BR0209975A - ácido lipoteicóico de bactérias de ácido lático e seu uso para modular respostas imunes mediadas por bactérias gram-negativas, potenciais bactérias gram-positivas patogênicas - Google Patents
ácido lipoteicóico de bactérias de ácido lático e seu uso para modular respostas imunes mediadas por bactérias gram-negativas, potenciais bactérias gram-positivas patogênicasInfo
- Publication number
- BR0209975A BR0209975A BR0209975-6A BR0209975A BR0209975A BR 0209975 A BR0209975 A BR 0209975A BR 0209975 A BR0209975 A BR 0209975A BR 0209975 A BR0209975 A BR 0209975A
- Authority
- BR
- Brazil
- Prior art keywords
- bacteria
- gram
- lactic acid
- immune responses
- acid
- Prior art date
Links
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title abstract 10
- 241000894006 Bacteria Species 0.000 title abstract 7
- 235000014655 lactic acid Nutrition 0.000 title abstract 5
- 239000004310 lactic acid Substances 0.000 title abstract 5
- 239000002253 acid Substances 0.000 title abstract 4
- 230000028993 immune response Effects 0.000 title abstract 4
- 241000192125 Firmicutes Species 0.000 title abstract 3
- 230000001404 mediated effect Effects 0.000 title abstract 3
- 230000001717 pathogenic effect Effects 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 208000034309 Bacterial disease carrier Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000012228 culture supernatant Substances 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000001508 eye Anatomy 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 abstract 1
- 235000019136 lipoic acid Nutrition 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 abstract 1
- 239000013588 oral product Substances 0.000 abstract 1
- 229940023486 oral product Drugs 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 abstract 1
- 229960002663 thioctic acid Drugs 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 229940025703 topical product Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Birds (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Genetics & Genomics (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
Abstract
"áCIDO LIPOTEICóICO DE BACTéRIAS DE áCIDO LáTICO E SEU USO PARA MODULAR RESPOSTAS IMUNES MEDIADAS POR BACTéRIAS GRAM-NEGATIVAS, POTENCIAIS BACTéRIAS GRAM POSITIVAS PATOGêNICAS". A invenção refere-se a uma composição para modulação de respostas imunes induzidas por bactérias Gram negativas, potenciais bactérias Gram positivas patogênicas e/ou seus derivados, compreendendo ácido lipoteicóico de bactérias de ácido lático como um ingrediente ativo. Ela também refere-se ao uso de um ácido lipoteicóico de bactérias de ácido lático como um ingrediente ativo e/ou bactérias de ácido lático produzindo o mesmo e /ou seu sobrenadante de cultura, na fabricação de um medicamento, um produto tópico ou oral para aplicações cosméticas, dermatológicas ou oftalmológicas, um alimento ou composição de alimento de animal doméstico para modulação de colonização bacterial, respostas imunes e diminuição de processos inflamatórios associados com doença e infecção bacterialmente mediadas no trato gastrointestinal, osso, pele, olho, ouvido, pulmão e cavidade oral. A invenção também refere-se a ácido lipoteicóico selecionado para a mesma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01201958A EP1260227A1 (en) | 2001-05-23 | 2001-05-23 | Lipoteichoic acid from lactic acid bacteria and its use to modulate immune responses mediated by gram-negative bacteria, potential pathogenic gram-positive bacteria |
