BR112013015687A2 - anticorpo anti-pcsk9 ou um fragmento de anticorpo que se liga a pcsk9, ácido nucleico isolado, vetor, célula hospedeira, método para fabricar um anticorpo anti-pcsk9, composição farmacêutica, método de redução do nível de colesterol ldl em um sujeito e método de tratamento de hipercolesterolemia em um sujeito - Google Patents
anticorpo anti-pcsk9 ou um fragmento de anticorpo que se liga a pcsk9, ácido nucleico isolado, vetor, célula hospedeira, método para fabricar um anticorpo anti-pcsk9, composição farmacêutica, método de redução do nível de colesterol ldl em um sujeito e método de tratamento de hipercolesterolemia em um sujeitoInfo
- Publication number
- BR112013015687A2 BR112013015687A2 BR112013015687A BR112013015687A BR112013015687A2 BR 112013015687 A2 BR112013015687 A2 BR 112013015687A2 BR 112013015687 A BR112013015687 A BR 112013015687A BR 112013015687 A BR112013015687 A BR 112013015687A BR 112013015687 A2 BR112013015687 A2 BR 112013015687A2
- Authority
- BR
- Brazil
- Prior art keywords
- pcsk9
- subject
- antibody
- hypercholesterolemia
- binds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061426343P | 2010-12-22 | 2010-12-22 | |
US201161477788P | 2011-04-21 | 2011-04-21 | |
PCT/US2011/066593 WO2012088313A1 (en) | 2010-12-22 | 2011-12-21 | Anti-pcsk9 antibodies and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013015687A2 true BR112013015687A2 (pt) | 2016-10-11 |
Family
ID=45476670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013015687A BR112013015687A2 (pt) | 2010-12-22 | 2011-12-21 | anticorpo anti-pcsk9 ou um fragmento de anticorpo que se liga a pcsk9, ácido nucleico isolado, vetor, célula hospedeira, método para fabricar um anticorpo anti-pcsk9, composição farmacêutica, método de redução do nível de colesterol ldl em um sujeito e método de tratamento de hipercolesterolemia em um sujeito |
Country Status (19)
Country | Link |
---|---|
US (1) | US20120195910A1 (pt) |
EP (1) | EP2655419A1 (pt) |
JP (1) | JP2014511106A (pt) |
KR (1) | KR20130118925A (pt) |
CN (1) | CN103261230A (pt) |
AR (1) | AR084456A1 (pt) |
AU (1) | AU2011348232A1 (pt) |
BR (1) | BR112013015687A2 (pt) |
CA (1) | CA2820953A1 (pt) |
CO (1) | CO6721041A2 (pt) |
CR (1) | CR20130336A (pt) |
EA (1) | EA201390929A1 (pt) |
EC (1) | ECSP13012786A (pt) |
MA (1) | MA34818B1 (pt) |
MX (1) | MX2013007168A (pt) |
SG (1) | SG191219A1 (pt) |
TW (1) | TW201307391A (pt) |
WO (1) | WO2012088313A1 (pt) |
ZA (1) | ZA201304153B (pt) |
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JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
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-
2011
- 2011-12-21 BR BR112013015687A patent/BR112013015687A2/pt not_active IP Right Cessation
- 2011-12-21 CA CA2820953A patent/CA2820953A1/en not_active Abandoned
- 2011-12-21 EP EP11808100.9A patent/EP2655419A1/en not_active Withdrawn
- 2011-12-21 EA EA201390929A patent/EA201390929A1/ru unknown
- 2011-12-21 MA MA36099A patent/MA34818B1/fr unknown
- 2011-12-21 AU AU2011348232A patent/AU2011348232A1/en not_active Abandoned
- 2011-12-21 TW TW100147837A patent/TW201307391A/zh unknown
- 2011-12-21 SG SG2013046792A patent/SG191219A1/en unknown
- 2011-12-21 MX MX2013007168A patent/MX2013007168A/es not_active Application Discontinuation
- 2011-12-21 WO PCT/US2011/066593 patent/WO2012088313A1/en active Application Filing
- 2011-12-21 JP JP2013546383A patent/JP2014511106A/ja active Pending
- 2011-12-21 CN CN2011800598912A patent/CN103261230A/zh active Pending
- 2011-12-21 KR KR1020137019208A patent/KR20130118925A/ko not_active Application Discontinuation
- 2011-12-21 AR ARP110104843A patent/AR084456A1/es not_active Application Discontinuation
- 2011-12-21 US US13/333,315 patent/US20120195910A1/en not_active Abandoned
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2013
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- 2013-06-21 CO CO13148383A patent/CO6721041A2/es unknown
- 2013-07-09 CR CR20130336A patent/CR20130336A/es unknown
- 2013-07-22 EC ECSP13012786 patent/ECSP13012786A/es unknown
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JP2014511106A (ja) | 2014-05-08 |
MA34818B1 (fr) | 2014-01-02 |
CA2820953A1 (en) | 2012-06-28 |
MX2013007168A (es) | 2013-11-04 |
EP2655419A1 (en) | 2013-10-30 |
WO2012088313A1 (en) | 2012-06-28 |
SG191219A1 (en) | 2013-07-31 |
TW201307391A (zh) | 2013-02-16 |
ECSP13012786A (es) | 2013-09-30 |
US20120195910A1 (en) | 2012-08-02 |
CO6721041A2 (es) | 2013-07-31 |
CR20130336A (es) | 2013-10-22 |
AR084456A1 (es) | 2013-05-15 |
AU2011348232A1 (en) | 2013-07-18 |
ZA201304153B (en) | 2014-08-27 |
EA201390929A1 (ru) | 2013-12-30 |
CN103261230A (zh) | 2013-08-21 |
KR20130118925A (ko) | 2013-10-30 |
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