PT1879901E - Pirrolobenzodiazepinas - Google Patents
PirrolobenzodiazepinasInfo
- Publication number
- PT1879901E PT1879901E PT06726846T PT06726846T PT1879901E PT 1879901 E PT1879901 E PT 1879901E PT 06726846 T PT06726846 T PT 06726846T PT 06726846 T PT06726846 T PT 06726846T PT 1879901 E PT1879901 E PT 1879901E
- Authority
- PT
- Portugal
- Prior art keywords
- me3sn
- nhr
- halo
- nitro
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0508084A GB0508084D0 (en) | 2005-04-21 | 2005-04-21 | Pyrrolobenzodiazepines |
| GB0522746A GB0522746D0 (en) | 2005-11-07 | 2005-11-07 | Pyrrolobenzodiazepines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1879901E true PT1879901E (pt) | 2010-03-29 |
Family
ID=36589321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06726846T PT1879901E (pt) | 2005-04-21 | 2006-04-21 | Pirrolobenzodiazepinas |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7612062B2 (pt) |
| EP (1) | EP1879901B1 (pt) |
| JP (1) | JP5061096B2 (pt) |
| KR (1) | KR101396095B1 (pt) |
| AT (1) | ATE452898T1 (pt) |
| AU (1) | AU2006238686B2 (pt) |
| BR (1) | BRPI0610284A8 (pt) |
| CA (1) | CA2604805C (pt) |
| CY (1) | CY1109911T1 (pt) |
| DE (1) | DE602006011300D1 (pt) |
| DK (1) | DK1879901T3 (pt) |
| ES (1) | ES2338696T3 (pt) |
| GB (1) | GB2439881C (pt) |
| MX (1) | MX2007013039A (pt) |
| NZ (1) | NZ563136A (pt) |
| PL (1) | PL1879901T3 (pt) |
| PT (1) | PT1879901E (pt) |
| SI (1) | SI1879901T1 (pt) |
| WO (1) | WO2006111759A1 (pt) |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5079103U (pt) * | 1973-11-24 | 1975-07-09 | ||
| GB9818730D0 (en) * | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
| GB0404577D0 (en) * | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
| US7741319B2 (en) * | 2004-03-01 | 2010-06-22 | Spirogen Limited | 11-hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines |
| GB0404574D0 (en) * | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Amino acids |
| WO2005085260A1 (en) * | 2004-03-09 | 2005-09-15 | Spirogen Limited | Pyrrolobenzodiazepines |
| GB0410725D0 (en) * | 2004-05-13 | 2004-06-16 | Spirogen Ltd | Pyrrolobenzodiazepine therapeutic agents |
| MX2007013039A (es) * | 2005-04-21 | 2008-03-13 | Spirogen Ltd | Pirrolobenzodiazepinas. |
| US8637664B2 (en) * | 2005-10-05 | 2014-01-28 | Spirogen Sarl | Alkyl 4- [4- (5-oxo-2,3,5, 11a-tetrahydo-5H-pyrrolo [2, 1-c] [1,4] benzodiazepine-8-yloxy)-butyrylamino]-1H-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease |
| KR100952137B1 (ko) * | 2008-04-18 | 2010-04-09 | 실리콘 디스플레이 (주) | 입체 영상 디스플레이 장치 및 그 제조방법 |
| WO2010008208A2 (ko) | 2008-07-17 | 2010-01-21 | 주식회사 파버나인코리아 | 유기 발광 다이오드 입체영상 표시장치 |
| GB0813432D0 (en) * | 2008-07-22 | 2008-08-27 | Spirogen Ltd | Pyrrolobenzodiazepines |
| GB0819095D0 (en) * | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
| GB0819097D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
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| EP2789622B1 (en) * | 2010-04-15 | 2017-03-01 | MedImmune Limited | Pyrrolobenzodiazepines used to treat proliferative diseases |
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| AR085091A1 (es) | 2011-01-26 | 2013-09-11 | Kolltan Pharmaceuticals Inc | Anticuerpos anti-kit y sus usos |
| ES2744226T3 (es) | 2011-05-08 | 2020-02-24 | Legochem Biosciences Inc | Conjugados de proteína-agente activo y método para preparar los mismos |
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| KR101961976B1 (ko) * | 2011-10-14 | 2019-03-25 | 시애틀 지네틱스, 인크. | 피롤로벤조디아제핀 및 표적 접합체 |