PCT/EP2002/004436 WO2002094296A1 (en) | 2001-05-23 | 2002-04-23 | Lipoteichoic acid from lactic acid bacteria and its use to modulate immune responses mediated by gram-negative bacteria, potential pathogenic gram-positive bacteria |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0209975A true BR0209975A (pt) | 2004-04-06 |
Family
ID=8180365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0209975-6A BR0209975A (pt) | 2001-05-23 | 2002-04-23 | ácido lipoteicóico de bactérias de ácido lático e seu uso para modular respostas imunes mediadas por bactérias gram-negativas, potenciais bactérias gram-positivas patogênicas |
Country Status (21)
Country | Link |
---|---|
US (3) | US20040147010A1 (pt) |
EP (2) | EP1260227A1 (pt) |
JP (1) | JP4738717B2 (pt) |
KR (1) | KR20040018375A (pt) |
CN (1) | CN100502888C (pt) |
AT (1) | ATE394111T1 (pt) |
AU (1) | AU2002338873B8 (pt) |
BR (1) | BR0209975A (pt) |
CA (1) | CA2449403C (pt) |
DE (1) | DE60226436D1 (pt) |
DK (1) | DK1395269T3 (pt) |
ES (1) | ES2305256T3 (pt) |
IN (1) | IN2003DE02242A (pt) |
MX (1) | MX260807B (pt) |
NO (1) | NO20035187L (pt) |
PL (1) | PL366455A1 (pt) |
PT (1) | PT1395269E (pt) |
RU (1) | RU2320356C2 (pt) |
SG (1) | SG101083A1 (pt) |
WO (1) | WO2002094296A1 (pt) |
ZA (1) | ZA200309821B (pt) |
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GB2408573A (en) * | 2003-11-25 | 2005-06-01 | Univ Leicester | Assay for the interaction of L-Ficolin with lipoteichoic acid |
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CA2680038A1 (en) * | 2007-03-08 | 2008-09-12 | The Governors Of The University Of Alberta | Bacterial endotoxin for the prevention of metabolic disorders and bacterial infections |
US20080299098A1 (en) * | 2007-04-24 | 2008-12-04 | Chea-Yun Se | Broad-Spectrum Antibacterial and Antifungal Activity of Lactobacillus Johnsonii D115 |
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CN111053789A (zh) * | 2019-11-26 | 2020-04-24 | 湖南营养树生物科技有限公司 | 调节免疫***的方法和组合物 |
CN115279380A (zh) * | 2019-12-27 | 2022-11-01 | 佰欧波利斯有限公司 | 来自双歧杆菌的脂磷壁酸的用途 |
KR102325947B1 (ko) * | 2020-02-05 | 2021-11-15 | 주식회사 에이치이엠파마 | 신규한 락토바실러스 사케이 hem224 균주, 및 상기 균주 또는 이의 배양물을 포함하는 염증 또는 천식의 치료용 조성물 |
JP2023179810A (ja) * | 2020-11-13 | 2023-12-20 | 味の素株式会社 | ラクトコッカス・ラクチス、ラクトバチルス属に属する微生物、又はこれらの混合微生物を含有する生菌剤及びその製造方法 |
JP2023128590A (ja) * | 2022-03-03 | 2023-09-14 | 株式会社アルソア慧央グループ | 腸管免疫賦活剤、IgA産生促進剤及び遺伝子発現促進剤 |
CN115068510A (zh) * | 2022-05-24 | 2022-09-20 | 宁波大学 | 一种乳杆菌脂磷壁酸的提取方法及其抗炎活性应用 |
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US4678773A (en) * | 1983-08-26 | 1987-07-07 | Chugai Seiyaku Kabushiki Kaisha | Antitumor agent |
JPS6048928A (ja) * | 1983-08-26 | 1985-03-16 | Chugai Pharmaceut Co Ltd | Tνf誘起剤 |
JPS61275217A (ja) * | 1985-05-29 | 1986-12-05 | Yakult Honsha Co Ltd | グラム陰性桿菌感染症防御剤 |
US5804179A (en) * | 1985-12-31 | 1998-09-08 | Research Corporation Technologies, Inc. | Lactobacillus compositions and methods for treating urinary tract infections |
DE3817762A1 (de) * | 1988-05-26 | 1989-11-30 | Sanum Kehlbeck Gmbh & Co Kg | Immunstimulierendes mittel aus propionibakterien sowie verfahren zur herstellung desselben |
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WO1994020115A2 (en) * | 1993-03-10 | 1994-09-15 | Miles, Inc. | Hyaluronic acid used as a cancer treatment |
US6180100B1 (en) * | 1994-09-30 | 2001-01-30 | Urex Biotech., Inc. | Lactobacillus compositions and methods for treating urinary tract infections |
JP3489930B2 (ja) * | 1996-03-08 | 2004-01-26 | 株式会社ヤクルト本社 | がん予防食品 |
DE69733594T2 (de) * | 1996-07-09 | 2005-11-03 | Société des Produits Nestlé S.A. | Verfahren zur Sprühtrocknung |
