable, e.g. a phosphodiester region covalently attached to a conjugate, a targeting group or blocking group to enhance the properties of the oligonucleotides, for example to improve the therapeutic index. [Fig. 3] 5 10
SG10201804331TA 2012-11-15 2013-11-14 Oligonucleotide conjugates SG10201804331TA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12192773 2012-11-15
EP13153296 2013-01-30
EP13157237 2013-02-28
EP13174092 2013-06-27

Publications (1)

Publication Number Publication Date
SG10201804331TA true SG10201804331TA (en) 2018-07-30

Family

ID=49584733

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201804331TA SG10201804331TA (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates
SG11201503821YA SG11201503821YA (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201503821YA SG11201503821YA (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Country Status (22)

Country Link
US (4) US20150291958A1 (en)
EP (3) EP2920304B1 (en)
JP (3) JP6452614B2 (en)
KR (2) KR102112892B1 (en)
CN (3) CN117126846A (en)
AU (2) AU2013346767B2 (en)
BR (2) BR112015011112A2 (en)
CA (2) CA2889596C (en)
DK (2) DK2920304T3 (en)
ES (1) ES2724853T3 (en)
HK (2) HK1210213A1 (en)
HR (1) HRP20190826T1 (en)
IL (2) IL238448B (en)
MX (2) MX2015005792A (en)
MY (1) MY173826A (en)
NZ (1) NZ708171A (en)
PL (1) PL2920304T3 (en)
RU (3) RU2653438C2 (en)
SG (2) SG10201804331TA (en)
SI (1) SI2920304T1 (en)
WO (2) WO2014076196A1 (en)
ZA (1) ZA201503375B (en)

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