| EP2751111B1 (en) | 2011-10-14 | 2017-04-26 | MedImmune Limited | Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases |
| CN108164551A (zh) | 2011-10-14 | 2018-06-15 | 西雅图基因公司 | 吡咯并苯并二氮杂卓和靶向结合物 |
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| US9102704B2 (en) | 2011-10-14 | 2015-08-11 | Spirogen Sarl | Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines |
| EA027386B1 (ru) | 2011-10-14 | 2017-07-31 | Медимьюн Лимитед | Пирролобензодиазепины |
| CN104684914B (zh) | 2012-04-30 | 2017-12-15 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓 |
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| DK3381943T3 (da) | 2012-07-25 | 2022-05-16 | Celldex Therapeutics Inc | Anti-kit-antistoffer og anvendelser deraf |
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| EP2906250B1 (en) | 2012-10-12 | 2018-05-30 | ADC Therapeutics SA | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
| RS61294B1 (sr) | 2012-10-12 | 2021-02-26 | Medimmune Ltd | Pirolobenzodiazepini i njihovi konjugati |
| EP2922818B1 (en) | 2012-11-24 | 2018-09-05 | Hangzhou Dac Biotech Co., Ltd | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
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| BR112015014669B1 (pt) | 2012-12-21 | 2023-09-26 | Medimmune Limited | Compostos pirrolobenzodiazepinas, conjugados compreendendo os mesmos e uso destes para tratar uma doença proliferativa |
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| DK3122757T3 (da) | 2014-02-28 | 2023-10-09 | Hangzhou Dac Biotech Co Ltd | Ladede linkere og anvendelse deraf til konjugering |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5569587A (en) * | 1978-11-17 | 1980-05-26 | Meiji Seika Kaisha Ltd | Novel antibiotic neothramycin derivative and its preparation |
| JPS5615289A (en) * | 1979-07-17 | 1981-02-14 | Green Cross Corp:The | Novel benzodiazepinnbased compound 3 |
| JPS58180487A (ja) | 1982-04-16 | 1983-10-21 | Kyowa Hakko Kogyo Co Ltd | 抗生物質ｄｃ−８１およびその製造法 |
| GB9205051D0 (en) | 1992-03-09 | 1992-04-22 | Cancer Res Campaign Tech | Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them |
| FR2696176B1 (fr) * | 1992-09-28 | 1994-11-10 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique. |
| US6187797B1 (en) | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
| GB9818732D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collection of compounds |
| GB9818731D0 (en) * | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Compounds |
| US7049311B1 (en) | 1998-08-27 | 2006-05-23 | Spirogen Limited | Pyrrolbenzodiazepines |
| GB9818730D0 (en) * | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
| US6909006B1 (en) * | 1999-08-27 | 2005-06-21 | Spirogen Limited | Cyclopropylindole derivatives |
| US6660856B2 (en) | 2002-03-08 | 2003-12-09 | Kaohsiung Medical University | Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues |
| US20040138269A1 (en) | 2002-10-11 | 2004-07-15 | Sugen, Inc. | Substituted pyrroles as kinase inhibitors |
| GB0226593D0 (en) * | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
| GB0321295D0 (en) | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
| GB0416511D0 (en) * | 2003-10-22 | 2004-08-25 | Spirogen Ltd | Pyrrolobenzodiazepines |
| WO2005040170A2 (en) | 2003-10-22 | 2005-05-06 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto |
| GB0404578D0 (en) * | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