PT862863E (pt) * | 1997-01-09 | 2002-04-29 | Nestle Sa | Produto cerealifero contendo probioticos |
US5998482A (en) * | 1997-11-10 | 1999-12-07 | David; Sunil A. | Use of synthetic polycationic amphiphilic substances with fatty acid or hydrocarbon substituents as anti-sepsis agents |
JP3046303B1 (ja) * | 1999-06-24 | 2000-05-29 | 明治乳業株式会社 | Helicobacterpylori除菌性飲食品 |
DE19963420A1 (de) * | 1999-12-28 | 2001-07-12 | Sebo Gmbh | Gewinnung von biologischen Komponenten aus Körperflüssigkeiten |
-
2001
- 2001-05-23 EP EP01201958A patent/EP1260227A1/en not_active Withdrawn
-
2002
- 2002-04-23 KR KR20037015185A patent/KR20040018375A/ko not_active Application Discontinuation
- 2002-04-23 RU RU2003136828/15A patent/RU2320356C2/ru not_active IP Right Cessation
- 2002-04-23 MX MXPA03010598 patent/MX260807B/es active IP Right Grant
- 2002-04-23 DK DK02742909T patent/DK1395269T3/da active
- 2002-04-23 SG SG200306895A patent/SG101083A1/en unknown
- 2002-04-23 PL PL02366455A patent/PL366455A1/xx not_active IP Right Cessation
- 2002-04-23 US US10/478,079 patent/US20040147010A1/en not_active Abandoned
- 2002-04-23 AU AU2002338873A patent/AU2002338873B8/en not_active Ceased
- 2002-04-23 PT PT02742909T patent/PT1395269E/pt unknown
- 2002-04-23 ES ES02742909T patent/ES2305256T3/es not_active Expired - Lifetime
- 2002-04-23 BR BR0209975-6A patent/BR0209975A/pt not_active Application Discontinuation
- 2002-04-23 CA CA2449403A patent/CA2449403C/en not_active Expired - Fee Related
- 2002-04-23 JP JP2002591013A patent/JP4738717B2/ja not_active Expired - Fee Related
- 2002-04-23 WO PCT/EP2002/004436 patent/WO2002094296A1/en active IP Right Grant
- 2002-04-23 EP EP02742909A patent/EP1395269B1/en not_active Expired - Lifetime
- 2002-04-23 AT AT02742909T patent/ATE394111T1/de active
- 2002-04-23 DE DE60226436T patent/DE60226436D1/de not_active Expired - Lifetime
- 2002-04-23 CN CNB02810479XA patent/CN100502888C/zh not_active Expired - Fee Related
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2003
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- 2003-12-18 ZA ZA200309821A patent/ZA200309821B/xx unknown
- 2003-12-23 IN IN2242DE2003 patent/IN2003DE02242A/xx unknown
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2008
- 2008-10-07 US US12/246,991 patent/US8329190B2/en not_active Expired - Fee Related
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2013
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PT1395269E (pt) | 2008-06-16 |
KR20040018375A (ko) | 2004-03-03 |
DK1395269T3 (da) | 2008-08-04 |
NO20035187L (no) | 2004-01-05 |
ZA200309821B (en) | 2005-03-18 |
US8329190B2 (en) | 2012-12-11 |
IN2003DE02242A (en) | 2006-01-20 |
ES2305256T3 (es) | 2008-11-01 |
US20090142375A1 (en) | 2009-06-04 |
JP2005500267A (ja) | 2005-01-06 |
PL366455A1 (en) | 2005-02-07 |
RU2003136828A (ru) | 2005-03-10 |
MX260807B (es) | 2008-09-25 |
JP4738717B2 (ja) | 2011-08-03 |
RU2320356C2 (ru) | 2008-03-27 |
ATE394111T1 (de) | 2008-05-15 |
CN100502888C (zh) | 2009-06-24 |
NO20035187D0 (no) | 2003-11-21 |
US20140056927A1 (en) | 2014-02-27 |
CA2449403A1 (en) | 2002-11-28 |
DE60226436D1 (de) | 2008-06-19 |
CN1525863A (zh) | 2004-09-01 |
EP1395269A1 (en) | 2004-03-10 |
MXPA03010598A (es) | 2004-03-09 |
EP1395269B1 (en) | 2008-05-07 |
CA2449403C (en) | 2011-11-15 |
US20040147010A1 (en) | 2004-07-29 |
AU2002338873B2 (en) | 2008-04-10 |
WO2002094296A1 (en) | 2002-11-28 |
SG101083A1 (en) | 2006-02-28 |
AU2002338873B8 (en) | 2008-05-08 |
AU2002338873A1 (en) | 2002-12-03 |
EP1260227A1 (en) | 2002-11-27 |
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