| US7741319B2 (en) * | 2004-03-01 | 2010-06-22 | Spirogen Limited | 11-hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines |
| GB0404574D0 (en) * | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Amino acids |
| GB0404577D0 (en) | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
| WO2005085260A1 (en) | 2004-03-09 | 2005-09-15 | Spirogen Limited | Pyrrolobenzodiazepines |
| GB0410725D0 (en) * | 2004-05-13 | 2004-06-16 | Spirogen Ltd | Pyrrolobenzodiazepine therapeutic agents |
| MX2007013039A (es) | 2005-04-21 | 2008-03-13 | Spirogen Ltd | Pirrolobenzodiazepinas. |
| US8637664B2 (en) * | 2005-10-05 | 2014-01-28 | Spirogen Sarl | Alkyl 4- [4- (5-oxo-2,3,5, 11a-tetrahydo-5H-pyrrolo [2, 1-c] [1,4] benzodiazepine-8-yloxy)-butyrylamino]-1H-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease |
-
2006
- 2006-04-21 MX MX2007013039A patent/MX2007013039A/es active IP Right Grant
- 2006-04-21 PL PL06726846T patent/PL1879901T3/pl unknown
- 2006-04-21 EP EP06726846A patent/EP1879901B1/en active Active
- 2006-04-21 JP JP2008507165A patent/JP5061096B2/ja not_active Expired - Fee Related
- 2006-04-21 AT AT06726846T patent/ATE452898T1/de active
- 2006-04-21 US US11/911,890 patent/US7612062B2/en not_active Expired - Fee Related
- 2006-04-21 NZ NZ563136A patent/NZ563136A/en not_active IP Right Cessation
- 2006-04-21 AU AU2006238686A patent/AU2006238686B2/en not_active Ceased
- 2006-04-21 BR BRPI0610284A patent/BRPI0610284A8/pt not_active Application Discontinuation
- 2006-04-21 ES ES06726846T patent/ES2338696T3/es active Active
- 2006-04-21 CA CA2604805A patent/CA2604805C/en not_active Expired - Fee Related
- 2006-04-21 GB GB0720721A patent/GB2439881C/en not_active Expired - Fee Related
- 2006-04-21 KR KR1020077027047A patent/KR101396095B1/ko active IP Right Grant
- 2006-04-21 DK DK06726846.6T patent/DK1879901T3/da active
- 2006-04-21 PT PT06726846T patent/PT1879901E/pt unknown
- 2006-04-21 WO PCT/GB2006/001456 patent/WO2006111759A1/en not_active Application Discontinuation
- 2006-04-21 SI SI200630604T patent/SI1879901T1/sl unknown
- 2006-04-21 DE DE602006011300T patent/DE602006011300D1/de active Active
-
2009
- 2009-11-02 US US12/610,478 patent/US8633185B2/en not_active Expired - Fee Related
-
2010
- 2010-03-18 CY CY20101100248T patent/CY1109911T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080004618A (ko) | 2008-01-09 |
| SI1879901T1 (sl) | 2010-04-30 |
| US20080167293A1 (en) | 2008-07-10 |
| EP1879901B1 (en) | 2009-12-23 |
| WO2006111759A1 (en) | 2006-10-26 |
| GB2439881A (en) | 2008-01-09 |
| GB0720721D0 (en) | 2007-12-05 |
| DE602006011300D1 (de) | 2010-02-04 |
| MX2007013039A (es) | 2008-03-13 |
| ES2338696T3 (es) | 2010-05-11 |
| US7612062B2 (en) | 2009-11-03 |
| EP1879901A1 (en) | 2008-01-23 |
| JP2008536905A (ja) | 2008-09-11 |
| US20100113425A1 (en) | 2010-05-06 |
| AU2006238686A1 (en) | 2006-10-26 |
| NZ563136A (en) | 2009-11-27 |
| CA2604805C (en) | 2014-05-27 |
| GB2439881B (en) | 2009-04-08 |
| AU2006238686B2 (en) | 2011-10-06 |
| CA2604805A1 (en) | 2006-10-26 |
| BRPI0610284A2 (pt) | 2010-06-08 |
| PL1879901T3 (pl) | 2010-06-30 |
| KR101396095B1 (ko) | 2014-05-15 |
| JP5061096B2 (ja) | 2012-10-31 |
| DK1879901T3 (da) | 2010-05-03 |
| BRPI0610284A8 (pt) | 2017-05-09 |
| CY1109911T1 (el) | 2014-09-10 |
| ATE452898T1 (de) | 2010-01-15 |
| US8633185B2 (en) | 2014-01-21 |
| GB2439881C (en) | 2011-08-10 |
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